SatoshiTashiro

Last Updated :2019/10/06

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, ., Professor
E-mail
ktashirohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Biological Sciences;Oncology;Tumor biology

Research Keywords

  • DNA repair
  • chromatin remodeling
  • higher order nuclear architecture
  • nuclear domains

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, 2Term, Introduction for medical research
  2. 2019, Undergraduate Education, Intensive, Practice for medical research
  3. 2019, Undergraduate Education, First Semester, Molecular Biology in Medicine
  4. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  5. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  6. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  7. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  8. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  9. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  10. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  11. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  12. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  13. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  14. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  15. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  16. 2019, Graduate Education (Master's Program) , First Semester, Physiology and biological chemistry
  17. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Cellular Biology
  18. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Cellular Biology
  19. 2019, Graduate Education (Master's Program) , First Semester, Research on Cellular Biology
  20. 2019, Graduate Education (Master's Program) , Second Semester, Research on Cellular Biology
  21. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Cellular Biology
  22. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Cellular Biology
  23. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Cellular Biology
  24. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Cellular Biology
  25. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  26. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  27. 2019, Graduate Education (Master's Program) , First Semester, Research
  28. 2019, Graduate Education (Master's Program) , Second Semester, Research
  29. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  30. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  31. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  32. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  33. 2019, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  34. 2019, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  35. 2019, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  36. 2019, Graduate Education (Doctoral Program) , 1Term, Integrated Radiation Medical Science
  37. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular Biology
  38. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular Biology
  39. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular Biology
  40. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular Biology

