Norimitsu Morioka

Last Updated :2024/10/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
mnorihiroshima-u.ac.jp
Other Contact Details
Kasumi 1-2-3, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5310 FAX : (+81)82-257-5314
Self-introduction
I specialize in the research for Neuropharmacology, especially pain and depression.

Basic Information

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1999/04, 2002/03
  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1997/04, 1999/03
  • Hiroshima University, Faculty of Medicine, Japan, 1993/04, 1997/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General pharmacology

Research Keywords

  • neuropathic pain
  • allodynia
  • connexin/gap junction
  • clock genes
  • HMGB1
  • astrocytes
  • microglia
  • nicotine/nACh receptor

Affiliated Academic Societies

  • The Society for Neuroscience

Educational Activity

Course in Charge

  1. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  2. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacology
  3. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacology
  4. 2024, Graduate Education (Master's Program) , First Semester, Research on Pharmacology
  5. 2024, Graduate Education (Master's Program) , Second Semester, Research on Pharmacology
  6. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacology
  7. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacology
  8. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacology
  9. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacology
  10. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Pharmacology
  11. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Pharmacology
  12. 2024, Undergraduate Education, 2Term, Functional Morphology
  13. 2024, Undergraduate Education, First Semester, Outline of Pathology
  14. 2024, Undergraduate Education, 3Term, Pharmacology I
  15. 2024, Undergraduate Education, Intensive, Pharmacology I
  16. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  17. 2024, Undergraduate Education, First Semester, Research Practice A
  18. 2024, Undergraduate Education, Second Semester, Research Practice B
  19. 2024, Undergraduate Education, First Semester, Practice of Biochemical Pharmacology
  20. 2024, Undergraduate Education, 4Term, Pharmacology II
  21. 2024, Undergraduate Education, 1Term, Pharmacology III
  22. 2024, Undergraduate Education, Intensive, Pharmacology III
  23. 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  24. 2024, Undergraduate Education, 4Term, Pharmacology IV
  25. 2024, Undergraduate Education, Intensive, Pharmacology IV
  26. 2024, Undergraduate Education, First Semester, Practice of Pharmacology
  27. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  28. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  29. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  30. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  31. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  32. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  33. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmacology for Pharmaceutical Sciences
  34. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmacology for Pharmaceutical Sciences
  35. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmacology for Pharmaceutical Sciences
  36. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmacology for Pharmaceutical Sciences
  37. 2024, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science

