磯部直樹NaokiIsobe

Last Updated :2019/09/02

所属・職名
大学院統合生命科学研究科生生・家畜生産機能学(生生支援室)准教授
ホームページ
メールアドレス
nisohiroshima-u.ac.jp
その他連絡先
東広島市鏡山1-4-4 大学院生物圏科学研究科大学院生物圏科学研究科B棟304号室
TEL:082-424-7993 FAX:082-424-7993
自己紹介
ウシ・ヤギにおける乳房炎予防のための研究を遂行している。

基本情報

主な職歴

  • 1996年08月01日, 2005年03月31日, 大学院国際協力研究科, 広島大学助手
  • 2016年09月26日, 2017年09月26日, ガジャマダ大学農学部, 農学部, 客員教授

学歴

  • 広島大学, 生物圏科学研究科, 生物生産学, 日本, 1993年04月, 1996年03月
  • 広島大学, 生物生産学部, 生物生産, 日本, 1987年04月, 1991年03月

学位

  • 博士(農学)(広島大学)
  • 修士(農学)(広島大学)

教育担当

  • 【学士課程】 生物生産学部 : 生物生産学科
  • 【博士課程前期】 統合生命科学研究科 : 統合生命科学専攻 : 生物資源科学プログラム
  • 【博士課程後期】 統合生命科学研究科 : 統合生命科学専攻 : 生物資源科学プログラム

担当主専攻プログラム

  • 動物生産科学プログラム

研究分野

  • 農学 / 動物生命科学 / 動物生産科学

研究キーワード

  • 乳腺
  • 酵素免疫測定法
  • 体細胞数
  • 免疫組織化学
  • ホルモン
  • 乳房炎
  • 自然免疫
  • 抗菌ペプチド

所属学会

  • 日本獣医学会, 2016年
  • 米国デイリーサイエンス学会, 2009年
  • 日本畜産学会, 1990年
  • 日本繁殖生物学会, 1993年
  • 日本乳房炎研究会, 2006年
  • 関西畜産学会, 1990年
  • 中四国乳房炎協議会, 2013年

教育活動

授業担当

  1. 2019年, 教養教育, 1ターム, 教養ゼミ
  2. 2019年, 学部専門, 集中, 基礎生物学実験II
  3. 2019年, 学部専門, 2ターム, 動物生産サイエンス入門
  4. 2019年, 学部専門, 3ターム, 動物生体機構学
  5. 2019年, 学部専門, 集中, 動物生体機構学実験実習
  6. 2019年, 学部専門, 年度, 卒業論文
  7. 2019年, 学部専門, 1ターム, 動物生産生理学
  8. 2019年, 学部専門, 集中, (AIMS) Introductory Physiology of Domestic Animals
  9. 2019年, 学部専門, 3ターム, Introductory Physiology of Domestic Animals
  10. 2019年, 修士課程・博士課程前期, 2ターム, 家畜機能形態学
  11. 2019年, 修士課程・博士課程前期, 2ターム, 家畜生体機構学
  12. 2019年, 修士課程・博士課程前期, 4ターム, 家畜機能調節学
  13. 2019年, 修士課程・博士課程前期, 4ターム, 家畜機能組織学
  14. 2019年, 修士課程・博士課程前期, セメスター(後期), 特別研究
  15. 2019年, 博士課程・博士課程後期, セメスター(前期), 陸域動物生産学演習(B)
  16. 2019年, 博士課程・博士課程後期, セメスター(後期), 陸域動物生産学演習(B)
  17. 2019年, 修士課程・博士課程前期, ターム外(前期), 陸域動物生産学実験実習
  18. 2019年, 修士課程・博士課程前期, 1ターム, 生物資源科学特別演習A
  19. 2019年, 修士課程・博士課程前期, 2ターム, 生物資源科学特別演習A
  20. 2019年, 修士課程・博士課程前期, 3ターム, 生物資源科学特別演習B
  21. 2019年, 修士課程・博士課程前期, 4ターム, 生物資源科学特別演習B
  22. 2019年, 修士課程・博士課程前期, 年度, 生物資源科学特別研究
  23. 2019年, 修士課程・博士課程前期, 2ターム, 家畜生産機能学Ⅰ
  24. 2019年, 修士課程・博士課程前期, 4ターム, 家畜生産機能学Ⅱ

研究活動

学術論文(★は代表的な論文)

