Koichiro Ozawa

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
ozawakhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1999/04/01, 2002/03/31, Hiroshima University

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy
  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Research Keywords

  • drug action
  • Exocytosis
  • Signal transduction
  • Pharnacotherapy
  • Tyrosine kinase
  • Pharnacotherapy
  • Video-enhanced light microscopy
  • Clinical Pharmacology
  • Mast cell
  • Clinical Pharmacology

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, Peace Messages from "Kasumi Campus"
  2. 2024, Liberal Arts Education Program1, 2Term, Foundation physics for life science
  3. 2024, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  4. 2024, Undergraduate Education, Intensive, Social Medicine
  5. 2024, Undergraduate Education, 1Term, Nuclear Pharmacy
  6. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  7. 2024, Undergraduate Education, First Semester, Research Practice A
  8. 2024, Undergraduate Education, Second Semester, Research Practice B
  9. 2024, Undergraduate Education, First Semester, Practice of Clinical Pharmacy
  10. 2024, Undergraduate Education, Second Semester, Biostatistics
  11. 2024, Undergraduate Education, 1Term, Pharmacotherapy A
  12. 2024, Undergraduate Education, 3Term, Clinical Pharmacology A
  13. 2024, Undergraduate Education, 2Term, Pharmaceutical Affairs Related Laws
  14. 2024, Undergraduate Education, 1Term, Clinical Pharmacology C
  15. 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  16. 2024, Undergraduate Education, 3Term, Practical English for Pharmaceutical Students
  17. 2024, Undergraduate Education, 3Term, Pharmacy Practice
  18. 2024, Undergraduate Education, Year, Clerkship in Clinical Pharmacy A
  19. 2024, Undergraduate Education, Year, Clerkship in Clinical Pharmacy B
  20. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  21. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  22. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  23. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  24. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  25. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  26. 2024, Undergraduate Education, 4Term, Seminar on school health II
  27. 2024, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  28. 2024, Graduate Education (Doctoral Program) , 4Term, Pharmacotherapeutic Research
  29. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacotherapy
  30. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacotherapy
  31. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacotherapy
  32. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacotherapy
  33. 2024, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  34. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  35. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacotherapy
  36. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacotherapy
  37. 2024, Graduate Education (Master's Program) , First Semester, Research on Pharmacotherapy
  38. 2024, Graduate Education (Master's Program) , Second Semester, Research on Pharmacotherapy
  39. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacotherapy for Medicinal Sciences
  40. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacotherapy for Medicinal Sciences
  41. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacotherapy for Medicinal Sciences
  42. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacotherapy for Medicinal Sciences

Research Activities

Academic Papers

  1. Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress, PLOS ONE, 17(12), 20221213
  2. COOH-terminal fragment of APP interacts with p62, forms an aggregate, and induces autophagic degradation in Alzheimer's cell model, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 323(6), C1633-C1641, 202212
  3. Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway, BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 27(5), 807-819, 202210
  4. Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli, FRONTIERS IN IMMUNOLOGY, 13, 20220928
  5. Coagulation factors induce human skin mast cell and basophil degranula-tion via activation of complement 5 and the C5a receptor, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(3), 1101-+, 202103
  6. Peripheral Immune Activation in Mice Elicits Unfolded Protein Responses Independent on MyD88 Pathway in the Liver but not the Hypothalamus and Hippocampus, FRONTIERS IN PHYSIOLOGY, 13, 20220428
  7. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities, CLINICAL SCIENCE, 118(1-2), 19-29, 201001
  8. MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298(2), R403-R410, 201002
