MAKIKO FUJII

Last Updated :2022/10/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
E-mail
fujiimhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Tokyo Medical and Dental University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Experimental pathology
  • Medicine,dentistry, and pharmacy;Dentistry;Pathobiological dentistry / Dental radiology

Research Keywords

  • Malignant Mesothelioma, Mucosal Melanoma, TGF-beta, Hippo Signal Pathway, Heavy Ion Radiation Therapy

Affiliated Academic Societies

  • Japanese Cancer Association
  • The Japanese Tissue Culture Association
  • American Association for Cancer Research

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 1Term, Development of International Collaboration in Medical Science
  2. 2022, Liberal Arts Education Program1, 3Term, Cell Science
  3. 2022, Undergraduate Education, First Semester, Introductory Japanese Culture
  4. 2022, Undergraduate Education, Second Semester, Introductory Japanese Culture
  5. 2022, Undergraduate Education, 4Term, Overview of Dentistry
  6. 2022, Undergraduate Education, 4Term, Life Science
  7. 2022, Undergraduate Education, 4Term, Genomic Medicine
  8. 2022, Undergraduate Education, 4Term, Research Start-Up
  9. 2022, Undergraduate Education, 2Term, Topics in Dental Research II
  10. 2022, Undergraduate Education, First Semester, Dental Research Practices
  11. 2022, Undergraduate Education, Second Semester, Dental Research Practices
  12. 2022, Undergraduate Education, 2Term, International Future Dentistry with the Outcomes of Researches
  13. 2022, Undergraduate Education, 2Term, Cancer Biology
  14. 2022, Undergraduate Education, First Semester, Dental Research Practices
  15. 2022, Undergraduate Education, 4Term, Research Start-Up
  16. 2022, Undergraduate Education, 4Term, Research Start-Up
  17. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  18. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  19. 2022, Graduate Education (Master's Program) , First Semester, Research
  20. 2022, Graduate Education (Master's Program) , Second Semester, Research
  21. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Genomic Oncology and Oral Medicine
  22. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Genomic Oncology and Oral Medicine
  23. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Genomic Oncology and Oral Medicine
  24. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Genomic Oncology and Oral Medicine

Research Activities

Academic Papers

  1. SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes., Molecular cell, 24(5), 2006
  2. Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells., Carcinogenesis, 30(7), 2009
  3. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation., The American journal of pathology, 160(3), 2002
  4. Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma., Cancer research, 69(23), 2009
  5. Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers., International journal of cancer, 127(9), 2010
  6. LATS2 is a tumor suppressor gene of malignant mesothelioma., Cancer research, 71(3), 2011
  7. Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis., The American journal of pathology, 178(4), 2011
  8. Activation of the PI3K-AKT pathway in human malignant mesothelioma cells., Molecular medicine reports, 2(2)
  9. Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(7), 2011
  10. Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour., Gut, 61(3), 2012
  11. TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth., The Journal of experimental medicine, 209(3), 2012
  12. Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma., Carcinogenesis, 33(7), 2012
  13. Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 7(5), 2012
  14. Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells., The Journal of biological chemistry, 287(33), 2012
  15. Exploration of a new drug that targets YAP., Journal of biochemistry, 152(3), 2012
  16. Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade., Cell cycle (Georgetown, Tex.), 11(18), 2012
  17. Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer., The Journal of surgical research, 179(1), 2013
  18. Hepatitis virus infection affects DNA methylation in mice with humanized livers., Gastroenterology, 146(2), 2014
  19. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer., Lung cancer (Amsterdam, Netherlands), 83(1), 2014
  20. Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer., Oncotarget, 9(59), 2018
  21. PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-beta (TGF-beta) signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(13), 4966-4980, 20190329
  22. Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation, Sci Rep., 10, 4134, 20200305