  1. Detection of APAF1 mutation in Holstein cows and mummified foetuses in Japanese dairy herds, REPRODUCTION IN DOMESTIC ANIMALS, 53巻, 1号, pp. 137-142, 201802
  2. Microcystin-leucine-arginine Modulates the Expression Patterns of Proinflammatory Cytokines and an Apoptotic Gene in Chicken Liver, JOURNAL OF POULTRY SCIENCE, 55巻, 1号, pp. 70-77, 201801
  3. Blood ionized calcium levels and acute-phase blood glucose kinetics in goats after intramammary infusion of lipopolysaccharide, JOURNAL OF VETERINARY MEDICAL SCIENCE, 80巻, 2号, pp. 242-246, 201802
  4. Innate antiviral immune response against infectious bronchitis virus and involvement of prostaglandin E2 in the uterine mucosa of laying hens, THERIOGENOLOGY, 110巻, pp. 122-129, 20180401
  5. Effects of Interleukin-1 beta and-6 on the Expression of Ion Transporters Involved in Eggshell Mineralization in Cultured Hen Uterine Mucosal Tissue, JOURNAL OF POULTRY SCIENCE, 55巻, 2号, pp. 142-149, 201804
  6. Changes in plasma concentrations of S100A7 and S100A8 in dairy cows during pregnancy, REPRODUCTION IN DOMESTIC ANIMALS, 53巻, 4号, pp. 1013-1015, 201808
  7. Effects of colostrum whey on immune function in the digestive tract of goats, ANIMAL SCIENCE JOURNAL, 89巻, 8号, pp. 1152-1160, 201808
  8. Changes in the concentrations of somatic cell counts, lingual antimicrobial peptide and lactoperoxidase activity in milk at periovulatory period in dairy cows, ANIMAL SCIENCE JOURNAL, 88巻, 3号, pp. 484-488, 2017
  9. Effects of inhibitors of transcription factors, nuclear factor-kappa B and activator protein 1, on the expression of proinflammatory cytokines and chemokines induced by stimulation with Toll-like receptor ligands in hen vaginal cells, POULTRY SCIENCE, 96巻, 3号, pp. 723-730, 2017
  10. Control mechanisms for producing antimicrobial factors in ruminant mammary gland, ANIMAL SCIENCE JOURNAL, 88巻, 7号, pp. 937-943, 2017
  11. Effect of steroid hormones on the innate immune response induced by Staphylococcus aureus in the goat mammary gland, REPRODUCTION IN DOMESTIC ANIMALS, 52巻, 4号, pp. 579-584, 2017
  12. Changes in the concentrations of somatic cell counts, lingual antimicrobial peptide and lactoperoxidase activity in milk at periovulatory period in dairy cows., Animal Science Journal, 88巻, 3号, pp. 484-488, 20170301
  13. Effect of nutrient levels during the far-off period on postpartum productivity in dairy cows., Animal Science Journal, 2017
  14. The extension of raw milk quality during storage through supplementation of hydrocyanic acid from fresh cassava peel in dairy cattle diet. Songklanakarin Journal of Science and Technology (in press), Songklanakarin Journal of Science and Technology, 2017
  15. The inhibitory effect of sodium thiocyanate and sodium percarbonate rations on microorganism growth in raw milk samples as an effective treatment to extend milk quality during storage., Songklanakarin Journal of Science and Technology, 39巻, 1号, 2017
  16. Effects of dietary levels of fresh cassava pulp in dairy cattle diet on productive performance and keeping quality of raw milk. Songklanakarin Journal of Science and Technology (in press), Songklanakarin Journal of Science and Technology, 2017
  17. Microcystin-LR modulates the expression patterns of proinflammatory cytokines and apoptotic gene in the liver of chicken. Journal of Poultry Science, Journal of Poultry Science, 2017
  18. Cellular and soluble components decrease the viable pathogen counts in milk from dairy cows with subclinical mastitis., The Journal of Veterinary Medical Science, 79巻, 8号, pp. 1389-1393, 201708
  19. Effects of Probiotics on the Expression of Cathelicidins in Response to Stimulation by Salmonella Minnesota Lipopolysaccharides in the Proventriculus and Cecum of Broiler Chicks, JOURNAL OF POULTRY SCIENCE, 53巻, 4号, pp. 298-304, 2016
  20. Change in viable bacterial count during preservation of milk derived from dairy cows with subclinical mastitis and its relationship with antimicrobial components in milk., The Journal of Veterinary Medical Science, 78巻, 8号, pp. 1245-1250, 201608
  21. Expression of lipases and lipid receptors in sperm storage tubules and possible role of fatty acids in sperm survival in the hen oviduct., Theriogenology, 85巻, pp. 1334-1342, 20160415
  22. 乳房炎Q&A「なぜ乳房炎が繁殖機能に影響を及ぼすのか, 臨床獣医, 34巻, 3号, pp. 4-5, 201603
  23. Effects of viral-associated molecular patterns on the expression of cathelicidins in the hen vagina., Journal of Poultry Science, 2016
  24. The inhibitory effect of sodium thiocyanate and sodium percarbonate rations on microorganism growth in raw milk samples as an effective treatment to extend milk quality during storage., Songklanakarin Journal of Science and Technology, 39巻, 1号, 2016
  25. Effects of inhibitors of transcription factors, nuclear factor-κB and activator protein 1, on the expression of proinflammatory cytokines and chemokines induced by stimulation with Toll-like receptor ligands in hen vaginal cells, Poultry Science, 2016
