岡田 剛GO OKADA

Last Updated :2020/08/03

所属・職名
大学院医系科学研究科(医) 講師

基本情報

学歴

  • 広島大学, 大学院医学系研究科, 博士課程内科系専攻, 日本, 1999年04月, 2003年03月
  • 広島大学, 医学部, 医学科, 日本, 1991年04月, 1998年03月

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 精神神経科学

研究キーワード

  • うつ病
  • 脳画像研究

教育活動

授業担当

  1. 2020年, 学部専門, 集中, 症候診断治療学
  2. 2020年, 学部専門, 集中, 医学研究実習
  3. 2020年, 学部専門, 1ターム, 精神科学
  4. 2020年, 学部専門, 1ターム, 精神科学

研究活動

学術論文(★は代表的な論文)

  1. ★, Attenuated left prefrontal activation during a verbal fluency task in patients with depression., Neuropsychobiology, 47巻, pp. 21-26, 20030401
  2. Brain activity during expectancy of emotional stimuli: an fMRI study., NeuroReport, 14巻, pp. 51-55, 20030401
  3. Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study., European Archives of Psychiatry and Clinical Neuroscience, 254巻, pp. 245-251, 20040401
  4. ★, Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops., Nature Neuroscience, 7巻, pp. 887-893, 20040401
  5. Brain mechanism of reward prediction under predictable and unpredictable environmental dynamics., Neural Networks in Healthcare: Potential and Challenges, 19巻, pp. 1233-1241, 20060401
  6. Gender differences in brain activity toward unpleasant linguistic stimuli concerning interpersonal relationships: an fMRI study., European Archives of Psychiatry and Clinical Neuroscience, 255巻, pp. 327-333, 20050401
  7. ★, Reduced activation of posterior cingulate cortex during imagery in subjects with high degrees of alexithymia: a functional magnetic resonance imaging study., Biological Psychiatry, 57巻, pp. 982-990, 20050401
  8. Functional MRI うつ病の補助診断法としての可能性, 精神医学, 49巻, 3号, pp. 285-291, 20070301
  9. うつ病の病態理解の進歩 うつ病の脳画像と分子生物, Progress in Medicine, 27巻, 9号, pp. 1965-1969, 20070901
  10. ★, Attenuated anterior cingulate activation during a verbal fluency task in elderly patients with a history of multiple-episode depression., American Journal of Geriatric Psychiatry, 15巻, 7号, pp. 594-603, 20070701
  11. ★, Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study, NEUROSCIENCE RESEARCH, 69巻, 2号, pp. 129-134, FEB 2011
  12. Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state, NEUROSCIENCE LETTERS, 492巻, 2号, pp. 109-113, APR 1 2011
  13. Inter-individual discount factor differences in reward prediction are topographically associated with caudate activation, EXPERIMENTAL BRAIN RESEARCH, 212巻, 4号, pp. 593-601, AUG 2011
  14. ★, The Effect of Negative and Positive Emotionality on Associative Memory: An fMRI Study, PLOS ONE, 6巻, 9号, SEP 14 2011
  15. ★, Neural and Personality Correlates of Individual Differences Related to the Effects of Acute Tryptophan Depletion on Future Reward Evaluation, NEUROPSYCHOBIOLOGY, 65巻, 2号, pp. 55-64, 2012
  16. Sadness Enhances the Experience of Pain and Affects Pain-Evoked Cortical Activities: An MEG Study, JOURNAL OF PAIN, 13巻, 7号, pp. 628-635, JUL 2012
  17. Effects of depression on reward-based decision making and variability of action in probabilistic learning, JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 43巻, 4号, pp. 1088-1094, DEC 2012
  18. SEX DIFFERENCES IN NEURAL ACTIVATION TO AMBIGUOUS FACIAL EXPRESSION IN HAPPY AND SAD CONTEXT, PERCEPTUAL AND MOTOR SKILLS, 115巻, 2号, pp. 349-359, OCT 2012
  19. Depressive symptoms and apathy are associated with psychomotor slowness and frontal activation, EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 262巻, 6号, pp. 493-499, SEP 2012
  20. Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 9巻, 4号, pp. 487-493, APR 2014
  21. Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder: A preliminary fMRI study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 68巻, 3号, pp. 188-196, MAR 2014
  22. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study, JOURNAL OF AFFECTIVE DISORDERS, 168巻, pp. 229-235, OCT 15 2014
  23. Hippocampal activation during associative encoding of word pairs and its relation to symptomatic improvement in depression: A functional and volumetric MRI study, JOURNAL OF AFFECTIVE DISORDERS, 152巻, pp. 462-467, JAN 2014
  24. fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support, PLOS ONE, 10巻, 5号, MAY 22 2015
  25. Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder, BMC PSYCHIATRY, 15巻, OCT 14 2015
  26. ★, Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task, JOURNAL OF AFFECTIVE DISORDERS, 189巻, pp. 254-262, JAN 1 2016
  27. ★, Childhood poverty and recruitment of adult emotion regulatory neurocircuitry, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 10巻, 11号, pp. 1596-1606, NOV 2015
  28. ★, Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder, JOURNAL OF AFFECTIVE DISORDERS, 194巻, pp. 135-143, APR 2016
  29. ★, Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations, TRANSLATIONAL PSYCHIATRY, 6巻, MAR 8 2016
  30. うつ病の脳内メカニズム Functional MRIを用いた検討, 精神神経学雑誌, 116巻, 10号, pp. 825-831
  31. Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices, JOURNAL OF AFFECTIVE DISORDERS, 208巻, pp. 610-614, JAN 15 2017
  32. Increased amygdala reactivity following early life stress: a potential resilience enhancer role, BMC PSYCHIATRY, 17巻, JAN 18 2017
  33. ★, Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study, PSYCHOLOGICAL MEDICINE, 47巻, 5号, pp. 877-888, APR 2017
  34. ★, Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression, NEUROPSYCHOBIOLOGY, 74巻, 2号, pp. 69-77, 2016
  35. Neural circuitry of emotion regulation: Effects of appraisal, attention, and cortisol administration, COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, 17巻, 2号, pp. 437-451, APR 2017
  36. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain, SCIENTIFIC REPORTS, 7巻, JUN 7 2017
  37. The neural correlates of the metacognitive function of other perspective: a multiple regression analysis study, NEUROREPORT, 28巻, 11号, pp. 671-676, AUG 2 2017
  38. Prediction of clinical depression scores and detection of changes in whole-brain using resting-state functional MRI data with partial least squares regression, PLOS ONE, 12巻, 7号, JUL 12 2017
  39. Patients with major depressive disorder exhibit reduced reward size coding in the striatum, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 79巻, pp. 317-323, OCT 3 2017
  40. Multiple co-clustering based on nonparametric mixture models with heterogeneous marginal distributions, PLOS ONE, 12巻, 10号, OCT 19 2017
  41. BDNF as a possible modulator of EEG oscillatory response at the parietal cortex during visuo-tactile integration processes using a rubber hand, NEUROSCIENCE RESEARCH, 124巻, pp. 16-24, NOV 2017
  42. Functional alterations of Postcentral gyrus Modulated by angry Facial expressions during intraoral Tactile stimuli in Patients with Burning Mouth syndrome: a Functional Magnetic resonance imaging study, FRONTIERS IN PSYCHIATRY, 8巻, NOV 6 2017
  43. Effects of behavioral activation on default mode network connectivity in subthreshold depression: A preliminary resting-state fMRI study, JOURNAL OF AFFECTIVE DISORDERS, 227巻, pp. 156-163, FEB 2018
  44. Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain, PSYCHOLOGICAL MEDICINE, 48巻, 7号, pp. 1148-1156, MAY 2018
  45. Effects of behavioural activation on the neural circuit related to intrinsic motivation, BJPSYCH OPEN, 4巻, 5号, pp. 317-323, SEP 2018
  46. A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity, ELIFE, 7巻, 20181210
  47. Distinctive Neuroanatomical Substrates for Depression in Bipolar Disorder versus Major Depressive Disorder, CEREBRAL CORTEX, 29巻, 1号, pp. 202-214, 201901
  48. Harmonization of resting-state functional MRI data across multiple imaging sites via the separation of site differences into sampling bias and measurement bias, PLOS BIOLOGY, 17巻, 4号, 201904
  49. Identification of depression subtypes and relevant brain regions using a data-driven approach, SCIENTIFIC REPORTS, 8巻, 20180920

