SHINJI MATSUDA

Last Updated :2025/04/17

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Associate Professor or Lecturer
E-mail
matsudashiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2025/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Associate professor or lecturer
  • 2022/07/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
  • 2011/07/01, 2022/06/30, Hiroshima University, Hospital, Assistant Professor

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Periodontology

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 4Term, Overview of Dentistry
  2. 2025, Undergraduate Education, 4Term, Periodontology II
  3. 2025, Undergraduate Education, 1Term, Basic Practice of Periodontics I
  4. 2025, Undergraduate Education, 2Term, Basic Practice of Periodontics II
  5. 2025, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  6. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  7. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  8. 2025, Undergraduate Education, 2Term, Advanced Course in Applied Oral Biology and Medicine
  9. 2025, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  10. 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
  11. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  12. 2025, Undergraduate Education, Academic Year, Clinical Practice (Periodontics)
  13. 2025, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  14. 2025, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  15. 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health
  16. 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  17. 2025, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry

Research Activities

Academic Papers

  1. Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis, Int J Implant Dent, 10(1), 59-59, 20241126
  2. Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis, BMC Oral Health, 24((1)), 1422-1422, 20241121
  3. Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw, Bone, 202407
  4. ★, Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement, BioFactors, 20240522
  5. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model, Oral Diseases, 202404
  6. Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families, JBMR PLUS, 9;8(6):ziae050(9;8(6):ziae050), 202406
  7. Periodontal tissue regeneration with cementogenesis after application of brain-derived neurotrophic factor in 3-wall inflamed intra-bony defect, Journal of Periodontal Research, 20240319
  8. Predictive factors of periodontal regeneration outcomes using rhFGF-2: a case-control study, Journal of Periodontal Research, 20240325
  9. Increasing the Apical Sizes of Root Enlarged for Root Canal Obturation Influences the Outcome of Single-Root-Canal Teeth Affected by Apical Periodontitis, European Endodontic Journal, 2023
  10. ★, Effect of periodontal treatment on reducing chronic inflammation in systemically healthy patients with periodontal disease: a multicenter study, THE AMERICAN JOURNAL of MEDICINE, 202403
  11. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 210(3), 321-330, 20221231
  12. Generalized periodontitis treated with periodontal, orthodontic, and prosthodontic therapy: A case report, WORLD JOURNAL OF CLINICAL CASES, 9(21), 6110-6124, 20210726
  13. Effect ofPorphyromonas gingivalisinfection on gut dysbiosis and resultant arthritis exacerbation in mouse model, ARTHRITIS RESEARCH & THERAPY, 22(1), 20201019
  14. Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530(2), 448-454, 20200917
  15. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
  16. Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis—A Cross-Sectional Study in Japan, Journal of Clinical Medicine, 8(10), 20191004
  17. Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(16), 20190802
  18. Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population., Matsuda S, Okanobu A, Hatano S, Kajiya M, Sasaki S, Hamamoto Y, Iwata T, Ouhara K, Takeda K, Mizuno N, Fujita T, Kurihara H., 20190215
  19. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, STEM CELL RESEARCH & THERAPY, 9, 20181207
  20. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, STEM CELL RESEARCH & THERAPY, 9, 20180321