  26. The effect of estrogen on the early cytotoxic response to IB virus infection in hen oviduct, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 164巻, 42737号, pp. 56-66, 20150315
  27. Dynamics of lingual antimicrobial peptide, lactoferrin concentrations and lactoperoxidase activity in the milk of cows treated for clinical mastitis, ANIMAL SCIENCE JOURNAL, 86巻, 2号, pp. 153-158, 201502
  28. Effects of Probiotics on the Expression and Localization of Avian beta-defensins in the Proventriculus of Broiler Chicks, JOURNAL OF POULTRY SCIENCE, 52巻, 1号, pp. 57-67, 201501
  29. Expression of cathelicidins mRNA in the goat mammary gland and effect of the intramammary infusion of lipopolysaccharide on milk cathelicidin-2 concentration, VETERINARY MICROBIOLOGY, 170巻, 42737号, pp. 125-134, 20140514
  30. Effects of different TLR ligands on the expression of proinflammatory cytokines and avian beta-defensins in the uterine and vaginal tissues of laying hens, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 162巻, 42798号, pp. 132-141, 20141215
  31. Innate immune functions in hen reproductive organs, AVIAN BIOLOGY RESEARCH, 7巻, 1号, pp. 39-47, 2014
  32. Effects of calcium salts of medium-chain fatty acids on plasma metabolite and hormone concentrations in early lactating dairy cows, ANIMAL PRODUCTION SCIENCE, 54巻, 10号, pp. 1699-1702, 2014
  33. Messenger RNA expression and immunolocalization of psoriasin in the goat mammary gland and its milk concentration after an intramammary infusion of lipopolysaccharide, VETERINARY JOURNAL, 202巻, 1号, pp. 89-93, 2014
  34. Effects of avian infectious bronchitis virus antigen on eggshell formation and immunoreaction in hen oviduct, THERIOGENOLOGY, 81巻, 8号, pp. 1129-1138, 2014
  35. Toll-like receptor signaling for the induction of mucin expression by lipopolysaccharide in the hen vagina, POULTRY SCIENCE, 93巻, 3号, pp. 673-679, 2014
  36. Relationship between the somatic cell count in milk and reproductive function in peripartum dairy cows, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 60巻, 6号, pp. 433-437, 2014
  37. Relationship between concentration of lingual antimicrobial peptide and somatic cell count in milk of dairy cows, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 153巻, 42798号, pp. 298-301, 20130615
  38. Expression of tight junction molecule claudins" in the lower oviductal segments and their changes with egg-laying phase and gonadal steroid stimulation in hens", THERIOGENOLOGY, 79巻, 2号, pp. 211-218, 20130115
  39. ウシ乳腺におけるlingual antimicrobial peptide (LAP)の役割, 家畜診療, 60巻, 7号, pp. 419-424, 201307
  40. Comparison of cadherin and integrin localization in bovine cystic and healthy follicles, ANIMAL SCIENCE JOURNAL, 84巻, 4号, pp. 303-309, 2013
  41. Dectin-1 gene polymorphism is associated with susceptibility to nonspecific digestive disorders and cytokine expression in rabbits, JOURNAL OF ANIMAL SCIENCE, 91巻, 9号, pp. 4051-4059, 2013
  42. Lingual antimicrobial peptide and lactoferrin concentrations and lactoperoxidase activity in bovine colostrum are associated with subsequent somatic cell count, ANIMAL SCIENCE JOURNAL, 84巻, 11号, pp. 751-756, 2013
  43. Induction of avian beta-defensins by CpG oligodeoxynucleotides and proinflammatory cytokines in hen vaginal cells in vitro, REPRODUCTION, 145巻, 6号, pp. 621-631, 2013
  44. Effects of Probiotics on the Localization of T Cell Subsets in the Intestine of Broiler Chicks, JOURNAL OF POULTRY SCIENCE, 50巻, 3号, pp. 275-281, 2013
  45. Effects of Lipopolysaccharide on the Recruitment of T Cells in the Seminal Tract of Roosters, JOURNAL OF POULTRY SCIENCE, 50巻, 1号, pp. 68-73, 2013
  46. Effects of Repeated Lipopolysaccharide Stimulation on the Development of Antigen-presenting Cells and T Cells Pool in Hen Vagina, JOURNAL OF POULTRY SCIENCE, 50巻, 1号, pp. 83-89, 2013
  47. Induction of mucin expression by estrogen and lipopolysaccharide in the lower oviductal segments in hens, POULTRY SCIENCE, 92巻, 12号, pp. 3205-3213, 2013
  48. Expression of Toll-like receptors and effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokine in the testis and epididymis of roosters, POULTRY SCIENCE, 91巻, 8号, pp. 1997-2003, 2012
  49. Differences in the mucosal surface barrier formed by mucin in the lower oviductal segments between laying and molting hens, POULTRY SCIENCE, 91巻, 5号, pp. 1173-1178, 20120501
  50. Differential immunolocalization between lingual antimicrobial peptide and lactoferrin in mammary gland of dairy cows, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 145巻, 42737号, pp. 499-504, 20120115
  51. Effect of enterotoxigenic Escherichia coli vaccine on innate immune function of bovine mammary gland infused with lipopolysaccharide, JOURNAL OF DAIRY SCIENCE, 95巻, 9号, pp. 5067-5074, 2012
