Satoshi Tashiro

Last Updated :2024/05/15

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Professor
E-mail
ktashirohiroshima-u.ac.jp
Self-introduction
To study the relationship between DNA repair and higher order nuclear structure, we have applied the latest bio-imaging and biochemical technology. Besides, we aim to establish the next-generation radiology with the findings and technology obtained from these studies.

Basic Information

Major Professional Backgrounds

  • 2004/12/01, Research Institute for Radiation Biology and Medicine, Hiroshima University, Professor
  • 2003/09/01, 2004/11/30, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2000/09/01, 2002/04/04, Hiroshima University, Faculty of Medicine, Lecturer
  • 1992/01/01, 1993/03/31, Hiroshima University, RIRBM, Instructor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medicine, Japan, 1989/04, 1992/03
  • Hiroshima University, Faculty of Medicine, Japan, 1980/04, 1986/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Biological Sciences;Oncology;Tumor biology

Research Keywords

  • DNA repair
  • chromatin remodeling
  • higher order nuclear architecture
  • nuclear domains

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, Radiation Biology & Radiation Health Risk Sciences
  2. 2024, Undergraduate Education, Year, Physiology and Biochemistry
  3. 2024, Undergraduate Education, 2Term, Introduction for medical research
  4. 2024, Undergraduate Education, Intensive, Practice for medical research
  5. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  6. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  7. 2024, Graduate Education (Master's Program) , First Semester, Research
  8. 2024, Graduate Education (Master's Program) , Second Semester, Research
  9. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  10. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  11. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  12. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  13. 2024, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  14. 2024, Graduate Education (Doctoral Program) , 1Term, Integrated Radiation Medical Science
  15. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular Biology
  16. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular Biology
  17. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular Biology
  18. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular Biology
  19. 2024, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology

