KAZUE NAKASHIMA

Last Updated :2024/07/22

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
E-mail
hisaokakhiroshima-u.ac.jp
Self-introduction
I specialize in the research for Neuropsychopharmacology, especially the effects of chronic pain on affective and cognitive function.

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
  • 2010/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 1998/10/01, 2010/03/31, National Hospital Organization Kure Medical Center, Researcher

Educational Backgrounds

  • Hiroshima University, Japan, 2002/04, 2004/03
  • Hiroshima University, Japan, 1994/04, 1998/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences

In Charge of Primary Major Programs

  • Pharmaceutical Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Research Keywords

  • Astrocyte, Microglia, Chronic pain, Mood disorders, HMGB1

Affiliated Academic Societies

  • Society for Neurosciences

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, Practice of Biochemical Pharmacology
  2. 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  3. 2024, Undergraduate Education, First Semester, Practice of Pharmacology
  4. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  5. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  6. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  7. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  8. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  9. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III

Research Activities

Academic Papers

  1. High mobility group box-1: A therapeutic target for analgesia and associated symptoms in chronic pain, BIOCHEMICAL PHARMACOLOGY, 222, 202404
    Link to Paper Search Results by DOI
  2. Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 47(1), 221-226, 202401
  3. Enhanced anxiety-like behavior induced by chronic neuropathic pain and related parvalbumin-positive neurons in male rats, BEHAVIOURAL BRAIN RESEARCH, 459, 20240229
    Link to Paper Search Results by DOI
  4. Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes, INTERNATIONAL IMMUNOPHARMACOLOGY, 127, 20240125
    Link to Paper Search Results by DOI
  5. Mitochondrial dysfunction and type I interferon signaling induce anxiodepressive-like behaviors in mice with neuropathic pain, EXPERIMENTAL NEUROLOGY, 367, 202309
    Link to Paper Search Results by DOI
  6. Inhibition of Nuclear Receptor Related Orphan Receptor y Ameliorates Mechanical Hypersensitivity Through the Suppression of Spinal Microglial Activation, NEUROSCIENCE, 526, 223-236, 20230821
    Link to Paper Search Results by DOI
  7. Evaluation of intracellular signal molecules that regulate TLR4-stimulated inflammatory mediator expression in cultured rat chondrocytes, JOURNAL OF PHARMACOLOGICAL SCIENCES, 152(2), 103-111, 202306
    Link to Paper Search Results by DOI
  8. Blockade of receptor for advanced glycation end-products with azeliragon ameliorates streptozotocin-induced diabetic neuropathy, NEUROCHEMISTRY INTERNATIONAL, 163, 202302
    Link to Paper Search Results by DOI
  9. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation, NEUROCHEMISTRY INTERNATIONAL, 160, 202211
    Link to Paper Search Results by DOI
  10. ★, Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation, INTERNATIONAL IMMUNOPHARMACOLOGY, 112, 202211
    Link to Paper Search Results by DOI
  11. ★, High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain, EXPERIMENTAL NEUROLOGY, 355, 202209
    Link to Paper Search Results by DOI
  12. Mirogabalin alleviates nociceptive hypersensitivity without causing sedation in a mouse model of post-traumatic trigeminal neuropathy, BEHAVIOURAL BRAIN RESEARCH, 425, 20220503
    Link to Paper Search Results by DOI
  13. Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor(1/3), Src, and extracellular signal-regulated kinase, EUROPEAN JOURNAL OF PHARMACOLOGY, 925, 20220615
    Link to Paper Search Results by DOI
  14. Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson's disease, BIOMEDICINE & PHARMACOTHERAPY, 145, 202201
    Link to Paper Search Results by DOI
  15. Pretreatment with High Mobility Group Box-1 Monoclonal Antibody Prevents the Onset of Trigeminal Neuropathy in Mice with a Distal Infraorbital Nerve Chronic Constriction Injury, MOLECULES, 26(7), 202104
    Link to Paper Search Results by DOI
  16. Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: Involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn, BIOCHEMICAL PHARMACOLOGY, 186, 202104
