Sachio Takeno

Last Updated :2025/03/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
http://home.hiroshima-u.ac.jp/jibika/
E-mail
takenohiroshima-u.ac.jp
Self-introduction
Professional Experience: experiences dedicated in endoscopic sinus surgery and middle ear surgery experiences dedicated in surgical management for severe allergic rhinitis research activities in the area of functional roles of nitric oxide in human nose and paranasal sinuses research activities in the area of pathological mechanisms and clinical features of eosinophilic chronic rhinosinusitis research activities in analysis and treatment strategies for refractory middle ear infection and cholesteatoma

Basic Information

Major Professional Backgrounds

  • 2005/04/01, 2018/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
  • 1996/04/01, Teikyo University, Research Associate
  • 2004/01/01, 2005/03/31, Hiroshima University, Hospital, Lecturer
  • 2018/04/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Kyoto University, Faculty of Medicine, Japan, 1981/04, 1987/03
  • Hiroshima University, Graduate School, Division of Medical Sciences, Otolaryngology, Head and Neck Surgery, Japan, 1987/04, 1991/03
  • University of Toronto, Research Fellowship, Department of Otolaryngology, Canada, 1992/07, 1994/06

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Otorhinolaryngology

Research Keywords

  • ototoxicity
  • cochlea
  • auditory function
  • middle ear surgery
  • nose and paranasal sinuses
  • nitric oxide
  • nasal allergy
  • allergy and inflammation in the upper airway
  • endoscopic sinus surgery

Affiliated Academic Societies

  • The Oto-Rhino-Laryngological Society of Japan
    Related URL
  • Japanese Society of Allergology
  • Association for Research in Otolaryngology
    Related URL
  • Japanese Rhinologic Society
  • Japan Otological Society
  • Japan Society for Head And Neck Surgery
  • American Rhinological Society

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2024, Undergraduate Education, Intensive, Practice for medical research
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2024, Undergraduate Education, 2Term, Otorhinology
  6. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  7. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  8. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery
  9. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery

Research Activities

Academic Papers

  1. Comparative analyses of short- and long-term outcomes between endoscopic submucosal dissection and endoscopic laryngo-pharyngeal surgery for superficial pharyngeal carcinomas., DEN Open, 5(1), e70003, 20240901
  2. Impaired Coordination of the Ciliary Movement in Patients with Chronic Rhinosinusitis with Nasal Polyps: The Role of Decreased Planar Cell Polarity Protein Expression. Immuno., Immuno, 4(3), 247-265, 20241001
  3. Practical guide for the diagnosis and management of primary ciliary dyskinesia., Auris Nasus Larynx, 20240326
  4. Swallowing Exercise Evaluated Using High-Density Surface Electromyography in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial., Medicina (Kaunas), 20231204
  5. Artificial intelligence-based diagnosis of the depth of laryngopharyngeal cancer, Auris Nasus Larynx, 20231012
  6. Exhaled Nitric Oxide and Olfactory Dysfunction in Patients with Asthma: Association with Chronic Rhinosinusitis., Medicina (Kaunas), 20231005
  7. An Evaluation of the Caudal End Deviation of the Nasal Septum Using the Quantita-tive Analysis of Computed Tomog-raphy, Surg. Tech. Dev., 2023
  8. Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy., J Pers Med, 20230712
  9. Effectiveness of nivolumab affected by prior cetuximab use and neck dissection in Japanese patients with recurrent or metastatic head and neck cancer: results from a retrospective observational study in a real-world setting., Int J Clin Oncol., 20210401
  10. Exhaled Nitric Oxide and Olfactory Dysfunction in Patients with Asthma: Association with Chronic Rhinosinusitis, Medicina (Kaunas), 59(10):1776, 20231005
  11. An Evaluation of the Caudal End Deviation of the Nasal Septum Using the Quantita-tive Analysis of Computed Tomography., Surg. Tech. Dev, 12, 3, 145-155, 2023
  12. Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy., J Pers Med, 13(7):1129, 20230712
  13. Severe multiple simultaneous immune-related adverse events in a patient with head and neck cancer., Auris Nasus Larynx., 50, 309-313, 20230401
    Link to Paper Search Results by DOI
  14. Consensus guidance of nebulizer therapy for acute rhinosinusitis., Auris Nasus Larynx, 47, 20200201
  15. ★, Functional Alteration and Differential Expression of the Bitter Taste Receptor T2R38 in Human Paranasal Sinus in Patients with Chronic Rhinosinusitis., Int J Mol Sci., 20230224
  16. Effectiveness of Expanded Instantaneous Input Dynamic Range Adjustment on Speech Perception., J Pers Med, 20221107
    Link to Paper Search Results by DOI
  17. Effectiveness of Expanded Instantaneous Input Dynamic Range Adjustment on Speech Perception. J Pers Med. 2022 Nov 7;12(11):1860., J Pers Med, 20221107
  18. Effectiveness of Expanded Instantaneous Input Dynamic Range Adjustment on Speech Perception, J Pers Med, 12(11), 1860, 20221107
    Link to Paper Search Results by DOI
  19. Prevalence of immune-related adverse events and anti-tumor efficacy following immune checkpoint inhibitor therapy in Japanese patients with various solid tumors., BMC Cancer, 22, 20221129
  20. Determining Invasion Depth in Superficial Pharyngeal Carcinoma by Transoral Ultrasonography., Laryngoscope, 20221128
  21. Deep Association between Transglutaminase 1 and Tissue Eosinophil Infiltration Leading to Nasal Polyp Formation and/or Maintenance with Fibrin Polymerization in Chronic Rhinosinusitis with Nasal Polyps., Int J Mol Sci, 23, 12955, 20221026
  22. A multicenter study to investigate the positive rate of SARS-CoV-2 in middle ear and mastoid specimens from otologic surgery patients., Auris Nasus Larynx, 20220729
  23. ★, Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era., Atmosphere, 13, 1000, 20220601
  24. A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor., Acta Med Okayama, 76(2), 229-233, 20220401
  25. Examination of micro-superficial lesions of up to 5 mm in size in the pharyngeal region, J Laryngol Otol., 20220802
  26. Swallowing function after transoral surgery for laryngopharyngeal cancer., PLoS One, 17(6), 20220624
  27. Peritonsillar abscesses in infants requiring intratracheal intubation: Two case reports, Otolaryngology Case Reports, 24, 100454, 20220401
  28. Distinct Gene Set Enrichment Profiles in Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Bulk RNA Barcoding and Sequencing, Int J Mol Sci, 23(10), 5653, 20220518
  29. Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma., Sci Rep, 12(1), 9316, 20220604