著書等出版物

  1. 2004年11月, ストレス疾患ナビゲーター , メディカルレビュー社, 2004年, 11, 単行本(学術書), 共著, 岡田 剛 岡本 泰昌 上田 一貴 , 490
  2. 2015年, 月5,日, 情動の仕組みとその異常, うつ病, 朝倉書店, 2015年, 5, 単行本(学術書), 共著, 岡田剛 岡本泰昌, 201, 100-111
  3. 専門医のための精神科臨床リュミエール21. 前頭葉でわかる精神疾患の臨床, 気分障害, 中山書店, 2010年, 単行本(学術書), 共著, 岡田剛、岡本泰昌, 112-119
  4. 専門医のための精神科臨床リュミエール27 精神科領域からみた心身症, 心理学と生物学的精神医学の接点, 中山書店, 2011年, 単行本(学術書), 共著, 岡田剛、岡本泰昌 山脇成人, 81-88
  5. 精神疾患と認知機能―最近の進歩, うつ病の認知機能障害の脳内機構, 新興医学出版社, 2011年, 単行本(学術書), 共著, 岡田剛、岡本泰昌、土岐 茂、志々田一宏、山脇成人, 63-70
  6. 精神疾患診断のための脳形態・機能検査法, 気分障害のMRI画像研究(fMRI研究を含む), 新興医学出版社, 2012年, 単行本(学術書), 単著, 岡田剛, 117-125

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(特定領域研究), 衝動性と将来報酬予測機能における脳内セロトニンの役割, 2008年, 2009年
  2. 科学研究費助成事業(基盤研究(B)), 情動-認知機能制御の脳内基盤とその障害に関する脳機能画像解析研究, 2008年, 2010年
  3. 科学研究費助成事業(若手研究(B)), 血管性うつ病の認知機能障害に関する脳機能画像研究, 2008年, 2009年
  4. 戦略的国際脳科学研究推進プログラム, 脳科学とAI技術に基づく精神神経疾患の診断と治療技術開発とその応用, 2018年06月28日, 2019年03月31日
  5. 科学研究費助成事業(基盤研究(C)), 認知機能と報酬予測機能の安静時fMRI指標開発とうつ状態バイオタイプ同定への応用, 2018年, 2020年

社会活動

委員会等委員歴

  1. 精神疾患専門委員会委員, 2019年02月, 2019年03月, 広島県地域保健対策協議会