    Link to Paper Search Results by DOI
  17. Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 566, 141-147, 20210820
    Link to Paper Search Results by DOI
  18. Treatment with Histone Deacetylase Inhibitor Attenuates Peripheral Inflammation-Induced Cognitive Dysfunction and Microglial Activation: The Effect of SAHA as a Peripheral HDAC Inhibitor, NEUROCHEMICAL RESEARCH, 46(9), 2285-2296, 202109
    Link to Paper Search Results by DOI
  19. ★, Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes, JOURNAL OF NEUROCHEMISTRY, 158(4), 849-864, 202108
    Link to Paper Search Results by DOI
  20. Downregulation of connexin43 potentiates noradrenaline-induced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes, JOURNAL OF CELLULAR PHYSIOLOGY, 236(10), 6777-6792, 202110
    Link to Paper Search Results by DOI
  21. Stimulation of nuclear receptor REV-ERBs suppresses inflammatory responses in spinal microglia, NEUROCHEMISTRY INTERNATIONAL, 151, 202112
    Link to Paper Search Results by DOI
  22. ★, Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms, CELLS, 9(5), 202005
    Link to Paper Search Results by DOI
  23. Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors, BEHAVIOURAL BRAIN RESEARCH, 391, 20200805
    Link to Paper Search Results by DOI
  24. Stimulation of toll-like receptor 4 downregulates the expression of alpha 7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia, NEUROCHEMISTRY INTERNATIONAL, 138, 202009
    Link to Paper Search Results by DOI
  25. TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia, JOURNAL OF PHARMACOLOGICAL SCIENCES, 144(1), 23-29, 202009
    Link to Paper Search Results by DOI
  26. Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freund's adjuvant, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 533(4), 971-975, 20201217
    Link to Paper Search Results by DOI
  27. ★, High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 92, 347-362, 20190608
    Link to Paper Search Results by DOI
  28. Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice, BRAIN BEHAVIOR AND IMMUNITY, 78, 116-130, 201905
    Link to Paper Search Results by DOI
  29. Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(6), 857-866, 201906
    Link to Paper Search Results by DOI
  30. ★, Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes, EUROPEAN JOURNAL OF PHARMACOLOGY, 860, 20191005
    Link to Paper Search Results by DOI
  31. Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1 beta in activated astrocytes, JOURNAL OF NEUROCHEMISTRY, 150(6), 738-758, 201909
    Link to Paper Search Results by DOI
  32. Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice, GLIA, 66(2), 428-444, 201802
    Link to Paper Search Results by DOI
  33. ★, Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(10), 1759-1766, 201710
  34. Depression: A novel mechanism of antidepressant action with a focus on astrocytes, Advances in Modern Medicine, 220-232, 20170217
  35. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469(2), 151-157, 20160108
    Link to Paper Search Results by DOI
  36. Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloprotease-9 up-regulation in mice with painful peripheral neuropathy, JOURNAL OF NEUROCHEMISTRY, 136(4), 837-850, 201602
    Link to Paper Search Results by DOI
  37. ★, Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia, BRAIN RESEARCH, 1634, 57-67, 20160301
    Link to Paper Search Results by DOI
  38. Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice, MOLECULAR AND CELLULAR NEUROSCIENCE, 72, 72-83, 201604
    Link to Paper Search Results by DOI
  39. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression, LIFE SCIENCES, 155, 116-122, 20160615
    Link to Paper Search Results by DOI
  40. ★, The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 479(4), 907-912, 20161028
    Link to Paper Search Results by DOI
  41. Stimulation of spinal dorsal horn beta 2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase, NEUROCHEMISTRY INTERNATIONAL, 101, 144-155, 201612
    Link to Paper Search Results by DOI
  42. ★, Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(53), 27364-+, 20161230
    Link to Paper Search Results by DOI
  43. Downregulation of Connexin36 in Mouse Spinal Dorsal Horn Neurons Leads to Mechanical Allodynia, JOURNAL OF NEUROSCIENCE RESEARCH, 93(4), 584-591, 201504
    Link to Paper Search Results by DOI