  21. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
  22. Anti-Inflammatory Effects of Geniposidic Acid on Porphyromonas gingivalis-Induced Periodontitis in Mice, BIOMEDICINES, 10(12), 202212
  23. Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
  24. Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-? induces rat calvarial bone regeneration, REGENERATIVE THERAPY, 20, 117-125, 202206
  25. Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption, BONE REPORTS, 16, 202206
  26. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification, BIOMEDICINES, 9(10), 202110
  27. External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), 202107
  28. ★, The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth, FASEB JOURNAL, 35(7), 202107
  29. Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
  30. IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier, BRAIN SCIENCES, 10(10), 202010
  31. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
  32. Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 68, 30-38, 201903
  33. Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient, INTERNATIONAL ENDODONTIC JOURNAL, 51(9), 1059-1066, 201809
  34. The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
  35. Regulation of defensive function on gingival epithelial cells can prevent periodontal disease, JAPANESE DENTAL SCIENCE REVIEW, 54(2), 66-75, 201805
  36. MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
  37. DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption, JOURNAL OF DENTAL RESEARCH, 96(6), 685-693, 201706
  38. A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation., Journal of Immunological Methods, 201703
  39. Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1beta-Treated Endothelial Cells., Cell Biochemistry and Biophysics, 201609
  40. A novel method of sampling gingival crevicular fluid from a mouse model of periodontitis., Journal of Immunological method, 201608
  41. Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117(7), 1543-1555, 201607
  42. Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF-beta-regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrin beta1/FAK cascade., Cellular Microbiology, 201604
  43. Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124(2), 141-150, 201604
  44. Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alpha, ARCHIVES OF ORAL BIOLOGY, 62, 64-69, 201602
  45. Involvement of smad2 and Erk/Akt cascade in TGF-beta 1-induced apoptosis in human gingival epithelial cells, CYTOKINE, 75(1), 165-173, 201509
  46. Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 479-485, 201508
  47. Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1b and tumor necrosis factror-a., Journal of periodontal research, 50(4), 444-451, 201507
  48. Houttuynia cordata suppresses the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells, JOURNAL OF DENTAL SCIENCES, 10(1), 88-94, 201503
  49. Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells, CELLULAR IMMUNOLOGY, 290(2), 201-208, 201408
  50. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19(2), 245-252, 201404
  51. Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans, INTERNATIONAL IMMUNOPHARMACOLOGY, 15(2), 340-347, 201302
  52. Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227(5), 2123-2129, 201205
  53. Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-alpha-stimulated human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 47(1), 55-61, 201202
  54. Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration., Tissue engineering. Part A, 45(4), 579-582, 201104
  55. rsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans., Biochemical pharmacology, 79(10), 1496-1505, 201005
  56. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
  57. Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis., International journal of molecular sciences, 20(16), 2019
  58. Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 39(5), 1777-1786, 2016
  59. The expressions of claudin-1 and E-cadherin in junctional epithelium., Journal of periodontal research, 45(4), 579-582, 2010

