YOHEI KAWANO

Last Updated :2023/06/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
kawanoyohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2005/04/01, 2013/10/31, Tokyo Medical and Dental University, Department of Immune Regulation, Research Associate
  • 2013/11/01, 2015/12/31, Max-Planck Institute for Infection Biology, Department of Lymphocyte Development, Postdoctral researcher
  • 2016/01/01, 2017/03/31, German Rheumatism research centre, Department of Lymphocyte Development, Postdoctral researcher
  • 2017/04/01, 2019/03/31, Tokyo Medical and Dental University, Department of Immune Regulation, Research Associate
  • 2019/04/01, 2020/05/31, Tokyo Medical and Dental University, Department of Molecular Immunology, Research Associate
  • 2020/06/01, Graduate School of Biomedical and HealthSciences, Hiroshima University, Department of Immunology, Associate Professor

Educational Backgrounds

  • Tokyo Medical and Dental University, Japan, 2001/04, 2005/03
  • Okayama University, Japan, 1999/04, 2001/03
  • Okayama University, Japan, 1995/04, 1999/03

Academic Degrees

  • Okayama University
  • Tokyo Medical and Dental University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology

Research Keywords

  • Immune system, hematopoiesis, hematopoietic progenitors

Affiliated Academic Societies

  • Japanese Society for Immunology (JSI)
  • The Molecular Biology Society of Japan (MBSJ)

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, Year, Biological Responses
  2. 2023, Graduate Education (Master's Program) , First Semester, Seminar
  3. 2023, Graduate Education (Master's Program) , Second Semester, Seminar
  4. 2023, Graduate Education (Master's Program) , First Semester, Research
  5. 2023, Graduate Education (Master's Program) , Second Semester, Research
  6. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  7. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  8. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  9. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  10. 2023, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense
  11. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Immunology
  12. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Immunology
  13. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Immunology
  14. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Immunology

Research Activities

Academic Papers

  1. ★, Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants, COMMUNICATIONS BIOLOGY, 6(1), 20230411
    Link to Paper Search Results by DOI
  2. ★, Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen, INTERNATIONAL IMMUNOLOGY, 35(4), 197-207, 20230404
    Link to Paper Search Results by DOI
  3. Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells, CANCERS, 14(17), 202209
    Link to Paper Search Results by DOI
  4. VSIG4/CRIg directly regulates early CD8(+) T cell activation through its counter-receptor in a narrow window, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 614, 100-106, 20220723
    Link to Paper Search Results by DOI
  5. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 535, 99-105, 20210108
    Link to Paper Search Results by DOI
  6. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting, Int Immunol, 20200728
  7. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils, 12, 576, 20190409
  8. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice., International immunology, 31(1), 41-49, 20190206
  9. How do basophils contribute to Th2 cell differentiation and allergic responses?, International immunology, 30(9), 391-396, 20180830
  10. ★, Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors., Blood, 131(18), 2026-2035, 20180503
  11. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice., European journal of immunology, 48(6), 975-989, 201806
  12. Skin CD4(+) Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites, FRONTIERS IN IMMUNOLOGY, 8, 1348, 201710
  13. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150(+) long-term repopulating murine hematopoietic stem cells, EUROPEAN JOURNAL OF IMMUNOLOGY, 47(9), 1477-1487, 201709
  14. ★, IL-7 and immobilized Kit-ligand stimulate serumand stromal cell-free cultures of precursor B-cell lines and clones, EUROPEAN JOURNAL OF IMMUNOLOGY, 47(1), 206-212, 201701
  15. Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 467(1), 70-75, 201511
  16. The skin is an important bulwark of acquired immunity against intestinal helminths, JOURNAL OF EXPERIMENTAL MEDICINE, 210(12), 2583-2595, 201311
  17. Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4, Immunity, 38(3), 570-580, 201303
  18. ★, A Novel Mechanism for the Autonomous Termination of Pre-B Cell Receptor Expression via Induction of Lysosome-Associated Protein Transmembrane 5, MOLECULAR AND CELLULAR BIOLOGY, 32(21), 4462-4471, 201211
  19. Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-alpha on macrophages through the autocrine action of IL-6, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 420(1), 114-118, 201203
  20. Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 415(4), 709-713, 201112
  21. NK Cell-Depleting Anti-Asialo GM1 Antibody Exhibits a Lethal Off-Target Effect on Basophils In Vivo, JOURNAL OF IMMUNOLOGY, 186(10), 5766-5771, 201105
  22. IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 402(4), 742-746, 201011
  23. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks, JOURNAL OF CLINICAL INVESTIGATION, 120(8), 2867-2875, 201008
  24. Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells, JOURNAL OF LEUKOCYTE BIOLOGY, 86(6), 1417-1425, 200912
  25. The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver, INTERNATIONAL IMMUNOLOGY, 21(1), 43-52, 200901
  26. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis, IMMUNITY, 28(4), 581-589, 200804
  27. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion, IMMUNITY, 28(4), 499-508, 200804
  28. Basophils are essential initiators of a novel type of chronic allergic inflammation, BLOOD, 110(3), 913-920, 200708
  29. BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement, BLOOD, 108(8), 2703-2711, 200610
  30. ★, Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals., Journal of immunology (Baltimore, Md. : 1950), 177(4), 2242-2249, 200608
  31. ★, Selection of stereotyped V(H)81X-mu H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells, INTERNATIONAL IMMUNOLOGY, 17(7), 857-867, 200507
  32. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase, FEBS LETTERS, 537(1-3), 203-209, 200302
  33. Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies, EUROPEAN JOURNAL OF IMMUNOLOGY, 32(4), 957-966, 200204
  34. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice., Frontiers in immunology, 9, 1540-1540, 2018

Invited Lecture, Oral Presentation, Poster Presentation

  1. Properties and functional analysis of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M)., Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda., The 51th Annual Meeting of The Japanese Society for Immunology, 2022/12/08, Without Invitation, English
  2. Properties and functional analysis of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M)., Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda., 2022/11/30, Without Invitation, English