  9. MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298(2), R403-R410, 201002
  10. Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(1), 84-90, 201201
  11. Skin surface electrical potential as an indicator of skin condition: observation of surfactant-induced dry skin and middle-aged skin, EXPERIMENTAL DERMATOLOGY, 20(9), 757-759, 201109
  12. Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118(3), 319-324, 201203
  13. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice, GENE, 497(2), 340-343, 20120415
  14. Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells, PLOS ONE, 7(6), 20120629
  15. TNF-alpha-857C > T Genotype is Predictive of Clinical Response after Treatment with Definitive 5-Fluorouracil/cisplatin-based Chemoradiotherapy in Japanese Patients with Esophageal Squamous Cell Carcinoma, INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 10(12), 1755-1760, 2013
  16. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, 20131001
  17. Serotonergic Modulation of Neuronal Activity in the Nucleus Accumbens Following Repeated Methamphetamine Administration in Rats, JOURNAL OF PHARMACOLOGICAL SCIENCES, 123(2), 140-146, 201310
  18. ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: Up- and down-regulation of PGE(2) + IFN gamma-induced IL-6 and iNOS expressions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(2), 525-528, 20131115
  19. ER stress upregulated PGE(2)/IFN gamma-induced IL-6 expression and down-regulated iNOS expression in glial cells, SCIENTIFIC REPORTS, 3, 20131202
  20. Determination of Insulin Content in Pancreatic B-cell Line MING Cell by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry, Biol. Pharm. Bull., 1240, 19980401
  21. 5-HT receptor activation stimulates phospholipid methylation in rat brain, European Journal of Phoracology, 205-206, 19910401
  22. Different isozymes of protein kinase C show each specific role in RBL-2H3 cells, Bulletin of the Japanese Neurochemical Society, 32(1), 270-271, 19930401
  23. Real time analysis of exocytosis in RBL-2H3 cells visualized by video-enhanced light microscopy, The Japanese Journal of Pharmacology, 112pー113p, 19930401
  24. Antiallergic dimeric prenylbenzoguinones from Ehretia Microphylla, Phytochemistry, 39(1), 105-110, 19950401
  25. Real-time analysis of PKC-translocation and exocytosis visualized by video-enhanced light/fluorescence microscopy., The Japanese Journal of Pharmacology, 67, 379-389, 19950401
  26. Real-time analysis of exocytosis and PKC-translocation in RBL-2H3 cells visvalized by video-enhanced light/fluorescence microscopy., Neurochemical Research, 20, 323-324, 19950401
  27. Real-time analysis of exocytosis and protein kinase C-translocation in RBL0-2H3 cells., The 1st International Symposium on Neuronal Receptor Mechanisms, 1, 61, 19950401
  28. Different pathways of inhibitory effects of wortmannin on exocytosis are revealed by video-enhanced light microscope., Biochemical and Biophysical Research Communications, 222, 243-248, 19960401
  29. Role of calcium, protein kinase C and map kinase in the activation of mast cells. (Review Article), Allergology International, 45, 49-60, 19960401
  30. Video-microscopy for analysis of molecular dynamics in cells, Journal of Pharmaceutical and Biomedical Analysis, 15, 1483-1488, 19970401
  31. Simultaneous analysis of membrane potential and calcium mobilization in a pancreatic beta-cell line MIN6 by use of a double-probe imaging microscope-system., Analytica Chimica Acta, 365, 3-7, 19980401
  32. Analysis of pharmacological and molecular mechanisms underlying insulin-secretion with video-microscopes in a pancreatic beta-cell line MIN6., Japanese Journal of Pharmacology, 76, 32-33, 19980401
  33. Analysis of pharmacological and molecular mechaisms underlying insulin-secretion with video-microscopes in a pancleatic beta-cell line MIN6., The Japanese Journal of Pharmacology, 76, 38-39, 19980401
  34. Trapping of secreted molecules at single-cell level using an HPLC resin particle under a videomicroscope., Biological and Pharmacentical Bulletin, 21(8), 886-888, 19980401
  35. Calcium mobilization in a pancreatic beta-cell line MIN6., The Japanese Journal of Pharmacology, 79, 25, 19990401
  36. Quantitative analysis of exocytosis visualized by video-microscopes in RBL-2H3 cells., The Japanese Journal of Pharmacology, 85, 12-15, 20010401
  37. Antiallergic Dimeric Prenylbenzoquinones from Ehretia microphylla, Phytochemistry, 39(1), 105-110, 19950701
  38. Antihistaminic flavonoids and aliphatic glycosides from Mentha spicata, Phytochemistry, 48(1), 131-136, 19980901
  39. Mechanism of Cu2+-induced elevation of [3H]cimetidine binding to membranes in rat brain, Neurochemistry International, 7(3), 435-440, 19850301
