KENSUKE SASAKI

Last Updated :2025/04/10

Affiliations, Positions
Hiroshima University Hospital(Department of Blood Purification), Associate Professor or Lecturer
E-mail
kensasakihiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2025/04/01, Hiroshima University Hospital, Associate Professor
  • 2021/04, Vanderbilt University School of Medicine, Adjunct Research Instructor
  • 2018/04, 2020/10, Vanderbit University Medical Center, Postdoctral Research Fellow
  • 2020/11, 2021/03, Vanderbit University Medical Center, Reseach　Instructor
  • 2012/04/01, 2013/03/31, Hiroshima University, Hospital, Clinical Fellow
  • 2014/04/01, 2016/01/31, Hiroshima University, Hospital, Clinical Fellow
  • 2016/02/01, 2017/02/28, Hiroshima University, Hospital, Assistant Professor
  • 2017/03/01, 2018/03/31, Hiroshima University, Hospital, Assistant Professor
  • 2021/04/01, Hiroshima University, Hospital, Assistant Professor

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Kidney internal medicine

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I

Research Activities

Academic Papers

  1. ★, Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis, JCI Insight., 7(4), e150723, 2022
  2. ★, Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation, J Am Soc Nephrol., 32(5), 1037-1052, 2021
  3. ★, Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(1), 203-215, 201601
    Link to Paper Search Results by DOI
  4. Peritoneal dialysis-associated polymicrobial peritonitis with slow onset after root canal treatment: the first case and review of the literature, BMC NEPHROLOGY, 26(1), 20250313
    Link to Paper Search Results by DOI
  5. Peritoneal dialysis-associated peritonitis, caused by superior mesenteric artery thrombosis with intestinal necrosis: a case report, CEN CASE REPORTS, 14(1), 1-5, 202502
    Link to Paper Search Results by DOI
  6. Selective activation of PPARα by pemafibrate mitigates peritoneal inflammation and fibrosis through suppression of NLRP3 inflammasome and modulation of inflammation, SCIENTIFIC REPORTS, 14(1), 20241011
    Link to Paper Search Results by DOI
  7. Impact of immunosuppressive drugs on efficacy of mesenchymal stem cell therapy for suppressing renal fibrosis, STEM CELLS TRANSLATIONAL MEDICINE, 13(11), 1067-1085, 20241014
    Link to Paper Search Results by DOI
  8. Comparison between the 0-and 30-s balloon dilation time in percutaneous transluminal angioplasty for restenosed arteriovenous fistula among hemodialysis patients: a multicenter, prospective, randomized trial (CARP study), CLINICAL AND EXPERIMENTAL NEPHROLOGY, 28(7), 647-655, 202407
    Link to Paper Search Results by DOI
  9. Mesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction, SCIENTIFIC REPORTS, 14(1), 20240504
    Link to Paper Search Results by DOI
  10. Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects, STEM CELL RESEARCH & THERAPY, 14(1), 20231122
    Link to Paper Search Results by DOI
  11. Comparison of the Therapeutic Effects of Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells on Renal Fibrosis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(23), 202312
    Link to Paper Search Results by DOI
  12. Cumulative Dialytic Glucose Exposure is a Risk Factor for Peritoneal Fibrosis and Angiogenesis in Pediatric Patients Undergoing Peritoneal Dialysis Using Neutral-pH Fluids, KIDNEY INTERNATIONAL REPORTS, 7(11), 2431-2445, 202211
    Link to Paper Search Results by DOI
  13. Comparison of therapeutic effects of mesenchymal stem cells derived from superficial and deep subcutaneous adipose tissues, STEM CELL RESEARCH & THERAPY, 14(1), 20230504
    Link to Paper Search Results by DOI
  14. Klotho protects chromosomal DNA from radiation-induced damage, JOURNAL OF BIOCHEMISTRY, 173(5), 375-382, 20230426
    Link to Paper Search Results by DOI
  15. Comparison of survival rates between incident hemodialysis patients and peritoneal dialysis patients: a 5-year prospective cohort study with propensity score matching, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 27(5), 419-426, 202305
    Link to Paper Search Results by DOI
  16. A case report of atypical anti-glomerular basement membrane disease, BMC NEPHROLOGY, 23(1), 20221119
    Link to Paper Search Results by DOI
  17. The hypoxia-inducible factor-alpha prolyl hydroxylase inhibitor FG4592 ameliorates renal fibrosis by inducing the H3K9 demethylase JMJD1A, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 323(5), F539-F552, 202211
