正木 崇生TAKAO MASAKI

Last Updated :2017/11/01

所属・職名
病院(医) 泌尿・生殖器診療科 教授
メールアドレス
masakithiroshima-u.ac.jp
その他連絡先
広島市南区霞1-2-3 臨床管理棟2階 207号室
TEL:082-257-1506 FAX:082-257-1508

基本情報

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 腎臓内科学

所属学会

  • 日本内科学会 日本腎臓学会 日本透析医学会 日本腎臓リハビリテーション学会 日本腹膜透析医学会 日本HDF研究会 American Society of Nephrology International Society of Nephrology European Renal Association

教育活動

授業担当

  1. 2017年, 学部専門, 集中, 器官・システム病態制御学I
  2. 2017年, 学部専門, 集中, 医学研究実習
  3. 2017年, 学部専門, 集中, 臨床実習・臨床実践学
  4. 2017年, 学部専門, 集中, アドバンスト医学実習
  5. 2017年, 博士課程・博士課程後期, セメスター(前期), 腎臓内科学特別演習
  6. 2017年, 博士課程・博士課程後期, セメスター(後期), 腎臓内科学特別演習
  7. 2017年, 博士課程・博士課程後期, セメスター(前期), 腎臓内科学特別実験
  8. 2017年, 博士課程・博士課程後期, セメスター(後期), 腎臓内科学特別実験

研究活動

学術論文(★は代表的な論文)

