広島大学

Basic Information

Major Professional Backgrounds

• 2025/04/01, Hiroshima University, Associate Professor
• 2020/04/01, Hiroshima University, Assistant Professor
• 2019/10/01, Hiroshima University, Specially Appointed Assistant Professor

Educational Backgrounds

• The University of Tokushima, Japan, 2009/04, 2012/03
• The University of Tokushima, Japan, 2007/04, 2009/03
• The University of Tokushima, Japan, 2000/04, 2003/03

Academic Degrees

• The University of Tokushima
• The University of Tokushima

Educational Activity

• [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
• [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
• [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
• [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

In Charge of Primary Major Programs

• Dentistry

Research Fields

• Medicine,dentistry, and pharmacy;Dentistry;Morphological basic dentistry

Research Keywords

• Bone, Vascular calcification, Skeletal muscle, Sarcopeia

Affiliated Academic Societies

• Japanese Association for Oral Biology
• The Japanese Society for Bone and Mineral Research
• The American Society of Bone and Mineral Research

Educational Activity

Course in Charge

1. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
2. 2025, Undergraduate Education, 3Term, Basic Practice of Anatomy I
3. 2025, Undergraduate Education, 4Term, Basic Practice of Anatomy II
4. 2025, Undergraduate Education, 2Term, Embryology
5. 2025, Undergraduate Education, 1Term, Histology and Oral Histology
6. 2025, Undergraduate Education, 1Term, Basic Practice of Histology I
7. 2025, Undergraduate Education, 2Term, Basic Practice of Histology II
8. 2025, Undergraduate Education, First Semester, Dental Research Practices I
9. 2025, Undergraduate Education, 3Term, Clinical Anatomy for Dentistry I
10. 2025, Undergraduate Education, 4Term, Clinical Anatomy for Dentistry II
11. 2025, Undergraduate Education, 3Term, Practice of Clinical Anatomy for Dentistry I
12. 2025, Undergraduate Education, 4Term, Practice of Clinical Anatomy for Dentistry II
13. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
14. 2025, Undergraduate Education, First Semester, Dental Research Practices III
15. 2025, Undergraduate Education, 1Term, Histology and Oral Histology
16. 2025, Undergraduate Education, 1Term, Histology and Oral Histology
17. 2025, Graduate Education (Master's Program) , First Semester, Human Anatomy

Research Activities

Academic Papers

1. Inhibition of skeletal muscle differentiation by calciprotein particles in human primary myoblasts, BIOMEDICAL RESEARCH-TOKYO, 45(4), 173-177, 202407
2. Extracellular histones promote calcium phosphate-dependent calcification in mouse vascular smooth muscle cells, The Journal of Biochemistry, 202402
3. 2,3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells, COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, 50, 202209
   Link to Paper Search Results by DOI
4. ★, An N-terminal-truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy, Life science alliance, 2(3), e201900340
5. Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(13), 202107
   Link to Paper Search Results by DOI

Publications such as books

1. 2024/01/12, Mineralizing Vesicles From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease, The roles of mineralizing extracellular vesicles in cell–cell communication, 2024, 1, Scholarly Book, Joint work, 英語, 11
2. 2022/06/20, MicroRNA as Disease Biomarkers and Its Applications for Medical Diagnosis, CMC Publishing Co.,Ltd., 2022, 2022, Scholarly Book, Joint work, 日本語

Invited Lecture, Oral Presentation, Poster Presentation

1. Extracellular histones promote vascular calcification in mouse vascular smooth muscle cells, Hoshino T, Kohno S, Minamizaki T, Kharaghani D, Yoshiko Y, ASBMR 2022 Annual Meeting, 2022/09/09, Without Invitation, English, Austin
2. MEPE-derived pASARM peptide selectively inhibits vascular calcification, Kohno S, Minamizaki T, Kharaghani D, Hoshino T, Yoshiko Y, ASBMR 2022 Annual Meeting, 2022/09/09, Without Invitation, English, Austin
3. MEPE-derived ASARM, an inhibitor of calciparticle protein formation, suppresses vascular calcification but not bone formation, Davood Kharaghani, Tomoko Minamizaki, Shohei Kohno, Tomonori Hoshino, Yuji Yoshiko, ASBMR 2021 Annual Meeting, 2021/10/01, Without Invitation, English
4. Calciprotein particles play a role in bone formation and vascular calcification, Davood Kharaghani, Eben Bashir Kurniawan, Shohei Kohno, Tomonori Hoshino, Tomoko Minamizaki, Yuji Yoshiko, 6th Joint Scientific Meeting in Dentistry, 2021/07/30, Without Invitation, English
5. High-resolution micro-computed tomography analysis of the microarchitecture in Klotho mutant mouse osteocyte lacunae., 2021/03/28, Without Invitation, Japanese
6. Overexpressing miR-125b in osteoblasts Confers a Significant Survival Benefit in Mice with Bone Metastasis, Kohno S., Sarmin N., Minamizaki T., Yoshiko Y., The American Society for Bone and Mineral Research 2020 Annual Meeting, 2020/09/11, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

1. 2023/02, 2025/01
2. 2023/03, 2025/03
3. 2022/12, 2024/11
4. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2021, 2023
5. 2021, 2023

Social Activities

History as Peer Reviews of Academic Papers

1. 2023, Journal of Nanobiotechnology, Others, Reviewer
2. 2023, Lipids in Health and Disease, Others, Reviewer
3. 2023, European Journal of Pharmacology, Others, Reviewer
4. 2022, Molecular Biology Reports, Others, Reviewer