Invited Lecture, Oral Presentation, Poster Presentation

  1. A study to explore factors affecting the outcome of periodontal tissue regeneration therapy using rhFGF-2, Shinji Matsuda, Noriyoshi Mizuno, FY2023 Joint Training Seminar by the Japanese Society of Periodontology, Chugoku-Shikoku Universities and the Japanese Society of Clinical Periodontology, Chugoku-Shikoku Branch, 2023/09/24, Without Invitation, Japanese
  2. Multi-centered Study ~Identification of new periodontal examination to evaluate the association between periodontitis and systemic diseases~ Analysis of oral examination data., Shinji Matsuda, Hiromichi Yumoto, Yasutaka Komatsu, Nanae Dewake, Takanori Iwata, Takatoshi Nagano, Toshiya Morozumi, Ryoma Goto, Satsuki Kato, Motozo Yamashita, Joichiro Hayashi, Satoshi Sekino, Akiko Yamashita, Keiko Yamashita, Atsutoshi Yoshimura, Tsutomu Sugaya, Shogo Takashiba, Yoichiro Taguchi, Eiji Nemoto, Yukihiro Numabe, Hiroyuki Kawaguchi, The 67th Spring Meeting of the Japanese Society of Periodontology, 2024/05/24, Without Invitation, Japanese
  3. Verification of the effect of sclerostin deficiency on the development of osteonecrosis of the jaw, Yoshifumi Nakashima, Shinji Matsuda, Chisa Shukunami, Noriyoshi Mizuno, The 41st Annual Meeting of the Japanese Society for Bone and Mineral Research, 2023/07/27, Without Invitation, Japanese
  4. Identification of new periodontal examination to evaluate the association between periodontitis and systemic diseases ~multi centered clinical study~ 2nd report., Shinji Matsuda, Tsutomu Sugaya, Satsuki Kato, Eiji Nemoto, Yasuo Takeuchi, Daichi Kita, Yukihiro Numabe, Tetsuya Nishida, Yorimasa Ogata, Kitetsu Shin, Takatoshi Nagano, Toshiya Morozumi, Yasutaka Komatsu, Nanae Dewake, Yosuke Kamiya, Masahiro Kitamura, Yoichiro Taguchi, Shogo Takashiba, Hiromichi Yumoto, Akiko Yamashita, Yasunori Yoshinaga, Atsutoshi Yoshimura, Hiroyuki Kawaguchi, The 66th Autumn Meeting of Japanese Society of Periodontology, 2023/05/27, Without Invitation, Japanese
  5. Identification of new periodontal examination to evaluate the association between periodontitis and systemic diseases ~multi centered clinical study~., 20220902, Shinji Matsuda, Tsutomu Sugaya, Satsuki Kato, Eiji Nemoto, Yasuo Takeuchi, Daichi Kita, Yukihiro Numabe, Tetsuya Nishida, Yorimasa Ogata, Kitetsu Shin, Takatoshi Nagano, Toshiya Morozumi, Yasutaka Komatsu, Nanae Dewake, Yosuke Kamiya, Masahiro Kitamura, Yoichiro Taguchi, Shogo Takashiba, Hiromichi Yumoto, Akiko Yamashita, Yasunori Yoshinaga, Atsutoshi Yoshimura, Hiroyuki Kawaguchi, The 64th Autumn Meeting of Japanese Society of Periodontology, 2022/09/02, Without Invitation, Japanese
  6. The role of Butylidenephthalide in drug-induced gingival overgrowth, Tomoya Ueda, Shinji Matsuda, Yurika Ninomiya, Ai Okanobu, Saki Hatano, Takumi Memida, Mikihito Kajiya, Kazuhisa Ouhara, Noriyoshi Mizuno, The 65th Spring Meeting of the Japanese Society of Periodontology, 2022/06/02, Without Invitation, Japanese
  7. Elucidation mechanisms of multiple root resorption in systemic sclerosis patients., Takumi Memida, Shinji Matsuda, Shigeki Suzuki, Mikihito Kajiya, Kazuhisa Ouhara, Ai Okanobu, Saki Hatano, Daisuke Furutama, Hideki Shiba, Satoru Yamada, Noriyoshi Mizuno, The 64th Autumn Meeting of Japanese Society of Periodontology, 2021/10/15, Without Invitation, Japanese
  8. The role of NR4A1 in Nifedipine or Phenytoin induced gingival overgrowth, Saki Hatano, Shinji Matsuda, Ai Okanobu, Mikihito Kajiya, Daisuke Furutama, Takumi Memida, Tsuyoshi Fujita, Hidemi Kurihara, The 62th Autumn Meeting of the Japanese Society of Periodontology, 2019/10/24, Without Invitation, Japanese
  9. The Role of IL-6 induced by Experimental Periodontitis on Inflammatory Response of Hippocampal Region in Mice, aisuke Furutama, Shinji Matsuda, Tsuyoshi Fujita, Mikihito Kajiya, Ai Okanobu, Saki Hatano, Takumi Memida, Noriyoshi Mizuno, Hidemi Kurihara, The 62th Autumn Meeting of the Japanese Society of Periodontology, 2019/10/24, Without Invitation, Japanese