Research Activities

Academic Papers

  1. Impact of lifting the mandatory evacuation order after the Fukushima Daiichi Nuclear Power Plant accident on the emergency medical system: a retrospective observational study at Minamisoma City with machine learning analysis., BMJ Open., 13(4), e067536-e067536, 20230404
    Link to Paper Search Results by DOI
  2. Klotho protects chromosomal DNA from radiation-induced damage, JOURNAL OF BIOCHEMISTRY, 173(5), 375-382, 20230426
    Link to Paper Search Results by DOI
  3. Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis, CLINICAL SCIENCE, 137(2), 163-180, 202301
    Link to Paper Search Results by DOI
  4. A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage., Radiat Res., 197(4), 384-395, 20220401
    Link to Paper Search Results by DOI
  5. DNA Damage Induced by Radiation Exposure from Cardiac Catheterization An Analysis in Patients and Operators, INTERNATIONAL HEART JOURNAL, 63(3), 466-475, 202205
    Link to Paper Search Results by DOI
  6. Biological and internal dosimetry for radiation medicine: current status and future perspectives, JOURNAL OF RADIATION RESEARCH, 63(2), 247-254, 20220317
    Link to Paper Search Results by DOI
  7. Bach1 plays an important role in angiogenesis through regulation of oxidative stress, MICROVASCULAR RESEARCH, 134, 202103
    Link to Paper Search Results by DOI
  8. Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients, RADIATION RESEARCH, 195(3), 244-252, 20210301
    Link to Paper Search Results by DOI
  9. Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution, ISCIENCE, 24(4), 20210315
    Link to Paper Search Results by DOI
  10. OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 20210629
    Link to Paper Search Results by DOI
  11. Lessons from the Fukushima Daiichi nuclear power plant accident -from a research perspective., Ann ICRP., 20210610
    Link to Paper Search Results by DOI
  12. Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci, EMBO JOURNAL, 40(18), 20210915
    Link to Paper Search Results by DOI
  13. Biological Effects of Low-Dose Chest CT on Chromosomal DNA, RADIOLOGY, 295(2), 439-445, 202005
    Link to Paper Search Results by DOI
  14. DNA Damage and Senescence-Associated Inflammation in Cardiovascular Disease, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(4), 531-537, 201904
    Link to Paper Search Results by DOI
  15. Role of dynamic nuclear deformation on genomic architecture reorganization, PLOS COMPUTATIONAL BIOLOGY, 15(9), 201909
    Link to Paper Search Results by DOI
  16. Matrin3 promotes homologous recombinational repair by regulation of RAD51, JOURNAL OF BIOCHEMISTRY, 166(4), 343-351, 201910
    Link to Paper Search Results by DOI
  17. SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites, NUCLEUS, 9(1), 87-94, 20180101
    Link to Paper Search Results by DOI
  18. Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations, ELIFE, 7, 20180508
    Link to Paper Search Results by DOI
  19. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59, 201804
    Link to Paper Search Results by DOI
  20. Estimation of the effects of medical diagnostic radiation exposure based on DNA damage, JOURNAL OF RADIATION RESEARCH, 59, 201804
    Link to Paper Search Results by DOI
  21. XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy, HYPERTENSION RESEARCH, 41(6), 426-434, 201806
    Link to Paper Search Results by DOI
  22. RELATIVE BIOLOGICAL EFFECTIVENESS OF NEUTRONS DERIVED FROM THE EXCESS RELATIVE RISK MODEL WITH THE ATOMIC BOMB SURVIVORS DATA MANAGED BY HIROSHIMA UNIVERSITY, RADIATION PROTECTION DOSIMETRY, 180(1-4), 346-350, 201808
    Link to Paper Search Results by DOI
  23. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure, RADIATION RESEARCH, 190(4), 424-432, 201810
    Link to Paper Search Results by DOI
  24. Cancer-associated mutations of histones H2B, H3.1 and H2AZ1 affect the structure and stability of the nucleosome, NUCLEIC ACIDS RESEARCH, 46(19), 10007-10018, 20181102
    Link to Paper Search Results by DOI
  25. A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization, JOURNAL OF MATHEMATICAL BIOLOGY, 74(1-2), 333-354, 201701
    Link to Paper Search Results by DOI
  26. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, EUROPEAN RADIOLOGY, 27(4), 1660-1666, 201704
    Link to Paper Search Results by DOI
  27. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7, 20170720
    Link to Paper Search Results by DOI
  28. Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T, BIOCHEMISTRY, 55(4), 637-646, 20160202
    Link to Paper Search Results by DOI
  29. Cytogenetic effects of radioiodine therapy: a 20-year follow-up study, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 55(2), 203-213, 201605
    Link to Paper Search Results by DOI
