Satoshi Tashiro

Last Updated :2017/11/01

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, ., Professor
E-mail
ktashirohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Biological Sciences;Oncology;Tumor biology

Research Keywords

  • DNA repair
  • chromatin remodeling
  • higher order nuclear architecture
  • nuclear domains

Educational Activity

Course in Charge

  1. 2017, Undergraduate Education, 2Term, Introduction for medical research
  2. 2017, Undergraduate Education, Intensive, Practice for medical research
  3. 2017, Undergraduate Education, First Semester, Molecular Biology in Medicine
  4. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  5. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  6. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  7. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  8. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  9. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  10. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  11. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  12. 2017, Graduate Education (Master's Program) , First Semester, Physiology and biological chemistry
  13. 2017, Graduate Education (Master's Program) , First Semester, Seminar on Cellular Biology
  14. 2017, Graduate Education (Master's Program) , Second Semester, Seminar on Cellular Biology
  15. 2017, Graduate Education (Master's Program) , First Semester, Research on Cellular Biology
  16. 2017, Graduate Education (Master's Program) , Second Semester, Research on Cellular Biology
  17. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced research on Cellular Biology
  18. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Cellular Biology
  19. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Cellular Biology
  20. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Cellular Biology
  21. 2017, Graduate Education (Doctoral Program) , First Semester, Natural Disasters and International Cooperation

Research Activities

Academic Papers

  1. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15(11), 1138-1146, NOV 2008
  2. Investigation on circular asymmetry of geographical distribution in cancer mortality of Hiroshima atomic bomb survivors based on risk maps: analysis of spatial survival data, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 51(2), 133-141, MAY 2012
  3. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil-induced DNA damage in esophageal cancer cell lines, INTERNATIONAL JOURNAL OF ONCOLOGY, 42(6), 1951-1960, JUN 2013
  4. Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition, CANCER SCIENCE, 104(12), 1593-1599, DEC 2013
  5. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin., J. Cell Biol., 150(2), 283-291, 20000701
  6. Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with PML nuclear bodies., J. Biol. Chem., 277, 20724-20733, 20020401
  7. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene., EMBO J., 21, 5216-5224, 20020401
  8. Instability of chromosome 7 in colony forming cells of patients with aplastic anemia., Int. J. Hematol, 70, 13-19, 19990401
  9. A role for RAD54B in homologous recombination in human cells., EMBO J., 21(1-2), 175-180, 20020401
  10. A new system for laser-UVA-microirradiation of living cells., J Microsc., 209, 71-75, 20030401
  11. Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages., J. Cell Biol., 160, 685-697, 20030401
  12. XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells, EMBO J., 23, 670-680, 20040201
  13. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1, EMBO J., 23, 2544-2553, 20040401
  14. The transcriptional programme of antibody class switching involves the repressor Bach2, Nature, 429(6991), 566-571, 20040401
  15. Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2., Mol. Cell. Biol., 24(8), 3473-3484, 20040401
  16. Polycomb group gene mel-18 regulates early T progenitors expansion by maintaining Hes-1 expression., The Journal of Immunology, 174, 2507-2516, 20050401
  17. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells., J Biol Chem., 281(50), 38226-34, 20061110
  18. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells., Genes Chromosomes Cancer., 46(1), 67-74, 20070101
  19. Dynamics and induction of the BACH2 gene by imatinib mesylate in chronic myeloid leukemia cells, Genes Chromosomes and Cancer, 46, 67-74, 20070110
  20. Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain., Neuroscience Letters, 440(2), 160, 20080801
  21. The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair., Exp Cell Res., 15(315), 206, 20090115
  22. The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification., Experimental cell research., 4(314), 903, 20080215
  23. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics., Mol Cell Biol., 27(20), 7028, 20071027
  24. Corepressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression., J. Biochem., 141(5), 719, 20070323
  25. Morphologic effects of epithelial ion channels on the mouse uterus: differences between raloxifene analog (LY117018) and estradiol treatments., Am J Obstet Gynecol (in press), 4(199), 363, 20081001
  26. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, PLoS ONE, 5(10), e13554, 20101001
  27. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin, JOURNAL OF CELL BIOLOGY, 150(2), 283-291, JUL 24 2000
  28. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(6), 1461-1466, FEB 10 2004
  29. The human actin-related protein hArp5: Nucleo-cytoplasmic shuttling and involvement in DNA repair, EXPERIMENTAL CELL RESEARCH, 315(2), 206-217, JAN 15 2009
  30. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(4), 752-757, MAR 20 2009
  31. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange, NUCLEIC ACIDS RESEARCH, 37(10), 3367-3376, JUN 2009
  32. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase, GENES & DEVELOPMENT, 24(4), 333-338, FEB 15 2010
  33. The putative nuclear localization signal of the human RAD52 protein is a potential sumoylation site, JOURNAL OF BIOCHEMISTRY, 147(6), 833-842, JUN 2010
  34. p130Cas, Crk-Associated Substrate Plays Essential Roles in Liver Development by Regulating Sinusoidal Endothelial Cell Fenestration, HEPATOLOGY, 52(3), 1089-1099, SEP 2010
  35. ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot, PLOS ONE, 5(10), OCT 27 2010
  36. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch, EMBO JOURNAL, 29(23), 4048-4061, DEC 1 2010
  37. Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination, MOLECULAR CELL, 41(5), 515-528, MAR 4 2011
  38. Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein, MOLECULAR CELL, 41(5), 554-566, MAR 4 2011
  39. Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51, GENES TO CELLS, 16(4), 427-436, APR 2011
  40. Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2, EMBO REPORTS, 13(1), 44-51, JAN 2012
  41. A Modified System for Analyzing Ionizing Radiation-Induced Chromosome Abnormalities, RADIATION RESEARCH, 177(5), 533-538, MAY 2012
  42. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9(4), APR 2013
  43. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases, NATURE COMMUNICATIONS, 4, MAY 2013
  44. Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage, JOURNAL OF CELL SCIENCE, 126(22), 5284-5292, NOV 15 2013
  45. Role of DNA Damage in Cardiovascular Disease, CIRCULATION JOURNAL, 78(1), 42-50, JAN 2014
  46. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1, SCIENTIFIC REPORTS, 4, MAY 6 2014
  47. Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 89(4), 736-744, JUL 15 2014
  48. Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells, PLOS ONE, 9(8), AUG 5 2014
  49. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program, NATURE IMMUNOLOGY, 15(12), 1171-1180, DEC 2014
  50. Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20, PLOS ONE, 10(3), MAR 23 2015
  51. The International Nucleome Consortium, NUCLEUS, 6(2), 89-92, MAR-APR 2015
  52. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, FASEB JOURNAL, 29(6), 2514-2525, JUN 2015
  53. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair, GENES TO CELLS, 20(9), 681-694, SEP 2015
  54. Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T, BIOCHEMISTRY, 55(4), 637-646, FEB 2 2016
  55. Cytogenetic effects of radioiodine therapy: a 20-year follow-up study, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 55(2), 203-213, MAY 2016
  56. Enhanced gefitinib-induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia-mutated kinase inhibition in non-small-cell lung cancer cells, CANCER SCIENCE, 107(4), 444-451, APR 2016
  57. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861(11), 1816-1827, NOV 2016
  58. A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization, JOURNAL OF MATHEMATICAL BIOLOGY, 74(1-2), 333-354, JAN 2017
  59. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 9(1), JAN 2016
  60. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, EUROPEAN RADIOLOGY, 27(4), 1660-1666, APR 2017
  61. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7, JUL 20 2017