Research Activities

Academic Papers

  1. High mobility group box-1: A therapeutic target for analgesia and associated symptoms in chronic pain, BIOCHEMICAL PHARMACOLOGY, 222, 202404
    Link to Paper Search Results by DOI
  2. Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 47(1), 221-226, 202401
  3. Enhanced anxiety-like behavior induced by chronic neuropathic pain and related parvalbumin-positive neurons in male rats, BEHAVIOURAL BRAIN RESEARCH, 459, 20240229
    Link to Paper Search Results by DOI
  4. Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes, INTERNATIONAL IMMUNOPHARMACOLOGY, 127, 20240125
    Link to Paper Search Results by DOI
  5. Mitochondrial dysfunction and type I interferon signaling induce anxiodepressive-like behaviors in mice with neuropathic pain, EXPERIMENTAL NEUROLOGY, 367, 202309
    Link to Paper Search Results by DOI
  6. Inhibition of Nuclear Receptor Related Orphan Receptor y Ameliorates Mechanical Hypersensitivity Through the Suppression of Spinal Microglial Activation, NEUROSCIENCE, 526, 223-236, 20230821
    Link to Paper Search Results by DOI
  7. Evaluation of intracellular signal molecules that regulate TLR4-stimulated inflammatory mediator expression in cultured rat chondrocytes, JOURNAL OF PHARMACOLOGICAL SCIENCES, 152(2), 103-111, 202306
    Link to Paper Search Results by DOI
  8. N-methyl-D-aspartate receptors and glycinergic transmission, respectively, mediate muscle relaxation and immobility of pentobarbital in mice, NEUROSCIENCE LETTERS, 802, 20230401
    Link to Paper Search Results by DOI
  9. Blockade of receptor for advanced glycation end-products with azeliragon ameliorates streptozotocin-induced diabetic neuropathy, NEUROCHEMISTRY INTERNATIONAL, 163, 202302
    Link to Paper Search Results by DOI
  10. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation, NEUROCHEMISTRY INTERNATIONAL, 160, 202211
    Link to Paper Search Results by DOI
  11. Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation, INTERNATIONAL IMMUNOPHARMACOLOGY, 112, 202211
    Link to Paper Search Results by DOI
  12. High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain, EXPERIMENTAL NEUROLOGY, 355, 202209
    Link to Paper Search Results by DOI
  13. Mirogabalin alleviates nociceptive hypersensitivity without causing sedation in a mouse model of post-traumatic trigeminal neuropathy, BEHAVIOURAL BRAIN RESEARCH, 425, 20220503
    Link to Paper Search Results by DOI
  14. Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor(1/3), Src, and extracellular signal-regulated kinase, EUROPEAN JOURNAL OF PHARMACOLOGY, 925, 20220615
    Link to Paper Search Results by DOI
  15. Pentobarbital may protect against neurogenic inflammation after surgery via inhibition of substance P release from peripheral nerves of rats, NEUROSCIENCE LETTERS, 771, 20220206
    Link to Paper Search Results by DOI
  16. Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson's disease, BIOMEDICINE & PHARMACOTHERAPY, 145, 202201
    Link to Paper Search Results by DOI
  17. Downregulation of connexin43 potentiates noradrenaline-induced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes, JOURNAL OF CELLULAR PHYSIOLOGY, 236(10), 6777-6792, 202110
    Link to Paper Search Results by DOI
  18. Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 566, 141-147, 20210820
    Link to Paper Search Results by DOI
  19. Treatment with Histone Deacetylase Inhibitor Attenuates Peripheral Inflammation-Induced Cognitive Dysfunction and Microglial Activation: The Effect of SAHA as a Peripheral HDAC Inhibitor, NEUROCHEMICAL RESEARCH, 46(9), 2285-2296, 202109
    Link to Paper Search Results by DOI
  20. Stimulation of nuclear receptor REV-ERBs suppresses inflammatory responses in spinal microglia, NEUROCHEMISTRY INTERNATIONAL, 151, 202112
    Link to Paper Search Results by DOI
  21. Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: Involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn, BIOCHEMICAL PHARMACOLOGY, 186, 202104
    Link to Paper Search Results by DOI
  22. Pretreatment with High Mobility Group Box-1 Monoclonal Antibody Prevents the Onset of Trigeminal Neuropathy in Mice with a Distal Infraorbital Nerve Chronic Constriction Injury, MOLECULES, 26(7), 202104
    Link to Paper Search Results by DOI
  23. p-Nitroterphenyl units for near-infrared two-photon uncaging of calcium ions, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 409, 20210315
    Link to Paper Search Results by DOI
  24. Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freund's adjuvant, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 533(4), 971-975, 20201217
    Link to Paper Search Results by DOI
  25. Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes, Journal of Neurochemistry, 2020
