SHINJI MATSUDA

Last Updated :2024/05/23

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
matsudashiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2022/07/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
  • 2011/07/01, 2022/06/30, Hiroshima University, Hospital, Assistant Professor

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Periodontology

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 3Term, Periodontology I
  2. 2024, Undergraduate Education, 4Term, Periodontology II
  3. 2024, Undergraduate Education, 1Term, Basic Practice of Periodontics I
  4. 2024, Undergraduate Education, 2Term, Basic Practice of Periodontics II
  5. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  6. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  7. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  8. 2024, Undergraduate Education, 2Term, Advanced Course in Applied Oral Biology and Medicine
  9. 2024, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  10. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  11. 2024, Undergraduate Education, Academic Year, Clinical Practice (Periodontics)
  12. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  13. 2024, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  14. 2024, Undergraduate Education, Intensive, Clinical practice on oral health
  15. 2024, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  16. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry

Research Activities

Academic Papers

  1. ★, Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement, BioFactors, 20240522
  2. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model, Oral Diseases, 202404
  3. Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families, JBMR PLUS, 9;8(6):ziae050(9;8(6):ziae050), 202406
    Link to Paper Search Results by DOI
  4. Periodontal tissue regeneration with cementogenesis after application of brain-derived neurotrophic factor in 3-wall inflamed intra-bony defect, Journal of Periodontal Research, 20240319
  5. Predictive factors of periodontal regeneration outcomes using rhFGF-2: a case-control study, Journal of Periodontal Research, 20240325
    Link to Paper Search Results by DOI
  6. Increasing the Apical Sizes of Root Enlarged for Root Canal Obturation Influences the Outcome of Single-Root-Canal Teeth Affected by Apical Periodontitis, European Endodontic Journal, 2023
  7. ★, Effect of periodontal treatment on reducing chronic inflammation in systemically healthy patients with periodontal disease: a multicenter study, THE AMERICAN JOURNAL of MEDICINE, 202403
  8. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 210(3), 321-330, 20221231
    Link to Paper Search Results by DOI
  9. Generalized periodontitis treated with periodontal, orthodontic, and prosthodontic therapy: A case report, WORLD JOURNAL OF CLINICAL CASES, 9(21), 6110-6124, 20210726
    Link to Paper Search Results by DOI
  10. Effect ofPorphyromonas gingivalisinfection on gut dysbiosis and resultant arthritis exacerbation in mouse model, ARTHRITIS RESEARCH & THERAPY, 22(1), 20201019
    Link to Paper Search Results by DOI
  11. Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530(2), 448-454, 20200917
    Link to Paper Search Results by DOI
  12. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
    Link to Paper Search Results by DOI
  13. Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis—A Cross-Sectional Study in Japan, Journal of Clinical Medicine, 8(10), 20191004
  14. Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(16), 20190802
    Link to Paper Search Results by DOI
  15. Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population., Matsuda S, Okanobu A, Hatano S, Kajiya M, Sasaki S, Hamamoto Y, Iwata T, Ouhara K, Takeda K, Mizuno N, Fujita T, Kurihara H., 20190215
  16. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, STEM CELL RESEARCH & THERAPY, 9, 20181207
    Link to Paper Search Results by DOI
  17. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, STEM CELL RESEARCH & THERAPY, 9, 20180321
    Link to Paper Search Results by DOI
  18. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
    Link to Paper Search Results by DOI
  19. Anti-Inflammatory Effects of Geniposidic Acid on Porphyromonas gingivalis-Induced Periodontitis in Mice, BIOMEDICINES, 10(12), 202212
    Link to Paper Search Results by DOI
  20. Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
    Link to Paper Search Results by DOI
  21. Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-? induces rat calvarial bone regeneration, REGENERATIVE THERAPY, 20, 117-125, 202206
    Link to Paper Search Results by DOI
  22. Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption, BONE REPORTS, 16, 202206