  52. Effects of lipopolysaccharide and interleukins on the expression of avian beta-defensins in hen ovarian follicular tissue, POULTRY SCIENCE, 91巻, 11号, pp. 2877-2884, 2012
  53. Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and influx of leukocytes in the hen ovary, POULTRY SCIENCE, 90巻, 9号, pp. 2054-2062, 20110901
  54. Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and the subsequent recruitment of immunocompetent cells in the oviduct of laying and molting hens, POULTRY SCIENCE, 90巻, 10号, pp. 2332-2341, 20111001
  55. Differential localization of lingual antimicrobial peptide in the digestive tract mucosal epithelium of calves, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 142巻, 42737号, pp. 87-94, 20110715
  56. Expression of Toll-like receptors and avian beta-defensins and their changes in response to bacterial components in chicken sperm, POULTRY SCIENCE, 90巻, 2号, pp. 417-425, 20110201
  57. Detection of Avian Beta-defensins mRNA and Proteins in Male Reproductive Organs in Chicken, JOURNAL OF POULTRY SCIENCE, 48巻, 4号, pp. 275-280, 2011
  58. Changes in the Density of Immunoreactive Avian beta-Defensin-3 and-11 in the Hen Uterus in Response to Lipopolysaccharide Inoculation, JOURNAL OF POULTRY SCIENCE, 48巻, 1号, pp. 73-77, 2011
  59. Lactoperoxidase activity in milk is correlated with somatic cell count in dairy cows, JOURNAL OF DAIRY SCIENCE, 94巻, 8号, pp. 3868-3874, 2011
  60. Follicular Persistence Induced by Adrenocorticotropic Hormone Administration in Goats, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 57巻, 2号, pp. 212-216, 2011
  61. Analysis of Changes in the Expression of Transforming Growth Factor-beta s in the Utero-vaginal Junction of Hen Oviduct in Response to Sperm Concerning Their Significance in Sperm Survivability, JOURNAL OF POULTRY SCIENCE, 47巻, 4号, pp. 326-332, 2010
  62. Effects of Feeding Probiotics on the Localization of Cells Containing Immunoreactive Interleukin-6 in the Intestine of Broiler Chicks, JOURNAL OF POULTRY SCIENCE, 47巻, 3号, pp. 250-255, 2010
  63. Changes in the Localization of Immunoreactive Avian Beta-Defensin-8,-10 and-12 in Hen Ovarian Follicles during Follicular Growth, JOURNAL OF POULTRY SCIENCE, 47巻, 1号, pp. 77-84, 2010
  64. Expression of Toll-like receptors (TLRs) and TLR4 response to lipopolysaccharide in hen oviduct, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127巻, 42798号, pp. 259-268, 20090215
  65. Co-transfer of parthenogenotes and single porcine embryos leads to full-term development of the embryos, ANIMAL REPRODUCTION SCIENCE, 112巻, 42737号, pp. 8-21, 2009
  66. Changes in the expression of interleukin-1 beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination, REPRODUCTION, 137巻, 3号, pp. 527-536, 2009
  67. Existence of functional lingual antimicrobial peptide in bovine milk, JOURNAL OF DAIRY SCIENCE, 92巻, 6号, pp. 2691-2695, 2009
  68. Identification of Ghrelin in Fertilized Eggs of Chicken, JOURNAL OF POULTRY SCIENCE, 46巻, 3号, pp. 257-259, 2009
  69. Intramammary challenge of lipopolysaccharide stimulates secretion of lingual antimicrobial peptide into milk of dairy cows, JOURNAL OF DAIRY SCIENCE, 92巻, 12号, pp. 6046-6051, 2009
  70. Immunolocalization of avian beta-defensins in the hen oviduct and their changes in the uterus during eggshell formation, REPRODUCTION, 138巻, 6号, pp. 971-978, 2009
  71. ★, Existence of Functional Lingual Antimicrobial Peptide (LAP) in Bovine Milk, Journal of Dairy Science, 92巻, 6号, pp. 2691-2695, 20090601
  72. Immunolocalization of lingual antimicrobial peptide (LAP) in the bovine mammary gland, ANIMAL SCIENCE JOURNAL, 80巻, 4号, pp. 446-450, 2009
  73. Immunolocalization of lingual antimicrobial peptide (LAP) in the bovine mammary gland, ANIMAL SCIENCE JOURNAL, 80巻, 4号, pp. 446-450, 2009
  74. Expression of avian beta-defensins in the oviduct and effects of lipopolysaccharide on their expression in the vagina of hens, POULTRY SCIENCE, 87巻, 5号, pp. 979-984, 2008
  75. Poultry production profile and expected future projection in Bangladesh, WORLDS POULTRY SCIENCE JOURNAL, 64巻, 1号, pp. 99-117, 2008
  76. Expression of vascular endothelial growth factor receptors in bovine cystic follicles, REPRODUCTION IN DOMESTIC ANIMALS, 43巻, 3号, pp. 267-271, 2008
  77. Changes in the localization of immunoreactive avian beta-defensin-12 in ovarian follicles during follicular growth and in response to lipopolysaccharide, JOURNAL OF POULTRY SCIENCE, 45巻, 3号, pp. 210-214, 2008
  78. Mechanism of Prolonged Sperm Storage and Sperm Survivability in Hen Oviduct: A Review, AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 60巻, 6号, pp. 477-481, 2008
  79. Expression of Avian beta-Defensin 3, an Antimicrobial Peptide, by Sperm in the Male Reproductive Organs and Oviduct in Chickens: An Immunohistochemical Study, POULTRY SCIENCE, 87巻, 12号, pp. 2653-2659, 2008