  26. The indirect gamma-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 198, 202011
    Link to Paper Search Results by DOI
  27. TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia, JOURNAL OF PHARMACOLOGICAL SCIENCES, 144(1), 23-29, 202009
    Link to Paper Search Results by DOI
  28. Stimulation of toll-like receptor 4 downregulates the expression of alpha 7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia, NEUROCHEMISTRY INTERNATIONAL, 138, 202009
    Link to Paper Search Results by DOI
  29. Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors, BEHAVIOURAL BRAIN RESEARCH, 391, 20200805
    Link to Paper Search Results by DOI
  30. Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms, CELLS, 9(5), 202005
    Link to Paper Search Results by DOI
  31. Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1 beta in activated astrocytes, JOURNAL OF NEUROCHEMISTRY, 150(6), 738-758, 201909
    Link to Paper Search Results by DOI
  32. Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes, EUROPEAN JOURNAL OF PHARMACOLOGY, 860, 20191005
    Link to Paper Search Results by DOI
  33. Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(6), 857-866, 201906
    Link to Paper Search Results by DOI
  34. Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice, BRAIN BEHAVIOR AND IMMUNITY, 78, 116-130, 201905
    Link to Paper Search Results by DOI
  35. High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 92, 347-362, 20190608
    Link to Paper Search Results by DOI
  36. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice, GLIA, 66(2), 428-444, 201802
    Link to Paper Search Results by DOI
  37. Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(10), 1759-1766, 201710
  38. Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(53), 27364-+, 20161230
    Link to Paper Search Results by DOI
  39. Stimulation of spinal dorsal horn beta 2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase, NEUROCHEMISTRY INTERNATIONAL, 101, 144-155, 201612
    Link to Paper Search Results by DOI
  40. The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 479(4), 907-912, 20161028
    Link to Paper Search Results by DOI
  41. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression, LIFE SCIENCES, 155, 116-122, 20160615
    Link to Paper Search Results by DOI
  42. Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice, MOLECULAR AND CELLULAR NEUROSCIENCE, 72, 72-83, 201604
    Link to Paper Search Results by DOI
  43. Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia, BRAIN RESEARCH, 1634, 57-67, 20160301
    Link to Paper Search Results by DOI
  44. Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloprotease-9 up-regulation in mice with painful peripheral neuropathy, JOURNAL OF NEUROCHEMISTRY, 136(4), 837-850, 201602
    Link to Paper Search Results by DOI
  45. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469(2), 151-157, 20160108
    Link to Paper Search Results by DOI
  46. The induction of Pen1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes, NEUROCHEMISTRY INTERNATIONAL, 90, 9-19, 201511
    Link to Paper Search Results by DOI
  47. Stimulation of alpha 7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia, BRAIN RESEARCH, 1625, 111-120, 20151102
    Link to Paper Search Results by DOI
  48. Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal-regulated kinase-dependent early growth response 1 production in rat primary cultured astrocytes, JOURNAL OF NEUROCHEMISTRY, 135(1), 27-37, 201510
    Link to Paper Search Results by DOI
  49. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice, BRAIN BEHAVIOR AND IMMUNITY, 49, 293-310, 201510
    Link to Paper Search Results by DOI
  50. Proinflammatory cytokines downregulate connexin 43-gap junctions via the ubiquitin-proteasome system in rat spinal astrocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(4), 1202-1208, 20150904
    Link to Paper Search Results by DOI
  51. Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive G alpha(i/o) Activation in Astroglial Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(22), 13678-13691, 20150529
    Link to Paper Search Results by DOI
  52. Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility, PSYCHOPHARMACOLOGY, 232(1), 39-46, 201501
    Link to Paper Search Results by DOI
  53. Downregulation of Connexin36 in Mouse Spinal Dorsal Horn Neurons Leads to Mechanical Allodynia, JOURNAL OF NEUROSCIENCE RESEARCH, 93(4), 584-591, 201504
    Link to Paper Search Results by DOI
  54. History of the G Protein-Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay, JOURNAL OF PHARMACOLOGICAL SCIENCES, 126(4), 302-309, 201412
    Link to Paper Search Results by DOI
