田代 聡Satoshi Tashiro

Last Updated :2018/09/18

所属・職名
原爆放射線医科学研究所 放射線障害機構研究部門 教授
メールアドレス
ktashirohiroshima-u.ac.jp

基本情報

学位

  • 博士(医学) (広島大学)

研究分野

  • 環境学 / 環境解析学 / 放射線・化学物質影響科学
  • 総合生物 / 腫瘍学 / 腫瘍生物学

研究キーワード

  • ゲノム修復
  • クロマチン構造変換
  • 高次核構造
  • 核内ドメイン

教育活動

授業担当

  1. 2018年, 学部専門, 2ターム, 医学研究序論
  2. 2018年, 学部専門, 集中, 医学研究実習
  3. 2018年, 学部専門, セメスター(前期), 医科歯科分子生物学
  4. 2018年, 修士課程・博士課程前期, セメスター(前期), 研究方法概論
  5. 2018年, 修士課程・博士課程前期, セメスター(前期), 研究方法概論
  6. 2018年, 修士課程・博士課程前期, セメスター(前期), 研究方法概論
  7. 2018年, 修士課程・博士課程前期, セメスター(前期), 研究方法概論
  8. 2018年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
  9. 2018年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
  10. 2018年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
  11. 2018年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
  12. 2018年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  13. 2018年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  14. 2018年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  15. 2018年, 博士課程・博士課程後期, セメスター(前期), 放射線統合医科学
  16. 2018年, 修士課程・博士課程前期, セメスター(前期), 人体の機能
  17. 2018年, 修士課程・博士課程前期, セメスター(前期), 医歯科学演習(細胞修復制御学)
  18. 2018年, 修士課程・博士課程前期, セメスター(後期), 医歯科学演習(細胞修復制御学)
  19. 2018年, 修士課程・博士課程前期, セメスター(前期), 医歯科学特別研究(細胞修復制御学)
  20. 2018年, 修士課程・博士課程前期, セメスター(後期), 医歯科学特別研究(細胞修復制御学)
  21. 2018年, 博士課程・博士課程後期, セメスター(前期), 細胞修復制御学特別演習
  22. 2018年, 博士課程・博士課程後期, セメスター(後期), 細胞修復制御学特別演習
  23. 2018年, 博士課程・博士課程後期, セメスター(前期), 細胞修復制御学特別実験
  24. 2018年, 博士課程・博士課程後期, セメスター(後期), 細胞修復制御学特別実験

研究活動

学術論文(★は代表的な論文)

