Keiji Tanimoto

Last Updated :2024/05/15

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
ktanimohiroshima-u.ac.jp
Self-introduction
Molecular Biology (Mechanisms of response to hypoxia or various stress stimuli, and transcriptional regulation of genes.)

Basic Information

Major Professional Backgrounds

  • 2007/04/01, 2020/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor
  • 2001/04/01, 2002/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine
  • 1996/04/01, 1997/09/30, Saitama Cancer Center, Research Institute
  • 2001/04/01, 2007/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Research Associate
  • 2000/01/01, 2001/03/31, Japan Society for the Promotion of Science, research fellow
  • 1998/07/01, 1999/12/31, Cell and Molecular Biology, Karolinska Institutet, guest researcher

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Dental Research, Japan, 1994/04, 1998/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1988/04, 1994/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry

Research Keywords

  • transcription
  • HIF-1
  • Transcription
  • hypoxia
  • individualized therapy
  • Pharmacogenetics

Affiliated Academic Societies

  • American Association for Cancer Research
  • The Japanese Pharmacological Society

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Intensive, Practice for medical research
  2. 2024, Graduate Education (Master's Program) , First Semester, Molecular Biology and Radiological Science
  3. 2024, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  4. 2024, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology

Research Activities

Academic Papers

  1. Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells., Breast Cancer, 20230511
  2. Bovine lactoferrin inhibits tumor angiogenesis through NF-KB pathway inhibition by binding to TRAF6., Pharmaceutics, 20230103
  3. p53 status modifies cytotoxic activity of lactoferrin under hypoxic conditions., Frontiers in Pharmacology, 20220901
  4. Low-Dose-Rate Irradiation Suppresses the Expression of Cell Cycle-Related Genes, Resulting in Modification of Sensitivity to Anti-Cancer Drugs, CELLS, 11(3), 202202
    Link to Paper Search Results by DOI
  5. Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(2), 202201
    Link to Paper Search Results by DOI
  6. IL-1 beta-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway, JOURNAL OF CELLULAR BIOCHEMISTRY, 113(10), 3246-3253, 201210
    Link to Paper Search Results by DOI
  7. Regulation of estragen receptar alpha gene mediated by prometer B responsible for its enhanced expression in human breast cancer, Nucleic Acids Research, 27(3), 903-909, 19990401
  8. ★, Mechanism of Regulation of Hypoxia-inducible Factor-1a by von Hippel-Lindan Tumor suppressor protein, EMBO Journal, 19(16), 4298-4309, 20000805
  9. Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose., Oral Oncology, 35, 191-196, 19990401
  10. Abnormal FHIT transcripts found in both lung cancer and normal lung tissue., Genes Chromosomes and Cancer, 24, 105-111, 19990401
  11. Abnormal FHIT Transcripts in Human Breast Carcinomas: A Clinicopathological and Epidemiological Analysis of 61 Japanese Case., Cancer Research, 57, 1981-1985, 19970401
  12. Antitumor Effect of Carboplatin Conbined with Radiation on Tumors in Mice., Anticancer Research, 17, 2535-2538, 19970401
  13. ★, Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-Inducible Factor-1a by the von Hippel-Lindau Tumor Suppresor Gene Product, Journal of Biological Chemistry, 278, 6816-6823, 20030401
  14. Targeted gene delivery to human osteosarcoma cells with magnetic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22, 1065-1071, 20030401
  15. The expression and function of estrogen receptor a and b in human breast cancer and its clinical application., Endocrine- Related Cancer, 10, 193-202, 20030401
  16. ★, Hypoxia-Inducible Factor-1a Polymorphisms Associated with Enhanced Transactivation Capacity, Implying Clinical Significance., Carcinogenesis, 24, 20030401
  17. Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: Association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1a, Cancer Science, 95, 149-153, 20040401
  18. Aberrant Methylation of Dihydropyrimidine Dehydrogenase Gene (DPYD) Promoter, DPYD Expression, and Cellular Sensitivity to 5-fluorouracil in Cancer Cells, Clinical Cancer Research, 10, 7100-7107, 20040401
  19. Activator Protein Accelerates Dihydropyrimidine Dehydrogenase Gene Transcription in Cancer Cells, Cancer Research, 65, 1055-1062, 20050401
  20. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, British Journal of Oral and Maxillofacial Surgery, 41, 348-350, 20030401
  21. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene., Int J Oncol, 24, 1435-1442, 20041201
  22. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, Mol Cancer Ther, 5(3), 767-775, 20060301