  10. Elucidation of the role of NR4A1 in CsA induced gingival overgrowth, Ai Okanobu, Shinji Matsuda, Saki Hatano, Mikihito Kajiya, Tsuyoshi Fujita, Hidemi Kurihara, 7th Hiroshima Conference, 2018/03/29, Without Invitation, English
  11. Effects of brain-derived neurotrophic factor (BDNF) as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, Shinya Sasaki, Katsuhiro Takeda, Manabu Takewaki, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 2017/09/22, Without Invitation, English
  12. Elucidation of the role of NR4A1 in CsA induced gingival overgrowth, Ai Okanobu, Shinji Matsuda, Mikihito Kajiya, Hidemi Kurihara, 2017/09/22, Without Invitation, English
  13. Case report that improved drug-induced gingival overgrowth with chronic periodontitis performed by initial treatment, Chika Kozono Shinji Matsuda,Yukiko Nagatani,Miyuki Nakaoka,Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/08, Without Invitation, Japanese
  14. The effects of optineurin on osteoblast differentiation, Noriyoshi Mizuno Shinji Matsuda, Tetsuya Yoshimoto, Tomoyuki Iwata, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tsuyoshi Fujita,Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/07, Without Invitation, Japanese
  15. Oral Elucidation of the role of NR4A1 in drug induced gingival overgrowth, Ai Okanobu,Shinji Matsuda, Mikihito Kajiya, Tsuyoshi Fujita, Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/07, Without Invitation, Japanese
  16. Effectiveness of the combination of SRP and brain-derived neurotrophic factor (BDNF) in the treatment of ligature-induced small periodontal defect in dogs, Sasaki S Takeda K, Takewaki M, Aida Y, Kajiya M, Matsuda S, Mizuno N, Fujita T, Kurihara H., The 59th fall meeting of the Japanese society of Periodontology, 2016/10/07, Without Invitation, Japanese
  17. Elucidation of the role of NR4A1 in drug induced gingival overgrowth, Ai Okanobu,Shinji Matsuda, Mikihito Kajiya, Tsuyoshi Fujita, Hidemi Kurihara, the 49th Hiroshima University Dental Society, 2016/07/02, Without Invitation, English
  18. The effects of optineurin on periodontal tissue destruction, Shinobu Matsui Noriyoshi Mizuno, Shinji Matsuda, Manabu Takewaki, Masahiro Yamakawa, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tomoyuki Iwata,Tsuyoshi Fujita,Hidemi Kurihara, 94th Annual Meeting of the International Association for Dental Research, 2016/06/22, Without Invitation, Japanese
  19. The effects of optineurin on periodontal tissue destruction, Shinobu Matsui Noriyoshi Mizuno, Shinji Matsuda, Mikihito Kajiya, Kazuhisa Ouhara,Tsuyoshi Fujita,Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05/20, Without Invitation, Japanese
  20. Evaluation of periodontitis with Porphyromonas gulae infection in debetes model mice, Keiichi Akutagawa, Tsuyoshi Fujita, Yuushi Uchida, Tasuku Takemura, Kazuhisa Ouhara, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05/20, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. The NSK Nakanishi Foundation 2024 research grant, Basic research to aim development novel anti-masticatory muscle sarcopenia drug – drug discovery research using DNA Encoded Library screening -, 2025/03, 2028/03
  2. 2025/01/13, 2026/03/31
  3. KAKENHI, 2014, 2015
  4. KAKENHI, 2012, 2014
  5. KAKENHI, Elucidation of the mechanism of BDNF-induced suppression of gingival epithelium invasion in the process of periodontal tissue regeneration, 2012, 2013
  6. KAKENHI, 2016, 2018
  7. KAKENHI, 2015, 2018
  8. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021

Social Activities

History as Committee Members

  1. NPO Japanese Society of Periodontology Young Researchers Training Working Group, 2021/04, 2022/03, Japanese Society of Periodontology

Other Social Contributions

  1. Kyushu Dental University Hiroshima Prefecture Alumni Association Academic Lecture 2023, Kyushu Dental University Hiroshima Prefecture Alumni Association Academic Lecture 2023, Lecturer, Lecture, Others