谷本 圭司Keiji Tanimoto

Last Updated :2019/07/01

所属・職名
原爆放射線医科学研究所 放射線災害医療研究センター 助教
メールアドレス
ktanimohiroshima-u.ac.jp

基本情報

学位

  • 博士(歯学) (広島大学)

研究分野

  • 医歯薬学 / 基礎医学 / 医化学一般
  • 医歯薬学 / 歯学 / 外科系歯学

研究キーワード

  • 遺伝子
  • 転写因子
  • 転写制御
  • 低酸素
  • 個別化療法

教育活動

授業担当

  1. 2019年, 学部専門, 集中, 医学研究実習
  2. 2019年, 学部専門, セメスター(前期), 医科歯科分子生物学
  3. 2019年, 修士課程・博士課程前期, セメスター(前期), 分子生物学と放射線防護
  4. 2019年, 修士課程・博士課程前期, セメスター(前期), 分子生物学と放射線防護

研究活動

学術論文(★は代表的な論文)

  1. ★, Genetics of the hypoxia-inducible factors in human cancers., Experimental Cell Research, 356巻, 2号, pp. 166-172, 2017
  2. The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms., Biochemical and Biophysical Research Communications, 441巻, 2号, pp. 499-506, 2013
  3. An association study between Hypoxia inducible Factor-1alpha (HIF-1) polymorphisms and osteonecrosis, PLOS ONE, 8巻, 11号, pp. e79647, 2013
  4. Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro, Neuroscience Letters, 545巻, pp. 29-34, 2013
  5. ★, Development of lymphoproliferative diseases by hypoxia-inducible factor-1α is associated with prolonged lymphocyte survival, PLOS ONE, 8巻, 4号, pp. e57833, 2013
  6. Abnormal FHIT Transcripts in Human Breast Carcinomas: A Clinicopathological and Epidemiological Analysis of 61 Japanese Case., Cancer Research, 57巻, pp. 1981-1985, 19970401
  7. Antitumor Effect of Carboplatin Conbined with Radiation on Tumors in Mice., Anticancer Research, 17巻, pp. 2535-2538, 19970401
  8. 口腔癌患者における薬物代謝酵素遺伝子多型と発癌感受性に関する研究, 広島大学歯学雑誌, 30巻, 1号, 19980401
  9. Regulation of estragen receptar alpha gene mediated by prometer B responsible for its enhanced expression in human breast cancer, Nucleic Acids Research, 27巻, 3号, pp. 903-909, 19990401
  10. Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose., European Journal of Cancer= Oral Oncology, 35巻, pp. 191-196, 19990401
  11. Abnormal FHIT transcripts found in both lung cancer and normal lung tissue., Genes= Chromosomes and Cancer, 24巻, pp. 105-111, 19990401
  12. ★, Mechanism of Regulation of Hypoxia-inducible Factor-1α by von Hippel-Lindan Tumor suppressor protein, The EMBO Journal, 19巻, 16号, pp. 4298-4309, 20000401
  13. Distinct mechanisms of loss of estrogen receptor α gene expression in human breast cancer : methylation of the gene and alteration of trans-acting factor, Carcinogenesis, 21巻, pp. 2193-2201, 20000401
  14. Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers, International Journal of Oncology, 20巻, 2号, pp. 333-338, 20010201
  15. Unique action determinants of double acting topoisomerase inhibitor, TAS-103, International Journal of Oncology, 19巻, 5号, pp. 921-927, 20011101
  16. O6-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives, Japanese Journal of Cancer Research, 93巻, 1号, pp. 93-102, 20020101
  17. Identification of Functional Hypoxia Response Elements in Promoter Region of the DEC1 and DEC2 Gene, Journal of Biological Chemistry, 277巻, 49号, pp. 47014-47021, 20021201
  18. Bcl-2 in cancer and normal tissue cells as a prediction marker of response to 5-fluorouracil, International Journal of Oncology, 22巻, 1号, pp. 181-186, 20030101
  19. ★, Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-Inducible Factor-1a by the von Hippel-Lindau Tumor Suppresor Gene Product, Journal of Biological Chemistry, 278巻, pp. 6816-6823, 20030401
  20. Targeted gene delivery to human osteosarcoma cells with magnetic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22巻, pp. 1065-1071, 20030401
  21. The expression and function of estrogen receptor a and b in human breast cancer and its clinical application., Endocrine- Related Cancer, 10巻, pp. 193-202, 20030401