  30. Enhanced gefitinib-induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia-mutated kinase inhibition in non-small-cell lung cancer cells, CANCER SCIENCE, 107(4), 444-451, 201604
    Link to Paper Search Results by DOI
  31. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861(11), 1816-1827, 201611
    Link to Paper Search Results by DOI
  32. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 9(1), 201601
    Link to Paper Search Results by DOI
  33. Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20, PLOS ONE, 10(3), 20150323
    Link to Paper Search Results by DOI
  34. The International Nucleome Consortium, NUCLEUS, 6(2), 89-92, 2015
    Link to Paper Search Results by DOI
  35. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, FASEB JOURNAL, 29(6), 2514-2525, 201506
    Link to Paper Search Results by DOI
  36. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair, GENES TO CELLS, 20(9), 681-694, 201509
    Link to Paper Search Results by DOI
  37. Role of DNA Damage in Cardiovascular Disease, CIRCULATION JOURNAL, 78(1), 42-50, 201401
    Link to Paper Search Results by DOI
  38. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1, SCIENTIFIC REPORTS, 4, 20140506
    Link to Paper Search Results by DOI
  39. Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 89(4), 736-744, 20140715
    Link to Paper Search Results by DOI
  40. Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells, PLOS ONE, 9(8), 20140805
    Link to Paper Search Results by DOI
  41. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program, NATURE IMMUNOLOGY, 15(12), 1171-1180, 201412
    Link to Paper Search Results by DOI
  42. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil-induced DNA damage in esophageal cancer cell lines, INTERNATIONAL JOURNAL OF ONCOLOGY, 42(6), 1951-1960, 201306
    Link to Paper Search Results by DOI
  43. Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition, CANCER SCIENCE, 104(12), 1593-1599, 201312
    Link to Paper Search Results by DOI
  44. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9(4), 201304
    Link to Paper Search Results by DOI
  45. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases, NATURE COMMUNICATIONS, 4, 201305
    Link to Paper Search Results by DOI
  46. Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage, JOURNAL OF CELL SCIENCE, 126(22), 5284-5292, 20131115
    Link to Paper Search Results by DOI
  47. Investigation on circular asymmetry of geographical distribution in cancer mortality of Hiroshima atomic bomb survivors based on risk maps: analysis of spatial survival data, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 51(2), 133-141, 201205
    Link to Paper Search Results by DOI
  48. Investigation on circular asymmetry of geographical distribution of mortality risk in Hiroshima atomic bomb survivors, IPSHU English Research Report Series, 28, 57-65, 20120401
  49. Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2, EMBO REPORTS, 13(1), 44-51, 201201
    Link to Paper Search Results by DOI
  50. A Modified System for Analyzing Ionizing Radiation-Induced Chromosome Abnormalities, RADIATION RESEARCH, 177(5), 533-538, 201205
    Link to Paper Search Results by DOI
  51. Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination, MOLECULAR CELL, 41(5), 515-528, 20110304
    Link to Paper Search Results by DOI
  52. Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein, MOLECULAR CELL, 41(5), 554-566, 20110304
    Link to Paper Search Results by DOI
  53. Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51, GENES TO CELLS, 16(4), 427-436, 201104
    Link to Paper Search Results by DOI
  54. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase, GENES & DEVELOPMENT, 24(4), 333-338, 20100215
    Link to Paper Search Results by DOI
  55. The putative nuclear localization signal of the human RAD52 protein is a potential sumoylation site, JOURNAL OF BIOCHEMISTRY, 147(6), 833-842, 201006
    Link to Paper Search Results by DOI
  56. p130Cas, Crk-Associated Substrate Plays Essential Roles in Liver Development by Regulating Sinusoidal Endothelial Cell Fenestration, HEPATOLOGY, 52(3), 1089-1099, 201009
    Link to Paper Search Results by DOI
  57. ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot, PLOS ONE, 5(10), 20101027
    Link to Paper Search Results by DOI
  58. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch, EMBO JOURNAL, 29(23), 4048-4061, 20101201
    Link to Paper Search Results by DOI
  59. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1., Biochemical and Biophysical Research Communications, 20090320
  60. The human actin-related protein hArp5: Nucleo-cytoplasmic shuttling and involvement in DNA repair, EXPERIMENTAL CELL RESEARCH, 315(2), 206-217, 20090115
    Link to Paper Search Results by DOI
  61. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(4), 752-757, 20090320
    Link to Paper Search Results by DOI