  40. Characterization of histamine H2-receptors with [3H]histamine binding in rat brain., Therapeutic Research, 7(1), 9-16, 19870101
  41. Histamine acting on H2-receptors stimulated phospholipid methylation in synaptic membranes of rat brain., Journal of Neurochemistry, 48(5), 1392-1398, 19870501
  42. Histamine H2-receptor-induced phospholipid-N-methylation., Neuroscience Research, 5(1), 128-129, 19870701
  43. Histamine increases phospholipid methylation and H2-receptor-adenylate cyclase coupling in rat brain., Journal of Neurochemistry, 50(5), 1551-1558, 19880501
  44. Regulation of [3H]histamine binding to H2-receptors by GTP-binding protein and phospholipid methylation in rat brain., Therapeutic Research, 10(2), 582-587, 19890201
  45. Regulation of [3H]histamine binding to H2-receptor in rat brain., Neurochemical Research, 14(6), 781-784, 19890601
  46. Phospholipid methylation participates in histamine H2-receptor-mediated cyclic AMP accumulation and positive chronotropic effect of guinea-pig atrium., Neurochemical Research, 15(3), 325-326, 19900101
  47. Solubilization and characterization of rat brain histamine H2-receptor., Therapeutic Research, 11(1), 90-95, 19900301
  48. Signalling mechanism of histamine H2-receptor in guinea-pig right atrium., Therapeutic Research, 11(1), 4-13, 19910301
  49. Uncoupling of histamine H2-receptors from GTP-binding proteins by sulfhydryl-modifying reagents., Therapeutic Research, 13(1), 191-197, 19920101
  50. Signalling mechanism of histamine H2-receptor in guinea-pig stomach., European Journal of Pharmacology, 188(1), 136-141, 19910601
  51. Solubilization and characterization of guinea-pig brain histamine H2-receptor., Therapeutic Research, 13(1), 198-204, 19920101
  52. Phospholipid methylation participates in H2-receptor mediated stimulation of adenylate cyclase in rat brain., Therapeutic Research, 13(1), 256-263, 19920101
  53. Regulation of [3H]cimetidine binding to H2-receptors by GTP-binding protein and phospholipid methylation in rat brain., Neurochemical Research, 15(3), 415-418, 19920101
  54. Signalling mechanism of histamine H2-receptor in guinea-pig brain., Neurochemical Research, 17(2), 415-418, 19930101
  55. ★, Ca2+-dependent and Ca2+-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells., The Journal of Biological Chemistry, 268(3), 1749-1756, 19930101
  56. ★, Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells., The Journal of Biological Chemistry, 268(4), 2280-2283, 19930201
  57. Real time analysis of exocytosis in RBL-2H3 cells visualized by video-enhanced light microscopy., Japanese Journal of Pharmacology, 64(2), 112-115, 19940201
  58. ★, Studies with transfected and permeabilized RBL-2H3 cells reveal unique inhibitory properties of protein kinase C g., Molecular Biology of the Cell, 5(4), 475-484, 19940401
  59. Each different isozyme of protein kinase C show a specific role in RBL-2H3 cells., Neurochemical Research, 19(8), 877-878, 19940801
  60. Antiallergic Mimeric Prenylbenzoquinones from Ehretis Microphylia., Phytochemistry, 39(1), 105-110, 19950101
  61. Real-time analysis of exocytosis and PKC-translocation in RBL-2H3 cells visualized by video-enhanced light/fluorescence microscopy., Neurochemical Research, 20(3), 323-324, 19950401
  62. Effect of tapsygargin on exocytosis in RBL-2H3 cells., Japanese Journal of Pharmacology, 66(2), 98-101, 19960201
  63. Effect of extracellular and intracellular calsium on exocytosis in MIN6 cells., Japanese Journal of Pharmacology, 66(2), 121-124, 19960201
  64. Simultaneous analysis of membrane potential and calcium mobilization in pancreatic ァ-cell line MIN6., Japanese Journal of Pharmacology, 69(1), 114-118, 19960401
  65. Differemt pathways of inhibitory effects of wortmannin on exocytosis are revealed by video-enhanced light microscope., Boichemical and Biophyssical Research, 222(2), 243-248, 19960601
  66. Quantitative analysis of Exocytosis visualized by video-enhanced light/fluorescence microscope reveals two distinct components of exocytosis in RBL-2H3 cells., FEBS Letters, 398, 67-73, 19961001
  67. ★, Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4,5-bisphosphate and phorbol 12-myristate 13-acetate., The Journal of Biological Chemistry, 272(20), 13033-13039, 19970501
  68. Video-microscopy for analysis of molecular dynamics in cells., Journal of Pharmaceutical and Biomedical Analysis, 15(7), 1483-1488, 19970801
  69. Release of Ca2+ from intracellular stores is necessary for Ca2+-influx and exocytosis in RBL-2H3 cells., Japanese Journal of Pharmacology, 73(1), 68-69, 19970301
  70. Effect of Ca2+-channel blocker on elevation of Ca2+ in MIN6 cells., Japanese Journal of Pharmacology, 79(1), 25-26, 19980301