  80. Ovarian Cyclicity and Reproductive Performance of Holstein Cows Carrying the Mutation of Complex Vertebral Malformation in Japan., Reproduction in Domestic Animals, pp. IN PRESS, 20080101
  81. Changes in fecal progestagen profile after excretion in miniature pigs, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 53巻, 5号, pp. 1107-1112, 2007
  82. Deficient proliferation and apoptosis in the granulosa and theca interna cells of the bovine cystic follicle, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 53巻, 5号, pp. 1119-1124, 2007
  83. Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus), REPRODUCTION, 133巻, 1号, pp. 127-133, 2007
  84. Follicular cysts in dairy cows, ANIMAL SCIENCE JOURNAL, 78巻, 1号, pp. 1-6, 2007
  85. Fecal progestagen and estrone during pregnancy in a giraffe: A case report, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 53巻, 1号, pp. 159-164, 2007
  86. Changes in the expression of Toll-like receptor mRNAs during follicular growth and in response to lipopolysaccharide in the ovarian follicles of laying hens, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 53巻, 6号, pp. 1227-1235, 2007
  87. Involvement of plasma progesterone, Oestradiol-17 beta and cortisol in ovulatory response to gonadotropin-releasing hormone in dairy cows with cystic follicles, REPRODUCTION IN DOMESTIC ANIMALS, 42巻, 4号, pp. 370-375, 2007
  88. Preparation and Application for Immunocytochemistry of Antibody to Gallinacin-3, an Antimicrobial Peptide, in Chicken., Journal of Poultry Science, 44巻, 4号, pp. 433-438, 20071001
  89. Changes in the mRNA expressions of sperm Transforming Growth Factor beta-isoforms and their receptors with reference to fertility during in vitro storage of fowl semen., Journal of Poultry Science, 44巻, 2号, pp. 189-197, 20070401
  90. 牛乳中ペルオキシダーゼと乳房炎との関係について, 広島大学FSC報告, 4巻, pp. 57-62, 20070301
  91. Studies of the role of steroid hormone in the regulation of oocyte maturation in cattle, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 4巻, 20060203
  92. Expression of transforming growth factor-beta isoforms and their receptors in utero-vaginal junction of hen oviduct in presence or absence of resident sperm with reference to sperm storage, REPRODUCTION, 132巻, 5号, pp. 781-790, 2006
  93. Effects of age and gonadal steroids on the localization of antigen presenting cells in the epididymis of the male chicken, gallus domesticus, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 52巻, 3号, pp. 363-371, 2006
  94. Effects of age, egg-laying activity, and Salmonella-inoculation on the expressions of gallinacin mRNA in the vagina of the hen oviduct, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 52巻, 2号, pp. 211-218, 2006
  95. Enzyme Histochemical Localization of Peroxidase Activity in the Oviduct of Immature, Laying and Non-laying Hens. (),, Journal of Poultry Science, 43巻, 4号, pp. 401-407, 20061001
  96. ダイレクト法によるミニブタ糞中プロジェステロン濃度の測定, 広島大学FSC報告, 3巻, pp. 27-29, 20060301
  97. Studies on substantially increased proteins in follicular fluid of bovine ovarian follicular cysts using 2-D PAGE and MALDI-TOF MS, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 3巻, 20050608
  98. Expression of gap junction protein connexin 43 during follicular atresia in the ovary of swamp buffaloes, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 51巻, 5号, pp. 675-681, 2005
  99. Microvascular distribution and vascular endothelial growth factor expression in bovine cystic follicles, DOMESTIC ANIMAL ENDOCRINOLOGY, 29巻, 4号, pp. 634-645, 2005
  100. Enzyme immunoassay of progesterone in the feces from beef cattle to monitor the ovarian cycle, ANIMAL REPRODUCTION SCIENCE, 87巻, 42737号, pp. 1-10, 2005
  101. Gonadotropin-induced Delta 14-reductase and Delta 7-reductase gene expression in cumulus cells during meiotic resumption of porcine oocytes, ENDOCRINOLOGY, 146巻, 1号, pp. 186-194, 2005
  102. Pregnancy diagnosis based on the fecal progesterone concentration in beef and dairy heifers and beef cows, ANIMAL REPRODUCTION SCIENCE, 90巻, 42798号, pp. 211-218, 2005
  103. Immunolocalization of von Willebrand factor and vascular endothelial growth factor during follicular atresia in the swamp buffalo ovary, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 51巻, 4号, pp. 419-426, 2005
  104. Apoptosis in the antral follicles of swamp buffalo and cattle ovary: TUNEL and caspase-3 histochemistry, REPRODUCTION IN DOMESTIC ANIMALS, 40巻, 2号, pp. 111-116, 2005
  105. Expressions of antimicrobial peptide gallinacin-1,-2 and -3 mRNAs in the oviduct of laying hens., Journal of Poultry Science, 42巻, 4号, pp. 337-345, 20051025
  106. Direct enzyme immunoassay of fecal estrone derivatives in dairy cows. :, Animal Science Journal, 76巻, 3号, pp. 203-207, 20050701
  107. Characteristics of cryopreserved spermatozoa from a holstein friesian bull thawed at different temperature., 国際協力研究誌, 12巻, 1号, pp. 107-110, 20050401