  62. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange, NUCLEIC ACIDS RESEARCH, 37(10), 3367-3376, 200906
    Link to Paper Search Results by DOI
  63. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 15(11), 1138-1146, 200811
    Link to Paper Search Results by DOI
  64. Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain., Neuroscience Letters, 440(2), 160, 20080801
  65. The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification., Experimental cell research., 4(314), 903, 20080215
  66. Morphologic effects of epithelial ion channels on the mouse uterus: differences between raloxifene analog (LY117018) and estradiol treatments, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 199(4), 200810
    Link to Paper Search Results by DOI
  67. Dynamics and induction of the BACH2 gene by imatinib mesylate in chronic myeloid leukemia cells, Genes Chromosomes and Cancer, 46, 67-74, 20070110
  68. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics., Mol Cell Biol., 27(20), 7028, 20071027
  69. Dynamics and induction of the BACH2 gene by imatinib mesylate in chronic myeloid leukemia cells, Genes Chromosomes and Cancer 2007, 46, 67-74, 20070301
  70. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells, GENES CHROMOSOMES & CANCER, 46(1), 67-74, 200701
    Link to Paper Search Results by DOI
  71. Non-SCN5A related Brugada syndromes: Verification of normal splicing and trafficking of SCN5A without exonic mutations, ANNALS OF HUMAN GENETICS, 71, 8-17, 200701
    Link to Paper Search Results by DOI
  72. Co-repressor SMRT and class II histone deacetylases promote bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression, JOURNAL OF BIOCHEMISTRY, 141(5), 719-727, 200705
    Link to Paper Search Results by DOI
  73. Embryonic lethality and teratogenic effects in rats of fast neutrons and gamma-rays following maternal exposure on day 9 of gestation., Birth Defects Res Part A Clin and Mol Teratol, 76(5), 386, 20060501
  74. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(50), 38226-38234, 20061215
    Link to Paper Search Results by DOI
  75. Conotruncal anomalies and Neurocristopathy following maternal excess Tretinoin exposure., Birth Defects Res Part A Clin and Mol Teratol, 73(5), 361, 20050501
  76. Conotruncal anomalies and Neurocristopathy following maternal gamma rays and excess Tretinoin exposure., Proceedings of the 48th Annual Meeting of the Japan Radiation Research Society/the first Asian Congress of Radiation Research., 121, 20051101
  77. Polycomb group gene mel-18 regulates early T progenitors expansion by maintaining Hes-1 expression., The Journal of Immunology, 174, 2507-2516, 20050401
  78. Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the notch pathway, JOURNAL OF IMMUNOLOGY, 174(5), 2507-2516, 20050301
    Link to Paper Search Results by DOI
  79. Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP, JOURNAL OF BIOCHEMISTRY, 137(3), 287-296, 200503
    Link to Paper Search Results by DOI
  80. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1, EMBO J., 23, 2544-2553, 20040401
  81. XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells, EMBO JOURNAL, 23(3), 670-680, 20040211
    Link to Paper Search Results by DOI
  82. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(6), 1461-1466, 20040210
    Link to Paper Search Results by DOI
  83. Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2, MOLECULAR AND CELLULAR BIOLOGY, 24(8), 3473-3484, 200404
    Link to Paper Search Results by DOI
  84. The transcriptional programme of antibody class switching involves the repressor Bach2, NATURE, 429(6991), 566-571, 20040603
    Link to Paper Search Results by DOI
  85. A new system for laser-UVA-microirradiation of living cells., J Microsc., 209, 71-75, 20030401
  86. Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages., J. Cell Biol., 160, 685-697, 20030401
  87. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(49), 49246-49253, 20031205
    Link to Paper Search Results by DOI
  88. A role for RAD54B in homologous recombination in human cells, EMBO JOURNAL, 21(1-2), 175-180, 20020115
    Link to Paper Search Results by DOI
  89. Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(23), 20724-20733, 20020607
    Link to Paper Search Results by DOI
  90. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene, EMBO JOURNAL, 21(19), 5216-5224, 20021001
    Link to Paper Search Results by DOI
  91. ★, Rad51 accumulation at sites of DNA damage and in postreplicative chromatin., J. Cell Biol., 150(2), 283-291, 20000701
  92. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin, JOURNAL OF CELL BIOLOGY, 150(2), 283-291, 20000724
    Link to Paper Search Results by DOI
  93. Instability of chromosome 7 in colony forming cells of patients with aplastic anemia., Int. J. Hematol, 70, 13-19, 19990401