  44. ★, Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive G alpha(i/o) Activation in Astroglial Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(22), 13678-13691, 20150529
    Link to Paper Search Results by DOI
  45. Proinflammatory cytokines downregulate connexin 43-gap junctions via the ubiquitin-proteasome system in rat spinal astrocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(4), 1202-1208, 20150904
    Link to Paper Search Results by DOI
  46. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice, BRAIN BEHAVIOR AND IMMUNITY, 49, 293-310, 201510
    Link to Paper Search Results by DOI
  47. Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal-regulated kinase-dependent early growth response 1 production in rat primary cultured astrocytes, JOURNAL OF NEUROCHEMISTRY, 135(1), 27-37, 201510
    Link to Paper Search Results by DOI
  48. Stimulation of alpha 7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia, BRAIN RESEARCH, 1625, 111-120, 20151102
    Link to Paper Search Results by DOI
  49. The induction of Pen1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes, NEUROCHEMISTRY INTERNATIONAL, 90, 9-19, 201511
    Link to Paper Search Results by DOI
  50. PRIMARY CULTURES OF RAT CORTICAL MICROGLIA TREATED WITH NICOTINE INCREASES IN THE EXPRESSION OF EXCITATORY AMINO ACID TRANSPORTER 1 (GLAST) VIA THE ACTIVATION OF THE alpha 7 NICOTINIC ACETYLCHOLINE RECEPTOR, NEUROSCIENCE, 258, 374-384, 20140131
    Link to Paper Search Results by DOI
  51. Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway, BRITISH JOURNAL OF PHARMACOLOGY, 171(11), 2854-2867, 201406
    Link to Paper Search Results by DOI
  52. Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-kappa B activation in spinal astrocytes, MOLECULAR AND CELLULAR NEUROSCIENCE, 59, 37-46, 201403
    Link to Paper Search Results by DOI
  53. A beta 1/2 Adrenergic Receptor-Sensitive Intracellular Signaling Pathway Modulates CCL2 Production in Cultured Spinal Astrocytes, JOURNAL OF CELLULAR PHYSIOLOGY, 229(3), 323-332, 201403
    Link to Paper Search Results by DOI
  54. Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 48, 236-244, 20140103
    Link to Paper Search Results by DOI
  55. History of the G Protein-Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay, JOURNAL OF PHARMACOLOGICAL SCIENCES, 126(4), 302-309, 201412
    Link to Paper Search Results by DOI
  56. ★, グリアと抗うつ薬, 分子精神医学, 14(4), 9-14, 2014
  57. Spinal astrocytes stimulated by tumor necrosis factor- and/or interferon- attenuate connexin 43-gap junction via c-jun terminal kinase activity, JOURNAL OF NEUROSCIENCE RESEARCH, 91(6), 745-756, 201306
    Link to Paper Search Results by DOI
  58. The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons, BRAIN RESEARCH, 1509, 20-31, 20130506
    Link to Paper Search Results by DOI
  59. GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(4), 779-784, 20130517
    Link to Paper Search Results by DOI
  60. Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1, PLOS ONE, 8(8), 20130821
    Link to Paper Search Results by DOI
  61. Tricyclic Antidepressant Amitriptyline Indirectly Increases the Proliferation of Adult Dentate Gyrus-Derived Neural Precursors: An Involvement of Astrocytes, PLOS ONE, 8(11), 20131118
    Link to Paper Search Results by DOI
  62. The activation of P2Y(6) receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-kappa B pathway, NEUROPHARMACOLOGY, 75, 116-125, 201312
    Link to Paper Search Results by DOI
  63. Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study, Neuropsychiatr Dis Treat., 8, 1867-1872, 2013
  64. Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121(4), 257-271, 201304
    Link to Paper Search Results by DOI
  65. ★, Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline, PLOS ONE, 7(12), 20121205
    Link to Paper Search Results by DOI
  66. ★, Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production., J Biol Chem., 286(11), 21118-21128, 2011
  67. ★, Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production., Brain Res., 53-58, 2008
  68. ★, Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells., J. Pharmacol. Exp. Ther., 321, 148-157, 2007
  69. Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders., Int J Neuropsychopharmacol, 9, 607-612, 2006
  70. ★, Serotonin increases glial cell line-derived neurotrophic factor release in rat C6 glioblastoma cells., Brain Research, 1002, 2004
  71. ★, Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells., J. Neurochem., 79, 25-34, 2001