  108. 糞中プロジェステロン測定によるミニブタの卵巣機能の把握, 広島大学FSC報告, 2巻, pp. 1-5, 20050301
  109. Atresia ani with diphallus and separate scrota in a calf: a case report, THERIOGENOLOGY, 61巻, 42924号, pp. 1205-1213, 2004
  110. Changes in the thecal vasculature during follicular atresia in the ovary of swamp buffalo, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 50巻, 3号, pp. 315-321, 2004
  111. Incidence of silent ovulation in dairy cows during post partum period, DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT, 111巻, 1号, pp. 35-38, 2004
  112. Pregnancy diagnosis in miniature pig by direct ELISA of oestrone derivatives in faeces, REPRODUCTION IN DOMESTIC ANIMALS, 39巻, 1号, pp. 48-51, 2004
  113. Cell proliferation in the atretic follicles of buffalo and cattle ovary, REPRODUCTION IN DOMESTIC ANIMALS, 39巻, 6号, pp. 405-409, 2004
  114. 血漿中プロジェステロン濃度測定によるミニブタの卵巣機能の把握と早期妊娠診断, 広島大学FSC報告, 1巻, pp. 25-28, 20040301
  115. Phosphatidylinositol 3-kinase in cumulus cells is responsible for both suppression of spontaneous maturation and induction of gonadotropin-stimulated maturation of porcine oocytes, JOURNAL OF ENDOCRINOLOGY, 179巻, 1号, pp. 25-34, 2003
  116. Distribution of cytochrome p450-side chain cleavage in the theca interna layers of bovine small antral and cystic follicles, REPRODUCTION IN DOMESTIC ANIMALS, 38巻, 5号, pp. 405-409, 2003
  117. Plasma concentration of estrone sulfate during pregnancy in different breeds of Japanese beef cattle, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 49巻, 5号, pp. 369-374, 2003
  118. Effects of body condition score in cows peripartum on the onset of postpartum ovarian cyclicity and conception rates after ovulation synchronization/fixed-time artificial insemination, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 49巻, 5号, pp. 381-388, 2003
  119. Immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase in the granulosa and theca interna layers of bovine cystic follicles, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 49巻, 3号, pp. 227-233, 2003
  120. Luteinizing hormone receptor formation in cumulus cells surrounding porcine oocytes and its role during meiotic maturation of porcine oocytes, BIOLOGY OF REPRODUCTION, 68巻, 4号, pp. 1142-1149, 2003
  121. Effects of estrone sulfate injection on reproductive functions in male Japanese quail., Journal of Poultry Science, 40巻, pp. 243-247, 20031001
  122. Direct enzyme immunoassay of progesterone in bovine plasma., Anim Sci J, 74巻, pp. 369-373, 20031001
  123. 受胚牛におけるCIDR-OVSYNCH併用法による排卵同期化およびEB-CIDR-RGF2alfa併用法による発情同期化効果, 広島大学農場報告, 14巻, pp. 1-5, 20030401
  124. Distribution of immunoreactive von Willebrand factor in the microvascular network of bovine cystic follicles, Anim. Sci. J, 73巻, 2号, pp. 123-129, 20020401
  125. Direct enzyme immunoassay of estrone sulfate in the plasma of cattle, J Reprod Dev, 48巻, 1号, pp. 75-78, 20020201
  126. Direct enzyme immunoassay of estrone sulfate in the plasma of cattle, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 48巻, 1号, pp. 75-78, 2002
  127. Survival of boar spermatozoa frozen in diluents of varying osmolality, THERIOGENOLOGY, 56巻, 3号, pp. 447-458, 20010801
  128. Changes in the Localization of Immunoreactive von Willebrand Factor in Microvascular Network of Bovine Ovarian Follicles during Atresia, Animal Science Journal, 72巻, 6号, pp. 473-482, 20011101
  129. An in situ hybridization study of the effects of artificial insemination on the localization of cells expressing MHC class II mRNA in the chicken oviduct, Reproduction, 122巻, 4号, pp. 581‐586, 20011001
  130. An in situ hybridization study of the effects of artificial insemination on the localization of cells expressing MHC class II mRNA in the chicken oviduct, REPRODUCTION, 122巻, 4号, pp. 581-586, 2001
  131. Effect of the Factor inhibiting germinal vesicle breakdown on the disruption of gap junctions and cumulus expansion of pig cumulus-oocyte complexes cultured in vitro, REPRODUCTION, 121巻, 2号, pp. 249-257, 2001
  132. Immunocytochemical study of cell proliferation in the cystic ovarian follicles in cows, THERIOGENOLOGY, 54巻, 7号, pp. 1159-1169, 20001015
  133. Localization of apoptotic cells in the cystic ovarian follicles of cows: A DNA-end labeling histochemical study, THERIOGENOLOGY, 53巻, 4号, pp. 897-904, 20000301
  134. Involvement of meiotic resumption in the disruption of gap junctions between cumulus cells attached to pig oocytes., Journal of Reproduction and Fertility, 113巻, pp. 167-172, 1998
  135. Cumulus cells suppress meiotic progression in pig oocytes cultured in vitro., Theriogenology, 45巻, pp. 1479-1489, 1996
  136. Investigation of the binding of goat cathelicidin-7 to lipopolysaccharide and leucocidal suppression of pro-inflammatory cytokines., Small Ruminant Research, 168:巻, pp. 101-106, 2018