  55. Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2, JOURNAL OF NEUROCHEMISTRY, 131(6), 755-766, 201412
    Link to Paper Search Results by DOI
  56. Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-kappa B activation in spinal astrocytes, MOLECULAR AND CELLULAR NEUROSCIENCE, 59, 37-46, 201403
    Link to Paper Search Results by DOI
  57. Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway, BRITISH JOURNAL OF PHARMACOLOGY, 171(11), 2854-2867, 201406
    Link to Paper Search Results by DOI
  58. PRIMARY CULTURES OF RAT CORTICAL MICROGLIA TREATED WITH NICOTINE INCREASES IN THE EXPRESSION OF EXCITATORY AMINO ACID TRANSPORTER 1 (GLAST) VIA THE ACTIVATION OF THE alpha 7 NICOTINIC ACETYLCHOLINE RECEPTOR, NEUROSCIENCE, 258, 374-384, 20140131
    Link to Paper Search Results by DOI
  59. Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121(4), 257-271, 201304
    Link to Paper Search Results by DOI
  60. Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor., J. Pharmacol. Sci., 20130301
  61. Spinal astrocytes stimulated by tumor necrosis factor- and/or interferon- attenuate connexin 43-gap junction via c-jun terminal kinase activity, JOURNAL OF NEUROSCIENCE RESEARCH, 91(6), 745-756, 201306
    Link to Paper Search Results by DOI
  62. Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1, PLOS ONE, 8(8), 20130821
    Link to Paper Search Results by DOI
  63. The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons, BRAIN RESEARCH, 1509, 20-31, 20130506
    Link to Paper Search Results by DOI
  64. Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline, PLOS ONE, 7(12), 20121205
    Link to Paper Search Results by DOI
  65. Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice, NEUROCHEMISTRY INTERNATIONAL, 60(8), 817-826, 201206
    Link to Paper Search Results by DOI
  66. Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons, JOURNAL OF NEUROCHEMISTRY, 120(6), 1036-1047, 201203
    Link to Paper Search Results by DOI
  67. The Roles of ATP Receptors in the Regulation of Various Functions in Spinal Microglia, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131(7), 1047-1052, 20110701
  68. Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production., Journal of Biological Chemistry, 20110601
  69. Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3, Neurochem. Int., 57(8), 923-934, 20101001
  70. Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with PKA-CREB and Src-GSK-3beta., J. Pharmacol. Sci., 113(3), 234-245, 20100601
  71. Paclitax and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels, Neuropharmacology, 57(1), 25, 20090701
  72. Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain, Pharmacology and Therapeutics, 123, 54-79, 20090701
  73. The regulation of glycine transporter GlyT1 is mainly mediated by protein kinase Calpha in C6 glioma cells., Neurochemical International, 53, 248-254, 20081201
  74. Spinal anti-allodynia action of glycine transporter inhibitors in neuropathic pain models in mice., J. Pharmacol. Exp. Ther., 326, 633-645, 20080801
  75. Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signaling in spinal cord in mice., Pain, 138, 525-536, 20080901
  76. Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca(2+) rise and migration of human neutrophils., J. Pharmacol. Sci., 106, 492-504, 20080301
  77. P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamates transporter., Glia, 56, 528-538, 20080401
  78. Involvement of Voltage-Gated Sodium Channel Na(v)1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons, J. Pharmacol. Sci., 108(2), 190-197, 200810
    Link to Paper Search Results by DOI
  79. Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice., Neurochemistry International, IN PRESS, 20071201
  80. Analgesic action of nicotine on tibial nervw transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord., Life. Sci., 80, 9-16, 20061001
  81. Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with localanesthetics., Brain Res., 1096, 97-103, 20061001
  82. Transport of dopamine and levodopa and their interaction in COS-7 cells heterologously expressing monoamine neurotransmitter transporters and in monoaminergic cell lines PC12 and SK-N-SH, Life Sciences, 76(1), 1603-1612, 20050101
  83. Non-steroidal anti-inflammatory drugs potentiate 1-methyl-4-phenylpyridinium (MPP+)-induced cell death by promoting the intracellular accumulation of MPP+ in PC12 cells, The Journal of Pharmacology and Experimental Therapeutics, 310(2), 800-807, 20040801
  84. Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice, Pain, 111(3), 351-359, 20041001
  85. Cannabis use disorder and treatment of dependence, 68(8), 1475, 20100801
  86. Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice, 130(6), 458-463, 20071201

