KYOTA YASUDA

Last Updated :2025/03/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
kyotay12hiroshima-u.ac.jp
Self-introduction
My research interest is in the mechanisms of cell-polarization, and how it contributes the bilological events, including human disease.

Basic Information

Major Professional Backgrounds

  • 2023/04/01, WPI-SKCM2, co-PI
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2018/12/01, RIKEN Center for Biosystems Dynamics Research Comprehensive Bioimaging Team, Visiting researcher
  • 2018/06/01, 2019/03/31, Hiroshima University, Graduate School of Science, Assistant Professor
  • 2017/10/01, 2018/05/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2013/04, 2017/09, National Center Institute, Visiting fellow
  • 2011, 2012, Japan Society for the Promotion of Science, Special Postdoctoral Researcher

Educational Backgrounds

  • HOKKAIDO UNIVERSITY, Graduate School of Life Science, Japan, 2010/04, 2013/03
  • HOKKAIDO UNIVERSITY, Graduate School of Life Science, Japan, 2008/04, 2010/03
  • HOKKAIDO UNIVERSITY, Japan, 2004/04, 2008/03

Academic Degrees

  • M.Sc. (Life Science), HOKKAIDO UNIVERSITY
  • Ph.D. (Life Science), HOKKAIDO UNIVERSITY

Educational Activity

  • [Bachelor Degree Program] School of Science : Chemistry : Chemistry
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Mathematical and Life Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Mathematical and Life Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biology;Basic biology;Morphology / Structure
  • Biology;Biological Science;Molecular biology
  • Biology;Biological Science;Cell biology

Research Keywords

  • RNA localization, Cancer, Tubulin modification, Neurodegeneration, Stress granule, TDP-43, FUS, Cell polarity, Interactome, Live imaging, protein-RNA aggregation, Liquid-Liquid Phase separation, Local translation