Publications such as books

  1. 2007/01, Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear domains. Nuclear Dynamics. , 2007, 01, Scholarly Book, Cocompilation, 4431300546, 29

Invited Lecture, Oral Presentation, Poster Presentation

  1. Radiation biology, medicine and Chromosome, Satoshi Tashiro, 5th Asian Congress of Radiation Research, 2022/11/20, With Invitation, English, Mumbai, India
  2. Biological and internal dosimetry for radiation medicine: current state and prospects for the future, Joint EURADOS WG 7 and WG 10 workshop, 2022/10/09, With Invitation, English, Estoril, Portugal
  3. Evaluation of DNA damage induced by radiological diagnosis, Satoshi Tashiro, 18th AOCR2021 Spring in YOKOHAMA, 2021/04/28, With Invitation, English, Asian Oceanian Congress of Radiology, WEB
  4. Response to Fukushima and lessons learned (2), Satoshi Tashiro, 5th QST International Symposium, 2021/09/22, Without Invitation, English, Web
  5. Evaluation of DNA damage induced by radiological diagnosis, Satoshi Tashiro, 18th AOCR2021 Spring in YOKOHAMA, 2021/04, With Invitation, English, Web
  6. Clinical Application of Cytogenetical Analysis in Patients Receiving CT Scan Exam and Radiotherapy, Satoshi Tashiro, IAEA Third Research Coordination Meeting on Applications of Biological Dosimetry Methods in Radiation Oncology, Nuclear Medicine, and Diagnostic and Interventional Radiology (MEDIBIODOSE), 2021/02/12, Without Invitation, English, Web
  7. Lessons from the Fukushima Daiichi Nuclear Power Plant Accident -From a research perspective, Satoshi Tashiro, ICRP International Conference on Recovery after Nuclear Accidents: Radiological Protection Lessons from Fukushima and Beyond, 2020/12/04, With Invitation, English, Web
  8. Biological effect of low-dose medical radiation, Satoshi Tashiro, IAEA Consultancy Meeting on Low-Dose Radiation for Patients and Population, 2020/10/21, Without Invitation, English
  9. Clinical applicaion of biological dosimetry in radiation oncology, Satoshi Tashiro, 2020/10/16, Without Invitation
  10. Mechanism of chromosome translocations in leukemia, Satoshi Tashiro, 2020/10/03, Without Invitation
  11. Individual differences in molecular sequelae of radiation exposure: what radiologists should know, Satoshi Tashiro, 2020/05/15, With Invitation, English, Web
  12. Clinical Applications of Biological Dosimetry, Satoshi Tashiro, Workshop on Biological and Internal Dosimetry; Recent advance and clinical application, 2020/02/20, With Invitation, English, HICARE/IAEA, Hiroshima, Japan
  13. Individual difference in the induction of chromosome aberrations after CT scan, Satoshi Tashiro, 2019/12/24, Without Invitation, Japanese
  14. Clinical Applications of Biological Dosimetry, Satoshi Tashiro, The Bilateral Workshop on the Radiation Medicine and Nuclear Emergency Preparedness between Hiroshima University and Soochow University 2019, 2019/12/02, Without Invitation, English, Suzhou, China
  15. Recent advances and clinical applications of biological dosimetry, Satoshi Tashiro, the 3th isRTB@Suzhou, 2019/11/30, With Invitation, English, Sizhou, China
  16. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Examination, Satoshi Tashiro, Radiation Research Society 65th Annual Meeting, 2019/11/06, Without Invitation, English, San Diego, USA
  17. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Examination, Satoshi Tashiro, 16th International Congress of Radiarion Research (ICRR) in Manchester, 2019/08/27, Without Invitation, English, Manchester, England
  18. Recent advances and clinical application of biological dosimetry, Satoshi Tashiro, Technical Meeting on Communication on Low-Dose Radiation - the Role of Science, Technology and Society, 2019/05/29, Without Invitation, English, Fukushima, Japan
  19. Clinical Application of Cytogenetical Analysis in Patients Receiving CT Scan Exam and Radiotherapy, Satoshi Tashiro, IAEA RCM Meeting, 2019/02/19, Without Invitation, English, IAEA, Recife, Brazil
  20. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2019/02/14, Without Invitation, English
  21. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2018/12/04, Without Invitation, English
  22. Regulation of ARP8 phosphorylation by ATM to prevent chromosome translocations, Satoshi Tashiro, 7th Meeting of the Asian Forum of Chromosome and Chromatin Biology, 2018/11/16, With Invitation, English, Bangalore, India