Invited Lecture, Oral Presentation, Poster Presentation

  1. The emerging role of HMGB1 in the brain during chronic pain, Nakamura Y, Nakashima K, Morioka N, 19th World Congress of Basic & Clinical Pharmacology 2023 (WCP2023), 2023/07/04, With Invitation, English
  2. Blockade of high mobility group box-1 function ameriolates mechanical hypersensitivity in a mouse model of Parkinson's disease, Nakamura Y, Sato F, Yamano K, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N, IAGG Asia/Oceania Regional Congress 2023, 2023/06/14, Without Invitation, English
  3. Effect of intranasal treatment with the anti-HMGB1 neutralizing antibody on mechanical hypersensitivity in a mouse model of hemi-Parkinson's disease, Nakamura Y, Sato F, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N, Society for Neuroscience Annual Meeting, 2022/11/15, Without Invitation, English
  4. Downregulation of connexin43 in primary cultured astrocytes potentiates the amitripryline-induced brain-derived neurotrophic factor through lysophosphatidic reecptor1/3, Src, and extraecllular signal-regulated kinase., Tokunaga N, Nakamura Y, Hisaoka-Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2022/11/13, Without Invitation, Japanese
  5. The possibility of HMGB1 as a therapeutic target for neuropathic pain.,, Nakamura Y, Nakashima K, Morioka N,, 9th International DAMPs and Alarmins Symposium, 2019/11/06, With Invitation, English
  6. Perineural treatment with anti-HMGB1 antibody alleviates trigeminal neuropathy in mouse with chronic constriction injury of distal infraorbital nerve., Kochi T, Nakamura Y, Nakashima K, Liu K, Wake H, Nishibori M, Irifune M, Morioka N.,, 9th International DAMPs and Alarmins Symposium, 2019/11/06, Without Invitation, English
  7. Peripheral inflammation induced cognitive impairment is attenuated by the regulation of activated glial cells and histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, Society for Neuroscience Annual Meeting, 2019/10/23, Without Invitation, English, Chicago
  8. Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia, Kodama K,Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka M, Society for Neuroscience Annual Meeting, 2019/10/22, Without Invitation, English, Chicago
  9. Systemic inflammation-induced memory disfunction is prevented by blockade either microglia activation or histone deacetylase, Takada N, Nakamura Y, Nakashima K, Morioka N, 6th Congress of Asian College of Neuropsychopharmacology, 2019/10/12, Without Invitation, English, Fukuoka
  10. The analysis of anxiety- and depression-related behaviors in neuropathic pain of mice - possible involvement of brain inflammation, Kazue Hisaoka-Nakashima, Yoshiaki Tomimura, Toshiki Yoshii, Fang Fang Zhang, Yoki Nakamura, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka, The 18th World Congress of Basic and Clinical Pharmacology (WCP2018), 2018/07/04, Without Invitation, English
  11. Downregulation of spinal astrocytic connexin43 leads to mechanical hypersensitivity through upregulation of interleukin-6 and cyclooxygenase-2 in mice, Norimitsu Morioka, Syun Kondo, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakata, The 18th World Congress of Basic and Clinical Pharmacology (WCP2018), 2018/07/04, Without Invitation, English
  12. Downregulation of astrocytic connexin43 leads to enhancement of neurotrophic factor production in cortical astrocytes, Kondo S, Hisaoka-Nakashima K, Nakata Y, Morioka N, The 18th World Congress of Basic and Clinical Pharmacology (WCP2018), 2018/07/04, Without Invitation, English
  13. Mechanisms for the high mobility group box-1-induced mechanical hypersensitivity in spinal dorsal horn of mice, 2017/03/16, Without Invitation, Japanese