Affiliated Academic Societies

  • The Pharmaceutical Society of Japan
  • The Biophysics Society of Japan
  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, English Seminar on Chemistry
  2. 2024, Undergraduate Education, Second Semester, English Seminar on Chemistry
  3. 2024, Undergraduate Education, First Semester, Chemical Experiments I
  4. 2024, Undergraduate Education, Second Semester, Chemical Experiments II
  5. 2024, Undergraduate Education, 4Term, Biopolymer Chemistry
  6. 2024, Graduate Education (Master's Program) , 1Term, English Presentation Methods in Science and Technology
  7. 2024, Graduate Education (Master's Program) , 1Term, Introduction to Life Science
  8. 2024, Graduate Education (Master's Program) , 1Term, Molecular Biophysics
  9. 2024, Graduate Education (Master's Program) , 2Term, Topical Seminar in Life Science C
  10. 2024, Graduate Education (Master's Program) , 4Term, Topical Seminar in Life Science D
  11. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  12. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  13. 2024, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  14. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  15. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  16. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties, ISCIENCE, 25(6), 20220617
    Link to Paper Search Results by DOI
  2. Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations, FEBS LETTERS, 596(11), 1412-1423, 202206
    Link to Paper Search Results by DOI
  3. ★, FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination., The Journal of cell biology, 216(4), 1015-1034, 201704
  4. Dysregulated axonal RNA translation in amyotrophic lateral sclerosis., Wiley interdisciplinary reviews. RNA, 7(5), 589-603, 201609
  5. ★, The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules., The Journal of cell biology, 203(5), 737-746, 20131209
  6. A cis-acting element in the coding region of cyclin B1 mRNA couples subcellular localization to translational timing., Developmental biology, 382(2), 517-529, 20131015
  7. Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules., The Journal of cell biology, 202(7), 1041-1055, 20130930
  8. Transgenic zebrafish reveals novel mechanisms of translational control of cyclin B1 mRNA in oocytes., Developmental biology, 348(1), 76-86, 20101201
  9. Visualization of spatially and temporally controlled translation by transgenesis, GENES & GENETIC SYSTEMS, 85(6), 416, 201012
  10. Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport, eLife, 20190710
  11. Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells, Stem Cell Research, 41, 20191024
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. hnRNPs bi-directionally regulate stress granule growth and disassembly., Kyota Yasuda, Miyu Murata, Rina Mihara, Hyun-woo Rhee, Shin-ichi Tate, 2024/11/28, Without Invitation, English
  2. Spatio-temporal control of biomolecular condensation and the involvement of amino acid chirality in it, Kyota Yasuda, WPI-SKCM² Spring Symposium: Nara, 2024/03/09, Without Invitation, English
  3. Time-resolved proteomics of stress granules to identify key regulatory proteins to be explored by NMR, Miyu Murata, Kyota Yasuda, Rina Mihara, Hyun-woo Rhee, Shin-ichi Tate, TJNMR, 2023/12/14, Without Invitation, English
  4. Spatio-Temperal Control of Biomolecular Condensation and the Role of Amino Acid Chirality, Kyota Yasuda, WPI-SKCM² 2023 Winter School, 2023/12/14, Without Invitation, English
  5. Proximity labaleling identified a protein essential for the proper formation and function of stress granule., 2023/11/15, Without Invitation, English
  6. VPC modualtes the dynaic assembly/disassembly of ALS-related FUS inclusions through ATP consumption in murine fibroblast., Kyota Yasuda, The 142nd Annual Meeting of the Pharmaceutical Society of Japan, 2022/03/28, Without Invitation, Japanese, Pharmaceutical society of Japan, Nagoya
  7. Local translational regulation and human disease, Kyota Yasuda, 5th HiHA Young Researchers Workshop, 2021/06/03, With Invitation, English, HiHA, Higashi Hiroshima
  8. Possible molecular entity for misdirected local translation caused by ALS-related inclusion formation identified with novel photo-activatable ligand., Kyota Yasuda, Hyun-woo Rhee , Tomonobu Watanabe , Stavroula Mili , Shin-ichi Tate, The Molecular Biology Society of Japan, 2019/12/03, With Invitation, English, MBSJ, Fukuoka/Japan
  9. Possible mechanisms to regulate cell morphology by RNA localization and local "silencing", Kyota Yasuda, 2019/06/18, With Invitation, Japanese, Hokkaido University, Sapporo
  10. Local RNA behavior and liquid-liquid Phase separation, Kyota Yasuda, India-Japan Join Seminar on Boundaries and FLows in Biological Systems, 2019/03/06, With Invitation, English
  11. Local protein synthesis is physiologically and pathologically regulated by liquid-liquid phase separation., Kyota Yasuda, The 1st Seoul National University ? Hiroshima University collaborative symposium, 2019/01/14, With Invitation, English, Seoul, Korea
  12. Dysregulation of local translation by ALS-associated protein aggregation., Kyota Yasuda, 2019/01/07, With Invitation, Japanese, Suita City, Osaka
  13. Pathologic inclusions of the FUS RNA-binding protein disrupt peripheral RNA localization and its local translation, 2017/12/09, Without Invitation, Japanese
  14. Pathologic inclusions of the FUS RNA-binding protein disrupt peripheral RNA localization and its local translation, 2017/12/08, Without Invitation, Japanese
  15. Fus inclusions disrupt RNA localization by sequestering Kinesin-1 and inhibiting microtubule detyrosination, Kyota Yasuda, Stavroula Mili, RNA biology symposium, 2017/04/24, Without Invitation, English, National Institutes of Health, MD, USA
  16. ALS-related protein aggregation affects RNA behavior through the disruption of tubulin post-translational modification, Kyota Yasuda, Stavroula Mili, 2017/04/20, With Invitation, Japanese, 浜松医科大学, Hamamatsu City, Shizuoka
  17. FUS INCLUSIONS DISRUPT RNA LOCALIZATION BY SEQUESTERING KINESIN-1 AND INHIBITING MICROTUBULE DETYROSINATION, Kyota Yasuda, Clatterbuck-Soper S., Jackrel M.E., Shorter J., Mili S., RNA biology symposium, 2016/11/01, Without Invitation, English, MD, USA
