YAICHIRO KOTAKE

Last Updated :2024/07/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
yaichirohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D., The University of Tokyo
  • MSc., The University of Tokyo

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy

Research Keywords

  • neurotoxicity

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 1Term, Public Health Chemistry I
  2. 2024, Undergraduate Education, 2Term, Public Health Chemistry II
  3. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  4. 2024, Undergraduate Education, First Semester, Research Practice A
  5. 2024, Undergraduate Education, Second Semester, Research Practice B
  6. 2024, Undergraduate Education, First Semester, Practice of xenobiotics and molecular toxicology
  7. 2024, Undergraduate Education, 3Term, Public Health Chemistry III
  8. 2024, Undergraduate Education, Intensive, Public Health Chemistry III
  9. 2024, Undergraduate Education, First Semester, Experiments of Public health Chemistry
  10. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  11. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  12. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  13. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  14. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  15. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  16. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Neurochemistry and Environmental Health Sciences
  17. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Neurochemistry and Environmental Health Sciences
  18. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Neurochemistry and Environmental Health Sciences
  19. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Neurochemistry and Environmental Health Sciences
  20. 2024, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  21. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  22. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Neurochemistry and Environmental Health Sciences
  23. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Neurochemistry and Environmental Health Sciences
  24. 2024, Graduate Education (Master's Program) , First Semester, Research on Neurochemistry and Environmental Health Sciences
  25. 2024, Graduate Education (Master's Program) , Second Semester, Research on Neurochemistry and Environmental Health Sciences
  26. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Neurotoxicology
  27. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Neurotoxicology
  28. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Neurochemistry and Environmental Health Sciences for Medicinal Sciences
  29. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Neurochemistry and Environmental Health Sciences for Medicinal Sciences
  30. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Neurochemistry and Environmental Health Sciences for Medicinal Sciences
  31. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Neurochemistry and Environmental Health Sciences for Medicinal Sciences