  71. Effect of thaspygargin on increase of Ca2+ in RBL-2H3 cells., Japanese Journal of Pharmacology, 79(1), 184-185, 19980301
  72. Overexpression of dominant negative mutant hepatocyte nuclear factor (HNF)-1a inhibits arginine-induced insulin secretion in 6 cells., Diabetologia, 42(8), 887-891, 19990801
  73. A convenient method for the evaluation of anti-tumor agents affecting the cell cycle., Journal of Bioscience and Bioengineering, 90(5), 574-576, 20000501
  74. Quantitative analysis of exocytosis visualized by video-microscopesin RBL-2H3 cells., Japanese Journal of Pharmacology, 85(1), 12-15, 20010301
  75. Antihistaminic flavones and aliphatic glycosides from mentha spicata., Phytochemistry, 48(1), 131-136, 19980501
  76. Antiallergic Dimeric Prenylbenzoquinones from Ehretia microphylla, Phytochemistry, 39(1), 105-110, 19950501
  77. Quantitative analysisi of exocytosis visualized by video-enhanced light/fluorescence microscope reveals two distinct components of exocytosis in RBL-2H3 cells, FEBS Letters, 398(1), 67-73, 19961101
  78. Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias., Blood, 91(6), 2067-2075, 19980301
  79. Identification of PU.1 and Sp1 as essential transcriptional factors for the promoter activity of mouse tec gene., Biochem. Biophys. Res. Commun., 234(2), 376-381, 19970501
  80. Cloning and characterization of mouse tec promoter., Biochem. Biophys. Res. Commun., 223(2), 422-426, 19980601
  81. Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway., Kidney Int., 58, 269-282, 20000401
  82. Involvement of mTOR/Bim, not Akt/Bad pathway in cytokine-mediated cells survival signaling downstream of PI3-kinase in murine hematopoietic progenitors., Blood 96 Suppl., 1, 568A, 20000401
  83. Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3(E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes., Mol. Cell. Biol., 19, 2754-2762, 19990401
  84. SLUG, a ces-1-related zinc-finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein., Mol. Cell, 4, 343-352, 19990401
  85. Essential role of the BH3 factor, Bim, in the cytokine-mediated apoptosis program: Implications in the antiapoptotic Ras pathways and in leukemogenesis., Blood 94 Suppl., 1, 688A, 19990401
  86. Involvement of Bim, the BH3-containing cell death activator, in cytokine-mediated apoptosis program and in leukemogenesis by the E2A-HLF chimera, Blood 92 Suppl., 1, 199A, 19980401
  87. Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells., Blood, 90, 3884-3892, 19970401
  88. Ras-dependent and -independent regulation of E4BP4/NFIL3 transcription factor in cytokine-mediated cell survival of pro-B lymphocytes: the target gene program for oncogenic Ras, Bcr-Abl and E2A-HLF chimeras in leukemogenesis., Blood 90 Suppl., 1, 47A, 19970401
  89. Novel approaches using video techniques for dynamic analysis, 299-314, 19990301
  90. Role of calcium, protein kinase C and MAP kinase in the activation of mast cells., Allergology International, 73-84, 19960901
  91. Different changes of disuse atrophy with normally temperature and low-temperature environment on hindlimb unloadong syrian hamster., Cryoletters, 215-222, 20021201
  92. Analysis of pharmacological and molecural mechanisms underlying histamine-secretion with video-micorscopes in RBL-2H3 cells., Histamine Research in the New Millennium, 103, 20011001
  93. Caspase 3-activating Factor and Early Apoptosis Signaling in Hindlimb Unloading-induced Muscle Atrophy, European Journal of Applied Physiology, 38(3), 115-122, 20030801
  94. Active involvement of pharmacists in initial treatments for acute poisoning and overdosed patients., The Japanese Journal of Toxicology, 16(4), 105-124, 20030901
  95. Disuse atrophy alterations in normal and low temperature environments during hindlimb unloading in Syrian hamsters., Cryoletters, 24(4), 245-252, 20031101
  96. Active involvement of pharmacists in initial treatments for acute poisoning and overdosed patients in the intensive care unit., Chudoku Kenkyu, 16(3), 433-440, 20031201
  97. Energy metabolism and nutritional support in the early phase of severely burned patients., Jap. J. Burn Injur., 23(7), 223-230, 20040701
  98. Augmentation of serotonin-induced inhibition of neuronal activity in the hippocampus following repeated treatment with methamphetamine., Annals of New York Academy of Sciences, 1025, 242-247, 20041001
  99. Early apoptosis signals in hindlimb unloading-induced muscle atrophy., Journal of Pharmacological Sciences, 94, 142, 20040301
  100. Model core curriculum for pharmaceutical education in Japan., FIP Abstracts 2004, 22, 20040901
  101. Environmental factors and lifestyles as risk facters for Japanese ceder pollinosis in recent urban areas
  102. Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Res., 17(2), 184-186, 20070201
