HIROSHI IWAMOTO

Last Updated :2020/09/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor or Lecturer
E-mail
hirhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • asthma
  • COPD

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2020, Undergraduate Education, Intensive, Symptomatology, Diagnosis and Treatment
  3. 2020, Undergraduate Education, Intensive, Introduction to clinical clerkship
  4. 2020, Undergraduate Education, First Semester, Internal Medicine Ⅱ

Research Activities

Academic Papers

  1. Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107(6), 875-882, 201306
  2. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 43(2), 421-429, 2014
  3. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67(6), 1465-9, 20110101
  4. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2, 167-170, 20110101
  5. Airflow limitation in smokers is associated with subclinical atherosclerosis., Am J Respir Crit Care Med., 20090101
  6. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20(1), 87-94, 201501
  7. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106(7), 921-928, 201507
  8. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, Pharmaceutical Research, 2015
  9. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical & Experimental Allergy, 2009
  10. Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulmonary Pharmacology & Therapeutics, 2008
  11. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, european respiratory journal, 2008
  12. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11(2), 20160209
  13. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., 301(6), 2011
  14. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients., Respirology (Carlton, Vic.), 20(1), 2015
  15. Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy., 60(1), 2011
  16. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers., Inhalation toxicology, 2016
  17. Soluble receptor for advanced glycation end-products and progression of airway disease, BMC PULMONARY MEDICINE, 14, 2014
  18. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
  19. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28(8), 343-348, JUL 2016
  20. Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76(11), 3285-3294, JUN 1 2016
  21. Characterization of sputum biomarkers for asthma-COPD overlap syndrome, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11, 2016
  22. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, Respirology, 22, 86-92
  23. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22(1), 86-92, JAN 2017
  24. Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74(5), 321-327, MAY 2017
  25. Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106, 1-9, MAY 2017
  26. AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22(5), 965-971, JUL 2017
  27. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
  28. Mustard gas exposure causing death due to respiratory tract cancer and chronic bronchitis in the long term, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
  29. COPD in Smokers with Atherosclerosis: Are We Missing the Trail?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(1), 103-104, 2009
  30. COMPARISON OF KL-6, SP-A, SP-D, 8-ISOPROSTANE, MMP-9, AND TIMP-1 AS SERUM BIOMARKERS FOR PATIENTS WITH COMBINED PULMONARY FIBROSIS AND EMPHYSEMA, RESPIROLOGY, 18, 58-58, 2013
  31. CHARACTERISTICS OF INSPIRATORY AND EXPIRATORY REACTANCE IN IDIOPATHIC PULMONARY FIBROSIS, RESPIROLOGY, 18, 137-137, 2013
  32. INCREASED OF RECEPTOR TYPE TYROSINE KINASE ROS1 IN INTERSTITIAL LUNG DISEASE, RESPIROLOGY, 18, 200-200, 2013
  33. A retrospective study comparing pemetrexed with taxanes as front-line cytotoxic chemotherapy for lung adenocarcinoma, ANNALS OF ONCOLOGY, 26, 123-123, 2015
  34. [A case of tumor microembolism diagnosed by perfusion scan and transbronchial lung biopsy]., Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47(8), 2009
  35. [Case report: A case of Hodgkin lymphoma required a differential diagnosis from sarcoidosis due to elevated serum level of angiotensin converting enzyme (ACE)]., Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 101(5), 2012
  36. Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18, AUG 18 2017
  37. CLINICAL AND MOLECULAR FEATURES OF RAPIDLY PROGRESSIVE CHRONIC HYPERSENSITIVITY PNEUMONITIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 34(1), 48-57, 2017
  38. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56(19), 2627-2631, 2017
  39. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8(55), 94382-94392, NOV 7 2017
  40. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56(24), 3327-3331, 2017
  41. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81(1), 131-139, JAN 2018
  42. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123, 105-109, FEB 2017
  43. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119, 21-24, MAY 2018
  44. Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51(5), MAY 1 2018
  45. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17, 263, 2017
  46. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study., BMC Cancer, 17, 263
  47. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis., Intern Med., 56, 3327
  48. Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32(5), 1155-1160, SEP-OCT 2018
  49. Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18(8), 1215-1218, AUG 2018
  50. Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 698-706, SEP 7 2018
  51. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(4), 3070-3076, OCT 2018
  52. Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9(5), 539-544, 201811
  53. Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97(49), 201812
  54. Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442, 31-39, 2019
  55. Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma A case report, MEDICINE, 98(12), 201903
  56. Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress, FREE RADICAL BIOLOGY AND MEDICINE, 136, 52-59, 20190520
  57. Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25(3), 275-280, 202003
  58. Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15, 1049-1059, 2020
  59. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21(1), 20200611

Invited Lecture, Oral Presentation, Poster Presentation

  1. Mild obesity is correlated with desaturation in voluntary breath-holding,, Iwamoto et al, European respiratory society, 2006, Without Invitation
  2. COPD as a systemic disease. Subclinical atherosclerosis in COPD, Iwamoto H, Japanese respiratory society, 2008, Without Invitation
  3. Airway resistance assessed by impulse oscillometry at varying respiratory rate and the effect of pretreatment with short-acting beta2 agonist in COPD patients., Iwamoto et al, European respiratory society, 2010, Without Invitation
  4. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap., Iwamoto H, Gao J, Koskela J, Kobayashi H, Laitinen T, Mazur W., European respiratory society, 2013, Without Invitation, Barcelona
  5. Soluble receptor for advanced glycation end-products and progression of airway disease, Iwamoto H, Gao J, Pulkkinen V, Toljamo T, Nieminen P, Mazur W, American thoracic society, 2014/05, Without Invitation
  6. Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis, Iwamoto H, Horimasu Y, Nakashima T, Senoo T, Ohshimo S, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Hattori N, Mazur W, Kohno N,, European respiratory society, 2014/09, Without Invitation
  7. HRCT Findings as a Predictive Factor for Acute Exacerbation of Idiopathic Pulmonary Fibrosis, Chihiro Yamaoka, Yasushi Horimasu, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hiroshi Murai, Noboru Hattori, Hironobu Hamada, Nobuoki Kohno, 2015/04/17, Without Invitation
  8. Long-term pulmonary complications of sulfur mustard exposure in former poison gas factory workers, Nishimura Y, Iwamoto H, Ishikawa N, Hattori N, Horimasu Y, Ohshimo S, Fujitaka K, Kondo K, Hamada H, Awai K, Kohno N, e 1st Asia Oceania Workshop of Pulmonary Functional Imaging (1st AOWPFI) and 8th meeting of the Japanese Society of Pulmonary Functional Imaging (8th JSPFI), 2016/01/29, Without Invitation, awaji
  9. Clinically remitted childhood asthma is a risk factor for airflow obstruction in middle-aged adults, Keitaro Omori, Noboru Hattori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Akihito Yokoyama, Nobuoki Kohno, European respiratory society annual congress, 2015/09/26, Without Invitation

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2015
  2. KAKENHI, Effects of zincchelator in asthma and interstitialpneumonia model mouse, 2010, 2012
  3. KAKENHI, Clinicopathological role of kl-6/muc1 with selectin ligand, 2007, 2009
  4. KAKENHI, 2013, 2016
  5. 2017, 2019
  6. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019