Research Activities

Academic Papers

  1. Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder, JOURNAL OF LIPID RESEARCH, 64(11), 202311
  2. Photodegradation profiling of nitrendipine: evaluation of active pharmaceutical ingredient, tablets and its altered forms, ANALYTICAL SCIENCES, 39(11), 1791-1803, 202311
  3. Evaluation of photostability of azelnidipine tablets and structure determination of its photoproducts, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 233, 20230905
  4. Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver, JOURNAL OF TOXICOLOGICAL SCIENCES, 48(2), 99-108, 2023
  5. Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46(2), 292-300, 202302
  6. Tributyltin activates the Keapl-Nrf2 pathway via a macroautophagy-independent reduction in Keapl, JOURNAL OF TOXICOLOGICAL SCIENCES, 48(3), 161-168, 2023
  7. Improved Predictability of Hepatic Clearance with Optimal pH for Acyl-Glucuronidation in Liver Microsomes, JOURNAL OF PHARMACEUTICAL SCIENCES, 111(11), 3165-3173, 202211
  8. Trehalose decreases mRNA and protein expressions of c-Jun and JunB in human cervical cancer HeLa cells, JOURNAL OF BIOCHEMISTRY, 172(3), 177-187, 20220905
  9. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation, NEUROCHEMISTRY INTERNATIONAL, 160, 105415, 202211
  10. Comparison of the Components of Three Types of Miso (Fermented Soybean Paste) by 1H NMR Metabolomic Analysis, BPB Reports, 4(5), 148-154, 2021
  11. Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays, JOURNAL OF TOXICOLOGICAL SCIENCES, 47(7), 277-288, 2022
  12. Tributyltin inhibits autophagy by decreasing lysosomal acidity in SH-SY5Y cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 592, 31-37, 20220212
  13. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination, JOURNAL OF NEUROCHEMISTRY, 114(5), 1291-1301, 201009
  14. Protein disulfide isomerase knockdown-induced cell death is cell-line-dependent and involves apoptosis in MCF-7 cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 36(1), 1-7, 201102
  15. Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity., Bioorg.Med.Chem.Lett., 1669-1771
  16. Regional distribution of parkinsonism-preventing endogenous tetrahydro-isoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain., Neurosci. Lett., 68-70
  17. Neurotoxicity of an endogenous amine in the brain, 1BnTIQ in organotypic slice co-culture of ventral mecensephalon and striatum., Neuroscience, 117(1), 63-70, 20030101
  18. Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity., Bioorg.Med.Chem.Lett., 10, 1669-1771, 20000401
  19. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine trnsporter expressed in HEK293 cells., Neurosci. Res., 30, 87-90, 19980401
  20. Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes., J.Neural.Transm., 105(6-7), 677-688, 19980401
  21. Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate., Neurosci. Lett., 217, 69-71, 19960401
  22. ★, 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF., J. Neurochem., 65(6), 2633-2638, 19950401
  23. Determination method of 1-methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay., Life Sci., 70, 2871-2883, 20020401
  24. Concentration dependence of the mechanisms of tributyltin-induced apoptosis, TOXICOLOGICAL SCIENCES, 97(2), 438-447, 200706
  25. Neurotoxicity induced by environmental low-molecular-weight substances, JOURNAL OF HEALTH SCIENCE, 53(6), 639-643, 200712
  26. Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death, TOXICOLOGY AND APPLIED PHARMACOLOGY, 230(3), 358-363, 20080801
  27. MODULATION OF CONNEXIN 43 IN ROTENONE-INDUCED MODEL OF PARKINSON'S DISEASE, NEUROSCIENCE, 160(1), 61-68, 20090421
  28. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate, TOXICOLOGY AND APPLIED PHARMACOLOGY, 240(2), 292-298, 20091015
  29. Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death, JOURNAL OF TOXICOLOGICAL SCIENCES, 35(2), 245-251, 201004
  30. Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver, DRUG METABOLISM AND DISPOSITION, 40(2), 322-328, 201202
  31. Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata, CHEMICAL & PHARMACEUTICAL BULLETIN, 60(2), 257-259, 201202
  32. Three new megastigmanes from the leaves of Annona muricata, JOURNAL OF NATURAL MEDICINES, 66(2), 284-291, 201204
  33. Guidelines for the use and interpretation of assays for monitoring autophagy, AUTOPHAGY, 8(4), 445-544, 201204
  34. Molecular Mechanisms of Environmental Organotin Toxicity in Mammals, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(11), 1876-1880, 201211
  35. Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes, DRUG METABOLISM AND DISPOSITION, 40(12), 2267-2272, 201212
  36. AMP-activated protein kinase-mediated glucose transport as a novel target of tributyltin in human embryonic carcinoma cells, METALLOMICS, 5(5), 484-491, 2013
  37. Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death, JOURNAL OF TOXICOLOGICAL SCIENCES, 38(3), 513-521, 201306
  38. Tributyltin-induced endoplasmic reticulum stress and its Ca2+-mediated mechanism, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 137-146, 20131001