  30. ★, Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis. European Journal of Inflammation., European Journal of Inflammation, 20220101
    Link to Paper Search Results by DOI
  31. Development of a radiomics and machine learning model for predicting occult cervical lymph node metastasis in patients with tongue cancer., Oral Surg Oral Med Oral Pathol Oral Radiol, 20211225
  32. Severe multiple simultaneous immune-related adverse events in a patient with head and neck cancer., Auris Nasus Larynx., 20220215
  33. Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis, Am J Rhinol Allergy, 20220106
    Link to Paper Search Results by DOI
  34. Association between subjective voice Assessment and psychological distress after thyroidectomy., J Perianesth Nurs, S1089-9472(21), 401-409, 20220206
  35. Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan., Laryngoscope Investig Otolaryngol, 7(1), 259-265, 20211211
  36. Maxillary sinus hypolasia -Embryology and radiology-, Archives of Otolaryngology= Head and Neck Surgery, 1353-1357, 19930401
  37. Carboplatin ototoxicity : an animal model., J Laryngol Otol, 585-589, 19930401
  38. Developmental plasticity of central auditory pathways : frequency representation after neonatal high frequency hearing loss., Canadian Acoustics, 129-130, 19930401
  39. Tissue culture of middle ear epithelium using fibroblast-reorganized collagen gels, J Otolaryngol, 380-384, 19930401
  40. ★, Cochlear function after selective inner hair cell degeneration inducecl by carboplatin., Hearing Research., 75, 93-102, 19940401
  41. Carboplatin ototoxicity in the chinchilla : Lesions of the vestibular sensorg epithelium., Acta Otolaryngol. (Stodh)., Suppl(519), 60-65, 19950401
  42. Induction of selective inner hair cell damage by carboplatin, Scanning Microscopy., 8, 97-106, 19940401
  43. Otoucoustieemission amplication after inner inner hair cell damage., Acta Otolaryngol. (Stodh)., 116, 374-381, 19960401
  44. Expression of Proliferating cell nuchear antigen in cultured middle ear epithelal cells of the guinea pig., Wound Rep Reg, 4, 115-120, 19960401
  45. Recording from the inferior colliculus following cochlear inner hair cell damage, Acta Otolaryngol (Stockh), 116, 714-720, 19960401
  46. Degeneration of spiral ganalion cells in the chinchilla after inner hair cell loss induced carboplatin, Audiology Neuro-Otolology, 3(5), 281-290, 19980401
  47. Transantral ligation of the maxillary artery for refractory epistaxis., Hiroshima J. Med. Sci., 40, 109-113, 1991
  48. Experimental evidence of selective axonal regeneration in allogenic and isogenic Y-chambers., Experimental Neurology, 115, 260-265, 1992
  49. Developmental plasticity of central auditory pathways: frequency representation after neonatal high frequency hearing loss., Canadian Acoustics, 21, 129-130, 1993
  50. The uncinate process. -A histological and morphological study-., Laryngoscope, 104, 364-369, 1994
  51. The early development of sino-nasal mucosa., Laryngoscope, 104, 850-855, 1994
  52. Selective inner hair cell ototoxicity induced by carboplatin., Laryngoscope, 104, 488-493, 1994
  53. The neonatal chinchilla cochlea: morphological and functional study., Scanning Microscopy., 10, 889-894, 1996
  54. Localization of nitric oxide synthase in human nasal mucosa with nasal allergy., Acta Otolaryngol (Stockh), Suppl(539), 65-70, 1998
  55. Increased expression of inducible nitric oxide synthase (iNOS) in nasal epithelial cells in patients with allergic rhinitis., Rhinology Suppl, 15, 76-78, 1999
  56. Histamine augments ciliary beat frequency and cell membrane recycling processes in cultured human nasal ethmoidal cells., Rhinology Suppl, 15, 126-127, 1999
  57. ★, Increased expression of inducible nitric oxide synthase in nasal epithelial cells in patients with allergic rhinitis., Laryngoscope, 109, 2015-2020, 1999
  58. Modulation of Ciliary Activity by Tumor Necrosis Factor-alpha in Cultured Sinus Epithelial Cells. Possible Roles of Nitric Oxide., Hiroshima J. Med. Sci., 49, 49-55, 2000
  59. ★, Analysis of local cytokine gene expression in patients with allergic rhinitis treated with carbon dioxide laser surgery., Laryngoscope, 110, 1168-1174, 2000
  60. Functional Role of Nitric Oxide in the Nasal Mucosa of the Guinea Pig after Instillation with Lipopolysaccharide, Acta Otolaryngol, 121, 510-516, 20010401
  61. Nuclear Factor-Kappa B Activation in the Nasal Polyp Epithelium:Relationship to Local Cytokine Gene Expression, Laryngoscope, 112, 53-58, 20020401
