KENSUKE SASAKI

Last Updated :2024/04/03

Affiliations, Positions
Hiroshima University Hospital(Department of Blood Purification), Assistant Professor
E-mail
kensasakihiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2021/04, Vanderbilt University School of Medicine, Adjunct Research Instructor
  • 2018/04, 2020/10, Vanderbit University Medical Center, Postdoctral Research Fellow
  • 2020/11, 2021/03, Vanderbit University Medical Center, Reseach　Instructor
  • 2012/04/01, 2013/03/31, Hiroshima University, Hospital, Clinical Fellow
  • 2014/04/01, 2016/01/31, Hiroshima University, Hospital, Clinical Fellow
  • 2016/02/01, 2017/02/28, Hiroshima University, Hospital, Assistant Professor
  • 2017/03/01, 2018/03/31, Hiroshima University, Hospital, Assistant Professor
  • 2021/04/01, Hiroshima University, Hospital, Assistant Professor

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Kidney internal medicine

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2024, Undergraduate Education, Intensive, Practice of Medicine I

Research Activities

Academic Papers

  1. ★, Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis, JCI Insight., 7(4), e150723, 2022
  2. Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury, Kidney Int ., 101(1), 79-91, 2022
  3. ★, Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation, J Am Soc Nephrol., 32(5), 1037-1052, 2021
  4. Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction, Am J Physiol Renal Physiol ., 320(4), F569-F577, 2021
  5. Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy, Diabetes., 70(2), 562-576, 2021
  6. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 INK4a, Kidney Int ., 96(5), 1162-1175, 2019
  7. Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice, Int J Mol Sci ., 20(19), 4680, 2019
  8. The Role of the EGF Receptor in Sex Differences in Kidney Injury, J Am Soc Nephrol ., 30(9), 1659-1673, 2019
  9. Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice, Diabetol Metab Syndr ., 11, 57, 2019
  10. microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress, PLoS One., 14(6), e0218468, 2019
  11. The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model, Int J Mol Sci ., 19(12), 3967, 2018
  12. TGF-beta promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration, JCI Insight ., 3(21), e123563, 2018
  13. TGF-beta1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA, Sci Rep ., 8(1), 14060, 2018
  14. Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction, PLoS One ., 13(8), e0202409, 2018
  15. Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis, PLoS One ., 13(5), e0196844, 2018
  16. Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis, NUTRIENTS, 14(12), 202206
    Link to Paper Search Results by DOI
  17. ★, Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(1), 203-215, 201601
    Link to Paper Search Results by DOI
  18. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression, KIDNEY INTERNATIONAL, 89(1), 147-157, 201601
    Link to Paper Search Results by DOI
  19. Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study., Clin Exp Nephrol., 19(4), 631-638, 2015
  20. Linagliptin Ameliorates MethylglyoxalInduced Peritoneal Fibrosis in Mice, PLOS ONE, 11(8), 20160811
    Link to Paper Search Results by DOI
  21. A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-alpha and TGF-beta(1) pathways, SCIENTIFIC REPORTS, 7, 20170515
    Link to Paper Search Results by DOI
  22. Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy, INTESTINAL RESEARCH, 19(4), 430-437, 202110
    Link to Paper Search Results by DOI
  23. Klotho overexpression protects against renal aging along with suppression of transforming growth factor-beta 1 signaling pathways, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 321(6), F799-F811, 202112
    Link to Paper Search Results by DOI
  24. Klotho deficiency intensifies hypoxia-induced expression of IFN-alpha/beta through upregulation of RIG-I in kidneys, PLOS ONE, 16(10), 2021
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Interferon regulatory factor 4 in macrophages promotes renal fibrosis in post-severe acute kidney injury through reducing monocyte/macrophage migration ability., Sasaki K, Wang Y, Zhang MZ, Harris RC., American Society of Nephrology Kidney Week 2019, 2019, Without Invitation, English, ASN, Washington DC (USA)
  2. Inhibitory Effect of the Chromatin Histone H3-lysine 4 Methyltransferase (SET7/9) on the Tubulointerstitial Fibrosis., Sasaki K, Nakashima A, Doi S, Masaki T, American Society of Nephrology Kidney Week 2014, Philadelphia (USA), 2014/11/14, Without Invitation, English, American Society of Nephrology, Philadelphia (USA)
  3. Chloride contributes to hypertension and renal injury in aldosterone-salt treated rats., Takahiro Yamauchi, Shigehiro Doi, Toshiki Doi, Kensuke Sasaki, Toshinori Ueno, Ayumu Nakashima, Takao Masaki, American Society of Nephrology 2015, 2015/11/07, Without Invitation, English, American Society of Nephrology, San Diego

External Funds

Acceptance Results of Competitive Funds

  1. 2016 JSPS KAKENHI, Grant-in-Aid for Young Scientists (B)