  1. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15巻, 11号, pp.1138-pp.1146, NOV 2008
  2. Investigation on circular asymmetry of geographical distribution in cancer mortality of Hiroshima atomic bomb survivors based on risk maps: analysis of spatial survival data, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 51巻, 2号, pp.133-pp.141, MAY 2012
  3. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil-induced DNA damage in esophageal cancer cell lines, INTERNATIONAL JOURNAL OF ONCOLOGY, 42巻, 6号, pp.1951-pp.1960, JUN 2013
  4. Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition, CANCER SCIENCE, 104巻, 12号, pp.1593-pp.1599, DEC 2013
  5. ★, Rad51 accumulation at sites of DNA damage and in postreplicative chromatin., J. Cell Biol., 150巻, 2号, pp.283-pp.291, 20000701
  6. Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with PML nuclear bodies., J. Biol. Chem., 277巻, pp.20724-pp.20733, 20020401
  7. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene., EMBO J., 21巻, pp.5216-pp.5224, 20020401
  8. Instability of chromosome 7 in colony forming cells of patients with aplastic anemia., Int. J. Hematol, 70巻, pp.13-pp.19, 19990401
  9. A role for RAD54B in homologous recombination in human cells., EMBO J., 21巻, 1-2号, pp.175-pp.180, 20020401
  10. A new system for laser-UVA-microirradiation of living cells., J Microsc., 209巻, pp.71-pp.75, 20030401
  11. Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages., J. Cell Biol., 160巻, pp.685-pp.697, 20030401
  12. DNA修復機構と核高次構造., 遺伝子医学, 5巻, pp.73-pp.77, 20010401
  13. 核高次構造と核機能:染色体領域ムクロマチン間領域モデルを中心として., 細胞工学, 10巻, pp.1154-pp.1156, 20020401
  14. 白血病発生と染色体異常・癌遺伝子, 臨床成人病, 20巻, 11号, 19901101
  15. CML細胞株におけるInterferon-alphaによるc-myc,c-myb,HLA-B7発現量の検討, 新薬と臨床, 43巻, 8号, 19940801
  16. 無ガンマグロブリン血症で発症し、慢性活動性EBウイルス感染症に悪性リンパ腫を合併した一女児例, 日本小児血液学会雑誌, 4巻, pp.109-pp.113, 19900401
  17. 神経芽細胞腫後発症した骨髄異形成症候群, 日本小児科学会雑誌, 99巻, pp.862-pp.867, 19950401
  18. 乳児白血病とMLL-1遺伝子再構成 pp. 10-12, 1994., 厚生省がん研究助成金:難治性小児がん特に難治性白血病及び類縁疾患の病態の解明と診断・治療法の開発報告書  平成3年度, pp.10-pp.12, 19940401
  19. A new system for laser-UVA-microirradiation of living cells, J. Microscopy, 209巻, pp.71-pp.75, 20030201
  20. XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells, EMBO J., 23巻, pp.670-pp.680, 20040201
  21. A role for RAD54B in homologous recombination in human cells, The European Molecular Biology Organization Journal, 21巻, 1号, pp.175-pp.180, 20020101
  22. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1, EMBO J., 23巻, pp.2544-pp.2553, 20040401
  23. The transcriptional programme of antibody class switching involves the repressor Bach2, Nature, 429巻, 6991号, pp.566-pp.571, 20040401
  24. Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2., Mol. Cell. Biol., 24巻, 8号, pp.3473-pp.3484, 20040401
  25. 思春期における腹痛と消化管運動異常-マーカー法を用いて-., Therapeutic Research, 16巻, pp.294-pp.300, 19950401
  26. 過敏性腸症候群に対するマレイン酸トリメブチンの効果-放射線非透過性マーカー法を用いて-., Progress in Medicine, 15巻, pp.875-pp.877, 19950401
  27. Polycomb group gene mel-18 regulates early T progenitors expansion by maintaining Hes-1 expression., The Journal of Immunology, 174巻, pp.2507-pp.2516, 20050401
  28. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells., J Biol Chem., 281巻, 50号, pp.38226-34, 20061110
  29. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells., Genes Chromosomes Cancer., 46巻, 1号, pp.67-pp.74, 20070101
  30. DNA修復とクロマチン構造変換, 蛋白質核酸酵素, 51巻, 4号, pp.310-4, 20061115
  31. 白血病のゲノム不安定性, 日本臨床, 65巻, 1号, pp.105-8, 20061108
  32. マルチカラー技術を用いたFISH法と免疫蛍光染色, 蛋白質核酸酵素, 51巻, 4号, pp.1978-pp.1980, 20061101
  33. ゲノム修復と細胞核ダイナミクス, 放射線生物研究, 41巻, 2号, pp.182-pp.195, 20061201
  34. Dynamics and induction of the BACH2 gene by imatinib mesylate in chronic myeloid leukemia cells, Genes Chromosomes and Cancer, 46巻, pp.67-pp.74, 20070110
  35. Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain., Neuroscience Letters, 440巻, 2号, pp.160, 20080801
  36. The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair., Exp Cell Res., 15巻, 315号, pp.206, 20090115
