GAKU NAGANO

Last Updated :2025/06/16

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
gnaganohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Intensive, Symptomatology, Diagnosis and Treatment
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  4. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment I

Research Activities

Academic Papers

  1. Immunoprecipitation with an Anti-Epitope Tag Affinity Gel to Study Protein-Protein Interactions., Journal of visualized experiments : JoVE, 2024
  2. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production., Hypertension (Dallas, Tex. : 1979), 75(2), 2020
  3. Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung., ERJ open research, 6(4), 2020
  4. Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations., Molecular and cellular endocrinology, 538, 2021
  5. ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation., International journal of molecular sciences, 22(20), 2021
  6. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma., Molecular and cellular endocrinology, 548, 2022
  7. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma., Endocrine-related cancer, 29(8), 2022
  8. NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes., iScience, 25(8), 2022
  9. Selective activation of PPARα maintains thermogenic capacity of beige adipocytes., iScience, 26(7), 2023
  10. NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 120(31), 2023
  11. NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes, ISCIENCE, 25(8), 20220819
  12. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma, ENDOCRINE-RELATED CANCER, 29(8), 495-502, 202208
  13. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma

    , MOLECULAR AND CELLULAR ENDOCRINOLOGY, 548, 20220515
  14. ★, Activation of classical brown adipocytes in the adult human perirenal depot is highly correlated with PRDM16-EHMT1 complex expression., PloS one, 10(3), 2015
  15. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program., Nature cell biology, 19(9), 2017
  16. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
  17. Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung, ERJ Open Res, 6(4), 00402-2020, 2020

Awards

  1. 2017, Young Investigator Award, The Japan Endocrine Society
  2. 2017, The student award of Graduate School of Biomedical and Health Sciences, Hiroshima University
  3. 2016, Young Investigator Award, The Japan Diabetes Society
  4. 2016, Visionary Award, Japan Society for the Study of Obesity

External Funds

Acceptance Results of Competitive Funds

  1. Research foundation, Epigenetic mechanism that control brown fat thermogenesis, 2021, 2022
  2. The Japan Diabetes Society Young Investigator Grant, 2019, 2020
  3. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2019, 2020