  14. Antidepressant amitriptyline activates matrix metalloproteinase in astroglial cells: involvement in glial cell line-derived neurotrophic factor expression., H. ABE, K. HISAOKA-NAKASHIMA, N. KAJITANI, M. OKADA-TSUCHIOKA, K. ITAGAKI, C. SHIBASAKI, M. MORIOKA, Y. NAKATA, M. TAKEBAYASHI, 30th CINP WORLD CONGRESS OF NEUROPSYCHOPHARMACOLOGY, 2016/07/03, Without Invitation, English
  15. Antidepressants activate matrix metalloproteinase (MMP) in astroglial cells: involvement in glial cell line-derived neurotrophic factor (GDNF) expression, H. ABE, K. HISAOKA-NAKASHIMA, N. KAJITANI, M. OKADA-TSUCHIOKA, K. ITAGAKI, M. MORIOKA, Y. NAKATA, M. TAKEBAYASHI, 45th Annual Meeting of Society for Neuroscience, Chicago, 2015/10/21, Without Invitation
  16. The role of spinal astrocytic Cx43 in the maintenance of neuropathic pain, F. ZHANG, *N. MORIOKA, Y. NAKAMURA, S. FUJII, K. HISAOKA-NAKASHIMA, Y. NAKATA, 45th Annual Meeting of Society for Neuroscience, 2015/10/19, Without Invitation, English
  17. A novel assay for detecting the activation of G protein-coupled receptors using cellular dielectric spectroscopy, Miyano K, Sudo Y, Yokoyama A, Nishimura H, Kawaida M, Sato S, Nemoto E, Hisaoka-Nakashima K, Takebayashi M, Morioka N, Shiraishi S, Higami Y, Fujii H, Nakata Y, Uezono Y., 2015/03/20, Without Invitation, English
  18. 神経因性疼痛誘発における時計遺伝子Per1 の関わり, 佐伯 宗紀、森岡 徳光、張 芳芳、中島 一恵、仲田 義啓, 2015/03/18, Without Invitation, Japanese
  19. Serum levels of MMP-3 in mood disorders and schizophrenia: A pilot study, SHIBASAKI C, ABE H, OKADA-TSUCHIOKA M, KAJITANI N, ITAGAKI K, HISAOKA-NAKASHIMA K, TAKEBAYASHI M, 44th Annual Meeting of Society for Neuroscience, 2014/11/18, Without Invitation, English
  20. Tricyclic antidepressant amitriptyline acts on astrocytes leading to the increase in the FGF2 expression: A role of early growth response 1 signaling, KAJITANI N, HISAOKA K, OKADA-TSUCHIOKA M, HOSOI M, SHIBASAKI C, MORIOKA N, NAKATA Y, TAKEBAYASHI M, 44th Annual Meeting of Society for Neuroscience, 2014/11/17, Without Invitation, English
  21. ラット初代培養ミクログリアにおいて三環系抗うつ薬アミトリプチリンが脳由来神経栄養因子(BDNF)mRNA 発現に及ぼす効果の検討, 重藤　貴大、中島　一恵、梶谷　直人、竹林　実、森岡　徳光、仲田　義啓, 2014/11/08, Without Invitation, Japanese
  22. アミトリプチリンによるグリア細胞株由来神経栄養因子産生メカニズムの解明：マトリックスメタロプロテアーゼの関与, 安部　裕美、中島　一恵、岡田　麻美、梶谷　直人、板垣　圭、森岡　徳光、竹林　実、仲田　義啓, 2014/11/08, Without Invitation, Japanese
  23. アドリアマイシン耐性ヒト卵巣癌細胞におけるアガリクス抽出物及び抗癌剤の併用効果の検討, 田中　真衣、香川　紘乃、青野　咲希、中島　一恵、森岡　徳光、仲田　義啓, 2014/11/08, Without Invitation, Japanese
  24. マウス坐骨神経損傷による慢性疼痛における末梢HMGB1 の役割, 原野　さくら、森岡　徳光、張　芳芳、中島　一恵、西堀　正洋、仲田　義啓, 2014/11/08, Without Invitation, Japanese
  25. 脊髄アストロサイトConnexin43 の神経障害性疼痛発症への関与, 北村　智哉、森岡　徳光、張　芳芳、藤井　志織、中島　一恵、仲田　義啓, 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会　, 2014/11/08, Without Invitation, Japanese
  26. 神経障害性疼痛に対する脊髄後角におけるアストロサイトCx43の関与, 張　芳芳、森岡徳光、北村智哉、藤井志織、中島一恵、仲田義啓, 第126回日本薬理学会近畿部会, 2014/10/24, Without Invitation, Japanese
  27. ラット初代培養ミクログリアにおける脳由来神経栄養因子（BDNF）発現に対する三環系抗うつ薬アミトリプチリンの影響, 重藤貴大、中島一恵、梶谷直人、竹林　実、森岡徳光、仲田義啓, 第125回日本薬理学会近畿部会　, 2014/06/20, Without Invitation, Japanese
  28. 脊髄アストロサイトgap junction-Cx43発現低下に対するproteasome系の役割, 張　芳芳、森岡徳光、北村智哉、藤井志織、中島一恵、仲田義啓, 第125回日本薬理学会近畿部会　, 2014/06/20, Without Invitation, Japanese
  29. Effect of intranasal treatment with the anti-HMGB1 neutralizing antibody on mechanical hypersensitivity in a mouse model of hemi-Parkinson's disease, Nakamura Y, Sato F, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N,, Society for Neuroscience Annual Meeting, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022
  2. KAKENHI, 2016, 2018
  3. 2015, 2017
  4. KAKENHI, 2013, 2015
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  5. 2012
  6. KAKENHI, The effect of antidepressant on Fibroblast growth factor (FGF) receptor, as a novel therapeutic target for major depression., 2011, 2012
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  7. 2010
  8. KAKENHI, Identification of novel targets related to induce expression of neurotrophic factors at antidepressant in glia, 2008, 2010
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