  23. SUMO modification system regulates DNA damage-depemdent exchange of histone variant H2A.Z-2, Satoshi Tashiro, 第77回日本癌学会学術総会, 2018/09/28, Without Invitation, Japanese
  24. Mechanism of accurate DNA repair to prevent chromosome translocations, Satoshi Tashiro, プロテイン・アイランド・松山(PIM)2018 第16回松山国際学術シンポジウム, 2018/09/12, With Invitation, English
  25. Prevention of chromosome translocations through ARP8 phosphorylation by ATM, Satoshi Tashiro, EMBO/EMBL Symposia, 2018/09/07, Without Invitation, English, EMBO/EMBL, Heidelberg, Germany
  26. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2018/07/26, Without Invitation, English
  27. Detection of chromosome aberrations after low dose irradiation in vitro and in vivo, Satoshi Tashiro, 物質･デバイス領域共同研究拠点H29年度成果報告会, 2018/06/28, Without Invitation, Japanese
  28. Radiation, chromosome and FISH, Satoshi Tashiro, HICARE研修, 2018/06/26, Without Invitation, English
  29. Nuclear topography of homologous recombinational repair, Satoshi Tashiro, The 3rd Hiroshima International Symposium on Future Science "Frontiers in Bioimagining Based Life Science", 2018/03/21, Without Invitation, English, 広島大学大学院理学研究科、クロマチン動態数理研究拠点（RcMcD)
  30. Clinical application of biodosimetry techniques, Satoshi Tashiro, 第2回放射線災害・医科学拠点国際シンポジウム, 2018/02/04, Without Invitation, English, Nagasaki
  31. ATM regulates phosphorylation of ARP8 to repress the loading of INO80 and RAD51 to chromosome translocation breakpoint hotspots, Satoshi Tashiro, 第33回京都大学放射線生物研究センター国際シンポジウム「放射線腫瘍生物学の最前線」, 2017/12/05, Without Invitation, English
  32. Nuclear Topography of homologous recombinational repair, Satoshi Tashiro, Friedrich Miescher Institute Seminar, 2017/11/06, With Invitation, English, Friedrich Miescher Institute（ＦＭＩ）, Basel, Switzerland
  33. Medical radiation exposure and DNA damage, Satoshi Tashiro, 第45回日本放射線技術学会秋季学術大会　（ICRST), 2017/10/21, Without Invitation, English
  34. Enhanced gefitinib-induced repression of the EGFR pathway by ATM kinase inhibition in non-small-cell lung cancer cells, Satoshi Tashiro, 第76回日本癌学会学術総会, 2017/09/29, Without Invitation, English
  35. Nuclear topography of DNA repair, Satoshi Tashiro, 4D Nuclome The Cell Nucleus in Space and Time, 2017/05/16, Without Invitation, English, Jagiellonian University in Krakow, Krakow, Poland
  36. Radiation, chromosome and FISH, Satoshi Tashiro, IAEA・HICARE協働センターによる先進的放射線治療に関する国際医療研修, 2017/02/02, With Invitation, English, IAEA/HICARE
  37. Nuclome Analysis of DNA repair, Satoshi Tashiro, 第39回日本分子生物学会, 2016/12/01, Without Invitation, Japanese
  38. Regulatory mechanism of the exchange of histone variant H2A,Z-2 at DNA damaged sites, Satoshi Tashiro, Atsuhiko Fukuto, 第9回広島－明治－龍谷合同合宿, 2016/08/30, With Invitation, Japanese
  39. Cytogenetic effects of radioiodine therapy and CT scan -Application of biodosimetry to medicine-, Satoshi Tashiro, IAEA-Consultants Meeting on Clinical applications of biodosimetry and BIODOSE/RADBIO lab concept, 2016/07/12, With Invitation, English, IAEA, IAEA's Headquarters in Vienna, Austria
  40. Nuclear Topography of Homologous Recombinational Repair, Satoshi Tashiro, Genomic Instability & Cancer Genetics Research Program Meeting, 2016/05/09, Without Invitation, English, Rutgers Cancer Institute of New Jersey, Rutgers Cancer Institute of New Jersey, NJ, USA
  41. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, Satoshi Tashiro, Nuclear Organization & Function, 2016/05/03, Without Invitation, English, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory
  42. CT scan-induced DNA damage in children measured using molecular markers and nanoscope technology, Satoshi Tashiro, 14th International Workshop on Radiation Damage to DNA, 2016/03/22, Without Invitation, English, The Australian Institute of Nuclear Science and Engineering (AINSE), supported by IARR and RRS, Victorian Treasury Theater and Old Treasury Building Melbourne Australia
  43. Detection of Translocations by the Fluorescence in Situ Hybridization (FISH) Technique Using Whole Chromosone Painting DNA Probes-Detection of Dicentric and Ring Chromosomes by the FISH Using Cnetromere and Telomere PNA Probes, Satoshi Tashiro, Yoshiaki Kodama, IAEA 3rd (final) Research Coordination Meeting, 2016/03/08, With Invitation, English, IAEA, IAEA Headquarters, Vienna, Austria
  44. Architecture of radiation-induced nuclear domains, Satoshi Tashiro, 第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会, 2015/12/04, Without Invitation, English
