YOSHIHIRO SAEKI

Last Updated :2024/04/03

Affiliations, Positions
Hiroshima University Hospital(Medical), Contributing Assistant Professor
E-mail
iop890hiroshima-u.ac.jp
Self-introduction
I provide clinical, research and education in gastrointestinal surgery and obesity treatment.

Basic Information

Major Professional Backgrounds

  • 2021/04/01, Hiroshima university hospital, Division of Endoscopic Surgery, Hofu Institute of Gastroenterology, Contributing Assistant Professor

Academic Degrees

  • Kochi University
  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Digestive surgery
  • Medicine,dentistry, and pharmacy;Clinical surgery;General surgery

Research Keywords

  • gastric cancer, severe obesity, visceral adipose tissue, laparoscopic sleeve gastrectomy

Affiliated Academic Societies

  • Japanese Society for Treatment of Obesity
  • Japanese Gastric Cancer Association
  • The Japanese Society of Gastroenterological Surgery
  • Japan Surgical Society
  • JAPAN SOCIETY FOR ENDOSCOPIC SURGERY

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2024, Undergraduate Education, First Semester, Surgery I
  6. 2024, Graduate Education (Doctoral Program) , 1Term, Practice of Oncology
  7. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  8. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  9. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Gastroenterological and Transplant Surgery
  10. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Gastroenterological and Transplant Surgery

Research Activities

Academic Papers

  1. Establishment of a novel overlay culture method that enables immune response assessment using gastric cancer organoids, HELIYON, 10(1), 20240115
  2. The involvement of circulating CD69+ CD56bright natural killer cells in weight loss before bariatric surgery: A retrospective cohort study, MEDICINE, 102(41), 20231013
  3. Successful management of multiple liver metastasis from gastric cancer with second conversion surgery: A case report, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 107, 202306
  4. Successful robotic proximal gastrectomy with side overlap esophagogastrostomy following preoperative chemotherapy: A case report, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 94, 202205
  5. Laparoscopic Proximal Gastrectomy with Hinged Double Flap Method Using Knotless Barbed Absorbable Sutures: A case series, Int J Surg Case Rep., 51, 165-169, 20180825
  6. ★, Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation, Scientific reports, 9(1), 1022, 20190131
  7. Role of Natural Killer Cells in the Innate Immune System After Intraportal Islet Transplantation in Mice., Transplantation proceedings, 49(1), 139-144, 201701
  8. Controlling the bleeding of jejunal varices formed at the site of choledochojejunostomy: report of 2 cases and a review of the literature., Surg Today, 43(5), 139-555, 201303
  9. Elucidation of activation mechanisms for intrahepatic natural killer cells aiming the protection of transplanted islets, Organ Biology, 22(2), 123-127, 2015
  10. Therapeutic effects of sleeve gastrectomy for non-alcoholic steatohepatitis estimated by paired liver biopsy in morbidly obese Japanese patients, MEDICINE, 100(26), 20210702
  11. Complete Response for Advanced Hepatocellular Carcinoma by Conversion Surgery Therapy Following a Good Response of Regorafenib Despite Rapid Progressive Disease with Sorafenib, INTERNAL MEDICINE, 60(13), 2047-2053, 20210701
  12. Iatrogenic hepatic granuloma (suspected liver metastatic lesion on imaging) caused by liver retraction during laparoscopic gastrectomy: A case report, Clinical Case Reports, 8(12), 2353-2357, 20200715
  13. Perioperative management of polycythemia vera with advanced gastric cancer: A case report, Int J Surg Case Rep ., 224-227, 20190416
  14. Cotransplantation of preactivated mesenchymal stem cells improves intraportal engraftment of islets by inhibiting liver natural killer cells in mice, Am J Transplant, 2732-2745, 20191019
  15. Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis, Ann Gastroenterol Surg, 20180718
  16. Revascularization for cavernous transformation radical lymphadenectomy in the treatment of gastric cancer: A case report, Int J Surg Case Rep, 20180726
  17. MELD and Child-Pugh Scores Are Related to Immune Status of Intrahepatic Natural Killer Cells in Liver Transplant Candidates, Transplant Proc, 201701
  18. Laparoscopic extra-abdominal suturing technique for the repair of Larrey's diaphragmatic hernia using the port closure needle (Endo Close ®): A case report, Int J Surg Case Rep., 20160921
  19. Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation, PLoS One., 20141030
  20. Multiple hepatic vein reconstruction using an all-in-one sleeve patch graft technique in living donor liver transplantation: a case report, Transplant Proc, 201404
  21. Bile CXC motif chemokine 10 levels correlate with anti-donor cytotoxic T cell responses after liver transplantation, Transplant Proc ., 201404
  22. Potential benefit of mixed lymphocyte reaction assay-based immune monitoring after living donor liver transplantation for recipients with autoimmune hepatitis, Transplant Proc., 201404
  23. Clinical efficacy of simultaneous splenectomy in liver transplant recipients with hepatitis C virus, Transplant Proc., 201404
  24. Distal Gastrectomy for Symptomatic Stage IV Gastric Cancer Contributes to Prognosis with Acceptable Safety Compared to Gastrojejunostomy, CANCERS, 14(2), 202201