  23. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, Int J Oncol, 28, 1153-1162, 20060501
  24. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, Oncology Reports, 17, 1405-1411, 20070601
  25. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts., Exp Lung Res, 34(7), 373-390, 20080901
  26. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma., Cancer Letters, 274(2009), 25-32, 20090201
  27. EMP3 as a candidate tumor suppressor gene for solid tumors., Expert Opin. Ther. Targets., 13(7), 811-822, 20090701
  28. Basic helix-loop-helix transcription factor DEC1 negatively regulates CyclinD1, Journal of Pathology, 224(3), 420-429, 20110701
  29. HIF-1a polymorphisms associate with genetic aberrations in lung cancer, Respirology, 16(5), 796-802, 20110701
  30. Carcinogenesis and cellular immortalization without persistent inactivation of p16/Rb pathway in lung cancer, International Journal of Oncology, 36(5), 1217-1227, 20100501
  31. Differentially expressed genes throughout the cellular immortalization processes are quite different between normal human fibroblasts and endothelial cells, International Journal of Oncology, 87-95, 20050701
  32. Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma, Oncology Reports, 1033-1037, 20041101
  33. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, International Journal of Cancer, 111(4), 617-626, 20040901
  34. Repression of PML Nuclear Body-Associated Transcription by Oxidative Stress-Activated Bach2, Molecular and Cellular Biology, 24(8), 3473-3484, 20040401
  35. Personalized Medicine, and Our Recent Approaches, Annals of Cancer Research and Therapy, 11, 61-72, 20031001
  36. Bcl-2 in cancer and normal tissue cells as a prediction marker of response to 5-fluorouracil, International Journal of Oncology, 22(1), 181-186, 20030101
  37. Identification of Functional Hypoxia Response Elements in Promoter Region of the DEC1 and DEC2 Gene, Journal of Biological Chemistry, 277(49), 47014-47021, 20021201
  38. O6-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives, Japanese Journal of Cancer Research, 93(1), 93-102, 20020101
  39. Unique action determinants of double acting topoisomerase inhibitor, TAS-103, International Journal of Oncology, 19(5), 921-927, 20011101
  40. Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers, International Journal of Oncology, 20(2), 333-338, 20010201
  41. Interactive effects of cell therapy and rehabilitation realize the full potential of neurogenesis in brain injury model, Neurosci Lett, 555(25), 73-78, 20131001
  42. Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field, INTERNATIONAL JOURNAL OF ONCOLOGY, 22(5), 1065-1071, 200305
    Link to Paper Search Results by DOI
  43. Hypoxia-inducible factor-1 alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance, CARCINOGENESIS, 24(11), 1779-1783, 200311
    Link to Paper Search Results by DOI
  44. High-flow arteriovenous malformation of the mandible: treatment and 7-year follow-up, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 41(5), 348-350, 200310
    Link to Paper Search Results by DOI
  45. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, INTERNATIONAL JOURNAL OF CANCER, 111(4), 617-626, 20040910
    Link to Paper Search Results by DOI
  46. Aberrant methylation of DPYD promoter, DPYD expression, and cellular sensitivity to 5-fluorouracil in cancer cells, CLINICAL CANCER RESEARCH, 10(20), 7100-7107, 20041015
    Link to Paper Search Results by DOI
  47. Single nucleotide polymorphism in the hypoxia-inducible factor-1 alpha gene in colorectal carcinoma, ONCOLOGY REPORTS, 12(5), 1033-1037, 200411
    Link to Paper Search Results by DOI
  48. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, MOLECULAR CANCER THERAPEUTICS, 5(3), 767-775, 200603
    Link to Paper Search Results by DOI
  49. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, INTERNATIONAL JOURNAL OF ONCOLOGY, 28(5), 1153-1162, 200605
    Link to Paper Search Results by DOI
  50. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17(6), 1405-1411, 200706
    Link to Paper Search Results by DOI
  51. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17(1), 1-10, 200701
    Link to Paper Search Results by DOI
  52. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17(4), 871-878, 200704
    Link to Paper Search Results by DOI
  53. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98(9), 1394-1401, 200709
    Link to Paper Search Results by DOI
  54. Selection of a novel drug-response predictor in esophageal cancer: A novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response, INTERNATIONAL JOURNAL OF ONCOLOGY, 32(2), 413-423, 200802
    Link to Paper Search Results by DOI
  55. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2, ONCOGENE, 27(30), 4200-4209, 200807
    Link to Paper Search Results by DOI
  56. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34(7), 373-390, 2008