Research Activities

Academic Papers

  1. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15(11), 1138-1146, 200811
  2. Investigation on circular asymmetry of geographical distribution in cancer mortality of Hiroshima atomic bomb survivors based on risk maps: analysis of spatial survival data, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 51(2), 133-141, 201205
  3. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil-induced DNA damage in esophageal cancer cell lines, INTERNATIONAL JOURNAL OF ONCOLOGY, 42(6), 1951-1960, 201306
  4. Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition, CANCER SCIENCE, 104(12), 1593-1599, 201312
  5. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin., J. Cell Biol., 150(2), 283-291, 20000701
  6. Instability of chromosome 7 in colony forming cells of patients with aplastic anemia., Int. J. Hematol, 70, 13-19, 19990401
  7. A new system for laser-UVA-microirradiation of living cells., J Microsc., 209, 71-75, 20030401
  8. Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages., J. Cell Biol., 160, 685-697, 20030401
  9. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1, EMBO J., 23, 2544-2553, 20040401
  10. Conotruncal anomalies and Neurocristopathy following maternal excess Tretinoin exposure., Birth Defects Res Part A Clin and Mol Teratol, 73(5), 361, 20050501
  11. Embryonic lethality and teratogenic effects in rats of fast neutrons and gamma-rays following maternal exposure on day 9 of gestation., Birth Defects Res Part A Clin and Mol Teratol, 76(5), 386, 20060501
  12. Polycomb group gene mel-18 regulates early T progenitors expansion by maintaining Hes-1 expression., The Journal of Immunology, 174, 2507-2516, 20050401
  13. Dynamics and induction of the BACH2 gene by imatinib mesylate in chronic myeloid leukemia cells, Genes Chromosomes and Cancer, 46, 67-74, 20070110
  14. Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain., Neuroscience Letters, 440(2), 160, 20080801
  15. The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification., Experimental cell research., 4(314), 903, 20080215
  16. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics., Mol Cell Biol., 27(20), 7028, 20071027
  17. Dynamics and induction of the BACH2 gene by imatinib mesylate in chronic myeloid leukemia cells, Genes Chromosomes and Cancer 2007, 46, 67-74, 20070301
  18. Investigation on circular asymmetry of geographical distribution of mortality risk in Hiroshima atomic bomb survivors, IPSHU English Research Report Series, 28, 57-65, 20120401
  19. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin, JOURNAL OF CELL BIOLOGY, 150(2), 283-291, 20000724
  20. A role for RAD54B in homologous recombination in human cells, EMBO JOURNAL, 21(1-2), 175-180, 20020115
  21. Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(23), 20724-20733, 20020607
  22. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene, EMBO JOURNAL, 21(19), 5216-5224, 20021001
  23. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(49), 49246-49253, 20031205
  24. XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells, EMBO JOURNAL, 23(3), 670-680, 20040211
  25. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(6), 1461-1466, 20040210
  26. Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2, MOLECULAR AND CELLULAR BIOLOGY, 24(8), 3473-3484, 200404
  27. The transcriptional programme of antibody class switching involves the repressor Bach2, NATURE, 429(6991), 566-571, 20040603
  28. Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the notch pathway, JOURNAL OF IMMUNOLOGY, 174(5), 2507-2516, 20050301
  29. Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP, JOURNAL OF BIOCHEMISTRY, 137(3), 287-296, 200503
  30. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(50), 38226-38234, 20061215
  31. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells, GENES CHROMOSOMES & CANCER, 46(1), 67-74, 200701
  32. Non-SCN5A related Brugada syndromes: Verification of normal splicing and trafficking of SCN5A without exonic mutations, ANNALS OF HUMAN GENETICS, 71, 8-17, 200701
  33. Co-repressor SMRT and class II histone deacetylases promote bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression, JOURNAL OF BIOCHEMISTRY, 141(5), 719-727, 200705
  34. The human actin-related protein hArp5: Nucleo-cytoplasmic shuttling and involvement in DNA repair, EXPERIMENTAL CELL RESEARCH, 315(2), 206-217, 20090115
  35. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(4), 752-757, 20090320
  36. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange, NUCLEIC ACIDS RESEARCH, 37(10), 3367-3376, 200906
  37. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase, GENES & DEVELOPMENT, 24(4), 333-338, 20100215
  38. The putative nuclear localization signal of the human RAD52 protein is a potential sumoylation site, JOURNAL OF BIOCHEMISTRY, 147(6), 833-842, 201006
  39. p130Cas, Crk-Associated Substrate Plays Essential Roles in Liver Development by Regulating Sinusoidal Endothelial Cell Fenestration, HEPATOLOGY, 52(3), 1089-1099, 201009
  40. ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot, PLOS ONE, 5(10), 20101027
  41. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch, EMBO JOURNAL, 29(23), 4048-4061, 20101201
  42. Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination, MOLECULAR CELL, 41(5), 515-528, 20110304
  43. Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein, MOLECULAR CELL, 41(5), 554-566, 20110304
  44. Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51, GENES TO CELLS, 16(4), 427-436, 201104
  45. Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2, EMBO REPORTS, 13(1), 44-51, 201201
  46. A Modified System for Analyzing Ionizing Radiation-Induced Chromosome Abnormalities, RADIATION RESEARCH, 177(5), 533-538, 201205
  47. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9(4), 201304
  48. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases, NATURE COMMUNICATIONS, 4, 201305
  49. Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage, JOURNAL OF CELL SCIENCE, 126(22), 5284-5292, 20131115
  50. Role of DNA Damage in Cardiovascular Disease, CIRCULATION JOURNAL, 78(1), 42-50, 201401
  51. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1, SCIENTIFIC REPORTS, 4, 20140506
  52. Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 89(4), 736-744, 20140715
  53. Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells, PLOS ONE, 9(8), 20140805
  54. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program, NATURE IMMUNOLOGY, 15(12), 1171-1180, 201412
  55. Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20, PLOS ONE, 10(3), 20150323
  56. The International Nucleome Consortium, NUCLEUS, 6(2), 89-92, 2015
  57. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, FASEB JOURNAL, 29(6), 2514-2525, 201506
  58. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair, GENES TO CELLS, 20(9), 681-694, 201509
  59. Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T, BIOCHEMISTRY, 55(4), 637-646, 20160202
  60. Cytogenetic effects of radioiodine therapy: a 20-year follow-up study, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 55(2), 203-213, 201605
  61. Enhanced gefitinib-induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia-mutated kinase inhibition in non-small-cell lung cancer cells, CANCER SCIENCE, 107(4), 444-451, 201604
  62. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861(11), 1816-1827, 201611
  63. A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization, JOURNAL OF MATHEMATICAL BIOLOGY, 74(1-2), 333-354, 201701
  64. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 9(1), 201601
  65. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, EUROPEAN RADIOLOGY, 27(4), 1660-1666, 201704
  66. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7, 20170720
  67. SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites, NUCLEUS, 9(1), 87-94, 20180101
  68. Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations, ELIFE, 7, 20180508
  69. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59, 201804
  70. Estimation of the effects of medical diagnostic radiation exposure based on DNA damage, JOURNAL OF RADIATION RESEARCH, 59, 201804
  71. XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy, HYPERTENSION RESEARCH, 41(6), 426-434, 201806
  72. RELATIVE BIOLOGICAL EFFECTIVENESS OF NEUTRONS DERIVED FROM THE EXCESS RELATIVE RISK MODEL WITH THE ATOMIC BOMB SURVIVORS DATA MANAGED BY HIROSHIMA UNIVERSITY, RADIATION PROTECTION DOSIMETRY, 180(1-4), 346-350, 201808
  73. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure, RADIATION RESEARCH, 190(4), 424-432, 201810
  74. Cancer-associated mutations of histones H2B, H3.1 and H2AZ1 affect the structure and stability of the nucleosome, NUCLEIC ACIDS RESEARCH, 46(19), 10007-10018, 20181102
  75. DNA Damage and Senescence-Associated Inflammation in Cardiovascular Disease, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(4), 531-537, 201904

