TAKAO MASAKI

Last Updated :2019/12/02

Affiliations, Positions
Hiroshima University Hospital, ., Professor
E-mail
masakithiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Kidney internal medicine

Affiliated Academic Societies

  • The Japanese Society of Internal Medicine Japanese Society of Nephrology The Japanese Society for Dialysis Therapy The Japanese Association of Rehabilitation Medicine Japanese Society for Peritoneal Dialysis Japanese Society for Hemodiafiltration American Society of Nephrology International Society of Nephrology European Renal Association

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, Intensive, Clinical diagnosis and treatment I
  2. 2019, Undergraduate Education, Intensive, Practice for medical research
  3. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Nephrology
  4. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Nephrology
  5. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Nephrology
  6. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Nephrology
  7. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Nephrology
  8. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Nephrology
  9. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Nephrology
  10. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Nephrology

Research Activities

Academic Papers

  1. 15-Deoxy-Delta 12,14-prostaglandin J(2) Inhibits Angiotensin II-induced Fibronectin Expression via Hepatocyte Growth Factor Induction in Human Peritoneal Mesothelial Cells, THERAPEUTIC APHERESIS AND DIALYSIS, 14(1), 43-51, 201002
  2. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta 1 signaling, KIDNEY INTERNATIONAL, 84(2), 297-307, 201308
  3. PDGF receptor tyrosine kinase inhibitor suppresses mesangial cell proliferation involving STAT3 activation., Clin Exp Immunol, 144(2), 353-361, 20060501
  4. Tenascin expression may reflect the activity and chronicity of human IgA nephropathy., 50(4), 205-213, 19981001
  5. Role of tenascin in human immunoglobulin A nephropathy., 25(5), 247-254, 19970901
  6. The influence of steroid therapy in patients with IgA nephropathy., Nephron, 86(6), 197-198, 20001001
  7. Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney., Kidney International, 63(4), 1256-1264, 20030401
  8. Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis., Nephrology Dialysis Transplantation, 18(1), 178-181, 20030101
  9. Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies., Journal of the American Society of Nephrology, 15(7), 1835-1843, 20040601
  10. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis., Clin Exp Nephrol, 20130701
  11. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16(6), 921-929, 201212
  12. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats, PLOS ONE, 9(4), 20140402
  13. Characteristic kidney pathology, gene abnormality and treatments in LCAT deficiency, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18(2), 189-193, 201404
  14. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18(3), 499-506, 201406
  15. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, 201412
  16. Successful treatment with plasma exchange for ANCA-negative pauci-immune crescentic glomerulonephritis with D-negative hemolytic uremic syndrome, CLINICAL NEPHROLOGY, 82(4), 268-272, 201410
  17. The Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, INTERNAL MEDICINE, 54(8), 887-894, 2015
  18. Hemodialysis Immediately After Cardiac Catheterization Is a Risk Factor for Intradialytic Hypotension, THERAPEUTIC APHERESIS AND DIALYSIS, 19(3), 245-249, 201506
  19. Expression of age-related factors during the development of renal damage in patients with IgA nephropathy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(5), 830-837, 201510
  20. Vascular access intervention by a nephrologist in Hiroshima, JOURNAL OF VASCULAR ACCESS, 16, S58-S61, 201511
  21. Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model., Nephron Exp Nephrol, 112(2), 59-69, 2009
  22. Effect of AST-120, an oral adsorbrnt, on inhibition of the loss of renal function in CRF patients, NEPHROLOGY DIALYSIS TRANSPLANTATION, 21, 383-383, 2006
  23. Glucose-based PD solution, but not icodextrin-based PD solution, induces plasminogen activator inhibitor-1 and tissue-type plasminogen activator in human peritoneal mesothelial cells via ERK1/2, THERAPEUTIC APHERESIS AND DIALYSIS, 11(2), 94-100, 2007