  18. CYTOPLASMIC FUS INCLUSIONS DISRUPT KINESIN-1 LEADING TO LOSS OF DETYROSINATED MICROTUBULES AND RNA MISLOCALIZATION, Kyota Yasuda, CLATTERBUCK-SOPER S.F., JACKREL M.E., SHORTER J., MILI S., CCR RNA biology workshop, 2016/11/01, Without Invitation, English, NIH, MD, USA
  19. Cytoplasmic inclusions of FUS and TDP-43 initiate distinct mechanisms to disrupt microtubule modification and RNA localization., Kyota Yasuda, Clatterbuck-Soper F.S, Jackrel M, Shorter J and Mili S, Gordon Research Conference (Post-Transcriptional Gene Regulation), 2016/07/16, Without Invitation, English, Gordon Research Conference, VT, USA
  20. Common effects of ALS-associated mutations on RNA localization: A role for cytoplasmic RNA inclusions., Kyota Yasuda, Stavroula Mili, EMBO Conference on RNA localization and local translation, 2015/07/28, Without Invitation, English, EMBO, Hersonissos, Greece
  21. RNA localization and neurodegenerative disease, Kyota Yasuda, Special lecture at Maryland University, 2015/04/15, With Invitation, English, Maryland university, MD, USA
  22. Common effects of ALS-associated mutations on RNA localization: a role for cytoplasmic RNA inclusions, Kyota Yasuda, Stavroula Mili, RNA biology Symposium, 2015/03/11, Without Invitation, English, NIH, MD, USA
  23. ALS-mutants converge on loss of Detyrosinated microtubules and RNA mislocalization., Kyota Yasuda, Sarah Clatterbuck-Soper, Meredith E. Jackrel, James Shorter, Stavroula Mili, NCI-UMD partnership symposium, 2015/01/22, Without Invitation, English, NIH, University of Maryland, MD, USA
  24. Spatial and translational regulation of APC-RNPs by ALS-associated mutants of the Fus RNA-binding protein., Kyota Yasuda, STavroula Mili, NIH-Japan-JSPS Symposium, 2014/10/24, Without Invitation, English, NIH, JSPS, MD, USA
  25. Deregulation of localized RNAs by pathologic granules of Fus/TLS, Stavroula Mili, Kyota Yasuda, RNA Granule, 2014/07/08, Without Invitation, English, NS, Canada
  26. Spatial and translational regulation of APC-RNPs by ALS-associated mutants of the Fus RNA-binding protein., Kyota Yasuda, Stavroula Mili, Gordon Research Conference (Cell biology of the Neuron), 2014/06/22, Without Invitation, English, Gordon Research Conference, NH, USA
  27. Regulation of localized APC-RNP by ALS-associated mutants of Fus RNA-binding protein, Kyota Yasuda, Stavroula Mili, Cancer Technology & Epidemiology Symposium, 2014/01/23, Without Invitation, English, NIH, Univeristy of Maryland, MD, USA
  28. Identification of a novel cis-acting element responsible for the translational regulation of zebrafish cyclin B1 mRNA during oocyte maturation., Kyota Yasuda, Tomoya Kotani, Masakane Yamashita, 83th Meeting of the Zoological Society of Japan, 2012/09/13, Without Invitation, Japanese, the Zoological Society of Japan, Osaka
  29. Transgenic zebrafish reveals a novel cis-acting element responsible for spatio-temporally regulated translational activation of cyclin B1 mRNA in oocytes., Kyota Yasuda, Tomoya Kotani, Masakane Yamashita, Joint Meeting of 45th Annual Meeting of Japanese Society of Developmental Biology and 64th Annual Meeting of Japan Society for Cell Biology, 2012/05/29, Without Invitation, Japanese, Japanese Society of Developmental Biology, Japan Society for Cell Biology, Hyogo
  30. Translational control of cyclin B1 mRNA by RNA granule formation in vertebrate oocytes, Tomoya Kotani, Kyota Yasuda, Ryoma Ota, Masakane Yamashita, Joint Meeting of 45th Annual Meeting of Japanese Society of Developmental Biology and 64th Annual Meeting of Japan Society for Cell Biology, 2012/05/29, Without Invitation, Japanese, Japanese Society of Developmental Biology, Japan Society for Cell Biology, Hyogo
  31. Transgenic zebrafish reveals a novel cis-acting element responsible for spatio-temporally regulated translational activation of cyclin B1 mRNA in oocytes., Kyota Yasuda, Tomoya Kotani, Masakane Yamashita, Joint Meeting of 45th Annual Meeting of Japanese Society of Developmental Biology and 64th Annual Meeting of Japan Society for Cell Biology, 2012/05/28, Without Invitation, Japanese, Japanese Society of Developmental Biology, Japan Society for Cell Biology, Hyogo
  32. Mechanisms regulating the localization and translational timing of cyclin B1 mRNA during oocyte maturation, as revealed by transgenic zebrafish., Kyota Yasuda, Tomyoa Kotani, Ryoma Ota, Masakane Yamashita, 43th Annual Meeting of Japanese Society of Developmental Biology, 2010/06/22, Without Invitation, Japanese, Japanese Society of Developmental Biology, Kyoto
  33. Translational control of cyclin B1 mRNA during oocyte maturation: Analysis using a transgenic zebrafishTranslational control of cyclin B1 mRNA during oocyte maturation: Analysis using a transgenic zebrafish, Kyota Yasuda, Tomoya Kotani, Masakane Yamashita, 32th Annual Meeting of Molecular Biology Society of Japan, 2009/12/09, Without Invitation, Japanese, Molecular Biology Society, Kanagawa

Awards

  1. 2014, Poster Award, NIH-Japan-JSPS Symposium

External Funds

Acceptance Results of Competitive Funds

  1. 2023/04, 2027/03
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2023, 2025
  3. 2020, 2021
  4. Grant-in-Aid for Early-Career Scientists, Analysis for the changing in RNA bahavior upon cytoplasmic RNA-protein aggregation observed in neurodegeneration., 2019, 2021
  5. 2019/04, 2021/03
  6. The Uehara Memorial Foundation, Research incentives, 2019/03, 2020/04
  7. Satake fundation, Neurodegeneration-related protein aggregation affects localized RNA behavior, 2018/10, 2019/03
  8. Grant aid for start up of your researcher, 2017/10, 2018/03
  9. KAITOKU-NIH fellowship, Regulation of localized APC-RNP by ALS-associated mutants of the FUS RNA-binding protein, 2014/04, 2016/03
  10. Research fellowship (DC2), 2011/04, 2013/03
  11. Support for reserch training, Faculty of advanced life science, Hokkaido University, 2010/04, 2013/03
  12. Grant-in-Aid for Scientific Research (B), 2019, 2023
  13. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2019, 2021