Last Updated :2017/09/25

Affiliations, Positions
Hiroshima University Hospital, ., Professor

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Kidney internal medicine

Affiliated Academic Societies

  • The Japanese Society of Internal Medicine Japanese Society of Nephrology The Japanese Society for Dialysis Therapy The Japanese Association of Rehabilitation Medicine Japanese Society for Peritoneal Dialysis Japanese Society for Hemodiafiltration American Society of Nephrology International Society of Nephrology European Renal Association

Educational Activity

Course in Charge

  1. 2017, Undergraduate Education, Intensive, Clinical diagnosis and treatment I
  2. 2017, Undergraduate Education, Intensive
  3. 2017, Undergraduate Education, Intensive, Practice for medical research
  4. 2017, Undergraduate Education, Intensive, Clinical Clerkship (Advanced Course)
  5. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Nephrology
  6. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Nephrology
  7. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced research on Nephrology
  8. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Nephrology

Research Activities

Academic Papers

  1. 15-Deoxy-Delta 12,14-prostaglandin J(2) Inhibits Angiotensin II-induced Fibronectin Expression via Hepatocyte Growth Factor Induction in Human Peritoneal Mesothelial Cells, THERAPEUTIC APHERESIS AND DIALYSIS, 14(1), 43-51, FEB 2010
  2. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta 1 signaling, KIDNEY INTERNATIONAL, 84(2), 297-307, AUG 2013
  3. PDGF receptor tyrosine kinase inhibitor suppresses mesangial cell proliferation involving STAT3 activation., Clin Exp Immunol, 144(2), 353-361, 20060501
  4. Tenascin expression may reflect the activity and chronicity of human IgA nephropathy., 50(4), 205-213, 19981001
  5. Role of tenascin in human immunoglobulin A nephropathy., 25(5), 247-254, 19970901
  6. The influence of steroid therapy in patients with IgA nephropathy., Nephron, 86(6), 197-198, 20001001
  7. Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney., Kidney International, 63(4), 1256-1264, 20030401
  8. Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis., Nephrology Dialysis Transplantation, 18(1), 178-181, 20030101
  9. Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies., Journal of the American Society of Nephrology, 15(7), 1835-1843, 20040601
  10. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis., Clin Exp Nephrol, 20130701
  11. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16(6), 921-929, DEC 2012
  12. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats, PLOS ONE, 9(4), APR 2 2014
  13. Characteristic kidney pathology, gene abnormality and treatments in LCAT deficiency, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18(2), 189-193, APR 2014
  14. Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 18(3), 499-506, JUN 2014
  15. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, DEC 2014
  16. Successful treatment with plasma exchange for ANCA-negative pauci-immune crescentic glomerulonephritis with D-negative hemolytic uremic syndrome, CLINICAL NEPHROLOGY, 82(4), 268-272, OCT 2014
  17. The Serum Lipids Levels may be Underestimated in Patients on Hemodialysis, INTERNAL MEDICINE, 54(8), 887-894, 2015
  18. Hemodialysis Immediately After Cardiac Catheterization Is a Risk Factor for Intradialytic Hypotension, THERAPEUTIC APHERESIS AND DIALYSIS, 19(3), 245-249, JUN 2015
  19. Expression of age-related factors during the development of renal damage in patients with IgA nephropathy, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19(5), 830-837, OCT 2015
  20. Vascular access intervention by a nephrologist in Hiroshima, JOURNAL OF VASCULAR ACCESS, 16, S58-S61, NOV 2015
  21. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(1), 203-215, JAN 2016
  22. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89(1), 147-157, JAN 2016
  23. High glucose promotes TGF-beta 1 production by inducing FOS expression in human peritoneal mesothelial cells, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 20(1), 30-38, FEB 2016
  24. Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model., Nephron Exp Nephrol, 112(2), 59-69
  25. Effect of AST-120, an oral adsorbrnt, on inhibition of the loss of renal function in CRF patients, NEPHROLOGY DIALYSIS TRANSPLANTATION, 21, 383-383, 2006
  26. Glucose-based PD solution, but not icodextrin-based PD solution, induces plasminogen activator inhibitor-1 and tissue-type plasminogen activator in human peritoneal mesothelial cells via ERK1/2, THERAPEUTIC APHERESIS AND DIALYSIS, 11(2), 94-100, 2007
  27. Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction, NEPHROLOGY, 12(6), 565-571, 2007
  28. Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury, TRANSPLANTATION, 84(2), 207-213, 2007
  29. Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice., PLoS One., 11(8), e0160993, 2016.8.11
  30. Hypomagnesemia as a predictor of mortality in hemodialysis patients and the role of proton pump inhibitors: A cross-sectional, 1-year, retrospective cohort study., Hemodial Int, 20(4), 580-588, 2016.10