    Link to Paper Search Results by DOI
  23. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification, BIOMEDICINES, 9(10), 202110
    Link to Paper Search Results by DOI
  24. External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), 202107
    Link to Paper Search Results by DOI
  25. ★, The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth, FASEB JOURNAL, 35(7), 202107
    Link to Paper Search Results by DOI
  26. Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
    Link to Paper Search Results by DOI
  27. IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier, BRAIN SCIENCES, 10(10), 202010
    Link to Paper Search Results by DOI
  28. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
    Link to Paper Search Results by DOI
  29. Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 68, 30-38, 201903
    Link to Paper Search Results by DOI
  30. Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient, INTERNATIONAL ENDODONTIC JOURNAL, 51(9), 1059-1066, 201809
    Link to Paper Search Results by DOI
  31. The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
    Link to Paper Search Results by DOI
  32. Regulation of defensive function on gingival epithelial cells can prevent periodontal disease, JAPANESE DENTAL SCIENCE REVIEW, 54(2), 66-75, 201805
    Link to Paper Search Results by DOI
  33. MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
    Link to Paper Search Results by DOI
  34. DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption, JOURNAL OF DENTAL RESEARCH, 96(6), 685-693, 201706
    Link to Paper Search Results by DOI
  35. A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation., Journal of Immunological Methods, 201703
  36. Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1beta-Treated Endothelial Cells., Cell Biochemistry and Biophysics, 201609
  37. A novel method of sampling gingival crevicular fluid from a mouse model of periodontitis., Journal of Immunological method, 201608
  38. Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117(7), 1543-1555, 201607
    Link to Paper Search Results by DOI
  39. Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF-beta-regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrin beta1/FAK cascade., Cellular Microbiology, 201604
  40. Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124(2), 141-150, 201604
    Link to Paper Search Results by DOI
  41. Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alpha, ARCHIVES OF ORAL BIOLOGY, 62, 64-69, 201602
    Link to Paper Search Results by DOI
  42. Involvement of smad2 and Erk/Akt cascade in TGF-beta 1-induced apoptosis in human gingival epithelial cells, CYTOKINE, 75(1), 165-173, 201509
    Link to Paper Search Results by DOI
  43. Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 479-485, 201508
    Link to Paper Search Results by DOI
  44. Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1b and tumor necrosis factror-a., Journal of periodontal research, 50(4), 444-451, 201507
    Link to Paper Search Results by DOI
  45. Houttuynia cordata suppresses the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells, JOURNAL OF DENTAL SCIENCES, 10(1), 88-94, 201503
    Link to Paper Search Results by DOI
  46. Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells, CELLULAR IMMUNOLOGY, 290(2), 201-208, 201408
    Link to Paper Search Results by DOI
  47. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19(2), 245-252, 201404
    Link to Paper Search Results by DOI
  48. Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans, INTERNATIONAL IMMUNOPHARMACOLOGY, 15(2), 340-347, 201302
    Link to Paper Search Results by DOI
  49. Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227(5), 2123-2129, 201205
    Link to Paper Search Results by DOI
  50. Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-alpha-stimulated human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 47(1), 55-61, 201202
    Link to Paper Search Results by DOI
  51. Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration., Tissue engineering. Part A, 45(4), 579-582, 201104
  52. rsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans., Biochemical pharmacology, 79(10), 1496-1505, 201005
  53. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
    Link to Paper Search Results by DOI
  54. Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis., International journal of molecular sciences, 20(16), 2019
  55. Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 39(5), 1777-1786, 2016
    Link to Paper Search Results by DOI
  56. The expressions of claudin-1 and E-cadherin in junctional epithelium., Journal of periodontal research, 45(4), 579-582, 2010