Publications such as books

  1. 2007/01, Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear domains. Nuclear Dynamics. , 2007, 01, 4431300546, 29

Invited Lecture, Oral Presentation, Poster Presentation

  1. Dynamics of BACH2 nuclear foci regualted by SUMOylation., 2007/01, With Invitation
  2. Dynamics of higher order nuclear architecture upon DNA damage., Satoshi Tashiro, 2008/10, With Invitation
  3. Regulation of DNA repair and nuclear lamina, Satoshi Tashiro, Institute for Protein Research (IPR) Seminar Nuclear organization and actin-dependent mechanisms in genome stability, 2015/05/18, With Invitation, Institute for Protein Research (IPR), Osaka University
  4. Nuclear topography of homologous recombinational repair, Satoshi Tashiro, The 15th International Congress of Radiation Research, 2015/05/28, With Invitation, Kyoto University Research Reactor Institute, Kyoto, The chromosome territory-interchromatin compartment (CT-IC) model argues that nuclei are built up from two principal components, chromosome territories and the interchromatin compartment (IC). Several line of evidence suggests that the periphery of a chromatin domain bordering the IC represents the major nuclear sub-compartment for transcription, or co-transcriptional RNA splicing and DNA replication. However, the association of DNA metabolism, including DNA repair, with the higher order nuclear architectures are largely unknown. Homologous recombination repair (HR) is one of the major repair pathways of DNA double-strand breaks (DSBs) produced by endogenous and exogenous factors. A fraction of proteins involved in the HR pathway have been shown to accumulate at sites containing DNA damage to form damage induced nuclear foci. On the other hand, damaged chromatin is shown to be mobile after induction of DNA damage in a manner dependent on HR factors. However, the biological significance of such dynamic rearrangements of higher order nuclear architectures in HR is still unclear. Recent development of super-resolution microscopy has been expected to contribute the further understanding of the association of DNA metabolisms, such as HR, with higher order nuclear structures. RAD51 is a key factor in the HR pathway loaded on single stranded DNA processed around DSBs. In our previous study, we showed that RAD51 forms nuclear foci in S phase and at sites containing DNA damages. Recently, we found that the overexpressed RAD51 is accumulated within bundle-like sub-compartments of IC in human cell nucleus. Single stranded DNA formed at sites containing DNA damage for HR was detected within the sub-compartments. These findings support the notion that damaged chromatins are moved into the bundle-like sub-compartment of IC for HR, or HR factory. The usefulness of the super resolution microscopy in these analyses will be discussed.
  5. Biological estimation of the DNA damage induced by CT scan, Satoshi Tashiro, The 15th International Congress of Radiation Research, 2015/06/27, With Invitation, Kyoto, Ionizing radiation can induce DNA damage. Human beings live under the environment with various types of DNA damaging agents, such as natural ionizing radiation and chemical agents. Therefore, human cells have DNA repair system to protect the genetic information from DNA damage. However, once cells received too much DNA damage to repair, apoptosis and/or changes of genetic information are induced. Accumulation of changes in genetic information has been shown to lead to carcinogenesis. Recent advance in medical image analysis, such as the development of high-speed multidetector CT, introduces the drastic progress in the field of diagnostic radiology. These progresses in diagnostic radiology strongly contribute to the progress in almost all fields of medicine. On the other hand, the health effect of medical exposure, especially CT scan, is still unclear. We have established a method to detect radiation-induced chromosome abnormalities, dicentric and ring chromosomes, by applying a fluorescence in situ hybridization (FISH) technique using telomere and centromere peptide nucleic acid (PNA) probes. We also examined the usefulness of immunofluorescence staining analysis using antibodies against DNA repair proteins in the estimation of DNA damage induced by CT scan. The possibility of the application of these techniques in the estimation of health effect of medical exposure will be discussed.