Publications such as books

  1. 2018/01, Nicotinic Acetylcholine Receptor Signaling in Neuroprotection, Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection, Springer, 2018, 01, Scholarly Book, Joint work, English, Morioka N, Hisaoka-Nakashima K, Nakata Y., 978-981-10-8487-4
  2. 2000/03, Neural-immune interactions in dorsal root ganglia , Folia Pharmacol. Jpn, 2000, 03, Scholarly Book, Cocompilation

Invited Lecture, Oral Presentation, Poster Presentation

  1. Preventive effect of anti-HMGB1 nAb on the onset of distal infraorbital nerve chronic constriction neuropathy in female mice., Ma S, Nakamura Y, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N, Society for Neuroscience Annual Meeting 2023, 2023/11/11, Without Invitation, English
  2. The possibility of HMGB1 as a therapeutic target for neuropathic pain., Nakamura Y, Nakashima K, Morioka N, 9th International DAMPs and Alarmins Symposium, 2019/11, With Invitation, English
  3. Perineural treatment with anti-HMGB1 antibody alleviates trigeminal neuropathy in mouse with chronic constriction injury of distal infraorbital nerve., Kochi T, Nakamura Y, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N, 9th International DAMPs and Alarmins Symposium, 2019/11, Without Invitation, English
  4. Peripheral inflammation induced cognitive impairment is attenuated by the regulation of activated glial cells and histone deacetylase., Takada N, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10, Without Invitation, English
  5. Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia., Kodama K, Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10, Without Invitation, English
  6. Systemic inflammation-induced memory dysfunction is prevented by blockade either microglia activation or histone deacetylase., Takada N, Nakamura Y, Nakashima K, Morioka N, 6th Congress of AsCNP, 2019/10, Without Invitation, English
  7. Downregulation of spinal astrocytic connexin43 leads to mechanical hypersensitivity through upregulation of interleukin-6 and cyclooxygenase-2 in mice, Morioka N., Kondo S., Nakamura Y., Hisaoka-Nakashima K., Nakata Y, WCP2018, 2018/07, Without Invitation, English, Kyoto, Japan
  8. The analysis of anxiety- and depression-related behaviors in neuropathic pain of mice - possible involvement of brain inflammation, Hisaoka-Nakashima K., Tomimura Y., Yoshii T., Zhang F.F., Nakamura Y., Liu K., Nishibori M., Nakata Y., Morioka N., WCP2018, 2018/07, Without Invitation, English, Kyoto, Japan
  9. Downregulation of astocytic connexin43 leads to enhancement of neurotrophic factor production in cortical astrocytes, Kondo S., Hisaoka-Nakashima K., Nakata Y., Morioka N., WCP2018, 2018/07, Without Invitation, English, Kyoto, Japan
  10. The analysis of depression-related behaviors in neuropathic pain of mice―possible involvement of brain microglia, Tomimura Y., Nakashima K., Yoshii Y., Zhang F.F., Nakata Y., Morioka N., 2017/03, Without Invitation, Japanese
  11. Mechanism for the high mobility group box-1-induced mechanical hypersensitivity in spinal dorsal horn of mice, Miyauchi K., Zhang F.F., Nakashima K., Nakata Y., Morioka N., 2017/03, Without Invitation, Japanese
  12. A role of spinal astrocytic connexin43 in maintenance of neuropathic pain., 2016/03, Without Invitation, Japanese
  13. Involvement of the striatal substance P nervous system in regulation of nociceptive transmission., 2016/03, Without Invitation, Japanese
  14. The downregulation of connexin43 expression in spinal astrocytes contributes to the maintenance of neuropathic pain, 2015/03/28, Without Invitation, Japanese
  15. Induction of neuropathic pain in mice by clock gene Per1, 2015/03/20, Without Invitation, Japanese
  16. Role of HMGB1 in neuropathic pain and anti-HMGB1 therapy for neuropathic pain, Norimitsu MORIOKA, Yoshihiro NAKATA, The 88th Annual Meeting of The Japanese Pharmacological Society, 2015/03/18, Without Invitation, English
  17. Tricyclic antidepressant amitriptyline acts on astrocytes leading to the increase in the FGF2 expression: A role of early growth response 1 signaling., Kajitani N, Hisaoka-Nakashima K, Okada-Tsuchioka M, Hosoi M, Shibasaki C, Morioka N, Nakata Y, Takebayashi M., Neuroscience 2014, 2014/11/17, Without Invitation, English
  18. The role of clock gene Per1 in the regulation of nociceptive transduction in spinal astrocytes, 2014/03/28, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  2. 2016
  3. 2016, 2018
  4. KAKENHI, 2015, 2018
  5. KAKENHI, 2014, 2016
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  6. KAKENHI, The role of astroglial gap juncton in the regulation of chronic pain, 2012, 2013
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  7. 2011
  8. 2011
  9. KAKENHI, A crosstalk between sensory neurons and surrounding cells, 2009, 2011
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  10. 2009
  11. KAKENHI, The modulation of pain transduction mechanism through circadian clock, 2007, 2008
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  12. KAKENHI, Role of glycine signal in the mechanism of neuropathic pain and development using siRNA for medicament., 2007, 2008
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  13. KAKENHI, 2006, 2008
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  14. KAKENHI, Evidence of a role for cyclic ADP-ribose in pain transduction in spinal cord, 2006, 2007
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  15. KAKENHI, 2005, 2006
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  16. KAKENHI, 2004, 2006
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  17. 2004
  18. KAKENHI, 2003, 2004
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  19. KAKENHI, The role of Platelet-Activating Factor (PAF) on the mechanisms of development of neuropathic pain. And its regulation, 2003, 2005
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  20. KAKENHI, Evidence of a role for cyclic ADP-ribose in calcium signaling and migration in human neutrophils, 2003, 2004
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