  1. 15-Deoxy-Delta 12,14-prostaglandin J(2) Inhibits Angiotensin II-induced Fibronectin Expression via Hepatocyte Growth Factor Induction in Human Peritoneal Mesothelial Cells, THERAPEUTIC APHERESIS AND DIALYSIS, 14巻, 1号, pp.43-pp.51, FEB 2010
  2. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta 1 signaling, KIDNEY INTERNATIONAL, 84巻, 2号, pp.297-pp.307, AUG 2013
  3. PDGF receptor tyrosine kinase inhibitor suppresses mesangial cell proliferation involving STAT3 activation., Clin Exp Immunol, 144巻, 2号, pp.353-pp.361, 20060501
  4. 15-Deoxy-Δ12,14-prostaglandin J2 inhibits angiotensin Ⅱ-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells, Ther Apher Dial, 14巻, 1号, pp.43-pp.51, 20100201
  5. Tenascin expression may reflect the activity and chronicity of human IgA nephropathy., 50巻, 4号, pp.205-pp.213, 19981001
  6. Role of tenascin in human immunoglobulin A nephropathy., 25巻, 5号, pp.247-pp.254, 19970901
  7. The influence of steroid therapy in patients with IgA nephropathy., Nephron, 86巻, 6号, pp.197-pp.198, 20001001
  8. Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney., Kidney International, 63巻, 4号, pp.1256-pp.1264, 20030401
  9. Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis., Nephrology Dialysis Transplantation, 18巻, 1号, pp.178-pp.181, 20030101
  10. Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies., Journal of the American Society of Nephrology, 15巻, 7号, pp.1835-pp.1843, 20040601
  11. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis., Clin Exp Nephrol, 20130701
  12. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16巻, 6号, pp.921-pp.929, DEC 2012
  13. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats, PLOS ONE, 9巻, 4号, APR 2 2014
  14. Characteristic kidney pathology, gene abnormality and treatments in LCAT deficiency, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18巻, 2号, pp.189-pp.193, APR 2014
  15. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18巻, 3号, pp.499-pp.506, JUN 2014
  16. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9巻, 12号, pp.2117-pp.2122, DEC 2014
  17. Successful treatment with plasma exchange for ANCA-negative pauci-immune crescentic glomerulonephritis with D-negative hemolytic uremic syndrome, CLINICAL NEPHROLOGY, 82巻, 4号, pp.268-pp.272, OCT 2014
  18. The Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, INTERNAL MEDICINE, 54巻, 8号, pp.887-pp.894, 2015
  19. Hemodialysis Immediately After Cardiac Catheterization Is a Risk Factor for Intradialytic Hypotension, THERAPEUTIC APHERESIS AND DIALYSIS, 19巻, 3号, pp.245-pp.249, JUN 2015
  20. Expression of age-related factors during the development of renal damage in patients with IgA nephropathy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19巻, 5号, pp.830-pp.837, OCT 2015
  21. Vascular access intervention by a nephrologist in Hiroshima, JOURNAL OF VASCULAR ACCESS, 16巻, pp.S58-pp.S61, NOV 2015
  22. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27巻, 1号, pp.203-pp.215, JAN 2016
  23. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89巻, 1号, pp.147-pp.157, JAN 2016
  24. High glucose promotes TGF-beta 1 production by inducing FOS expression in human peritoneal mesothelial cells, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 20巻, 1号, pp.30-pp.38, FEB 2016
  25. Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model., Nephron Exp Nephrol, 112巻, 2号, pp.59-pp.69
  26. Effect of AST-120, an oral adsorbrnt, on inhibition of the loss of renal function in CRF patients, NEPHROLOGY DIALYSIS TRANSPLANTATION, 21巻, pp.383-pp.383, 2006
  27. Glucose-based PD solution, but not icodextrin-based PD solution, induces plasminogen activator inhibitor-1 and tissue-type plasminogen activator in human peritoneal mesothelial cells via ERK1/2, THERAPEUTIC APHERESIS AND DIALYSIS, 11巻, 2号, pp.94-pp.100, 2007
  28. Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction, NEPHROLOGY, 12巻, 6号, pp.565-pp.571, 2007
  29. Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury, TRANSPLANTATION, 84巻, 2号, pp.207-pp.213, 2007
  30. Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice., PLoS One., 11巻, 8号, pp.e0160993, 2016.8.11
  31. Hypomagnesemia as a predictor of mortality in hemodialysis patients and the role of proton pump inhibitors: A cross-sectional, 1-year, retrospective cohort study., Hemodial Int, 20巻, 4号, pp.580-pp.588, 2016.10
  32. Calcium channel antagonists reduce restenosis after percutaneous transluminal angioplasty of an arteriovenous fistula in hemodialysis patients, THERAPEUTIC APHERESIS AND DIALYSIS, 12巻, 3号, pp.232-pp.236, 2008
  33. Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis, NEPHROLOGY DIALYSIS TRANSPLANTATION, 23巻, 11号, pp.3418-pp.3426, 2008
  34. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta, LABORATORY INVESTIGATION, 89巻, 1号, pp.47-pp.58, 2009
  35. Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model, NEPHRON EXPERIMENTAL NEPHROLOGY, 112巻, 2号, pp.E59-pp.E69, 2009
  36. C-C Chemokine Receptor 2 Expression by Circulating Monocytes Influences Atherosclerosis in Patients on Chronic Hemodialysis, THERAPEUTIC APHERESIS AND DIALYSIS, 13巻, 3号, pp.205-pp.212, 2009
  37. 15-Deoxy-Delta 12,14-prostaglandin J(2) Inhibits Angiotensin II-induced Fibronectin Expression via Hepatocyte Growth Factor Induction in Human Peritoneal Mesothelial Cells, THERAPEUTIC APHERESIS AND DIALYSIS, 14巻, 1号, pp.43-pp.51, 2010
  38. A SUPER HIGH-FLUX DIALYZER (PS: APS-EA) ELIMINATES 40% OF INJECTED RECOMBINANT HUMAN (RH) ERITHROPOIETIN (EPO) DURING 4-HOUR HEMODIALYSIS (HD), NEPHROLOGY DIALYSIS TRANSPLANTATION, 27巻, pp.213-pp.213, 2012
  39. PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) HETERODIMERS REDUCE SERUM LDL-CHOLESTEROL (LDL-C) LEVELS IN MAINTENANCE HEMODIALYSIS (HD) PATIENTS ASSOCIATED WITH DYSLIPIDEMIA CHARACTERIZED BY INCREASED TRIGLYCERIDE-RICH LIPOPROTEINS, NEPHROLOGY DIALYSIS TRANSPLANTATION, 27巻, pp.215-pp.216, 2012
  40. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16巻, 6号, pp.921-pp.929, 2012
  41. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta 1 signaling, KIDNEY INTERNATIONAL, 84巻, 2号, pp.297-pp.307, 2013
  42. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats, PLOS ONE, 9巻, 4号, 2014
  43. Characteristic kidney pathology, gene abnormality and treatments in LCAT deficiency, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18巻, 2号, pp.189-pp.193, 2014
  44. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18巻, 3号, pp.499-pp.506, 2014
  45. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9巻, 12号, pp.2117-pp.2122, 2014
  46. Successful treatment with plasma exchange for ANCA-negative pauci-immune crescentic glomerulonephritis with D-negative hemolytic uremic syndrome, CLINICAL NEPHROLOGY, 82巻, 4号, pp.268-pp.272, 2014
  47. The Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, INTERNAL MEDICINE, 54巻, 8号, pp.887-pp.894, 2015
  48. Hemodialysis Immediately After Cardiac Catheterization Is a Risk Factor for Intradialytic Hypotension, THERAPEUTIC APHERESIS AND DIALYSIS, 19巻, 3号, pp.245-pp.249, 2015
  49. Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19巻, 4号, pp.631-pp.638, 2015
  50. Expression of age-related factors during the development of renal damage in patients with IgA nephropathy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19巻, 5号, pp.830-pp.837, 2015
  51. Vascular access intervention by a nephrologist in Hiroshima, JOURNAL OF VASCULAR ACCESS, 16巻, pp.S58-pp.S61, 2015
  52. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27巻, 1号, pp.203-pp.215, 2016
  53. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89巻, 1号, pp.147-pp.157, 2016
  54. High glucose promotes TGF-beta 1 production by inducing FOS expression in human peritoneal mesothelial cells, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 20巻, 1号, pp.30-pp.38, 2016

社会活動

学術雑誌論文査読歴

  1. 2015年, Kidney International Selebtion 日本語版, その他, 査読委員