Invited Lecture, Oral Presentation, Poster Presentation

  1. Verification of the effect of sclerostin deficiency on the development of osteonecrosis of the jaw, Yoshifumi Nakashima, Shinji Matsuda, Chisa Shukunami, Noriyoshi Mizuno, The 41st Annual Meeting of the Japanese Society for Bone and Mineral Research, 2023/07/27, Without Invitation, Japanese
  2. Identification of new periodontal examination to evaluate the association between periodontitis and systemic diseases ~multi centered clinical study~ 2nd report., Shinji Matsuda, Tsutomu Sugaya, Satsuki Kato, Eiji Nemoto, Yasuo Takeuchi, Daichi Kita, Yukihiro Numabe, Tetsuya Nishida, Yorimasa Ogata, Kitetsu Shin, Takatoshi Nagano, Toshiya Morozumi, Yasutaka Komatsu, Nanae Dewake, Yosuke Kamiya, Masahiro Kitamura, Yoichiro Taguchi, Shogo Takashiba, Hiromichi Yumoto, Akiko Yamashita, Yasunori Yoshinaga, Atsutoshi Yoshimura, Hiroyuki Kawaguchi, The 66th Autumn Meeting of Japanese Society of Periodontology, 2023/05/27, Without Invitation, Japanese
  3. Identification of new periodontal examination to evaluate the association between periodontitis and systemic diseases ~multi centered clinical study~., 20220902, Shinji Matsuda, Tsutomu Sugaya, Satsuki Kato, Eiji Nemoto, Yasuo Takeuchi, Daichi Kita, Yukihiro Numabe, Tetsuya Nishida, Yorimasa Ogata, Kitetsu Shin, Takatoshi Nagano, Toshiya Morozumi, Yasutaka Komatsu, Nanae Dewake, Yosuke Kamiya, Masahiro Kitamura, Yoichiro Taguchi, Shogo Takashiba, Hiromichi Yumoto, Akiko Yamashita, Yasunori Yoshinaga, Atsutoshi Yoshimura, Hiroyuki Kawaguchi, The 64th Autumn Meeting of Japanese Society of Periodontology, 2022/09/02, Without Invitation, Japanese
  4. Elucidation mechanisms of multiple root resorption in systemic sclerosis patients., Takumi Memida, Shinji Matsuda, Shigeki Suzuki, Mikihito Kajiya, Kazuhisa Ouhara, Ai Okanobu, Saki Hatano, Daisuke Furutama, Hideki Shiba, Satoru Yamada, Noriyoshi Mizuno, The 64th Autumn Meeting of Japanese Society of Periodontology, 2021/10/15, Without Invitation, Japanese
  5. The effects of optineurin on periodontal tissue destruction, Shinobu Matsui Noriyoshi Mizuno, Shinji Matsuda, Mikihito Kajiya, Kazuhisa Ouhara,Tsuyoshi Fujita,Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05/20, Without Invitation, Japanese
  6. Evaluation of periodontitis with Porphyromonas gulae infection in debetes model mice, Keiichi Akutagawa, Tsuyoshi Fujita, Yuushi Uchida, Tasuku Takemura, Kazuhisa Ouhara, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05/20, Without Invitation, Japanese
  7. The effects of optineurin on periodontal tissue destruction, Shinobu Matsui Noriyoshi Mizuno, Shinji Matsuda, Manabu Takewaki, Masahiro Yamakawa, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tomoyuki Iwata,Tsuyoshi Fujita,Hidemi Kurihara, 94ｔｈ Annual Meeting of the International Association for Dental Research, 2016/06/22, Without Invitation, Japanese
  8. Elucidation of the role of NR4A1 in drug induced gingival overgrowth, Ai Okanobu,Shinji Matsuda, Mikihito Kajiya, Tsuyoshi Fujita, Hidemi Kurihara, the 49th Hiroshima University Dental Society, 2016/07/02, Without Invitation, English
  9. The effects of optineurin on osteoblast differentiation, Noriyoshi Mizuno Shinji Matsuda, Tetsuya Yoshimoto, Tomoyuki Iwata, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tsuyoshi Fujita,Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/07, Without Invitation, Japanese
  10. Oral Elucidation of the role of NR4A1 in drug induced gingival overgrowth, Ai Okanobu,Shinji Matsuda, Mikihito Kajiya, Tsuyoshi Fujita, Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/07, Without Invitation, Japanese
  11. Effectiveness of the combination of SRP and brain-derived neurotrophic factor (BDNF) in the treatment of ligature-induced small periodontal defect in dogs, Sasaki S Takeda K, Takewaki M, Aida Y, Kajiya M, Matsuda S, Mizuno N, Fujita T, Kurihara H., The 59th fall meeting of the Japanese society of Periodontology, 2016/10/07, Without Invitation, Japanese
  12. Case report that improved drug-induced gingival overgrowth with chronic periodontitis performed by initial treatment, Chika Kozono Shinji Matsuda,Yukiko Nagatani,Miyuki Nakaoka,Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/08, Without Invitation, Japanese
  13. Effects of brain-derived neurotrophic factor (BDNF) as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, Shinya Sasaki, Katsuhiro Takeda, Manabu Takewaki, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 2017/09/22, Without Invitation, English
  14. Elucidation of the role of NR4A1 in CsA induced gingival overgrowth, Ai Okanobu, Shinji Matsuda, Mikihito Kajiya, Hidemi Kurihara, 2017/09/22, Without Invitation, English
  15. Elucidation of the role of NR4A1 in CsA induced gingival overgrowth, Ai Okanobu, Shinji Matsuda, Saki Hatano, Mikihito Kajiya, Tsuyoshi Fujita, Hidemi Kurihara, 7th Hiroshima Conference, 2018/03/29, Without Invitation, English

Social Activities

History as Committee Members

  1. NPO Japanese Society of Periodontology Young Researchers Training Working Group, 2021/04, 2022/03, Japanese Society of Periodontology

Other Social Contributions

  1. Kyushu Dental University Hiroshima Prefecture Alumni Association Academic Lecture 2023, Kyushu Dental University Hiroshima Prefecture Alumni Association Academic Lecture 2023, Lecturer, Lecture, Others