  62. Human osteoclast maturation from bone marrow cells co-cultured with osteoblast from ethmoid sinus, Rhinology, 41, 49-53, 20030401
  63. Establishment of osteoblast culture from human ethmoidal sinus, Auris Nasus Larynx, 30, 45-51, 20030401
  64. Suppression of the Th2 Pathway by Suplatast Tosilate in Patients with Perennial Nasal Allergies, American Journal of Rhinology, 16, 329-336, 20020401
  65. Expression and localization of nuclear factor-kappa B subunits in cultured human paranasal sinus mucosal cells, Rhinology, 41, 80-86, 20030401
  66. Laser Surgery of the Inferior Turbinate for Allergic Rhinitis with Seasonal Exacerbation:an Acoustic Rhinometry Study, Ann Otol Rhinol Laryngol, 112(5), 455-460, 20030501
  67. Leukotriene Receptor Antagonist Pranlukast Suppresses Eosinophil Infiltration and Cytokine Production in Human Nasal Mucosa of Perennial Allergic Rhinitis, Ann Otol Rhinol Laryngol , 112(11), 955-961, 20031101
  68. Comparison of local cytokine gene expression and the distribution of eosinophils and CD4-positive cell subsets in the paranasal sinus mucosa between atopic and non-atopic subjects, Allergology International, 53, 135-144, 20040401
  69. Changes in voice-onset time due to auditory feedback through a cochlear implant in the post-lingually deaf., International Proceedings of the 5th Asia Pacific Symposium on Cochlear Implant and Related Sciences, 111-115, 20051128
  70. Bone constructing cells from ethmoid bone may have multilineage differentiation potential ? Preliminary report ?, Acta Otolaryngologica, Suppl(553), 1-4, 20040503
  71. Surgical treatment of the inferior turbinate for allergic rhinitis: clinical evaluation and therapeutic mechanisms of the different techniques., Clinical and Experimental Allergy Reviews, 9, 80-85, 2009., 9, 18-23, 20090401
  72. ★, Increased nitric oxide production in nasal epithelial cells from allergic patients - RT-PCR analysis and direct imaging by a fluorescence indicator: DAF-2 DA., Clin Exp Allergy , 31, 881-888, 20010401
  73. Study of eosinophil activation in nasal mucosa in patients with perennial nasal allergy: Effects of CO2 laser surgery, American Journal of Rhinology, 16(1), 1-6, 2002
    Link to Paper Search Results by DOI
  74. Bone-constructing cells from ethmoid bone may have multilineage differentiation potential: Preliminary report, ACTA OTO-LARYNGOLOGICA, 124, 105-108, 200408
    Link to Paper Search Results by DOI
  75. Cytokine profile in paranasal effusions in patients with chronic sinusitis using the YAMIK sinus catheter with and without betamethasone, EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 262(1), 50-54, 200501
    Link to Paper Search Results by DOI
  76. Submucous turbinectomy combined with posterior nasal neurectomy in the management of severe allergic rhinitis: Clinical outcomes and local cytokine changes, AURIS NASUS LARYNX, 34(3), 319-326, 200709
    Link to Paper Search Results by DOI
  77. Vitamin D3, vitamin K2, and warfarin regulate bone metabolism in human paranasal sinus bones, RHINOLOGY, 45(3), 208-213, 200709
    Link to Paper Search Results by DOI
  78. Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx, ACTA OTO-LARYNGOLOGICA, 128(6), 685-693, 2008
    Link to Paper Search Results by DOI
  79. Bilateral allergic fungal rhinosinusitis caused by Schizophillum commune and Aspergillus niger. A case report, RHINOLOGY, 47(2), 217-221, 20090701
    Link to Paper Search Results by DOI
  80. Glucocorticoids suppress NF-kappa B activation induced by LPS and PGN in paranasal sinus epithelial cells, RHINOLOGY, 47(4), 413-418, 200912
    Link to Paper Search Results by DOI
  81. Expression and distribution of glucocorticoid receptor isoforms in eosinophilic chronic rhinosinusitis, AURIS NASUS LARYNX, 37(6), 700-707, 201012
    Link to Paper Search Results by DOI
  82. ★, Measurements of Nasal Fractional Exhaled Nitric Oxide with a Hand-held Device in Patients with Allergic Rhinitis: Relation to Cedar Pollen Dispersion and Laser Surgery, ALLERGOLOGY INTERNATIONAL, 61(1), 93-100, 201203
    Link to Paper Search Results by DOI
  83. ★, Monitoring of oral and nasal exhaled nitric oxide in eosinophilic chronic rhinosinusitis: A prospective study, AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 26(4), 255-259, 2012
    Link to Paper Search Results by DOI
  84. Expression of Trefoil factor family peptides in the nasal allergic mucosa, RHINOLOGY, 50(4), 408-416, 201212
