岩本 博志HIROSHI IWAMOTO

Last Updated :2020/10/08

所属・職名
大学院医系科学研究科(医) 講師
メールアドレス
hirhiroshima-u.ac.jp

基本情報

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 呼吸器内科学

研究キーワード

  • COPD
  • 気管支喘息

教育活動

授業担当

  1. 2020年, 学部専門, 通年, 器官・システム病態制御学I
  2. 2020年, 学部専門, 集中, 症候診断治療学
  3. 2020年, 学部専門, 集中, 臨床実習入門プログラム
  4. 2020年, 学部専門, セメスター(前期), 内科学II

研究活動

学術論文(★は代表的な論文)

  1. Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107巻, 6号, pp. 875-882, 201306
  2. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 43巻, 2号, pp. 421-429, 2014
  3. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67巻, 6号, pp. 1465-9, 20110101
  4. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2巻, pp. 167-170, 20110101
  5. ★, Airflow limitation in smokers is associated with subclinical atherosclerosis., Am J Respir Crit Care Med., 20090101
  6. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20巻, 1号, pp. 87-94, 201501
  7. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106巻, 7号, pp. 921-928, 201507
  8. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, Pharmaceutical Research, 2015
  9. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical & Experimental Allergy, 2009
  10. Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulmonary Pharmacology & Therapeutics, 2008
  11. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, european respiratory journal, 2008
  12. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11巻, 2号, 20160209
  13. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., 301巻, 6号, 2011
  14. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients., Respirology (Carlton, Vic.), 20巻, 1号, 2015
  15. Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., 60巻, 1号, 2011
  16. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers., Inhalation toxicology, 2016
  17. Soluble receptor for advanced glycation end-products and progression of airway disease, BMC PULMONARY MEDICINE, 14巻, 2014
  18. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
  19. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28巻, 8号, pp. 343-348, JUL 2016
  20. Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76巻, 11号, pp. 3285-3294, JUN 1 2016
  21. Characterization of sputum biomarkers for asthma-COPD overlap syndrome, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11巻, 2016
  22. ★, Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, Respirology, 22巻, pp. 86-92
  23. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22巻, 1号, pp. 86-92, JAN 2017
  24. Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74巻, 5号, pp. 321-327, MAY 2017
  25. Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106巻, pp. 1-9, MAY 2017
  26. AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22巻, 5号, pp. 965-971, JUL 2017
  27. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 42巻, 2013
  28. Mustard gas exposure causing death due to respiratory tract cancer and chronic bronchitis in the long term, EUROPEAN RESPIRATORY JOURNAL, 42巻, 2013
  29. COPD in Smokers with Atherosclerosis: Are We Missing the Trail?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180巻, 1号, pp. 103-104, 2009
  30. COMPARISON OF KL-6, SP-A, SP-D, 8-ISOPROSTANE, MMP-9, AND TIMP-1 AS SERUM BIOMARKERS FOR PATIENTS WITH COMBINED PULMONARY FIBROSIS AND EMPHYSEMA, RESPIROLOGY, 18巻, pp. 58-58, 2013
  31. CHARACTERISTICS OF INSPIRATORY AND EXPIRATORY REACTANCE IN IDIOPATHIC PULMONARY FIBROSIS, RESPIROLOGY, 18巻, pp. 137-137, 2013
  32. INCREASED OF RECEPTOR TYPE TYROSINE KINASE ROS1 IN INTERSTITIAL LUNG DISEASE, RESPIROLOGY, 18巻, pp. 200-200, 2013
  33. A retrospective study comparing pemetrexed with taxanes as front-line cytotoxic chemotherapy for lung adenocarcinoma, ANNALS OF ONCOLOGY, 26巻, pp. 123-123, 2015
  34. [A case of tumor microembolism diagnosed by perfusion scan and transbronchial lung biopsy]., Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47巻, 8号, 2009
  35. [Case report: A case of Hodgkin lymphoma required a differential diagnosis from sarcoidosis due to elevated serum level of angiotensin converting enzyme (ACE)]., Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 101巻, 5号, 2012
  36. Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18巻, AUG 18 2017
  37. CLINICAL AND MOLECULAR FEATURES OF RAPIDLY PROGRESSIVE CHRONIC HYPERSENSITIVITY PNEUMONITIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 34巻, 1号, pp. 48-57, 2017
  38. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56巻, 19号, pp. 2627-2631, 2017
  39. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8巻, 55号, pp. 94382-94392, NOV 7 2017
  40. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56巻, 24号, pp. 3327-3331, 2017
  41. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81巻, 1号, pp. 131-139, JAN 2018
  42. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123巻, pp. 105-109, FEB 2017
  43. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119巻, pp. 21-24, MAY 2018
  44. Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51巻, 5号, MAY 1 2018
  45. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17巻, pp. 263, 2017
  46. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17巻, pp. 263
  47. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis., Intern Med., 56巻, pp. 3327
  48. 喘息管理手帳を用いた医薬連携の有用性についての検討, 日本病院薬剤師会雑誌, 53巻, pp. 201
  49. Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32巻, 5号, pp. 1155-1160, SEP-OCT 2018
  50. Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18巻, 8号, pp. 1215-1218, AUG 2018
  51. Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12巻, pp. 698-706, SEP 7 2018
  52. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16巻, 4号, pp. 3070-3076, OCT 2018
  53. Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9巻, 5号, pp. 539-544, 201811
  54. Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97巻, 49号, 201812
  55. Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442巻, pp. 31-39, 2019
  56. Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma A case report, MEDICINE, 98巻, 12号, 201903
  57. Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress, FREE RADICAL BIOLOGY AND MEDICINE, 136巻, pp. 52-59, 20190520
  58. Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25巻, 3号, pp. 275-280, 202003
  59. Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15巻, pp. 1049-1059, 2020
  60. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21巻, 1号, 20200611