  24. Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction, NEPHROLOGY, 12(6), 565-571, 2007
  25. Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury, TRANSPLANTATION, 84(2), 207-213, 2007
  26. Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice., PLoS One., 11(8), e0160993, 2016.8.11
  27. Hypomagnesemia as a predictor of mortality in hemodialysis patients and the role of proton pump inhibitors: A cross-sectional, 1-year, retrospective cohort study., Hemodial Int, 20(4), 580-588, 2016.10
  28. Calcium channel antagonists reduce restenosis after percutaneous transluminal angioplasty of an arteriovenous fistula in hemodialysis patients, THERAPEUTIC APHERESIS AND DIALYSIS, 12(3), 232-236, 2008
  29. Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis, NEPHROLOGY DIALYSIS TRANSPLANTATION, 23(11), 3418-3426, 2008
  30. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta, LABORATORY INVESTIGATION, 89(1), 47-58, 2009
  31. Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model, NEPHRON EXPERIMENTAL NEPHROLOGY, 112(2), E59-E69, 2009
  32. C-C Chemokine Receptor 2 Expression by Circulating Monocytes Influences Atherosclerosis in Patients on Chronic Hemodialysis, THERAPEUTIC APHERESIS AND DIALYSIS, 13(3), 205-212, 2009
  33. 15-Deoxy-Delta 12,14-prostaglandin J(2) Inhibits Angiotensin II-induced Fibronectin Expression via Hepatocyte Growth Factor Induction in Human Peritoneal Mesothelial Cells, THERAPEUTIC APHERESIS AND DIALYSIS, 14(1), 43-51, 2010
  34. A SUPER HIGH-FLUX DIALYZER (PS: APS-EA) ELIMINATES 40% OF INJECTED RECOMBINANT HUMAN (RH) ERITHROPOIETIN (EPO) DURING 4-HOUR HEMODIALYSIS (HD), NEPHROLOGY DIALYSIS TRANSPLANTATION, 27, 213-213, 2012
  35. PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) HETERODIMERS REDUCE SERUM LDL-CHOLESTEROL (LDL-C) LEVELS IN MAINTENANCE HEMODIALYSIS (HD) PATIENTS ASSOCIATED WITH DYSLIPIDEMIA CHARACTERIZED BY INCREASED TRIGLYCERIDE-RICH LIPOPROTEINS, NEPHROLOGY DIALYSIS TRANSPLANTATION, 27, 215-216, 2012
  36. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16(6), 921-929, 2012
  37. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta 1 signaling, KIDNEY INTERNATIONAL, 84(2), 297-307, 2013
  38. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats, PLOS ONE, 9(4), 2014
  39. Characteristic kidney pathology, gene abnormality and treatments in LCAT deficiency, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18(2), 189-193, 2014
  40. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18(3), 499-506, 2014
  41. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, 2014
  42. Successful treatment with plasma exchange for ANCA-negative pauci-immune crescentic glomerulonephritis with D-negative hemolytic uremic syndrome, CLINICAL NEPHROLOGY, 82(4), 268-272, 2014
  43. The Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, INTERNAL MEDICINE, 54(8), 887-894, 2015
  44. Hemodialysis Immediately After Cardiac Catheterization Is a Risk Factor for Intradialytic Hypotension, THERAPEUTIC APHERESIS AND DIALYSIS, 19(3), 245-249, 2015
  45. Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(4), 631-638, 2015
  46. Expression of age-related factors during the development of renal damage in patients with IgA nephropathy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(5), 830-837, 2015
  47. Vascular access intervention by a nephrologist in Hiroshima, JOURNAL OF VASCULAR ACCESS, 16, S58-S61, 2015
  48. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(1), 203-215, 2016
  49. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89(1), 147-157, 2016
  50. High glucose promotes TGF-beta 1 production by inducing FOS expression in human peritoneal mesothelial cells, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 20(1), 30-38, 2016
  51. Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis., Clin Exp Nephrol, 2017
  52. Valproic acid attenuates renal fibrosis through the induction of autophagy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 21(5), 771-780, 201710
  53. Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury, CEN CASE REPORTS, 6(2), 140-147, 201711
  54. Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP), AMERICAN JOURNAL OF HYPERTENSION, 31(1), 43-47, 201801