  103. Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17(2), 184-186, 20070201
  104. Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070604
  105. Geladanamycin induces CHOP expression through a 4-(2-aminoethyl)- benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17(2), 184-186, 20070201
  106. Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070324
  107. Nanokinetics of drug molecule transport into a single cell., Nanomedicine, 1(3), 345-350, 20061001
  108. Determination of insulin content in pancreatic beta cell line MIN6 cells by matrix-assisted laser desorption ionization time-of-flight mass spectrometry., Biol. Pharm. Bull., 21(11), 1240-1241, 19981101
  109. Trapping of secreted molecules at single-cell level using an HPLC resin particle under a videomicroscope., Biol. Pharm. Bull., 21(8), 886-888, 19980801
  110. ★, Endoplasmic Reticulum Stress Induces Leptin Resistanc, Molecular Pharmacology, 74(6), 1610-1619, 20080828
  111. The activation of apoptosis factor in hindlimb unloading-induced mescle atrophy under normal and low^temperature environmental conditions., acta histochemica, 110, 505-518, 20080101
  112. TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress., Journal of Pharmacological Sciences, 114, 230-233, 20100201
  113. Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice., PLoS ONE, 5, e12537, 20100901
  114. Potential down-regulation of salivary gland AQP5 by LPS via Cross-Coupling of NF-kB and p-c-Jun/c-Fos., The American Journal of Pathology, 177, 724-734, 20101101
  115. A unique modulator of endoplasmic reticulum stress-signaling pathways: the novel pharmacological properties of amiloride., British Journal of Pharmacology, 159(2), 428-437, 20100501
  116. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance (Mini-Review)., The Journal of Medical Investigation, 56, 296-298, 20091001
  117. Vanadate inhibits endoprasmic reticulum stress responses., European Journal of Pharmacology, 594, 44-48, 20080101
  118. Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression., European Journal of Pharmacology, 554, 8*11, 20071001
  119. Geladanamycin induces CHOP expression through a 4-(2-aminoethyl)- benzenesulfonyl fluoride-responsive serine protease., Cell Research, 17, 184-186, 20071101
  120. Akt up- and down-regulation in response to endoplasmic reticulum stress., Brain Research, 1152, 27-31, 20070901
  121. Development of clinical application for a nutritional prescription support system for total parenteral/enteral nutrition., YAKUGAKU ZASSHI, 129(9), 1077-1086, 20090901
  122. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells., Neurochemistry International, 54, 1-6, 20090101
  123. Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition., Experimental Dermatology, 17, 688-692, 20080901
  124. Development of advanced pharmacy practoce experience in national unibersities., Yakugaku Zassi, 3, 345-350, 20120301
  125. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Frontiers in Endocrinology, 12, 20120401
  126. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells., Biochemical and Biophysical Research Communications, 1, 286-90, 20060201
  127. 2-Aminopurine inhibits leptin receptor signal transduction., European Journal of Pharmacology, 1-3, 61-66, 20061201
  128. LPS induces stefin A3 expression in mouse primary cultured glial cells., Molecular Brain Research, 1-2, 138-41, 20051001
  129. Improvement of the Teaching Method for Active Learning-Introduction of Problem-based Learning to the first-year seminar ―, in press, 20131201
  130. Augmentation of serotonin-induced inhibition of neuronal activity in the hippocampus following repeated treatment with methamphetamine, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 242-247, 2004
  131. LPS induces stefin A3 expression in mouse primary cultured glial cells, MOLECULAR BRAIN RESEARCH, 140(1-2), 138-141, 20051031
  132. A low temperature environment delays the changes in muscle fiber type composition induced by unloading, ACTA HISTOCHEMICA ET CYTOCHEMICA, 38(5), 305-312, 2005
  133. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340(1), 286-290, 20060203
  134. Akt up- and down-regulation in response to endoplasmic reticulum stress, BRAIN RESEARCH, 1152, 27-31, 20070604
  135. 2-aminopurine inhibits leptin receptor signal transduction, EUROPEAN JOURNAL OF PHARMACOLOGY, 553(1-3), 61-66, 20061228
  136. Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression, EUROPEAN JOURNAL OF PHARMACOLOGY, 554(1), 8-11, 20070105
  137. Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition, EXPERIMENTAL DERMATOLOGY, 17(8), 688-692, 200808
  138. Comparative study of drug efficacy and drug additives between generic drugs and original drugs, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127(12), 2035-2044, 200712
