TAKAO HAMAMOTO

Last Updated :2026/08/05

Affiliations, Positions
Hiroshima University Hospital, Associate Professor/Lecturer
E-mail
takao0320hiroshima-u.ac.jp
Self-introduction
I belong to department of oto-rhino-laryngology, head and neck surgery, Hiroshima university hospital. My major part is treatment of head and neck cancer.

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Otorhinolaryngology

Research Keywords

  • head and neck cancer, swallowing function study

Affiliated Academic Societies

  • The Oto-Rhino-Laryngological Society of Japan, Japan society for head and neck surgery, Japan society for head and neck cancer, The Japan broncho-esophagological society, The society of practical otolaryngology

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2026, Undergraduate Education, 2Term, Otorhinology
  3. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  4. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  5. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery
  6. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery

Research Activities

Academic Papers

  1. Machine learning-based analysis of the relationship between brain lesion sites and swallowing and cognitive functions in stroke patients, Sci Rep., 202605
  2. Rebuilding the Mucociliary Apparatus in ECRS: TSLP/IL-33 Signaling Synergy and the Residual Molecular Scar of DNASE1L3 Following IL-4/13 Blockade, Cells, 202605
  3. Nasal nitric oxide is inversely associated with radiologic severity and eosinophilic inflammation in chronic rhinosinusitis, Auris Nasus Laynx, 202606
  4. Comparison of Transoral Robotic Surgery and Endoscopic Laryngopharyngeal Surgery for Hypopharyngeal and Supraglottic Laryngeal Cancers, DEN Open, 202507
  5. Association between geriatric 8 (G8) scores and self-care decline in elderly patients with head and neck squamous cell carcinoma undergoing radiotherapy, Support Care Cancer, 202509
  6. Impact of hearing impairment in unilateral hearing loss: A multicenter study of standardized sound localization tests in Japan, Auris Nasus Laynx, 202501
  7. Corrigendum to "Impact of hearing impairment in unilateral hearing loss: A multicenter study of standardized sound localization tests in Japan.", Auris Nasus Laynx, 202501
  8. Outcomes of Near-Infrared Photoimmunotherapy for Head and Neck Cancer: A Single-Center Retrospective Study, 18(3), 20260123
    Link to Paper Search Results by DOI
  9. Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma, Otolaryngol Head Neck Surg, 22, 202601
    Link to Paper Search Results by DOI
  10. Factors Influencing Oral Intake Restoration at Discharge in Patients Undergoing Fasting During Acute Care Hospitalization, Journal of Oral Rehabilitation, 20251121
  11. Evaluation of real-time pharmacokinetics using fluorescence imaging system in Near-infrared photoimmunotherapy for head and neck cancer., Auris Nasus Larynx, 2025
  12. Seven cases of total laryngo-glossectomy combined with mandibulectomy: A retrospective case series from a single institution., Auris Nasus Larynx, 2025
  13. Treatment outcomes and failure patterns in postoperative radiotherapy for major salivary gland carcinoma., Jpn J Clin Oncol., 2025
    Link to Paper Search Results by DOI
  14. Efficacy of Vascular Ligation for the Prevention of Intra- and Postoperative Bleeding in Transoral Robotic Surgery for Oropharyngeal Cancer., Cancers, 2025
  15. Minimally Invasive Cutting and Suture Technique for the Management of Caudal Septal Deviation, 2025
    Link to Paper Search Results by DOI
  16. Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial, J Pers Med., 2023
  17. Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan, Laryngoscope investigative otolaryngology, 2022
  18. Association Between Subjective Voice Assessment and Psychological Distress After Thyroidectomy, Journal of Perianesthesia nursing, 2022
  19. Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma, SCIENTIFIC REPORTS, 2022
  20. Effectiveness of Expanded Instantaneous Input Dynamic Range Adjustment on Speech Perception, 2022
  21. Deep Association between Transglutaminase 1 and Tissue Eosinophil Infiltration Leading to Nasal Polyp Formation and/or Maintenance with Fibrin Polymerization in Chronic Rhinosinusitis with Nasal Polyps, 2022
  22. Determining Invasion Depth in Superficial Pharyngeal Carcinoma by Transoral Ultrasonography, LARYNGOSCOPE, 2022
  23. Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis, 2022
  24. Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era, ATMOSPHERE, 2022
  25. Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis, AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2022
  26. Examination of micro-superficial lesions of up to 5 mm in size in the pharyngeal region, J Laryngol Oto, 202208
  27. Swallowing function after transoral surgery for laryngopharyngeal cancer, PLoS One, 2022
  28. Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma, Sci Rep, 202206
  29. Distinct Gene Set Enrichment Profiles in Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Bulk RNA Barcoding and Sequencing, Int J Mol Sci., 202205
  30. A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor, Acta Med Okayama, 202204
  31. ★, Severe multiple simultaneous immune-related adverse events in a patient with head and neck cancer, Auris Nasus Larynx, 202202
  32. Association between subjective voice Assessment and psychological distress after thyroidectomy, Journal of perianesthesia nursing, 202202