著書等出版物

  1. 2007年07月, 公開講座シリーズ6 動物とのふれあいを通じて学ぶアニマルサイエンス, 広大生物圏出版会, 2007年, 7, 教科書, 共編著, 小櫃 剛人 都築 政起 島田 昌之 豊後 貴嗣 磯部 直樹, 133
  2. 2018年10月, 牛の乳房炎Q&A 基礎と臨床の視点から一問二答方式で解説, 乳房炎 炎症 免疫, 緑書房, 2018年, 10, 単行本(学術書), 共著, 日本語, 編:日本乳房炎研究会 監修:河合一洋/林 智人, 978-4-89531-354-4, 181, 6

招待講演、口頭・ポスター発表等

  1. 乳中の抗菌因子による菌培養試験への影響  , 磯部直樹, 東北乳房炎協議会, 招待, 日本語, 東北乳房炎協議会, 東北大学
  2. 発情すると乳房炎になる? ー自然免疫の視点から再考するー, 磯部直樹, 第111回日本繁殖生物学会大会, 招待, 日本語, 日本繁殖生物学会, 信州大学
  3. Different concentration of antimicrobial components in bovine milk infected with different pathogens., Isobe N, Kawai K, Shinozuka Y, Purba YF, Nii T, Yoshimura Y, The 30th World Buiatrics Congress, 通常, 英語, World Buiatrics, Sapporo Convention Center, Sapporo
  4. Effect of mastitis on the reproductive functions in pregnant goat., Isobe N, Kodama N, Nii T, Yoshimura Y, 18th AAAP Congress., 2018年81月, 通常, 英語, Asian Austrasian Animal Production, Sarawak, Malaysia
  5. 暑熱時における乳房免疫の機能変化, 磯部直樹, 暑熱対策セミナー, 招待, 日本語, 熊本県らくのうマザーズ, らくのうマザーズ
  6. Effect of tentative cessation of milking for 3 days on innate immune components in goat milk, Naoki Isobe, Jo Ueda, Yukinori Yoshimura, 2018 Annual Meeting of the American Dairy Science Association, 通常, 英語, American Dairy Science Association, Knoxville,Tennessee, USA
  7. 初乳製剤を用いたウシの健康管理, 磯部直樹, 第41回NOSAI診療技術研究発表会, 2018年37月, 招待, 日本語, NOSAI広島, NOSAI広島 家畜臨床研修所 東広島家畜診療所
  8. 乳房炎の防除管理について, 磯部直樹, 酪農経営支援研修会, 2017年12月19日, 招待, 日本語, 一般社団法人 広島県畜産協会, グランラセーレ三次
  9. 乳房炎防除のための自然免疫機能の利用, 磯部直樹, 中四国乳房炎協議会第22回勉強会, 2017年12月16日, 招待, 日本語, 中四国乳房炎協議会, 広島大学東広島キャンパス
  10. 乳腺の抗菌因子と乳房炎防除管理, 磯部直樹, 第3回広島大学酪農技術セミナー, 2017年10月10日, 招待, 日本語, RCAS, 東広島芸術文化ホールくらら
  11. 乳房炎防除のための自然免疫機能の利用, 磯部直樹, 第22回日本乳房炎研究会学術集会, 2017年10月06日, 招待, 日本語, 日本乳房炎研究会, 国立科学博物館
  12. 乳房炎と自然免疫機構, 磯部直樹, 第21回大動物臨床教育セミナー, 2017年05月27日, 招待, 日本語, 酪農学園大学, 酪農学園大学
  13. ショート乾乳と抗菌因子, 磯部直樹, Bovine Mastitis Research (BMR)勉強会, 2017年04月15日, 招待, 日本語, Bovine Mastitis Research (BMR), 日本全薬工業株式会社 東京支社
  14. ルーメンアシドーシスによる乳房炎について, 磯部直樹, ルーメン研究会, 2017年03月27日, 招待, 日本語, ルーメン研究会, 神戸大学
  15. 乳房炎と自然免疫機構, 磯部直樹, 大動物臨床研究会第7回東京シンポジウム, 2017年03月11日, 招待, 日本語, 大動物臨床研究会, 東京大学
  16. 乳房炎乳保存中における生菌数の変化とその原因, 磯部直樹, 第40回NOSAI診療技術研究発表会, 2017年03月07日, 招待, 日本語, NOSAI広島, NOSAI広島 家畜臨床研修所 東広島家畜診療所
  17. 乳房炎と自然免疫機構, 磯部直樹, 第40回大動物臨床研究会, 2016年11月05日, 招待, 日本語, 大動物臨床研究会, 酪農学園大学
  18. 黄色ブドウ球菌により誘起されたヤギ乳腺の自然免疫応答に及ぼす性ステロイドホルモンの影響., 6.磯部直樹・桑原謙太・吉村幸則, 第109回日本繁殖生物学会大会, 2016年09月12日, 通常, 日本語, 日本繁殖生物学会, 麻布大学
  19. Effect of steroid hormone on innate immune response induced by Staphylococcus aureus in mammary gland of goat., Isobe N, Kuwahara K, Yoshimura Y, The 17th AAAP Animal Science Congress, 2016年08月22日, 通常, 英語, AAAP, 九州産業大学
  20. Changes in pathogen number during preservation of milk derived from mastitic dairy cows., Isobe N, Hisaeda K, Koshiishi T, Watanabe M, Miyake H, Yoshimura Y, The 6th International Seminar on Tropical Animal Production (ISTAP), 2015年10月20日, 通常, 英語, ジョグジャカルタ
  21. 乳牛の高体細胞数乳汁における保存中生菌数の変化と抗菌因子との関係., 磯部直樹・久枝啓一・輿石智子・渡部雅子・三宅肇・吉村幸則, 日本畜産学会第120回大会, 2015年09月11日, 通常, 日本語, 日本畜産学会, 酪農学園大学
  22. 乳腺における抗菌因子群の役割, 磯部直樹, 第38回NOSAI診療技術研究発表会, 2015年03月06日, 招待, 日本語, NOSAI広島 家畜臨床研修所 東広島家畜診療所, NOSAI広島 家畜臨床研修所 東広島家畜診療所
  23. 乳腺で活躍する自然免疫因子, 磯部直樹, 平成26年度日本獣医師会獣医学術学会年次大会, 2015年02月15日, 招待, 日本語, 日本獣医師会獣医学術学会, 岡山コンベンションセンター
  24. Association of reproductive performance with somatic cell count in milk of dairy cows., Isobe N, Iwamoto C, Yoshimura Y, The 16th AAAP Animal Science Congress, 2014年10月10日, 通常, 英語, ジョグジャカルタ、インドネシア
  25. 乳中に含まれる抗菌因子, 磯部直樹, 淡路獣医師勉強会, 2014年08月22日, 招待, 日本語, 淡路家畜保健衛生所, 淡路家畜保健衛生所

