KYOTA YASUDA

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
kyotay12hiroshima-u.ac.jp
Self-introduction
My research interest is in the mechanisms of cell-polarization, and how it contributes the bilological events, including human disease.

Basic Information

Major Professional Backgrounds

  • 2017/10/01, 2018/05/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2011, 2012, Japan Society for the Promotion of Science, Special Postdoctoral Researcher
  • 2013/04, 2017/09, National Center Institute, Visiting fellow
  • 2018/06/01, 2019/03/31, Hiroshima University, Graduate School of Science, Assistant Professor
  • 2018/12/01, RIKEN Center for Biosystems Dynamics Research Comprehensive Bioimaging Team, Visiting researcher

Educational Backgrounds

  • HOKKAIDO UNIVERSITY, Graduate School of Life Science, Japan, 2010/04, 2013/03
  • HOKKAIDO UNIVERSITY, Graduate School of Life Science, Japan, 2008/04, 2010/03
  • HOKKAIDO UNIVERSITY, Japan, 2004/04, 2008/03

Academic Degrees

  • M.Sc. (Life Science), HOKKAIDO UNIVERSITY
  • Ph.D. (Life Science), HOKKAIDO UNIVERSITY

Research Keywords

  • RNA localization, Cancer, Tubulin modification, Neurodegeneration, Stress granule, TDP-43, FUS, Cell polarity, Interactome, Live imaging, protein-RNA aggregation, Liquid-Liquid Phase separation, Local translation

Affiliated Academic Societies

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, English Seminar on Chemistry
  2. 2024, Undergraduate Education, Second Semester, English Seminar on Chemistry
  3. 2024, Undergraduate Education, 4Term, Biopolymer Chemistry
  4. 2024, Graduate Education (Master's Program) , 1Term, English Presentation Methods in Science and Technology
  5. 2024, Graduate Education (Master's Program) , 1Term, Introduction to Life Science
  6. 2024, Graduate Education (Master's Program) , 1Term, Molecular Biophysics
  7. 2024, Graduate Education (Master's Program) , 2Term, Topical Seminar in Life Science A
  8. 2024, Graduate Education (Master's Program) , 4Term, Topical Seminar in Life Science B
  9. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  10. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  11. 2024, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  12. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  13. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  14. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Function and regulatory mechanism of intracellular FUS-LLPS, The Cell, 54(8), 26-29, 20220720
  2. Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties, ISCIENCE, 25(6), 20220617
  3. Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations, FEBS LETTERS, 596(11), 1412-1423, 202206
  4. ★, FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination., The Journal of cell biology, 216(4), 1015-1034, 201704
  5. Dysregulated axonal RNA translation in amyotrophic lateral sclerosis., Wiley interdisciplinary reviews. RNA, 7(5), 589-603, 201609
  6. ★, The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules., The Journal of cell biology, 203(5), 737-746, 20131209
  7. A cis-acting element in the coding region of cyclin B1 mRNA couples subcellular localization to translational timing., Developmental biology, 382(2), 517-529, 20131015
  8. Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules., The Journal of cell biology, 202(7), 1041-1055, 20130930
  9. Transgenic zebrafish reveals novel mechanisms of translational control of cyclin B1 mRNA in oocytes., Developmental biology, 348(1), 76-86, 20101201
  10. Visualization of spatially and temporally controlled translation by transgenesis, GENES & GENETIC SYSTEMS, 85(6), 416, 201012
  11. Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport, eLife, 20190710
  12. Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells, Stem Cell Research, 41, 20191024