  139. Vanadate inhibits endoplasmic reticulum stress responses, EUROPEAN JOURNAL OF PHARMACOLOGY, 594(1-3), 44-48, 20081010
  140. Endoplasmic Reticulum Stress Induces Leptin Resistance, MOLECULAR PHARMACOLOGY, 74(6), 1610-1619, 200812
  141. The activation of apoptosis factor in hindlimb unloading-induced muscle atrophy under normal and low-temperature environmental conditions, ACTA HISTOCHEMICA, 110(6), 505-518, 2008
  142. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells, NEUROCHEMISTRY INTERNATIONAL, 54(1), 1-6, 200901
  143. Development of Clinical Application for a Nutritional Prescription Support System for Total Parenteral/Enteral Nutrition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 129(9), 1077-1086, 200909
  144. Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos, AMERICAN JOURNAL OF PATHOLOGY, 177(2), 724-734, 201008
  145. A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells, BRITISH JOURNAL OF PHARMACOLOGY, 159(2), 428-437, 201001
  146. Homocysteine induces X-box-binding protein 1 splicing in the mice brain, NEUROCHEMISTRY INTERNATIONAL, 56(2), 216-220, 201001
  147. Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice, PLOS ONE, 5(9), 20100902
  148. TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114(2), 230-233, 201010
  149. Development of Advanced Pharmacy Practice Experience in National Universities, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 132(3), 345-350, 201203
  150. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress, EMBO MOLECULAR MEDICINE, 6(3), 335-346, 201403
  151. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447(2), 378-382, 20140502
  152. Inhibition of inducible nitric oxide synthase and interleukin-1 beta expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide, BRAIN RESEARCH, 1558, 11-17, 20140416
  153. Caffeine attenuated ER stress-induced leptin resistance in neurons, NEUROSCIENCE LETTERS, 569, 23-26, 20140521
  154. Therapeutic potential of flurbiprofen against obesity in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 449(1), 132-134, 20140620
  155. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells, SCIENTIFIC REPORTS, 4, 20141118
  156. Possible involvement of 15-deoxy-Delta(12,14)-prostaglandin J(2) in the development of leptin resistance, JOURNAL OF NEUROCHEMISTRY, 133(3), 343-351, 201505
  157. Synthesis of a peptide that can translocate to the endoplasmic reticulum, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 460(3), 628-632, 20150508
  158. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(2), 337-350, 201602
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  160. Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells., PLoS ONE, 7, e40144, 2012
  161. Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance., Frontiers in Endocrinology, 3, 1-5, 2012
  162. Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice., PLoS ONE, 5, e12537
  163. Endoplasmic reticulum stress induces leptin resistance., Molecular Pharmacology, 74, 1610-1619, 2008
  164. Potential down-regulation of salivary gland AQP5 by LPS via Cross-Coupling of NF-kB and p-c-Jun/c-Fos., The American Journal of Pathology, 177, 230-233, 2010
  165. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice. S. Yokoyama, T. Hosoi, and K. Ozawa., GENE, 497, 340-343, 2012
  166. ER stress upregulated PGE2/IFNg-induced IL-6 expression and down-regulated iNOS expression in glial cells., Scientific Reports, 3, DOI 10.1038/srep03388, 2013
  167. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells., Scientific Reports, Nov 18;4, 7096
  168. Possible involvement of 15-deoxy-delta 12,14 -prostaglandin J 2 in the development of leptin resistance., Journal of Neurochemistry, 133, 343-351, 2015
  169. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
  170. Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance, The Journal of Medical Investigation, 56, 19-29, 2009
  171. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
  172. Therapeutic potential of flurbiprofen against obesity in mice., Biochemical and Biophysical Research Communications, 449, 132-134, 2014
  173. Inhibition of inducible nitric oxide synthase and interleukin-1b expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide., Brain Research, 1558, 11-17, 2014
  174. TNF-alpha -857C>T Genotype is Predictive of Clinical Response after Treatment with Definitive 5-Fluorouracil/cisplatin-based Chemoradiotherapy in Japanese Patients with Esophageal Squamous Cell Carcinoma., International Journal of Medical Sciences, 10(12), 1755-1760, 2013
  175. Serotonergic modulation of neuronal activity in the nucleus accumbens following repeated methamphetamine administration in rats., Journal of Pharmacological Sciences, 123, 140-146, 2013