    Link to Paper Search Results by DOI
  18. Relationships of hyperchloremia with hypertension and proteinuria in patients with chronic kidney disease, CLINICAL AND EXPERIMENTAL NEPHROLOGY, 26(9), 880-885, 202209
    Link to Paper Search Results by DOI
  19. Upregulation of Mineralocorticoid Receptor Contributes to Development of Salt-Sensitive Hypertension after Ischemia-Reperfusion Injury in Rats, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(14), 202207
    Link to Paper Search Results by DOI
  20. Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury, Kidney Int ., 101(1), 79-91, 2022
  21. Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction, Am J Physiol Renal Physiol ., 320(4), F569-F577, 2021
  22. Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy, Diabetes., 70(2), 562-576, 2021
  23. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 INK4a, Kidney Int ., 96(5), 1162-1175, 2019
  24. Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice, Int J Mol Sci ., 20(19), 4680, 2019
  25. The Role of the EGF Receptor in Sex Differences in Kidney Injury, J Am Soc Nephrol ., 30(9), 1659-1673, 2019
  26. Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice, Diabetol Metab Syndr ., 11, 57, 2019
  27. microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress, PLoS One., 14(6), e0218468, 2019
  28. The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model, Int J Mol Sci ., 19(12), 3967, 2018
  29. TGF-beta promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration, JCI Insight ., 3(21), e123563, 2018
  30. TGF-beta1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA, Sci Rep ., 8(1), 14060, 2018
  31. Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction, PLoS One ., 13(8), e0202409, 2018
  32. Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis, PLoS One ., 13(5), e0196844, 2018
  33. pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock, Clin Exp Nephrol., 22(5), 1167-1173, 2018
  34. Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis, NUTRIENTS, 14(12), 202206
    Link to Paper Search Results by DOI
  35. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89(1), 147-157, 201601
    Link to Paper Search Results by DOI
  36. Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study., Clin Exp Nephrol., 19(4), 631-638, 2015
  37. Linagliptin Ameliorates MethylglyoxalInduced Peritoneal Fibrosis in Mice, PLOS ONE, 11(8), 20160811
    Link to Paper Search Results by DOI
  38. A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-alpha and TGF-beta(1) pathways, SCIENTIFIC REPORTS, 7, 20170515
    Link to Paper Search Results by DOI
  39. Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy, INTESTINAL RESEARCH, 19(4), 430-437, 202110
    Link to Paper Search Results by DOI
  40. Klotho overexpression protects against renal aging along with suppression of transforming growth factor-beta 1 signaling pathways, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 321(6), F799-F811, 202112
    Link to Paper Search Results by DOI
  41. Klotho deficiency intensifies hypoxia-induced expression of IFN-alpha/beta through upregulation of RIG-I in kidneys, PLOS ONE, 16(10), 2021
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Interferon regulatory factor 4 in macrophages promotes renal fibrosis in post-severe acute kidney injury through reducing monocyte/macrophage migration ability., Sasaki K, Wang Y, Zhang MZ, Harris RC., American Society of Nephrology Kidney Week 2019, 2019, Without Invitation, English, ASN, Washington DC (USA)
  2. Inhibitory Effect of the Chromatin Histone H3-lysine 4 Methyltransferase (SET7/9) on the Tubulointerstitial Fibrosis., Sasaki K, Nakashima A, Doi S, Masaki T, American Society of Nephrology Kidney Week 2014, Philadelphia (USA), 2014/11/14, Without Invitation, English, American Society of Nephrology, Philadelphia (USA)
  3. Chloride contributes to hypertension and renal injury in aldosterone-salt treated rats., Takahiro Yamauchi, Shigehiro Doi, Toshiki Doi, Kensuke Sasaki, Toshinori Ueno, Ayumu Nakashima, Takao Masaki, American Society of Nephrology 2015, 2015/11/07, Without Invitation, English, American Society of Nephrology, San Diego

External Funds

Acceptance Results of Competitive Funds

  1. 2016 JSPS KAKENHI, Grant-in-Aid for Young Scientists (B)