  6. Regulation of DNA Repair and Nuclear Lamina, Satoshi Tashiro, International Symposium on Chromatin Structure, Dynamics, and Function, 2015/08/25, Without Invitation, Awaji Yumebutai International Conference Center Awaji, Among the various types of DNA damage induced by ionizing radiation (IR), double strand breaks (DSBs) are regarded as the most serious impairment leading to cell death. In mammalian cells, DSBs are repaired mainly by one of two genetically distinct processes, non-homologous end joining (NHEJ) and homologous recombination (HR). RAD51, a recA homolog that forms helical filaments, binds to single-strand DNA, thus promoting recombinational repair. RAD51-dependent HR is one of the most important pathways in DSB repair and genome integrity maintenance. However, the mechanism of HR regulation by RAD51 remains unclear. To understand the mechanism of RAD51-dependent HR, we searched for interacting partners of RAD51 by a proteomics analysis and identified lamin B1 in human cells. Lamins are nuclear lamina proteins that play important roles in the structural organization of the nucleus and the regulation of chromosome functions. Immunoblotting analyses revealed that siRNA-mediated lamin B1 depletion repressed the DNA damage-dependent increase of RAD51 after IR. The repression was abolished by the proteasome inhibitor MG132, suggesting that lamin B1 stabilizes RAD51 by preventing proteasome-mediated degradation in cells with IR-induced DNA damage. We also showed that lamin B1 depletion repressed RAD51 focus formation and decreased the survival rates after IR. Based on these results, we propose that lamin B1 promotes DSB repair and cell survival by maintaining the RAD51 protein levels for HR, upon DSB induction after IR.
  7. Biological estimation of DNA damage induced by CT scan - Application of biodosimetry to medicine -, Satoshi Tashiro, Future of Biodosimetry in Asia: Promoting a Regional Network NIRS/IAEA Technical Meeting, 2015/09/16, With Invitation, National Institute of Radiological Science in collaboration with the International Atomic Energy Agency, Chiba
  8. Regulation of homologous recombinational repair by nuclear structure-associated proteins, Satoshi Tashiro, Satoshi Tashiro, Tsuyoshi Ikura, Jiying Sun, 74th Annual Meeting of the Japanese Cancer Association, 2015/10/10, Without Invitation, Nagoya Congress Center, DNA double-strand breaks (DSBs) are the major lethal lesion induced by ionizing radiation (IR). RAD51-dependent homologous recombination (HR) is one of the most important pathways in DSB repair and genome integrity maintenance. To understand the mechanism of RAD51-dependent HR, we searched for interacting partners of RAD51 by a proteomics analysis and identified lamin B1 in human cells. Lamins are nuclear lamina proteins that play important roles in the structural organization of the nucleus and the regulation of chromosome functions. Lamin B1 depletion repressed the DNA damage-dependent increase of RAD51 after IR. The repression was abolished by the proteasome inhibitor MG132, suggesting that lamin B1 stabilizes RAD51 by preventing proteasome-mediated degradation in cells with IR-induced DNA damage. We also showed that lamin B1 depletion repressed RAD51 focus formation and decreased the survival rates after IR. Based on these results, we propose that lamin B1 promotes DSB repair and cell survival by maintaining the RAD51 protein levels for HR, upon DSB induction after IR.
  9. Architecture of radiation-induced nuclear domains, Satoshi Tashiro, 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会, 2015/12/04, Without Invitation
  10. Detection of Translocations by the Fluorescence in Situ Hybridization (FISH) Technique Using Whole Chromosone Painting DNA Probes-Detection of Dicentric and Ring Chromosomes by the FISH Using Cnetromere and Telomere PNA Probes, Satoshi Tashiro, Yoshiaki Kodama, IAEA 3rd (final) Research Coordination Meeting, 2016/03/08, With Invitation, IAEA, IAEA Headquarters, Vienna, Austria