招待講演、口頭・ポスター発表等

  1. COPDと心血管疾患, 岩本 博志, 第51回日本呼吸器学会総会, 2011年, 招待, 日本語
  2. Mild obesity is correlated with desaturation in voluntary breath-holding,, Iwamoto et al, European respiratory society, 2006年, 通常, 日本語
  3. 高齢者喘息の治療状況についての実態調査, 岩本 博志, 日本呼吸器学会総会, 2010年, 通常, 日本語
  4. COPD as a systemic disease. Subclinical atherosclerosis in COPD, Iwamoto H, 日本呼吸器学会, 2008年, 通常, 日本語
  5. 気管支喘息合併のGERDの実態と診断についての検討‐FSSGを用いた検討‐, 岩本 博志, アレルギー学会春季臨床大会, 2006年, 通常, 日本語
  6. Airway resistance assessed by impulse oscillometry at varying respiratory rate and the effect of pretreatment with short-acting beta2 agonist in COPD patients., Iwamoto et al, European respiratory society, 2010年, 通常, 日本語
  7. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap., Iwamoto H, Gao J, Koskela J, Kobayashi H, Laitinen T, Mazur W., European respiratory society, 2013年, 通常, 英語
  8. Soluble receptor for advanced glycation end-products and progression of airway disease, Iwamoto H, Gao J, Pulkkinen V, Toljamo T, Nieminen P, Mazur W, 2014年05月, 通常, 日本語
  9. Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis, 2014年09月, 通常, 英語
  10. 重症喘息のフェノタイプ -広島末梢気道研究会の喘息コホート研究よりー, 岩本博志, 第65回日本アレルギー学会学術大会, 2016年06月19日, 招待, 日本語, 東京
  11. ACOSのバイオマーカー, 岩本博志, 第56回日本呼吸器学会学術講演会, 2016年04月08日, 招待, 日本語, 東京
  12. HRCT Findings as a Predictive Factor for Acute Exacerbation of Idiopathic Pulmonary Fibrosis, 第55回日本呼吸器学会学術講演会, 2015年04月17日, 通常, 英語, 東京
  13. Long-term pulmonary complications of sulfur mustard exposure in former poison gas factory workers, e 1st Asia Oceania Workshop of Pulmonary Functional Imaging (1st AOWPFI) and 8th meeting of the Japanese Society of Pulmonary Functional Imaging (8th JSPFI), 2016年01月29日, 通常, 日本語, awaji
  14. Clinically remitted childhood asthma is a risk factor for airflow obstruction in middle-aged adults, Keitaro Omori, Noboru Hattori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Akihito Yokoyama, Nobuoki Kohno, 2015年09月26日, 通常, 英語
  15. 小児喘息の既往を有する中年成人の肺機能と呼吸器症状についての検討, 大森慶太郎 岩本博志 春田吉則 山根高 佐々木英夫 倉岡敏彦 佐久間和代 伊藤千賀子 山根公則 服部登 横山彰仁 河野修興, 第55回日本呼吸器学会学術講演会, 2015年04月17日, 通常, 日本語

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(若手研究(B)), I型肺胞上皮由来の新規特発性肺線維症バイオマーカーRAGEの開発と創薬の試み, 2013年, 2015年
  2. 科学研究費助成事業(若手研究(B)), 気管支喘息・間質性肺炎モデルマウスにおける亜鉛キレート剤の効果の検討, 2010年, 2012年
  3. 科学研究費助成事業(基盤研究(C)), セレクチンリガンドを有するKL-6/MUC1分子の臨床病理学的意義, 2007年, 2009年
  4. 科学研究費助成事業(基盤研究(A)), 国際共同研究による間質性肺炎の新規バイオマーカーの開発と創薬の試み, 2013年, 2016年
  5. 基盤研究(C), Ⅰ型肺胞上皮由来物質RAGEを用いた特発性肺線維症の病態解明の試み, 2017年, 2019年
  6. 科学研究費助成事業(基盤研究(C)), Ⅰ型肺胞上皮由来物質RAGEを用いた特発性肺線維症の病態解明の試み, 2017年, 2019年

社会活動

委員会等委員歴

  1. 閉塞性肺疾患学術部会, 2019年, 日本呼吸器学会
  2. 代議員, 2016年, 日本呼吸器学会