  22. ★, Hypoxia-Inducible Factor-1a Polymorphisms Associated with Enhanced Transactivation Capacity, Implying Clinical Significance., Carcinogenesis, 24巻, 20030401
  23. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, British Journal of Oral and Maxillofacial Surgery, 41巻, pp. 348-350, 20030401
  24. 低酸素と遺伝子不安定性, 癌治療と宿主, 15巻, pp. 233-238, 20030401
  25. Personalized Medicine, and Our Recent Approaches, Annals of Cancer Research and Therapy, 11巻, pp. 61-72, 20031001
  26. cDNAマイクロアレイにより選択した関連遺伝子群の発現解析による抗癌剤効果予測システム, 癌の臨床, 50巻, 1号, pp. 15-20, 20040201
  27. Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: Association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1a, Cancer Science, 95巻, pp. 149-153, 20040401
  28. Aberrant Methylation of Dihydropyrimidine Dehydrogenase Gene (DPYD) Promoter, DPYD Expression, and Cellular Sensitivity to 5-fluorouracil in Cancer Cells, Clinical Cancer Research, 10巻, pp. 7100-7107, 20040401
  29. Repression of PML Nuclear Body-Associated Transcription by Oxidative Stress-Activated Bach2, Molecular and Cellular Biology, 24巻, 8号, pp. 3473-3484, 20040401
  30. 特集:呼吸器のpharmacogenomics 肺癌のpharmacogenomics, THE LUNG perspectives, 12巻, 3号, pp. 20-26, 20040701
  31. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, International Journal of Cancer, 111巻, 4号, pp. 617-626, 20040901
  32. Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma, Oncology Reports, 12号, pp. 1033-1037, 20041101
  33. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene., Int J Oncol, 24巻, pp. 1435-1442, 20041201
  34. Activator Protein Accelerates Dihydropyrimidine Dehydrogenase Gene Transcription in Cancer Cells, Cancer Research, 65巻, pp. 1055-1062, 20050401
  35. 分子情報に基づく癌化学療法の治療効果予測, 放射線生物研究, 40巻, 2号, pp. 202-213, 20050601
  36. Differentially expressed genes throughout the cellular immortalization processes are quite different between normal human fibroblasts and endothelial cells, International Journal of Oncology, 27号, pp. 87-95, 20050701
  37. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, Mol Cancer Ther, 5巻, 3号, pp. 767-775, 20060301
  38. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, Int J Oncol, 28巻, pp. 1153-1162, 20060501
  39. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17巻, 1号, pp. 1-10, 2007
  40. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17巻, 4号, pp. 871-878, 2007
  41. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17巻, 6号, pp. 1405-1411, 2007
  42. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98巻, 9号, pp. 1394-1401, 2007
  43. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17巻, 1号, pp. 1-10, 2007
  44. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, Oncology Reports, 17巻, pp. 1405-1411, 20070601
  45. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34巻, 7号, pp. 373-390, 2008
  46. 固形癌の治療抵抗性に関わる低酸素応答分子機構, 放射線生物研究, 43巻, 1号, pp. 54-67, 20080101
  47. 固形癌の治療抵抗性に関わる低酸素応答分子機構, 癌の臨床, 54巻, 2号, pp. 91-96, 20080201
  48. 分子標的治療法開発にむけた低酸素研究., 日本癌病態治療研究会誌, 20080601
  49. 癌と低酸素., 医学のあゆみ, 20080601
  50. 肺癌とテロメア・テロメラーゼ,肺癌-基礎・臨床研究のアップデート-,疫学・基礎研究Ⅱ., 分子生物学, 66巻, 6号, pp. 59-64, 20080801
  51. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts., Exp Lung Res, 34巻, 7号, pp. 373-390, 20080901
  52. 肺癌の分子生物学①-carcinogenesisとはなにか-.特集「肺癌のUp-To-Date」., THE LUNG perspectives, 16巻, 4号, pp. 503-507, 20081001
  53. 日本における遺伝子診療・研究の現状., 腫瘍内科, 2巻, 5号, pp. 433-439, 20081001
  54. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma., Cancer Letters, 274巻, 2009号, pp. 25-32, 20090201