受賞

  1. 2016年03月28日, 日本畜産学会賞, 日本畜産学会, 反芻家畜の乳腺における抗菌因子産生の調節機構に関する研究
  2. 2014年10月10日, 日本乳房炎研究会高居百合子学術賞, 日本乳房炎研究会, 周産期乳牛における乳房炎が繁殖機能に及ぼす影響
  3. 2006年09月, The Journal of Poultry Science 優秀論文賞(日本家禽学会), 日本家禽学会長 菅原邦生, Expressions of Antimicrobial Peptide Gallinacin-1,-2 and-3 mRNAs in the Oviduct of Laying Hens
  4. 2007年03月, 日本畜産学会優秀論文賞, 日本畜産学会理事長 泉水直人, Direct enzyme immunoassay of progesterone in bovine plasma
  5. 2005年10月, 日本産業動物獣医学会(中国)学会長賞, 牛の糞中プロゲステロン測定による早期妊娠診断の可能性の検討
  6. 2003年03月, 日本畜産学会奨励賞, 日本畜産学会, ウシ嚢腫卵胞形成に関する免疫組織化学的研究
  7. 2016年03月28日, 日本畜産学会第121回 優秀発表賞, 日本畜産学会理事長
  8. 2018年03月28日, The 2018 Award for Excellence in Reviewing for Animal Science Journal in 2017, 公益社団法人日本畜産学会編集委員長
  9. 2015年03月28日, Animal Science Journal Reviewers Award (Reviewers賞), 日本畜産学会編集委員会

外部資金

競争的資金等の採択状況

  1. 伊藤記念財団研究助成, 初乳に含まれる抗菌因子の機能を利用した子牛の下痢症予防, 2017年, 2017年
  2. 科学研究費助成事業(基盤研究(C)), 抗菌因子の高濃度暴露による難治性乳房炎治療プログラムの開発, 2015年, 2017年
  3. 農林水産業におけるロボット技術開発実証事業(研究開発), 栄養生理機能マルチセンシングによる搾乳ロボットを用いた精密飼養管理システムの開発, 2015年
  4. 科学研究費助成事業(基盤研究(C)), 乳牛の乳腺免疫機能に及ぼす性ステロイドホルモンの影響に関する研究, 2012年, 2014年
  5. 旗影会研究助成, ウシ乳房における抗菌性ペプチドの活性化メカニズムの解明, 2012年
  6. 農林水産業・食品産業科学技術研究推進事業(農林水産省), 高泌乳牛における泌乳平準化を図る新たな周産期栄養管理技術の開発, 2011年, 2013年
  7. 科学研究費助成事業(基盤研究(B)), 鳥類卵管の抗菌ペプチド発現機構の解明による自然免疫機能の強化戦略, 2009年, 2012年
  8. 科学研究費助成事業(基盤研究(C)), 乳牛の分娩後生殖機能回復モニタリングに基づく繁殖効率向上プログラムの開発, 2008年, 2010年
  9. 科学研究費助成事業(基盤研究(B)), 鳥類生殖器の自然免疫機能強化を目指した抗菌ペプチドの産生とその調節機構の解明, 2006年, 2008年
  10. 科学研究費助成事業(萌芽研究), 鳥類卵管のグレリン産生制御による胚子発育促進戦略, 2006年, 2008年
  11. 科学研究費助成事業(若手研究(B)), 牛嚢腫卵胞のホルモン感受性に関する応用学的および分子細胞学的研究, 2004年, 2005年
  12. 科学研究費助成事業(基盤研究(B)), 性ステロイドによる環境汚染と動物・植物への影響評価, 2003年, 2004年
  13. 科学研究費助成事業(基盤研究(C)), ジャイアントパンダの人工繁殖に関する調査, 2000年, 2000年
  14. 科学研究費助成事業(基盤研究(B)), 熱帯アジアにおける在来反芻家畜の潜在能力の把握に関する調査研究-資源の持続的有効利用に基づいた乳肉生産を目指して-, 2000年, 2003年
  15. 科学研究費助成事業(基盤研究(C)), ウシの妊娠期における胎子胎盤機能と新生子の健康, 2000年, 2001年

社会活動

学術雑誌論文査読歴

  1. 2014年, Animal Science Journal, その他
  2. 2014年
  3. 2014年
  4. 2014年
  5. 2014年