    Link to Paper Search Results by DOI
  85. Increased exhaled nitric oxide and its oxidation metabolism in eosinophilic chronic rhinosinusitis, AURIS NASUS LARYNX, 40(5), 458-464, 201310
    Link to Paper Search Results by DOI
  86. Guiding principles of subcutaneous immunotherapy for allergic rhinitis in Japan, AURIS NASUS LARYNX, 41(1), 1-5, 20140201
    Link to Paper Search Results by DOI
  87. ★, Comparison of Nasal Nitric Oxide Levels between the Inferior Turbinate Surface and the Middle Meatus in Patients with Symptomatic Allergic Rhinitis, ALLERGOLOGY INTERNATIONAL, 63(3), 475-483, 20140901
    Link to Paper Search Results by DOI
  88. Frontal recess anatomy in Japanese subjects and its effect on the development of frontal sinusitis: computed tomography analysis, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 44, 20150529
    Link to Paper Search Results by DOI
  89. Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study, ALLERGY, 70(8), 995-1003, 20150801
    Link to Paper Search Results by DOI
  90. Morphological evaluation of pathological changes to ethmoidal bone in chronic sinusitis., Proceeding of Airway Secretion Research, 3, 1-3, 2001
  91. Increased expression of eosinophil-related cytokines is associated with epithelial nuclear factor-kappa B activation in human nasal polyps., Proceeding of Airway Secretion Research, 4, 15-19, 2002
  92. Establishment of osteoblast-like cell culture of human ethmoidal sinus., Proceeding of Airway Secretion Research, 3, 5-6, 2001
  93. The influence of eosinophil infiltration on the ciliary beat freaquency (CBF) of human sinus epithelial cells., Proceeding of Airway Secretion Research, 4, 1-5, 2002
  94. Expression of TGF-b and IL-1b on the cell derived from sinus hard tissue by LPS stimulation., Proceeding of Airway Secretion Research, 5, 25-25, 2003
  95. Human cultured cells constructing paranasal sinuses may have a multilineage differentiation potential., Proceeding of Airway Secretion Research, 6, 33-38, 2004
  96. Analysis of syndecan-1 and TGF-beta expression in the nasal mucosa and nasal polyps., Auris Nasus Larynx, 37, 427-435, 2010
  97. Expression of RANKL and proliferation abilities of cultured human middle ear cholesteatoma epithelial cells., Hiroshima J Med Sci, 62, 1-6, 2013
  98. Nitric oxide is a possible reliable marker for evaluation of nasal allergy and chronic sinusitis., Proceeding of Airway Secretion Research, 14, 25-26, 2012
  99. Novel NOG mutation in Japanese patients with stapes ankylosis with broad thumbs and toes., Eur J Med Genet., 20150723
  100. ★, Influence of Pneumococcal Conjugate Vaccine on Acute Otitis Media with Severe Middle Ear Inflammation: A Retrospective Multicenter Study., PLoS One, 20150908
  101. Comparison of arginase isoform expression in patients with different subtypes of chronic rhinosinusitis., J Laryngol Otol, 1-7, 20151021
  102. Guiding principles of sublingual immunotherapy for allergic rhinitis in Japanese patients, AURIS NASUS LARYNX, 43(1), 1-9, 201602
    Link to Paper Search Results by DOI
  103. IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 46, 20170502
    Link to Paper Search Results by DOI
  104. The role of nasal fractional exhaled nitric oxide as an objective parameter independent of nasal airflow resistance in the diagnosis of allergic rhinitis, AURIS NASUS LARYNX, 44(4), 435-441, 201708
    Link to Paper Search Results by DOI
  105. ★, The role of nasal fractional exhaled nitric oxide as an objective parameter independent of nasal airflow resistance in the diagnosis of allergic rhinitis., Auris Nasus Larynx, 44(4), 435-441, 2017
  106. Influence of Pneumococcal Conjugate Vaccine on Otitis Media., Otolaryngology, 6(3), 1-2, 2016
  107. IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients., J Otolaryngol Head Neck Surg, 46(1), 36, 20170502
  108. Extraskeletal osteosarcoma in the parotid gland: A case report., Auris Nasus Larynx, 2017pii: S0385-8146(17)30534-5(Sep. 22), 2017
  109. Pemphigus vulgaris with marked stenosis of the esophageal orifice from an osteoporosis drug: a case study with long-term follow-up., Hiroshima J Med Sci, 66(2), 27-30, 2017
  110. Influence of pneumococcal conjugate vaccines on acute otitis media in Japan., Auris Nasus Larynx, Nov 1. pii: S0385-8146(17)30516-3., 2017