  55. EMP3 as a candidate tumor suppressor gene for solid tumors., Expert Opin. Ther. Targets., 13巻, 7号, pp. 811-822, 20090701
  56. Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393巻, 4号, pp. 800-805, 2010
  57. 食道癌における新規癌抑制遺伝子EMP3の同定と放射線感受性因子としての検討, 広島医学, 63巻, 4号, pp. 307-310, 20100401
  58. Carcinogenesis and cellular immortalization without persistent inactivation of p16/Rb pathway in lung cancer, International Journal of Oncology, 36巻, 5号, pp. 1217-1227, 20100501
  59. Genetic variations in detoxification enzymes and HIF-1α in Japanese patients with COPD, Clinical Respiratory Journal, 20110601
  60. Basic helix-loop-helix transcription factor DEC1 negatively regulates CyclinD1, Journal of Pathology, 224巻, 3号, pp. 420-429, 20110701
  61. Interactive effects of cell therapy and rehabilitation realize the full potential of neurogenesis in brain injury model, Neurosci Lett, 555巻, 25号, pp. 73-78, 20131001
  62. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17巻, 4号, pp. 871-878, 200704
  63. ★, The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer, PLOS ONE, 10巻, 8号, 20150811
  64. Selection of a novel drug-response predictor in esophageal cancer: A novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response, INTERNATIONAL JOURNAL OF ONCOLOGY, 32巻, 2号, pp. 413-423, 200802
  65. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist, MOLECULAR CANCER THERAPEUTICS, 17巻, 2号, pp. 432-442, 201802
  66. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLOS ONE, 13巻, 2号, 20180221
  67. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17巻, 1号, pp. 1-10, 200701
  68. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha, Nature Communications, 6巻, 201501
  69. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 443巻, 4号, pp. 1286-1290, 20140124
  70. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2, ONCOGENE, 27巻, 30号, pp. 4200-4209, 200807
  71. The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation, ONCOGENE, 35巻, 27号, pp. 3598-3606, 20160707
  72. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, MOLECULAR CANCER THERAPEUTICS, 5巻, 3号, pp. 767-775, 200603
  73. Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22巻, 5号, pp. 1065-1071, 200305
  74. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, INTERNATIONAL JOURNAL OF ONCOLOGY, 28巻, 5号, pp. 1153-1162, 200605
  75. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5巻, 20151112
  76. Unique action determinants of double acting topoisomerase inhibitor, TAS-103, INTERNATIONAL JOURNAL OF ONCOLOGY, 19巻, 5号, pp. 921-927, 200111
  77. Hypoxia-inducible factor-1 alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance, CARCINOGENESIS, 24巻, 11号, pp. 1779-1783, 200311
  78. Single nucleotide polymorphism in the hypoxia-inducible factor-1 alpha gene in colorectal carcinoma, ONCOLOGY REPORTS, 12巻, 5号, pp. 1033-1037, 200411
  79. Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers, JOURNAL OF THORACIC ONCOLOGY, 9巻, 11号, pp. 1709-1713, 201411
  80. Aberrant methylation of DPYD promoter, DPYD expression, and cellular sensitivity to 5-fluorouracil in cancer cells, CLINICAL CANCER RESEARCH, 10巻, 20号, pp. 7100-7107, 20041015
  81. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 41巻, 5号, pp. 348-350, 200310
  82. IL-1 beta-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway, JOURNAL OF CELLULAR BIOCHEMISTRY, 113巻, 10号, pp. 3246-3253, 201210
  83. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, INTERNATIONAL JOURNAL OF CANCER, 111巻, 4号, pp. 617-626, 20040910
  84. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98巻, 9号, pp. 1394-1401, 200709