  55. Rationale and design of oBservational clinical Research In chronic kidney disease patients with renal anemia: renal proGnosis in patients with Hyporesponsive anemia To Erythropoiesis-stimulating agents, darbepoetiN alfa (BRIGHTEN Trial), CLINICAL AND EXPERIMENTAL NEPHROLOGY, 22(1), 78-84, 201802
  56. Addition of Novel Biomarkers for Predicting All-Cause and Cardiovascular Mortality in Prevalent Hemodialysis Patients, THERAPEUTIC APHERESIS AND DIALYSIS, 22(1), 31-39, 201802
  57. A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-alpha and TGF-beta(1) pathways, SCIENTIFIC REPORTS, 7, 20170515
  58. N-terminal pro brain natriuretic peptide as a cardiac biomarker in Japanese hemodialysis patients, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 41(3), 135-143, 201803
  59. Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report, BMC NEPHROLOGY, 19, 20180503
  60. Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis, PLOS ONE, 13(5), 20180503
  61. A case of immunotactoid glomerulopathy with false-negative IgG staining, BMC NEPHROLOGY, 19, 20180615
  62. High-normal albuminuria and incident chronic kidney disease in a male nondiabetic population, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 22(4), 835-842, 201808
  63. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9(808), 20180724
  64. Klotho as a Therapeutic Target during the Development of Renal Fibrosis, SCIENTIFIC ASPECTS OF DIALYSIS THERAPY: JSDT/ISBP ANNIVERSARY EDITION, 189, 178-183, 2017
  65. Na+-Cl- cotransporter-mediated chloride uptake contributes to hypertension and renal damage in aldosterone-infused rats, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 315(2), 300-312, 2018
  66. Dec1 and CLOCK Regulate Na+/K+-ATPase 1 Subunit Expression and Blood Pressure, HYPERTENSION, 72(3), 746-754, 201809
  67. A Case of Fibronectin Glomerulopathy Caused by Missense Mutations in the Fibronectin 1 Gene, kidney Int Rep, 2(5), 969-972, 2017
  68. Coronary artery calcification score and common iliac artery calcification score in non-dialysis CKD patients, Nephrology (Carlton), 23(9), 837-845, 2018
  69. AA Amyloidosis and Atypical Familial Mediterranean Fever with Exon 2 and 3 Mutations., Case Rep Nephrol Dial, 7, 102-107, 2017
  70. Coronary artery calcification score and common iliac artery calcification score in non-dialysis CKD patients, NEPHROLOGY, 23(9), 837-845, SEP 2018
  71. Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction, PLOS ONE, 13(8), AUG 16 2018
  72. Comparing the 12-month patency of low- versus high-pressure dilation in failing arteriovenous fistulae: A prospective multicenter trial (YOROI study), JOURNAL OF VASCULAR ACCESS, 19(5), 477-483, SEP 2018
  73. pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 22(5), 1167-1173, OCT 2018
  74. TGF-beta 1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA, SCIENTIFIC REPORTS, 8, SEP 19 2018
  75. Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis, STEM CELLS TRANSLATIONAL MEDICINE, 7(12), 893-905, 201812
  76. NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(1), 101-115, 20190104
  77. The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(12), 201812
  78. Tocilizumab histologically improved AA renal amyloidosis in a patient with multicentric Castleman disease: A case report, CLINICAL NEPHROLOGY, 90(3), 232-236, 201809
  79. Long-term maintenance of hemoglobin levels in hemodialysis patients treated with bi-weekly epoetin beta pegol switched from darbepoetin alfa: a single-center, 12-month observational study in Japan, JOURNAL OF ARTIFICIAL ORGANS, 22(2), 146-153, 201906
  80. Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis, PLOS ONE, 12(3), 20170309
  81. Hypomagnesemia is not an independent risk factor for mortality in Japanese maintenance hemodialysis patients, INTERNATIONAL UROLOGY AND NEPHROLOGY, 51(6), 1043-1052, 201906
  82. Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(1), 217-223, 20190618
  83. Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
  84. microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress, PLOS ONE, 14(6), 20190614
  85. Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice, DIABETOLOGY & METABOLIC SYNDROME, 11, 20190722
  86. Novel Asp511Thr mutation in McArdle disease with acute kidney injury caused by rhabdomyolysis, CEN CASE REPORTS, 8(3), 194-199, 201908

