久米 一規KAZUNORI KUME

Last Updated :2020/11/02

所属・職名
大学院統合生命科学研究科 准教授
メールアドレス
kume513hiroshima-u.ac.jp

基本情報

学位

  • 博士(理学) (広島大学)
  • 修士(理学) (広島大学)

研究分野

  • 生物学 / 生物科学 / 細胞生物学
  • 農学 / 農芸化学 / 応用生物化学

教育活動

授業担当

  1. 2020年, 学部専門, セメスター(後期), 基礎化学実験
  2. 2020年, 学部専門, セメスター(後期), 生物工学実験II
  3. 2020年, 学部専門, 3ターム, 情報分子生物学
  4. 2020年, 修士課程・博士課程前期, セメスター(後期), 分子生命機能科学セミナー
  5. 2020年, 修士課程・博士課程前期, セメスター(前期), 分子生命機能科学セミナー
  6. 2020年, 修士課程・博士課程前期, 1ターム, 科学技術英語表現法
  7. 2020年, 修士課程・博士課程前期, 4ターム, 生命科学社会実装論
  8. 2020年, 修士課程・博士課程前期, 年度, 生物工学演習
  9. 2020年, 修士課程・博士課程前期, 年度, 生物工学演習
  10. 2020年, 修士課程・博士課程前期, 1ターム, 生物工学特別演習A
  11. 2020年, 修士課程・博士課程前期, 2ターム, 生物工学特別演習A
  12. 2020年, 修士課程・博士課程前期, 3ターム, 生物工学特別演習B
  13. 2020年, 修士課程・博士課程前期, 4ターム, 生物工学特別演習B
  14. 2020年, 修士課程・博士課程前期, 年度, 生物工学特別研究
  15. 2020年, 博士課程・博士課程後期, 年度, 統合生命科学特別研究
  16. 2020年, 修士課程・博士課程前期, 3ターム, 生命医科学セミナー A
  17. 2020年, 修士課程・博士課程前期, 3ターム, 生命医科学セミナー B
  18. 2020年, 修士課程・博士課程前期, 1ターム, 先端生命技術概論
  19. 2020年, 博士課程・博士課程後期, 3ターム, 生命医科学セミナーC
  20. 2020年, 博士課程・博士課程後期, 3ターム, 生命医科学セミナーD

研究活動

学術論文(★は代表的な論文)