Invited Lecture, Oral Presentation, Poster Presentation

  1. Intraesophageal Pressure in Patients Receiving Laparoscopic Proximal Gastrectomy, Saeki Y, 2020/03/06, Without Invitation, English, Japanese Gastric Cancer Association
  2. Mesenchymal Stem Cells Suppress Cytotoxic Activity of Natural Killer Cells in Islet Cell Transplantation, Saeki Y, Ishiyama K, Hirata F, Tanaka Y, Ohdan H., American Transplant Congress, 2013/05/18, Without Invitation, English, Seattle, America
  3. Clinical Outcome of Cryptogenic Cirrhosis Including Nonalcoholic Steatohepatitis After Liver Transplantation, Saeki Y, Ishiyama K, Tanaka Y, Ide K, Ohira M, Tahara H, Kobayashi T, Abe T, Hashimoto S, Hirata F, Morimoto H, Shimizu S, Tanimine N, Sakai H, Yano T, Tashiro H, Ohdan H., The 13th Congress of the Asian Society of Transplantation (CAST2013), 2013/09/03, Without Invitation, English, Kyoto, Japan
  4. Liver DX5- natural killer cells play a crucial role on the instant blood-mediated inflammatory reaction after islet transplantation, Saeki Y, K. Ishiyama, F. Hirata, Y. Tanaka, H. Ohdan, American Transplant Congress/WTC 2014, 2014/07/26, Without Invitation, English, San Francisco, America
  5. Persistent expansion of DX5- memory natural killer cells in the liver after intraportal islet transplantation., Saeki Y, K. Ishiyama, F. Hirata, Y. Tanaka, H. Ohdan, American Transplant Congress2015, 2015/05/02, Without Invitation, English, Philadelphia, America
  6. The depletion of liver natural killer cells lead to successful engraftment of intraportal transplanted islet when insufficient number of islets used for islet transplantation, Saeki Y, K. Ishiyama, F. Hirata, Y. Tanaka, H. Ohdan, Transplantation Science Symposium Asian Regional Meeting 2016, 2016/04/08, Without Invitation, English, Tokyo, Japan
  7. Long-lasting expansion of memory-like natural killer cells in the liver after intraportal syngeneic islet transplantation in mice, Saeki Y, Ishiyama K, Hirata F, Tanaka Y, Ohdan H., 26th internatinoal congress of the transplantation society, 2016/08/18, Without Invitation, English, Hongkong
  8. Conversion surgery in patients with liver metastasis from gastric cancer, Saeki Y, Tanabe K., Ota H., Yanagawa S., Yamamoto Y., Hotta R , Ohdan H., Global Academic Programs GAP 2018, 2018/05/15, Without Invitation, English, Stockholm, Sweden
  9. Liver-resident natural killer cells exposed to instant blood-mediated inflammatory reaction after intraportal islet transplantation persistently sustain memory phenotype with cytotoxicity against islets, Saeki Y, K. Ishiyama, Ishida N., Y. Tanaka, H. Ohdan, 14th Transplantation Science Symposium, 2015/11/11, Without Invitation, English, Lorne, Australia

Awards

  1. 2019/04/20, Japan Surgical Society Young Researcher Award, Japan Surgical Society, 肥満症における慢性炎症誘導機構の解明と制御法の開発
  2. 2015/11/11, The International Transplantation Science Scientific Travel Grant Awards for the 14th Transplantation Science Symposium (TSS 2015), Transplantation Science Symposium, Liver-resident natural killer cells exposed to instant blood-mediated inflammatory reaction after intraportal islet transplantation persistently sustain memory phenotype with cytotoxicity against is

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2020, 2023

Social Activities

History as Peer Reviews of Academic Papers

  1. 2024, International Journal of Surgery, Others, reviewer, 4
  2. 2023, International Journal of Surgery, Others, reviewer, 6