    Link to Paper Search Results by DOI
  57. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 443(4), 1286-1290, 20140124
    Link to Paper Search Results by DOI
  58. Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers, JOURNAL OF THORACIC ONCOLOGY, 9(11), 1709-1713, 201411
    Link to Paper Search Results by DOI
  59. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha, Nature Communications, 6, 201501
    Link to Paper Search Results by DOI
  60. ★, The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer, PLOS ONE, 10(8), 20150811
    Link to Paper Search Results by DOI
  61. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17(1), 1-10, 2007
  62. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17(4), 871-878, 2007
  63. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17(6), 1405-1411, 2007
  64. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions, CANCER SCIENCE, 98(9), 1394-1401, 2007
  65. Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393(4), 800-805, 2010
  66. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro, PHARMACOGENETICS AND GENOMICS, 17(1), 1-10, 2007
  67. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 20151112
    Link to Paper Search Results by DOI
  68. The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation, ONCOGENE, 35(27), 3598-3606, 20160707
    Link to Paper Search Results by DOI
  69. The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms., Biochemical and Biophysical Research Communications, 441(2), 499-506, 2013
  70. An association study between Hypoxia inducible Factor-1alpha (HIF-1) polymorphisms and osteonecrosis, PLOS ONE, 8(11), e79647, 2013
  71. Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro, Neuroscience Letters, 545, 29-34, 2013
  72. ★, Development of lymphoproliferative diseases by hypoxia-inducible factor-1a is associated with prolonged lymphocyte survival, PLOS ONE, 8(4), e57833, 2013
  73. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist, MOLECULAR CANCER THERAPEUTICS, 17(2), 432-442, 201802
    Link to Paper Search Results by DOI
  74. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLOS ONE, 13(2), 20180221
    Link to Paper Search Results by DOI
  75. Genetics of the hypoxia-inducible factors in human cancers, EXPERIMENTAL CELL RESEARCH, 356(2), 166-172, 20170715
    Link to Paper Search Results by DOI
  76. Simulated microgravity attenuates myogenic differentiation via epigenetic regulations, NPJ MICROGRAVITY, 4, 20180523
    Link to Paper Search Results by DOI
  77. Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells, PLOS ONE, 14(7), e0219363, 20190719
  78. GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A., Carcinogenesis, 41(9), 1184-1194, 202009
  79. A step forward into respiratory genetics: overview contribution of genetics in respiratory diseases, ASIAN BIOMEDICINE, 6(5), 639-651, 2012
  80. Development of Lymphoproliferative Diseases by Hypoxia Inducible Factor-1alpha Is Associated with Prolonged Lymphocyte Survival, PLOS ONE, 8(4), 2013
  81. The Kruppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(2), 499-506, 2013
  82. Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers, JOURNAL OF THORACIC ONCOLOGY, 9(11), 1709-1713, 2014
  83. Studies on Genetic Polymorphisms of the Xenobiotic Metabolizing Enzymes in Oral Cancer Patients and Susceptibility to Oral Cancer, 30(1), 115-128, 19980601
  84. Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer, PLOS ONE, 16(6), 20210608
    Link to Paper Search Results by DOI
  85. ★, Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal, Scientific Reports, 11(1), 16629, 20210817
  86. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha, Nature Communications, 6, 2015
  87. The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 202110
    Link to Paper Search Results by DOI
  88. The roles of Y-box-binding protein (YB)-1 and C-X-C motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling, BIOENGINEERED, 12(2), 9128-9139, 20211220
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. The regulation mechanisms of ADAM32 highly expressed in Hepatoblastoma, 2022/11/30, Without Invitation, Japanese
  2. Significance of up-regulation of the hypoxia-inducible EFEMP2 in cancer cells, 2021/12/01, Without Invitation, Japanese
  3. Resveratrol enhances hypoxia-induced p53 protein stabilization resulting in increase of apoptosis in breast cancer cells, Takako Sakamoto, Keiji Tanimoto, Hidetaka Eguchi, Sahoko Ichihara, 2021/12/01, Without Invitation, Japanese
  4. Significance of low-dose-rate irradiation in anti-cancer therap, 2021/05/22, Without Invitation, Japanese
  5. The effects of low-dose irradiation on the hypoxic cells., Kiichi Shimabukuro, Keiji Tanimoto, Naoya Kakimoto, Nobuyuki Hirohashi, The 4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2020/02/12, Without Invitation, English, Hiroshima