  33. Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan, LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY, 7(1), 259-265, 202202
    Link to Paper Search Results by DOI
  34. Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis, EUROPEAN JOURNAL OF INFLAMMATION, 20, 20220101
    Link to Paper Search Results by DOI
  35. Differential expression of angiotensin-converting enzyme-2 in human paranasal sinus mucosa in patients with chronic rhinosinusitis, JOURNAL OF LARYNGOLOGY AND OTOLOGY, 135(9), 773-778, 202109
    Link to Paper Search Results by DOI
  36. The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 202107
    Link to Paper Search Results by DOI
  37. Baseline Neutrophil-to-Lymphocyte Ratio and Glasgow Prognostic Score are Associated with Clinical Outcome in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Treated with Nivolumab, ACTA MEDICA OKAYAMA, 75(3), 335-343, 202106
  38. Identification of a Novel Copy Number Variation of EYA4 Causing Autosomal Dominant Non-syndromic Hearing Loss, OTOLOGY & NEUROTOLOGY, 42(7), E866-E874, 202108
    Link to Paper Search Results by DOI
  39. ★, A long survival patient of anaplastic thyroid carcinoma treated with lenvatinib, Auris Nasus Larynx, 2020
  40. A Case Report of Bulky Venous Malformation in the Parapharyngeal Space, International Journal of Practical Otolaryngology, 2020
  41. Lacrimal Gland Adenocarcinoma with Apocrine Metaplasia: A Case Report, Journal of Head and Neck Surgery, 2019
  42. A Single Institution's Experience of Definitive Radiotherapy Using Volumetric-modulated Arc Therapy for Hypopharyngeal Cancers, ANTICANCER RESEARCH, 40(7), 4183-4190, 202007
    Link to Paper Search Results by DOI
  43. Increased Tissue Expression of Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Is Associated with Disease Severity in Chronic Rhinosinusitis with Nasal Polyps, DIAGNOSTICS, 10(4), 202004
    Link to Paper Search Results by DOI
  44. Extra-axial chordoma of the gingiva, AURIS NASUS LARYNX, 47(2), 299-304, 202004
    Link to Paper Search Results by DOI
  45. Baseline neutrophil-to-lymphocyte ratio (NLR) is associated with clinical outcome in recurrent or metastatic head and neck cancer patients treated with nivolumab, Acta Oto-Laryngologica, 2019
  46. ★, Evaluation of role of prophylactic swallowing rehabilitation in chemoradiotherapy for advanced head and neck cancer using novel software analysis of videofluorography images, Hirosihma Journal of Medical Sciences, 68(2.3), 27-34, 2019
  47. Ganglioneuroma in the neck region: a case report, Hiroshima Journal of Medical Sciences, 68(2.3), 49-53, 2019
  48. Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report, AURIS NASUS LARYNX, 46(5), 813-817, 201910
    Link to Paper Search Results by DOI
  49. Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids in allergic rhinitis: A prospective study, AURIS NASUS LARYNX, 46(4), 507-512, 201908
    Link to Paper Search Results by DOI
  50. Low-dose dexamethasone with fosaprepitant and palonosetron to prevent cisplatin-induced nausea and vomiting in head and neck cancer patients, ACTA OTO-LARYNGOLOGICA, 138(10), 921-925, 2018
    Link to Paper Search Results by DOI
  51. Management of Intractable Nasal Hyperreactivity by Selective Resection of Posterior Nasal Nerve Branches, Int J Otolaryngol
  52. Extraskeletal osteosarcoma in the parotid gland: A case report, Auris Nasus Larynx, 45(3), 644-647, 2018
  53. ★, Nine cases of carcinoma with neuroendocrine features in the head and neck: clinicopathological characteristics and clinical outcomes, Jpn J Clin Oncol,, 45(4), 328-335, 2015
  54. Age-dependent changes in the expression of klotho protein, TPRV5 and TRPV6 in mouse inner ear., Acta Otolaryngol, 129(12), 1340-1350, 2009
  55. Expression of transient receptor potential vanilloid (TRPV) families 1, 2, 3 and 4 in the mouse olfactory epithelium., Rhinology, 47(3), 242-247, 2009
  56. Expression of transient receptor potential channel melastin (TRPM) 1-8 and TRPA1 (ankyrin) in mouse inner ear., Acta Otoralyngol, 129(10), 1050-1060, 2009
  57. ★, Localization of transient receptor potential vanilloid in the human larynx., Acta Otoralyngol, 129(5), 560-568, 2009
  58. ★, Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx, Acta Otolaryngol, 128(6), 685-693, 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Safety Study of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Undergoing Chemoradiotherapy, 2023/01/18, Without Invitation, English, published
  2. Localization of transient receptor potential channel vanilloid subfamilies in the larynx., Hamamoto T, Takumida M, Hirakawa K, et al, 2008, Without Invitation, English
  3. Nine cases of carcinoma with neuroendocrine features in the head and neck, Hamamoto. T, Hayashi R, Fujii S, et al, 2th Congress of Asian Society of Head and Neck Oncology, 2013, Without Invitation, Japanese
  4. Clinical Study of Parotid Cancer, Hamamoto. T, Hirakawa K, Takeno S, et al., 4th Congress of Asian Society of Head and Neck Oncology, 2015, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2023, 2025
  2. 2022/04/01, 2025/03/31
  3. 2019/04/01, 2023/03/31
  4. 2009
  5. 2006
  6. 2016, 2018

Social Activities

History as Peer Reviews of Academic Papers

  1. 2021, American Journal of Case Reports, Others
  2. 2020, Current Oncology, Others, 1
  3. 2020, JCM, Others
  4. 2020, Archives of Otolaryngology and Rhinology, Others
  5. 2017, SAGE Open Medical Case Reports, Others
  6. 2019, BMJ Case Reports, Others