Invited Lecture, Oral Presentation, Poster Presentation

  1. VPC modualtes the dynaic assembly/disassembly of ALS-related FUS inclusions through ATP consumption in murine fibroblast., Kyota Yasuda, The 142nd Annual Meeting of the Pharmaceutical Society of Japan, 2022/03/28, Without Invitation, Japanese, Pharmaceutical society of Japan, Nagoya
  2. Local translational regulation and human disease, Kyota Yasuda, 5th HiHA Young Researchers Workshop, 2021/06/03, With Invitation, English, HiHA, Higashi Hiroshima
  3. Possible molecular entity for misdirected local translation caused by ALS-related inclusion formation identified with novel photo-activatable ligand., Kyota Yasuda, Hyun-woo Rhee , Tomonobu Watanabe , Stavroula Mili , Shin-ichi Tate, The Molecular Biology Society of Japan, 2019/12/03, With Invitation, English, MBSJ, Fukuoka/Japan
  4. Possible mechanisms to regulate cell morphology by RNA localization and local "silencing", Kyota Yasuda, 2019/06/18, With Invitation, Japanese, Hokkaido University, Sapporo
  5. Local RNA behavior and liquid-liquid Phase separation, Kyota Yasuda, India-Japan Join Seminar on Boundaries and FLows in Biological Systems, 2019/03/06, With Invitation, English
  6. Local protein synthesis is physiologically and pathologically regulated by liquid-liquid phase separation., Kyota Yasuda, The 1st Seoul National University ? Hiroshima University collaborative symposium, 2019/01/14, With Invitation, English, Seoul, Korea
  7. Dysregulation of local translation by ALS-associated protein aggregation., Kyota Yasuda, 2019/01/07, With Invitation, Japanese, Suita City, Osaka
  8. Pathologic inclusions of the FUS RNA-binding protein disrupt peripheral RNA localization and its local translation, 2017/12/09, Without Invitation, Japanese
  9. Pathologic inclusions of the FUS RNA-binding protein disrupt peripheral RNA localization and its local translation, 2017/12/08, Without Invitation, Japanese
  10. Fus inclusions disrupt RNA localization by sequestering Kinesin-1 and inhibiting microtubule detyrosination, Kyota Yasuda, Stavroula Mili, RNA biology symposium, 2017/04/24, Without Invitation, English, National Institutes of Health, MD, USA
  11. ALS-related protein aggregation affects RNA behavior through the disruption of tubulin post-translational modification, Kyota Yasuda, Stavroula Mili, 2017/04/20, With Invitation, Japanese, 浜松医科大学, Hamamatsu City, Shizuoka
  12. FUS INCLUSIONS DISRUPT RNA LOCALIZATION BY SEQUESTERING KINESIN-1 AND INHIBITING MICROTUBULE DETYROSINATION, Kyota Yasuda, Clatterbuck-Soper S., Jackrel M.E., Shorter J., Mili S., RNA biology symposium, 2016/11/01, Without Invitation, English, MD, USA
  13. Cytoplasmic inclusions of FUS and TDP-43 initiate distinct mechanisms to disrupt microtubule modification and RNA localization., Kyota Yasuda, Clatterbuck-Soper F.S, Jackrel M, Shorter J and Mili S, Gordon Research Conference (Post-Transcriptional Gene Regulation), 2016/07/16, Without Invitation, English, Gordon Research Conference, VT, USA
  14. Common effects of ALS-associated mutations on RNA localization: A role for cytoplasmic RNA inclusions., Kyota Yasuda, Stavroula Mili, EMBO Conference on RNA localization and local translation, 2015/07/28, Without Invitation, English, EMBO, Hersonissos, Greece
  15. RNA localization and neurodegenerative disease, Kyota Yasuda, Special lecture at Maryland University, 2015/04/15, With Invitation, English, Maryland university, MD, USA
  16. Common effects of ALS-associated mutations on RNA localization: a role for cytoplasmic RNA inclusions, Kyota Yasuda, Stavroula Mili, RNA biology Symposium, 2015/03/11, Without Invitation, English, NIH, MD, USA