  45. Regulation of homologous recombinational repair by nuclear structure-associated proteins, Satoshi Tashiro, Satoshi Tashiro, Tsuyoshi Ikura, Jiying Sun, 74th Annual Meeting of the Japanese Cancer Association, 2015/10/10, Without Invitation, English, Nagoya Congress Center, DNA double-strand breaks (DSBs) are the major lethal lesion induced by ionizing radiation (IR). RAD51-dependent homologous recombination (HR) is one of the most important pathways in DSB repair and genome integrity maintenance. To understand the mechanism of RAD51-dependent HR, we searched for interacting partners of RAD51 by a proteomics analysis and identified lamin B1 in human cells. Lamins are nuclear lamina proteins that play important roles in the structural organization of the nucleus and the regulation of chromosome functions. Lamin B1 depletion repressed the DNA damage-dependent increase of RAD51 after IR. The repression was abolished by the proteasome inhibitor MG132, suggesting that lamin B1 stabilizes RAD51 by preventing proteasome-mediated degradation in cells with IR-induced DNA damage. We also showed that lamin B1 depletion repressed RAD51 focus formation and decreased the survival rates after IR. Based on these results, we propose that lamin B1 promotes DSB repair and cell survival by maintaining the RAD51 protein levels for HR, upon DSB induction after IR.
  46. Biological estimation of DNA damage induced by CT scan - Application of biodosimetry to medicine -, Satoshi Tashiro, Future of Biodosimetry in Asia: Promoting a Regional Network NIRS/IAEA Technical Meeting, 2015/09/16, With Invitation, English, National Institute of Radiological Science in collaboration with the International Atomic Energy Agency, Chiba
  47. Regulation of DNA Repair and Nuclear Lamina, Satoshi Tashiro, International Symposium on Chromatin Structure, Dynamics, and Function, 2015/08/25, Without Invitation, English, Awaji Yumebutai International Conference Center Awaji, Among the various types of DNA damage induced by ionizing radiation (IR), double strand breaks (DSBs) are regarded as the most serious impairment leading to cell death. In mammalian cells, DSBs are repaired mainly by one of two genetically distinct processes, non-homologous end joining (NHEJ) and homologous recombination (HR). RAD51, a recA homolog that forms helical filaments, binds to single-strand DNA, thus promoting recombinational repair. RAD51-dependent HR is one of the most important pathways in DSB repair and genome integrity maintenance. However, the mechanism of HR regulation by RAD51 remains unclear. To understand the mechanism of RAD51-dependent HR, we searched for interacting partners of RAD51 by a proteomics analysis and identified lamin B1 in human cells. Lamins are nuclear lamina proteins that play important roles in the structural organization of the nucleus and the regulation of chromosome functions. Immunoblotting analyses revealed that siRNA-mediated lamin B1 depletion repressed the DNA damage-dependent increase of RAD51 after IR. The repression was abolished by the proteasome inhibitor MG132, suggesting that lamin B1 stabilizes RAD51 by preventing proteasome-mediated degradation in cells with IR-induced DNA damage. We also showed that lamin B1 depletion repressed RAD51 focus formation and decreased the survival rates after IR. Based on these results, we propose that lamin B1 promotes DSB repair and cell survival by maintaining the RAD51 protein levels for HR, upon DSB induction after IR.
  48. Biological estimation of the DNA damage induced by CT scan, Satoshi Tashiro, The 15th International Congress of Radiation Research, 2015/06/27, With Invitation, English, Kyoto, Ionizing radiation can induce DNA damage. Human beings live under the environment with various types of DNA damaging agents, such as natural ionizing radiation and chemical agents. Therefore, human cells have DNA repair system to protect the genetic information from DNA damage. However, once cells received too much DNA damage to repair, apoptosis and/or changes of genetic information are induced. Accumulation of changes in genetic information has been shown to lead to carcinogenesis. Recent advance in medical image analysis, such as the development of high-speed multidetector CT, introduces the drastic progress in the field of diagnostic radiology. These progresses in diagnostic radiology strongly contribute to the progress in almost all fields of medicine. On the other hand, the health effect of medical exposure, especially CT scan, is still unclear. We have established a method to detect radiation-induced chromosome abnormalities, dicentric and ring chromosomes, by applying a fluorescence in situ hybridization (FISH) technique using telomere and centromere peptide nucleic acid (PNA) probes. We also examined the usefulness of immunofluorescence staining analysis using antibodies against DNA repair proteins in the estimation of DNA damage induced by CT scan. The possibility of the application of these techniques in the estimation of health effect of medical exposure will be discussed.