  1. Casein Kinase 1 gamma Ensures Monopolar Growth Polarity under Incomplete DNA Replication Downstream of Cds1 and Calcineurin in Fission Yeast, MOLECULAR AND CELLULAR BIOLOGY, 35巻, 9号, pp. 1533-1542, 201505
  2. Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79巻, 5号, pp. 790-794, 20150504
  3. Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79巻, 7号, pp. 1191-1199, 20150703
  4. The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts, YEAST, 32巻, 9号, pp. 607-614, 201509
  5. Casein kinase 1 gamma acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast, GENES TO CELLS, 20巻, 12号, pp. 1046-1058, 201512
  6. Late-maturing cooking rice Sensyuraku has excellent properties, equivalent to sake rice, for high-quality sake brewing, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78巻, 11号, pp. 1954-1962, 20141102
  7. Ras/cAMP-dependent Protein Kinase (PKA) Regulates Multiple Aspects of Cellular Events by Phosphorylating the Whi3 Cell Cycle Regulator in Budding Yeast, JOURNAL OF BIOLOGICAL CHEMISTRY, 288巻, 15号, pp. 10558-10566, 20130412
  8. Fission Yeast Leucine-Rich Repeat Protein Lrp1 Is Essential for Cell Morphogenesis as a Component of the Morphogenesis Orb6 Network (MOR), BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77巻, 5号, pp. 1086-1091, 201305
  9. Evidence of Antagonistic Regulation of Restart from G(1) Delay in Response to Osmotic Stress by the Hog1 and Whi3 in Budding Yeast, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77巻, 10号, pp. 2002-2007, 201310
  10. Polishing Properties of Sake Rice Koshitanrei for High-Quality Sake Brewing, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77巻, 10号, pp. 2160-2165, 201310
  11. Isolation of a Non-Urea-Producing Sake Yeast Strain Carrying a Discriminable Molecular Marker, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77巻, 12号, pp. 2505-2509, 201312
  12. Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth., Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth., 13巻, 3号, pp. 234-U357, 2011
  13. DNA複製と細胞極性をつなぐ経路:癌細胞の異常な形を理解するヒント, 細胞工学, 30巻, 8号, pp. 854-855, 20110801
  14. Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75巻, 1号, pp. 140-144, 201101
  15. Implication of Ca2+ in the Regulation of Replicative Life Span of Budding Yeast, JOURNAL OF BIOLOGICAL CHEMISTRY, 286巻, 33号, pp. 28681-28687, 20110819
  16. Fission Yeast Germinal Center (GC) Kinase Ppk11 Interacts with Pmo25 and Plays an Auxiliary Role in Concert with the Morphogenesis Orb6 Network (MOR) in Cell Morphogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 285巻, 45号, pp. 35196-35205, 20101105
  17. The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe, JOURNAL OF CELL BIOLOGY, 190巻, 5号, pp. 793-805, 20100906
  18. A method for Pmo25-associated kinase assay in fission yeast: The activity is dependent on two GC kinases Nak1 and Sid1, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71巻, 2号, pp. 615-617, 200702
  19. The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint, MOLECULAR BIOLOGY OF THE CELL, 17巻, 3号, pp. 1421-1435, 200603
  20. Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis, EMBO JOURNAL, 24巻, 17号, pp. 3012-3025, 20050907
  21. Mal3, the fission yeast EB1 homologue, cooperates with Bub1 spindle checkpoint to prevent monopolar attachment, EMBO REPORTS, 6巻, 12号, pp. 1194-1200, 200512
  22. Effect of ethanol on cell growth of budding yeast: Genes that are important for cell growth in the presence of ethanol, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68巻, 4号, pp. 968-972, 200404
  23. Search for kinases related to transition of growth polarity in fission yeast., BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74巻, 5号, 2010
  24. Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80巻, 8号, pp. 1657-1662, 201608
  25. Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5, ELIFE, 5巻, 20160730
  26. Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113巻, 42号, pp. 11913-11918, 20161018
  27. A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control, PLOS GENETICS, 13巻, 5号, 201705
  28. Identification of three signaling molecules required for calcineurin-dependent monopolar growth induced by the DNA replication checkpoint in fission yeast, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 491巻, 4号, pp. 883-889, 20170930
  29. A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast, MOLECULAR BIOLOGY OF THE CELL, 28巻, 25号, pp. 3647-3659, 20171201
  30. Role of nucleocytoplasmic transport in interphase microtubule organization in fission yeast, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 503巻, 2号, pp. 1160-1167, 20180905
  31. Evidence of antagonistic regulation of restart from G(1) delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast., Evidence of antagonistic regulation of restart from G(1) delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast., 77巻, 10号, 2013
  32. Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR)., Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR)., 77巻, 5号, 2013
  33. Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast., Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast., 288巻, 15号, 2013
  34. Implication of Ca2+ in the regulation of replicative life span of budding yeast., Implication of Ca2+ in the regulation of replicative life span of budding yeast., 286巻, 33号, 2011

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(挑戦的萌芽研究), 細胞核サイズの制御機構, 2014年, 2016年
  2. 科学研究費助成事業(若手研究(B)), 細胞形態形成と細胞増殖とを連携制御する細胞極性ネットワーク, 2009年, 2011年
  3. 科学研究費助成事業(若手研究(スタートアップ)), 細胞形態形成と細胞増殖とを連携制御する細胞極性ネットワーク, 2007年, 2008年
  4. 科学研究費助成事業(基盤研究(C)), 進化上保存された細胞極性形成ネットワークによる新規の微小管制御機構の解明, 2017年, 2019年