  176. Improvement of the Teaching Method for Active Learning-Introduction of Problem-based Learning to the first-year seminar-, 19, 25-36
  177. Differential activation of the ER stress factor XBP1 by oligomeric assemblies., Neurochemical Research, 37, 1834-1837, 2012
  178. The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(6), 827-830, 201606
  179. Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity, FRONTIERS IN ENDOCRINOLOGY, 7, 20160608
  180. Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation, BRITISH JOURNAL OF PHARMACOLOGY, 173(15), 2434-2445, 201608
  181. Immobilization stress-induced anorexia is mediated independent of MyD88, NEUROREPORT, 27(13), 974-977, 20160907
  182. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629, 241-244, 20160826
  183. Unique pharmacological property of ISRIB in inhibition of A beta-induced neuronal cell death, JOURNAL OF PHARMACOLOGICAL SCIENCES, 131(4), 292-295, 201608
  184. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(2), 716-720, 20160916
  185. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78, SCIENTIFIC REPORTS, 6, 20160928
  186. Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance, FRONTIERS IN PHARMACOLOGY, 7, 20160930
  187. Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis., Frontiers in Endocrinology, 10.3389/fendo.2016.00138, 2016
  188. Flurbiprofen ameliorates glucose deprivation-induced leptin resistance., Frontiers in Pharmacology, doi: 10.3389/fphar.2016.00354, 2016
  189. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78. (Mini Review), Scientific Reports, 6, 34312, 2016
  190. Mechanisms and pharmacological strategy targeting dysfunction of endoplasmic reticulum., YAKUGAKU ZASSHI, 136(6), 827-830, 2016
  191. The mechanisms and pharmacological strategy for treatment on ER stress-iduced metabolic syndrome., YAKUGAKU ZASSHI, 136(6), 799-800, 2016
  192. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death., Neuroscience Letters, 629, 241-244, 2016
  193. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells., Biochemical and Biophysical Research Communications, 478, 716-720, 2016
  194. Unique pharmacological property of ISRIB in inhibition of Ab-induced neuronal cell death., Journal of Pharmacological Sciences, 131(4), 292-295, 2016
  195. Possible pharmacological approach targeting endoplasmic reticulum stress to ameliorate leptin resistance in obesity., Frontiers in Endocrinology, 10.3389/fendo.2016.00059, 2016
  196. Key role of HSP90 in leptin-induced STAT3 activation and feeding regulation., British Journal of Pharmacology, 173, 2434-2445, 2016
  197. Implementation and evaluation of genetic testing seminars on lifestyle-related disease prevention for pharmacy students., YAKUGAKU ZASSHI, 136(2), 337-350, 2016
  198. Possible involvement of 15-deoxy-delta 12,14 -prostaglandin J 2 in the development of leptin resistance., Journal of Neurochemistry, 133, 345-351, 2015
  199. Synthesis of a peptide that can translocate to the endoplasmic reticulum., Biochemical and Biophysical Research Communications, 460, 628-632, 2015
  200. Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells., Scientific Reports, doi: 10.1038/srep07096, 2014
  201. Therapeutic potential of flurbiprofen against obesity in mice., Biochemical and Biophysical Research Communications, 449, 132-134, 2014
  202. Inhibition of inducible nitric oxide synthase and interleukin-1b expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide., Brain Research, 1558, 11-17, 2014
  203. TERT attenuated ER stress-induced cell death., Biochemical and Biophysical Research Communications, 447, 378-382, 2014
  204. Caffeine attenuated ER stress-induced leptin resistance in neurons., Neuroscience Letters, 569, 23-26, 2014
  205. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress., EMBO Molecular Medicine, 6(3), 335-346, 2014
  206. Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling, MOLECULAR METABOLISM, 6(1), 159-172, 201701
  207. Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(8), 1161-1164, 201708
  208. Implementation and Evaluation of Genetic Testing Seminars about Lifestyle-related Disease Prevention in Pharmacy Insurance -The Need for Cooperation between the Pharmacy and the University in Genetic Testing-, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137(12), 1517-1531, 201712
  209. Mechanisms of the action of adenine on anti-allergic effects in mast cells, IMMUNITY INFLAMMATION AND DISEASE, 6(1), 97-105, 201803
  210. TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses, BIOTECHNOLOGY LETTERS, 40(6), 915-922, 201806
  211. Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases. (Review), Journal of Health Science, 5, 9-17, 2017