Invited Lecture, Oral Presentation, Poster Presentation

  1. Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, Toshinori Ueno, Shigehiro Doi, Toru Kawai, Takao Masaki, WCN 2014 Satellite Symposium Kidney and Lipids, 2013/06/06, Without Invitation, fukuoka
  2. High Glucose Promotes TGF-β1 Productiono by Inducing FOS Expression in Human Peritoneal Mesothelial Cells, Shigehiro Doi, Keiko Kokoroishi, Ayumu Nakashima, Toshiki Doi, Takao Masaki, American Society of Nephrology 2013, 2013/11/06, Without Invitation
  3. Mizoribine Suppressed Pyroptosis and Ameliorated Renal Inflammation in Aldosterone-Salt Treated Rats, Toshiki Doi, Shigehiro Doi, Ayumu Nakashima, Takao Masaki, American Society of Nephrology 2013, 2013/11/06, Without Invitation
  4. Inhibitory Effect the Chromatin Histone H3-Lysine 4 Methyltransferase(SET7/9)on the Tubulointerstitial Fibrosis, Kensuke Sasaki, Ayumu Nakashima, Shigehiro Doi, Takao Masaki, American Society of Nephrology 2014, 2014/11/11, Without Invitation
  5. Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis by their strong immunosuppressive effects, Ken Yoshida, Ayumu Nakashima, Shigehiro Doi, Toshinori Ueno, Yukio Kato, Yukihito Higashi, Takao Masaki, American Society of Nephrology 2017, 2017/10/31, Without Invitation
  6. Prognostic Factors in sepsis patients who have undergone direct hemoperfusion with polymyxin b-immobilized fibers, Aiko Okubo, Ayumu Nakashima, Shigehiro Doi, Toshihiro Ueno, Takao Masaki, American Society of Nephrology 2017, 2017/10/31, Without Invitation
  7. MicroRNA-200c is involved in Klotho reduction by oxidative stress in human tubular cells, Kenichi Morii, Satoshi Yamasaki, Shigehiro Doi, Kensuke Sasaki, Toshinori Ueno, Ayumu Nakashima, Takao Masaki, American Society of Nephrology 2017, 2017/10/31, Without Invitation
  8. TGF-b1 promotes fibrotic gene expression through induction of histone variant H3.3 and histone chaperone HIRA, Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki, American Society of Nephrology 2017, 2017/10/31, Without Invitation
  9. Inhibition of H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis, Ryo Tamura, Shigehiro Doi, Toshinori Ueno, Takao Masaki, American Society of Nephrology 2017, 2017/10/31, Without Invitation
  10. Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis by their strong immunosuppressive effects, Ken Yoshida, Ayumu Nakashima, Shigehiro Doi, Toshinori Ueno, Yukio Kato, Yukihito Higashi, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  11. Prognostic Factors in sepsis patients who have undergone direct hemoperfusion with polymyxin b-immobilized fibers, Aiko Okubo, Ayumu Nakashima, Shigehiro Doi, Toshihiro Ueno, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  12. MicroRNA-200c is involved in Klotho reduction by oxidative stress in human tubular cells, Kenichi Morii, Satoshi Yamasaki, Shigehiro Doi, Kensuke Sasaki, Toshinori Ueno, Ayumu Nakashima, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  13. TGF-b1 promotes fibrotic gene expression through induction of histone variant H3.3 and histone chaperone HIRA, Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation
  14. Inhibition of H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis, Ryo Tamura, Shigehiro Doi, Toshinori Ueno, Takao Masaki, ISN FRONTIERS MEETINGS 2018, 2018/02/22, Without Invitation

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2014, 2016
  2. KAKENHI, 2013, 2015
  3. KANENHI, 2016, 2018
  4. KAKENHI, 2017, 2020
  5. KAKEN, 2016, 2018
  6. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  7. KAKENHI, 2019, 2022
  8. KAKENHI, 2016, 2018