  37. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1., 生化的生物物理学的研究報告集, 20090320
  38. The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification., Experimental cell research., 4巻, 314号, pp.903, 20080215
  39. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics., Mol Cell Biol., 27巻, 20号, pp.7028, 20071027
  40. Corepressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression., J. Biochem., 141巻, 5号, pp.719, 20070323
  41. Morphologic effects of epithelial ion channels on the mouse uterus: differences between raloxifene analog (LY117018) and estradiol treatments., Am J Obstet Gynecol (in press), 4巻, 199号, pp.363, 20081001
  42. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics, Mol Cell Biol., 27巻, 20号, pp.7028-pp.7040, 20071001
  43. 染色体転座形成の分子機構, 放射線生物研究, 44巻, 4号, pp.419-pp.430, 20091201
  44. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, PLoS ONE, 5巻, 10号, pp.e13554, 20101001
  45. Dynamics and induction of the BACH2 gene by imatinib mesylate in chronic myeloid leukemia cells, Genes Chromosomes and Cancer 2007, 46巻, pp.67-pp.74, 20070301
  46. The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification, Experimental Cell Research, 314巻, 4号, pp.903-13, 20080401
  47. 広島原爆被爆者コホート1970~2010年におけるリスク地図の推定., 広島医学, 65巻, pp.255-pp.258, 20120101
  48. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin, JOURNAL OF CELL BIOLOGY, 150巻, 2号, pp.283-pp.291, JUL 24 2000
  49. A role for RAD54B in homologous recombination in human cells, EMBO JOURNAL, 21巻, 1-2号, pp.175-pp.180, JAN 15 2002
  50. Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies, JOURNAL OF BIOLOGICAL CHEMISTRY, 277巻, 23号, pp.20724-pp.20733, JUN 7 2002
  51. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene, EMBO JOURNAL, 21巻, 19号, pp.5216-pp.5224, OCT 1 2002
  52. A new system for laser-UVA-microirradiation of living cells, JOURNAL OF MICROSCOPY-OXFORD, 209巻, pp.71-pp.75, FEB 2003
  53. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene, JOURNAL OF BIOLOGICAL CHEMISTRY, 278巻, 49号, pp.49246-pp.49253, DEC 5 2003
  54. XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells, EMBO JOURNAL, 23巻, 3号, pp.670-pp.680, FEB 11 2004
  55. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101巻, 6号, pp.1461-pp.1466, FEB 10 2004
  56. Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2, MOLECULAR AND CELLULAR BIOLOGY, 24巻, 8号, pp.3473-pp.3484, APR 2004
  57. The transcriptional programme of antibody class switching involves the repressor Bach2, NATURE, 429巻, 6991号, pp.566-pp.571, JUN 3 2004
  58. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1, EMBO JOURNAL, 23巻, 13号, pp.2544-pp.2553, JUL 7 2004
  59. Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the notch pathway, JOURNAL OF IMMUNOLOGY, 174巻, 5号, pp.2507-pp.2516, MAR 1 2005
  60. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 281巻, 50号, pp.38226-pp.38234, DEC 15 2006
  61. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells, GENES CHROMOSOMES & CANCER, 46巻, 1号, pp.67-pp.74, JAN 2007
  62. Non-SCN5A related Brugada syndromes: Verification of normal splicing and trafficking of SCN5A without exonic mutations, ANNALS OF HUMAN GENETICS, 71巻, pp.8-pp.17, JAN 2007
  63. Co-repressor SMRT and class II histone deacetylases promote bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression, JOURNAL OF BIOCHEMISTRY, 141巻, 5号, pp.719-pp.727, MAY 2007
  64. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics, MOLECULAR AND CELLULAR BIOLOGY, 27巻, 20号, pp.7028-pp.7040, OCT 2007
  65. Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain, NEUROSCIENCE LETTERS, 440巻, 2号, pp.160-pp.165, AUG 1 2008
  66. The human actin-related protein hArp5: Nucleo-cytoplasmic shuttling and involvement in DNA repair, EXPERIMENTAL CELL RESEARCH, 315巻, 2号, pp.206-pp.217, JAN 15 2009
  67. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380巻, 4号, pp.752-pp.757, MAR 20 2009
  68. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange, NUCLEIC ACIDS RESEARCH, 37巻, 10号, pp.3367-pp.3376, JUN 2009