  39. NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells, SCIENTIFIC REPORTS, 4, 20140805
  40. Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function, JOURNAL OF NEUROCHEMISTRY, 130(6), 826-838, 201409
  41. Detection of a novel neurotoxic metabolite of Parkinson's disease-related neurotoxin, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, JOURNAL OF TOXICOLOGICAL SCIENCES, 39(5), 749-754, 201410
  42. Tributyltin induces mitochondrial fission through NAD-IDH dependent mitofusin degradation in human embryonic carcinoma cells, METALLOMICS, 7(8), 1240-1246, 2015
  43. Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates, Toxicology in Vitro, 28(6), 1176-1182, 201409
  44. Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(1), 155-164, 201602
  45. Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction, SCIENTIFIC REPORTS, 6, 20160222
  46. Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(2), 207-215, 201604
  47. Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(2), 255-264, 201604
  48. Protein extracts from cultured cells contain nonspecific serum albumin, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(6), 1164-1167, 2016
  49. Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver., Xenobiotica, 45(7):605-14(7), 605-614, 2015
  50. Development of a simple measurement method for GluR2 protein expression as an index of neuronal vulnerability., Toxicology Reports, 2, 450-460, 2015
  51. ★, Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism, JOURNAL OF NEUROCHEMISTRY, 139(2), 294-308, 201610
  52. ★, Perfluorooctane sulfonate induces neuronal vulnerability by decreasing GluR2 expression, ARCHIVES OF TOXICOLOGY, 91(2), 885-895, 201702
  53. Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(3), 303-309, 201703
  54. Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 486(3), 639-644, 20170506
  55. ★, Mild MPP+ exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation, SCIENTIFIC REPORTS, 7, 20170426
  56. Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(7), 1121-1124, 201707
  57. ★, Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8), E1754, 201708
  58. Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver, JOURNAL OF TOXICOLOGICAL SCIENCES, 42(5), 589-596, 201710
  59. Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis, JOURNAL OF TOXICOLOGICAL SCIENCES, 42(5), 605-613, 201710
  60. ★, Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons, ARCHIVES OF TOXICOLOGY, 92(1), 401-409, 201801
  61. ★, Tributyltin induces epigenetic changes and decreases the expression of nuclear respiratory factor-1, METALLOMICS, 10(2), 337-345, 201802
  62. Development of a simple measurement method for GluR(2) protein expression as an index of neuronal vulnerability, TOXICOLOGY REPORTS, 2, 450-460, 2015
  63. Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions, BIOCHEMICAL PHARMACOLOGY, 154, 28-38, 201808
  64. Neurotoxicity Mechanism of Environmental Chemicals and Its Evaluation System, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 138(10), 1227-1233, 201810
  65. Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 509(1), 287-293, 20190129
  66. Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy, TOXICOLOGY AND APPLIED PHARMACOLOGY, 370, 133-144, 20190501
  67. Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(8), 1366-1375, 201908
  68. CYP1A2 Downregulation by Obeticholic Acid: Usefulness as a Positive Control for the In Vitro Evaluation of Drug-Drug Interactions, JOURNAL OF PHARMACEUTICAL SCIENCES, 108(12), 3903-3910, 201912
  69. Changes in bile acid concentrations in chimeric mice transplanted with different replacement indexes of human hepatocytes, BPB Reports, 2(2), 29-34, 2019
  70. Changes in bile acid concentrations in chimeric mice transplanted with different replacement indexes of human hepatocytes, BPB Reports, 2(2), 29-34, 2019
  71. Amiodarone bioconcentration and suppression of metamorphosis in Xenopus, AQUATIC TOXICOLOGY, 228, 105623, 202011
  72. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), AUTOPHAGY, 17(1), 1-382, 2021
  73. MiT/TFE family members suppress L-leucyl L-leucine methyl ester-induced cell death, JOURNAL OF TOXICOLOGICAL SCIENCES, 46(3), 143-156, 2021
  74. Treatment with Histone Deacetylase Inhibitor Attenuates Peripheral Inflammation-Induced Cognitive Dysfunction and Microglial Activation: The Effect of SAHA as a Peripheral HDAC Inhibitor, NEUROCHEMICAL RESEARCH, 46(9), 2285-2296, 202109
  75. Triphenyltin inhibits GA-binding protein alpha nuclear translocation., Fundamental Toxicological Sciences, 7(1), 33-40, 20200123
  76. Involvement of aldehyde oxidase in the metabolism of aromatic and aliphatic aldehyde-odorants in the mouse olfactory epithelium, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 715, 109099, 20220115
  77. Prediction of human pharmacokinetics for low-clearance compounds using pharmacokinetic data from chimeric mice with humanized livers, CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 15(1), 79-91, 202201