  17. ALS-mutants converge on loss of Detyrosinated microtubules and RNA mislocalization., Kyota Yasuda, Sarah Clatterbuck-Soper, Meredith E. Jackrel, James Shorter, Stavroula Mili, NCI-UMD partnership symposium, 2015/01/22, Without Invitation, English, NIH, University of Maryland, MD, USA
  18. Spatial and translational regulation of APC-RNPs by ALS-associated mutants of the Fus RNA-binding protein., Kyota Yasuda, STavroula Mili, NIH-Japan-JSPS Symposium, 2014/10/24, Without Invitation, English, NIH, JSPS, MD, USA
  19. Spatial and translational regulation of APC-RNPs by ALS-associated mutants of the Fus RNA-binding protein., Kyota Yasuda, Stavroula Mili, Gordon Research Conference (Cell biology of the Neuron), 2014/06/22, Without Invitation, English, Gordon Research Conference, NH, USA
  20. Regulation of localized APC-RNP by ALS-associated mutants of Fus RNA-binding protein, Kyota Yasuda, Stavroula Mili, Cancer Technology & Epidemiology Symposium, 2014/01/23, Without Invitation, English, NIH, Univeristy of Maryland, MD, USA
  21. Identification of a novel cis-acting element responsible for the translational regulation of zebrafish cyclin B1 mRNA during oocyte maturation., Kyota Yasuda, Tomoya Kotani, Masakane Yamashita, 83th Meeting of the Zoological Society of Japan, 2012/09/13, Without Invitation, Japanese, the Zoological Society of Japan, Osaka
  22. Transgenic zebrafish reveals a novel cis-acting element responsible for spatio-temporally regulated translational activation of cyclin B1 mRNA in oocytes., Kyota Yasuda, Tomoya Kotani, Masakane Yamashita, Joint Meeting of 45th Annual Meeting of Japanese Society of Developmental Biology and 64th Annual Meeting of Japan Society for Cell Biology, 2012/05/28, Without Invitation, Japanese, Japanese Society of Developmental Biology, Japan Society for Cell Biology, Hyogo
  23. Mechanisms regulating the localization and translational timing of cyclin B1 mRNA during oocyte maturation, as revealed by transgenic zebrafish., Kyota Yasuda, Tomyoa Kotani, Ryoma Ota, Masakane Yamashita, 43th Annual Meeting of Japanese Society of Developmental Biology, 2010/06/22, Without Invitation, Japanese, Japanese Society of Developmental Biology, Kyoto
  24. Translational control of cyclin B1 mRNA during oocyte maturation: Analysis using a transgenic zebrafishTranslational control of cyclin B1 mRNA during oocyte maturation: Analysis using a transgenic zebrafish, Kyota Yasuda, Tomoya Kotani, Masakane Yamashita, 32th Annual Meeting of Molecular Biology Society of Japan, 2009/12/09, Without Invitation, Japanese, Molecular Biology Society, Kanagawa

Awards

  1. 2014, Poster Award, NIH-Japan-JSPS Symposium

External Funds

Acceptance Results of Competitive Funds

  1. Grant-in-Aid for Scientific Research (C), 2023, 2026
  2. 2020, 2021
  3. Grant-in-Aid for Early-Career Scientists, Analysis for the changing in RNA bahavior upon cytoplasmic RNA-protein aggregation observed in neurodegeneration., 2019, 2021
  4. 2019/04, 2021/03
  5. The Uehara Memorial Foundation, Research incentives, 2019/03, 2020/04
  6. Satake fundation, Neurodegeneration-related protein aggregation affects localized RNA behavior, 2018/10, 2019/03
  7. Grant aid for start up of your researcher, 2017/10, 2018/03
  8. KAITOKU-NIH fellowship, Regulation of localized APC-RNP by ALS-associated mutants of the FUS RNA-binding protein, 2014/04, 2016/03
  9. Research fellowship (DC2), 2011/04, 2013/03
  10. Support for reserch training, Faculty of advanced life science, Hokkaido University, 2010/04, 2013/03
  11. Grant-in-Aid for Scientific Research (B), 2019, 2023