  11. CT scan-induced DNA damage in children measured using molecular markers and nanoscope technology, Satoshi Tashiro, 14th International Workshop on Radiation Damage to DNA, 2016/03/22, Without Invitation, The Australian Institute of Nuclear Science and Engineering (AINSE), supported by IARR and RRS, Victorian Treasury Theater and Old Treasury Building Melbourne Australia
  12. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, Satoshi Tashiro, Nuclear Organization & Function, 2016/05/03, Without Invitation, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory
  13. Nuclear Topography of Homologous Recombinational Repair, Satoshi Tashiro, Genomic Instability & Cancer Genetics Research Program Meeting, 2016/05/09, Without Invitation, Rutgers Cancer Institute of New Jersey, Rutgers Cancer Institute of New Jersey, NJ, USA
  14. Cytogenetic effects of radioiodine therapy and CT scan -Application of biodosimetry to medicine-, Satoshi Tashiro, IAEA-Consultants Meeting on Clinical applications of biodosimetry and BIODOSE/RADBIO lab concept, 2016/07/12, With Invitation, IAEA, IAEA's Headquarters in Vienna, Austria
  15. Regulatory mechanism of the exchange of histone variant H2A,Z-2 at DNA damaged sites, Satoshi Tashiro, Atsuhiko Fukuto, 第9回広島-明治-龍谷合同合宿, 2016/08/30, With Invitation
  16. Nuclome Analysis of DNA repair, Satoshi Tashiro, 第39回日本分子生物学会, 2016/12/01, Without Invitation
  17. Radiation, chromosome and FISH, Satoshi Tashiro, IAEA・HICARE協働センターによる先進的放射線治療に関する国際医療研修, 2017/02/02, With Invitation, IAEA/HICARE
  18. Nuclear topography of DNA repair, Satoshi Tashiro, 4D Nuclome The Cell Nucleus in Space and Time, 2017/05/16, Without Invitation, Jagiellonian University in Krakow, Krakow, Poland
  19. Enhanced gefitinib-induced repression of the EGFR pathway by ATM kinase inhibition in non-small-cell lung cancer cells, Satoshi Tashiro, 第76回日本癌学会学術総会, 2017/09/29, Without Invitation
  20. Medical radiation exposure and DNA damage, Satoshi Tashiro, 第45回日本放射線技術学会秋季学術大会 (ICRST), 2017/10/21, Without Invitation
  21. Nuclear Topography of homologous recombinational repair, Satoshi Tashiro, Friedrich Miescher Institute Seminar, 2017/11/06, With Invitation, Friedrich Miescher Institute(FMI), Basel, Switzerland
  22. ATM regulates phosphorylation of ARP8 to repress the loading of INO80 and RAD51 to chromosome translocation breakpoint hotspots, Satoshi Tashiro, 第33回京都大学放射線生物研究センター国際シンポジウム「放射線腫瘍生物学の最前線」, 2017/12/05, Without Invitation
  23. Nuclear topography of homologous recombinational repair, Satoshi Tashiro, The 3rd Hiroshima International Symposium on Future Science "Frontiers in Bioimagining Based Life Science", 2018/03/21, Without Invitation, 広島大学大学院理学研究科、クロマチン動態数理研究拠点(RcMcD)
  24. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2018/06/26, Without Invitation
  25. Detection of chromosome aberrations after low dose irradiation in vitro and in vivo, Satoshi Tashiro, 物質・デバイス領域共同研究拠点H29年度成果報告会, 2018/06/28, Without Invitation
  26. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2018/07/26, Without Invitation
  27. Prevention of chromosome translocations through ARP8 phosphorylation by ATM, Satoshi Tashiro, EMBO/EMBL Symposia, 2018/09/07, Without Invitation, EMBO/EMBL, Heidelberg, Germany
  28. Mechanism of accurate DNA repair to prevent chromosome translocations, Satoshi Tashiro, プロテイン・アイランド・松山(PIM)2018 第16回松山国際学術シンポジウム, 2018/09/12, With Invitation
  29. SUMO modification system regulates DNA damage-depemdent exchange of histone variant H2A.Z-2, Satoshi Tashiro, 第77回日本癌学会学術総会, 2018/09/28, Without Invitation
  30. Regulation of ARP8 phosphorylation by ATM to prevent chromosome translocations, Satoshi Tashiro, 7th Meeting of the Asian Forum of Chromosome and Chromatin Biology, 2018/11/16, With Invitation, Bangalore, India
  31. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2018/12/04, Without Invitation
  32. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2019/02/14, Without Invitation
  33. Clinical Application of Cytogenetical Analysis in Patients Receiving CT Scan Exam and Radiotherapy, Satoshi Tashiro, IAEA RCM Meeting, 2019/02/19, Without Invitation, IAEA, Recife, Brazil

External Funds

Acceptance Results of Competitive Funds

  1. The Center of World Intelligence Project for Nuclear S&T and Human Resource Development, 2015/10/01, 2016/03/31
  2. KAKENHI, 2014, 2015