Invited Lecture, Oral Presentation, Poster Presentation

  1. Exploring mRNA markers for assessing developmental neurotoxicity using primary rat neurons, Ryoga Fujihara, Masatsugu Miyara, Yuki Takehara, Tomoki Takabayashi, Yuki Yamamoto, Hidetoshi Tahara, Yaichiro Kotake, 2023 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology, 2023/09, Without Invitation, Japanese
  2. Evaluation of chemical toxicity by using GluA2 expression in neurons as an index, Yaichiro Kotake, the 126th Annual Meeting of The Japanese Association of Anatomists / the 98th Annual Meeting of The Physiological Society of Japan, 2021/03, With Invitation, English, Online
  3. Endogenous parkinsonian neurotoxin 1BnTIQ impairs autophagic degradation, Masatusgu Miyara, Ayaka Yabuki, Natsumi Okada, Kanae Umeda, Takafumi Nishio, Shigeru Yamada, Yasunari Kanda, Tsuyoshi Nakanishi, Shigeru Ohta, Yaichiro Kotake, 2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Enviuronmental Toxicology, 2019/08, Without Invitation, English, Kyoto
  4. Tributyltin decrease the expresion of nuclear respiratory factor-1 via epigenetic changes, Yaichiro Kotake, Saki Hanaoka, Keishi Ishida, Shuichiro Sakamoto, Katsuhiro Okuda, Seigo Sanoh, Shigeru Ohta, 15th International Congress of Toxicology, 2019/07, Without Invitation, Japanese, Honolulu, Hawaii
  5. Environmental organotin and its mammalian neurotoxicity, Yaichiro Kotake, Graduate School Lecture, GIP-TRIAD, University of Tsukuba, 2018/11/07, With Invitation, English, Tsukuba
  6. PFOS Increases Neuronal Vulnerability to Excitotoxicity via Decrease of AMPA receptor Subunit GluR2 expression, Keishi Ishida, Yaichiro Kotake, Yumi Tsuyama, Seigo Sanoh, Shigeru Ohta, Society of Toxicology 56th Annual Meeting, 2017/03, Without Invitation, English, Baltimore, USA
  7. Neurotoxicity of perfluorooctane sulfonate (PFOS) via GluR2 decrease, Keishi Ishida, Yaichiro Kotake, Yumi Tsuyama, Takashi Saiki, Seigo Sanoh, Shigeru Ohta, 2016 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology, 2016/09, Without Invitation, English, Tokyo
  8. Organotin decreases GluR2 expression in nuclear respiratory factor-1-dependent manner., Yaichiro Kotake, Keishi Ishida, Kaori Aoki, Tomoko Takishita, Tomoki Kimura, Yasunari Kanda, Shigeru Ohta, International Society for Trace Element Research in Humans (ISTERH) 2015, 2015/10, Without Invitation, English, International Society for Trace Element Research in Humans (ISTERH), Dubrovnik, Croatia
  9. Increased expression of glutamate transporter EAAT3 by rotenone, Yaichiro Kotake, Tomomi Yamamoto, Satoshi Adachi, Kouta Kouno, Shigeru Ohta, 50th Congress of the European Societies of Toxicology, 2014/09, Without Invitation, English, the European Societies of Toxicology, Edinburgh
  10. Characterization of varidations in CYP expression during liver regeneration after partial hepatectomy in mice: possible contribution of endogeneous molecules, Chieri Fujino, Seigo Sanoh, Chise Tateno, Shigeru Ohta, Yaichiro Kotake, 2018 International Meeting on 22nd MDO and 33rd JSSX, 2018/10, Without Invitation, Japanese, Kanazqwq
  11. Assessment of inhibitory effects of drugs on mouse and human aldehyde oxidase through in silico, in vitro, and in vivo approaches, Naoki Takaoka, Seigo, Sanoh, Katsuhiro Okuda, Go Sugahara, Ami Yanagi, Yuji Ishida, Chise Tateno, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Mami Kurosaki, Mineko Terao, Enrico Garattini, Shigeru Ohta, Yaichiro Kotake, 2018 International Meeting on 22nd MDO and 33rd JSSX, 2018/10, Without Invitation, English, Kanazawa