  69. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase, GENES & DEVELOPMENT, 24巻, 4号, pp.333-pp.338, FEB 15 2010
  70. The putative nuclear localization signal of the human RAD52 protein is a potential sumoylation site, JOURNAL OF BIOCHEMISTRY, 147巻, 6号, pp.833-pp.842, JUN 2010
  71. p130Cas, Crk-Associated Substrate Plays Essential Roles in Liver Development by Regulating Sinusoidal Endothelial Cell Fenestration, HEPATOLOGY, 52巻, 3号, pp.1089-pp.1099, SEP 2010
  72. ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot, PLOS ONE, 5巻, 10号, OCT 27 2010
  73. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch, EMBO JOURNAL, 29巻, 23号, pp.4048-pp.4061, DEC 1 2010
  74. Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination, MOLECULAR CELL, 41巻, 5号, pp.515-pp.528, MAR 4 2011
  75. Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein, MOLECULAR CELL, 41巻, 5号, pp.554-pp.566, MAR 4 2011
  76. Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51, GENES TO CELLS, 16巻, 4号, pp.427-pp.436, APR 2011
  77. Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2, EMBO REPORTS, 13巻, 1号, pp.44-pp.51, JAN 2012
  78. A Modified System for Analyzing Ionizing Radiation-Induced Chromosome Abnormalities, RADIATION RESEARCH, 177巻, 5号, pp.533-pp.538, MAY 2012
  79. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9巻, 4号, APR 2013
  80. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases, NATURE COMMUNICATIONS, 4巻, MAY 2013
  81. Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage, JOURNAL OF CELL SCIENCE, 126巻, 22号, pp.5284-pp.5292, NOV 15 2013
  82. Role of DNA Damage in Cardiovascular Disease, CIRCULATION JOURNAL, 78巻, 1号, pp.42-pp.50, JAN 2014
  83. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1, SCIENTIFIC REPORTS, 4巻, MAY 6 2014
  84. Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 89巻, 4号, pp.736-pp.744, JUL 15 2014
  85. Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells, PLOS ONE, 9巻, 8号, AUG 5 2014
  86. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program, NATURE IMMUNOLOGY, 15巻, 12号, pp.1171-pp.1180, DEC 2014
  87. Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20, PLOS ONE, 10巻, 3号, MAR 23 2015
  88. The International Nucleome Consortium, NUCLEUS, 6巻, 2号, pp.89-pp.92, MAR-APR 2015
  89. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, FASEB JOURNAL, 29巻, 6号, pp.2514-pp.2525, JUN 2015
  90. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair, GENES TO CELLS, 20巻, 9号, pp.681-pp.694, SEP 2015
  91. Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T, BIOCHEMISTRY, 55巻, 4号, pp.637-pp.646, FEB 2 2016
  92. Cytogenetic effects of radioiodine therapy: a 20-year follow-up study, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 55巻, 2号, pp.203-pp.213, MAY 2016
  93. Enhanced gefitinib-induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia-mutated kinase inhibition in non-small-cell lung cancer cells, CANCER SCIENCE, 107巻, 4号, pp.444-pp.451, APR 2016
  94. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861巻, 11号, pp.1816-pp.1827, NOV 2016
  95. A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization, JOURNAL OF MATHEMATICAL BIOLOGY, 74巻, 1-2号, pp.333-pp.354, JAN 2017
  96. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 9巻, 1号, JAN 2016
  97. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, EUROPEAN RADIOLOGY, 27巻, 4号, pp.1660-pp.1666, APR 2017
  98. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7巻, JUL 20 2017
  99. SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites, NUCLEUS, 9巻, 1号, pp.87-pp.94, 2018
  100. Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations, ELIFE, 7巻, MAY 8 2018
  101. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59巻, APR 2018
  102. Estimation of the effects of medical diagnostic radiation exposure based on DNA damage, JOURNAL OF RADIATION RESEARCH, 59巻, APR 2018
  103. XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy, HYPERTENSION RESEARCH, 41巻, 6号, pp.426-pp.434, JUN 2018