  212. Link between endoplasmic reticulum stress and autophagy in neurodegenerative disesases. (Review), Endoplasimic Reticulum Stress in Diseases, 4, 37-45, 2017
  213. Alteration of the composition of memberane lipid on endplasmic reticulum stress and phathophysiology of obesity., 50(3), 154-156, 2018
  214. Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells., Biochemical and Biophysical Research Communications, 478, 292-295, 2016
  215. Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes, FRONTIERS IN PHYSIOLOGY, 9, 20180926
  216. Immobilization stress induces XBP1 splicing in the mouse brain, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 508(2), 516-520, 20190108
  217. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kappa B, and STAT3, PHARMACOLOGICAL REPORTS, 71(2), 289-298, 201904
  218. Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 316(5), C641-C648, 201905
  219. Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer's disease, ENDOPLASMIC RETICULUM STRESS IN DISEASES, 2(1), 107-118, 201501
  220. Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases, ENDOPLASMIC RETICULUM STRESS IN DISEASES, 4(1), 37-45, 201704
  221. Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis, CYTOTECHNOLOGY, 71(4), 769-783, 201908
  222. Progress of Pharmacy Education in Japan —MODEL CORE CURRICULUM FOR PHARMACY EDUCATION and THE EVALUATION STANDARDS— (Review), Journal of Asian Association of Schools of Pharmacy, 7, 8-14, 2018
  223. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kB, and STAT3., Pharmacological Reports, 71(2), 289-298, 2019
  224. Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity., American Journal of Physiology, 316, C641-C648, 2019
  225. Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis., Cytotechnology, 71, 769-783, 201908
  226. Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1 beta, JOURNAL OF DERMATOLOGY, 47(11), 1293-1300, 202011
  227. Possible Involvement of MyD88 in Regulating Stress Response in Mice, FRONTIERS IN NEUROSCIENCE, 15, 20210312
  228. Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus, ANTIOXIDANTS, 10(5), 202105
  229. The possible role of biochanin A in ameliorating endoplasmic reticulum stress-induced leptin resistance, NEUROREPORT, 32(12), 983-987, 20210811
  230. The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria, CELLS, 10(7), 202107
  231. Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline, MOLECULAR PHARMACOLOGY, 100(3), 181-192, 20210901

Publications such as books

  1. 2000, Analysis of pharmacological and molecular mechanisms underlying histamine-secretion with video-microscopes in RBL-2H3 cells. , Histamine Research in the New Millenium, 2000
  2. 1988/10, Neuroreceptors and Signal Transduction , Plenum Press, 1988, 10, Joint work
  3. 1989/07, Biosignalling in Cardiac and Vascular Systems , Pergamon press, 1989, 07, Joint work
  4. 1990/02, The Biology and Medicine of Signal Transduction , Raven Press, 1990, 02, Joint work
  5. 2001/03, Histamine Research in the New Millennium , Pergamon press, 2001, 03, Scholarly Book, Cocompilation, 521
  6. 2004/10, Current status of drug dependence/abuse studies , Annals New York Academy of Sciences, 2004, 10, Scholarly Book, Cocompilation, 642

Invited Lecture, Oral Presentation, Poster Presentation

  1. Accreditation for pharmaceutical education in Japan., Koichiro Ozawa, 3rd AASP Pharmacy Deans Forum, With Invitation, English, TOKYO
  2. Accreditation of Pharmacy School in Japan., Koichiro Ozawa, 7TH Asian Association of Schools of Pharmacy (AASP), 2015/10/30, With Invitation, English
  3. Accreditation for pharmaceutical education in Japan., Koichiro Ozawa, 7rd Asian Association of Schools of Pharmacy, 2015/10/30, With Invitation, English, Taipei
  4. Accreditation for Pharmaceutical Education in Japan, Koichiro Ozawa, Symposium of Accreditation for Pharmaceutical Education in Korea, 2015/05/21, With Invitation, English, Seoul, Korea
  5. Possible involvement of 4-hydroxy-2-nonenal on development of leptin resistance., Toru Hosoi, Ayaka Kuwamura, and Koichiro Ozawa, The 90th Annual Meeting of the Japanese Pharmacological Society, 2017/03/15, Without Invitation, Japanese, the Japanese Pharmacological Society, Nagasaki
  6. Comparing the pharmacy education between Japan and the foreign countries., Koichiro Ozawa, 137th Annual Meeting of the Pharmaceutical Society of Japan, 2017/03/26, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Sendai
  7. Harmonization of pharmaceutical education in the world - A PROJECT COMMISSIONED TO PSJ FROM THE MEXT, Koichiro Ozawa, 138th Annual Meeting of the Pharmaceutical Society of Japan, 2018/03/27, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Kanazawa