  111. Effects of Cerebral Blood Flow and Vessel Conditions on Speech Recognition in Patients With Postlingual Adult Cochlear Implant: Predictable Factors for the Efficacy of Cochlear Implant., Ear Hear, 2017
  112. ★, Management of Intractable Nasal Hyperreactivity by Selective Resection of Posterior Nasal Nerve Branches., International Journal of Otolaryngology, Article ID 1907862, 2017
  113. Extraskeletal osteosarcoma in the parotid gland: A case report, AURIS NASUS LARYNX, 45(3), 644-647, 201806
    Link to Paper Search Results by DOI
  114. Influence of pneumococcal conjugate vaccines on acute otitis media in Japan, AURIS NASUS LARYNX, 45(4), 718-721, 201808
    Link to Paper Search Results by DOI
  115. Effects of Cerebral Blood Flow and Vessel Conditions on Speech Recognition in Patients With Postlingual Adult Cochlear Implant: Predictable Factors for the Efficacy of Cochlear Implant, EAR AND HEARING, 39(3), 540-547, 2018
    Link to Paper Search Results by DOI
  116. Low-dose dexamethasone with fosaprepitant and palonosetron to prevent cisplatin-induced nausea and vomiting in head and neck cancer patients., Acta Otolaryngol, 20180717
    Link to Paper Search Results by DOI
  117. Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report., Auris Nasus Larynx, 20181112
    Link to Paper Search Results by DOI
  118. ★, Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids in allergic rhinitis: A prospective study., Auris Nasus Larynx, 20181204
    Link to Paper Search Results by DOI
  119. かぜ後の後鼻漏と副鼻腔炎。　特集　今さら聞けない風邪診療のABC。, 耳鼻咽喉科・頭頚部外科, 90, 914-917, 2018
  120. 慢性副鼻腔炎かと思っていたらアレルギー性真菌性副鼻腔炎（AFS）だった。特集　見逃してはならない耳鼻咽喉科疾患, 耳鼻咽喉科・頭頸部外科, 90(12), 1028-1031, 2018
  121. 好酸球性副鼻腔炎・中耳炎の診断と病態分類, 日耳鼻会報, 121, 1152-1159, 2018
  122. 胃酸逆流と副鼻腔炎。, 耳鼻臨床, 111(11), 727-737, 2018
  123. Nishida M, Taruya T, Kono T, Hamamoto T, Ishino T, Ueda T and Takeno S. Lacrimal Gland Adenocarcinoma with Apocrine Metaplasia: A Case Report., Journal of Head and Neck Surgery, 2, 9-12, 2019
  124. A genetic variant near TSLP is associated with chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease in Japanese populations., Allergol Int., 2019
  125. Consensus guidance of nebulizer therapy for acute rhinosinusitis., Auris Nasus Larynx, 47, 18-24, 2020
  126. Evaluation of Role of Prophylactic Swallowing Rehabilitation in Chemoradiotherapy for Advanced Head and Neck Cancer Using Novel Software Analysis of Videofluorography Images., Hiroshima Journal of Medical Sciences, 68, 27-34, 2019
  127. Ganglioneuroma in The Neck Region: A Case Report., Hiroshima Journal of Medical Sciences, 68, 49-53, 2019
  128. Single Institution's Experience of Definitive Radiotherapy Using Volumetric-modulated Arc Therapy for Hypopharyngeal Cancers., Anticancer Res, 40(7), 4183-4190, 2020
  129. Long-term outcomes of induction chemotherapy followed by chemoradiotherapy using volumetric-modulated arc therapy as an organ preservation approach in patients with stage IVA-B oropharyngeal or hypopharyngeal cancers., J Radiat Res, 61(4), 554-562, 2020
  130. A Case Report of Bulky Venous Malformation in the Parapharyngeal Space., International Journal of Practical Otolaryngology, 3, e10-e15, 2020
  131. Extensive solitary fibrous tumor centered on the temporal bone: A case report, Otolaryngology Case Reports
  132. The Effect of Dupilumab on Intractable Chronic Rhinosinusitis with Nasal Polyps in Japan., Laryngoscope, 20201123
  133. Extra-axial chordoma of the gingiva., Auris Nasus Larynx, 47(2), 299-304, 2020
  134. A long survival patient of anaplastic thyroid carcinoma treated with lenvatinib, Auris Nasus Larynx., 2020
  135. Vocal cord dysfunction detected by a three-dimensional image of dynamic change in respiratory resistance in a patient with difficult-to-treat asthma: A case report., J Asthma, 2021
  136. ★, Differential expression of angiotensin-converting enzyme-2 in human paranasal sinus mucosa in patients with chronic rhinosinusitis., J Laryngol Otol, 2021
  137. Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status., Allergy, 2021
  138. A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis., Am J Rhinol Allergy, Apr 11:19458924211009429, 20210411
  139. Baseline Neutrophil-to-Lymphocyte Ratio and Glasgow Prognostic Score are Associated with Clinical Outcome in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Treated with Nivolumab., Acta Med Okayama, 75(3), 335-343, 20210601
    Link to Paper Search Results by DOI
  140. ★, The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis., Int J Mol Sci, 22(14), 20210715