  49. Nuclear topography of homologous recombinational repair, Satoshi Tashiro, The 15th International Congress of Radiation Research, 2015/05/28, With Invitation, English, Kyoto University Research Reactor Institute, Kyoto, The chromosome territory-interchromatin compartment (CT-IC) model argues that nuclei are built up from two principal components, chromosome territories and the interchromatin compartment (IC). Several line of evidence suggests that the periphery of a chromatin domain bordering the IC represents the major nuclear sub-compartment for transcription, or co-transcriptional RNA splicing and DNA replication. However, the association of DNA metabolism, including DNA repair, with the higher order nuclear architectures are largely unknown. Homologous recombination repair (HR) is one of the major repair pathways of DNA double-strand breaks (DSBs) produced by endogenous and exogenous factors. A fraction of proteins involved in the HR pathway have been shown to accumulate at sites containing DNA damage to form damage induced nuclear foci. On the other hand, damaged chromatin is shown to be mobile after induction of DNA damage in a manner dependent on HR factors. However, the biological significance of such dynamic rearrangements of higher order nuclear architectures in HR is still unclear. Recent development of super-resolution microscopy has been expected to contribute the further understanding of the association of DNA metabolisms, such as HR, with higher order nuclear structures. RAD51 is a key factor in the HR pathway loaded on single stranded DNA processed around DSBs. In our previous study, we showed that RAD51 forms nuclear foci in S phase and at sites containing DNA damages. Recently, we found that the overexpressed RAD51 is accumulated within bundle-like sub-compartments of IC in human cell nucleus. Single stranded DNA formed at sites containing DNA damage for HR was detected within the sub-compartments. These findings support the notion that damaged chromatins are moved into the bundle-like sub-compartment of IC for HR, or HR factory. The usefulness of the super resolution microscopy in these analyses will be discussed.
  50. Regulation of DNA repair and nuclear lamina, Satoshi Tashiro, Institute for Protein Research (IPR) Seminar Nuclear organization and actin-dependent mechanisms in genome stability, 2015/05/18, With Invitation, English, Institute for Protein Research (IPR), Osaka University
  51. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot in therapy-related leukemia., Satoshi Tashiro, 2009/03, With Invitation, Japanese
  52. Dynamics of higher order nuclear architecture upon DNA damage., Satoshi Tashiro, 2008/10, With Invitation, Japanese
  53. Dynamics of BACH2 nuclear foci regualted by SUMOylation., 2007/01, With Invitation, Japanese

Awards

  1. 2022/11/20, The AARR SENIOR LEVEL AWARD, Asian Association for Radiation Research(AARR), Radiation biology, medicine, and Chromosome

External Funds

Acceptance Results of Competitive Funds

  1. The Center of World Intelligence Project for Nuclear S&T and Human Resource Development, 2015/10/01, 2018/03/31

Social Activities

History as Peer Reviews of Academic Papers

  1. 2020, Radiation and Environmengal Biophysics, Editor
  2. 2019, Radiaton and Environmental Biophysics, Editor
  3. 2018, Radiation and Environmental Biophysics, Editor
  4. 2017, Radiation and Environmental Biophysics, Editor
  5. 2016, Radiatin and Environmental Biophysics, Editor
  6. 2015, Radiation and Environmental Biophysics, Editor
  7. 2014, Radiation and Environmengal Biophysics, Editor
  8. 2013, Radiation and Environmental Biophysics, Editor
  9. 2012, Radiation and Environmental Biophysics, Editor
  10. 2011, Radiation and Environmental Biophysics, Editor
  11. 2010, Radiation and Environmental Biophysics, Editor
  12. 2009, Radiation and Environmental Biophysics, Editor
  13. 2008, Radiation and Environmental Biophysics, Editor