Publications such as books

  1. 1996, Pocket Atlas of Diseases of the Nose and Paranasal sinuses. Michael Hawke, M.D. , Eisai ENT Network, 1996, Textbook, Joint Translation, 日本語
  2. Regenerative processes of cultured nasal and middle ear epithelia. , Abstracts of the International Symposium on Wound Healing and Tissue Regeneration, Joint work, 英語

Invited Lecture, Oral Presentation, Poster Presentation

  1. Symposium, Impaired Coordination of the Ciliary Movement in Chronic Rhinosinusitis with Nasal Polyps. -Possible roles of nitric oxide to restore the memory of the sinus mucosa -, Takeno S, The 69th Korean Rhinologic Society Annual Congress, 2025/03/08, With Invitation, English
  2. CRS phenotypes in Japanese population and functional roles of nitric oxide for endotype evaluation., Sachio Takeno, 2024 Taiwan Rhinology Society Annual Meeting, 2024/10/06, With Invitation, English
  3. Distinct gene set enrichment profiles in chronic rhinosinusitis with nasal polyps and possible association between PAF stimulation and nasal polyp formation., Takashi Ishino, Yuichiro Horibe, Kota Takemoto, Chie Ishikawa, Manabu Nishida, Takashi Oda, Tomohiro Kawasumi, Kensuke Yamato, Nobuyuki Chikuie, Tsutomu Ueda, Sachio Takeno, EAACI (European Academy of Allergy & Clinical Immunology) Congress 2023, 2023/07/01, Without Invitation, English
  4. Distinct gene set enrichment profiles in chronic rhinosinusitis with nasal polyps and possible association between PAF stimulation and nasal polyp formation., Takashi Ishino, Yuichiro Horibe, Kota Takemoto, Chie Ishikawa, Manabu Nishida, Takashi Oda, Tomohiro Kawasumi, Kensuke Yamato, Nobuyuki Chikuie, Tsutomu Ueda, Sachio Takeno, EAACI (European Academy of Allergy & Clinical Immunology) Congress 2023, 2323/06/01, Without Invitation, English
  5. Utility of plasma circulating tumor DNA in head and neck squamous cell carcinoma, Nobuyuki Chikuie, Tsutomu Ueda, Takao Hamamoto, Takayuki Taruya, Yuuki Satou, Takayoshi Hattori, Sachio Takeno, 2024/05/17, Without Invitation, English
  6. Management of Olfactory Dysfunction., Takeno S, 42nd Congress of the International Society of Inflammation and Allergy of the Nose and 24th Congress of the International Rhinologic Society, 2024/04/04, With Invitation, English, Tokyo
  7. Rhino-Symposium 6 Nasal Septum and Beyond., Takeno S, 19th Korea-Japan Joint Meeting of Otorhinolaryngology - Head and Neck Surgery (KJJM 2024), 2024/03/22, With Invitation, English
  8. The Prevalence of Elevated Exhaled Nitric Oxide and Olfactory Dysfunction associated with CRS comorbidity in Asthma Patients., 19th Korea-Japan Joint Meeting of Otorhinolaryngology - Head and Neck Surgery (KJJM 2024, 2024/03/21, Without Invitation, English
  9. Photoimmunotherapy for recurrent head and neck cancer, short-term effect in 3 cases at our hospital., BACO International 2023 (British Academic Conference in Otorhinolaryngology), 2023/02/15, Without Invitation, English, Burgingham, UK
  10. Endoscopic resection of posterior nasal nerves for severe allergic rhinitis in the COVID-19 era in Japan., BACO International 2023, 2023/02/14, Without Invitation, English, Burgingham, UK
  11. Combination flap technique for choanal atresia., Takashi Ishino*, Daisuke Takahara, Yuichiro Horibe, Kota Takemoto, Manabu Nishida, Takashi Oda, Sachio Takeno, the 20th Asian Research Symposium in Rhinology (ARSR), 2021/09/23, Without Invitation, English, Otsu
  12. Free mucosal grafting of the inferior turbinate facilitates drainage pathways after extended frontal sinus surgeries., Kawasumi T, Ishino T, Takahara D, Nishida M, Horibe Y, Takeno S, 15th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery, 2019/12/06, Without Invitation, English, Hakata
  13. A quantitative radiological analysis of the caudal end deviation treated with hemitransfixion septoplasty in Japan., Nishida M, Hirai T, Fukushima N, Takeno S, 8th Pan Asia Academy of Facial Plastic and Reconstructive Surgery, 2018/08/09, With Invitation, English
    Related URL
  14. Endoscopic resection of posterior nasal nerves for management of severe allergic rhinitis with intractable nasal hyper-reactivity., Takeno S, Takahara D, Ishino T, Wake M, Wake M, BACO International 2018, 2018/07/04, Without Invitation, English, ENT UK, Manchester
    Related URL
  15. 副鼻腔炎に対するprecision medicine。　一酸化窒素（NO）濃度、胃酸逆流の観点からの病態の相違に応じた治療, 石野岳志、竹野幸夫, 第56回日本鼻科学会, 2017/09/29, With Invitation, Japanese, 日本鼻科学会, Kohu
  16. Management of intractable nasal hyper reactivity by selective resection of posterior nasal nerves combined with inferior turbinectomy., Takeno S, Rhinology World Congress – Hong Kong 2017, 2017/09/03, Without Invitation, English, Hong Kong
  17. Nasal nitric oxide measurement in the inferior turbinate can be an objective parameter for monitoring the therapeutic effects of intranasal steroids., Takeno S, The 66th Annual Meeting of Japanese Society of Allergology, 2017/06/16, Without Invitation, English, Tokyo
  18. Clinical effectiveness and therapeutic aspects of posterior nasal neurectomy for the treatment of intractable allergic rhinitis., Takeno S, 16th Asian Research Symposium in Rhinology, 2013/08, Without Invitation, English, Tokyo, Japan,
  19. Educational Lecture "Functional roles of nitric oxide in the inflammatory responses in human nose and paranasal sinuses., Takeno S, Kyung Hee International Rhinologic Symposium (KIRS) 2007 , 2007/11, With Invitation, English, Seoul, Korea
  20. Surgical treatment of the inferior turbinate for allergic rhinitis: clinical evaluation and therapeutic mechanisms of the different techniques., Takeno S, AR Forum 2008, 2008/08, With Invitation, English, Tokyo, Japan,

Awards

  1. 1994, The Best Presentation in the category of Work undertahen by Post-Residency Research Fellows. The Annual Departmental Aca, University of Toronto
  2. 1995, The Best Presentation in the category of Work undertahen by Post-Residency Research Fellows. The Annual Departmental Aca, University of Toronto

External Funds

Acceptance Results of Competitive Funds

  1. 2022, 2024
  2. KAKENHI, 2013, 2015
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  3. KAKENHI, Molecular analysis of pathology of eosinophilic chronic rhinosinusitis and regulatory mechanism of nitric oxide production, 2010, 2012
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  4. KAKENHI, Molecular analysis of effects of gtucocorticoids on eosinophilic rhinosinusitis with reference to regulation of inflammatory transcription factors., 2006, 2007
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  5. KAKENHI, Molecular analysis of persistency of chronic sinus inflammation in relation to allergic diathesis., 2003, 2004
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  6. KAKENHI, Functional analysis of eosinophil infiltration mechanisms in chronic sinusitis in relation to transcription factor activation, 2002, 2003
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  7. KAKENHI, Functional roles of nitric oxide in human nose and paranasal sinuses in relation to regulatory mechanisms by transcription factors, 2001, 2002
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  8. KAKENHI, 1998, 1999
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  9. KAKENHI, 1994, 1994
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  10. 1995, 1995
  11. KAKENHI, 2016, 2018
  12. 2016