MAKIKO FUJII

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
E-mail
fujiimhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Tokyo Medical and Dental University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Experimental pathology
  • Medicine,dentistry, and pharmacy;Dentistry;Pathobiological dentistry / Dental radiology

Research Keywords

  • Malignant Mesothelioma, Mucosal Melanoma, TGF-beta, Hippo Signal Pathway, Heavy Ion Radiation Therapy

Affiliated Academic Societies

  • Japanese Association for medical artificial intelligence
  • Japanese Cancer Association
  • The Japanese Tissue Culture Association
  • American Association for Cancer Research

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 1Term, Development of International Collaboration in Medical Science
  2. 2025, Liberal Arts Education Program1, 3Term, Cell Science
  3. 2025, Undergraduate Education, First Semester, Introductory Japanese Culture
  4. 2025, Undergraduate Education, Second Semester, Introductory Japanese Culture
  5. 2025, Undergraduate Education, 4Term, Overview of Dentistry
  6. 2025, Undergraduate Education, 4Term, Life Science
  7. 2025, Undergraduate Education, 4Term, Genomic Medicine
  8. 2025, Undergraduate Education, 4Term, Research Start-Up
  9. 2025, Undergraduate Education, 1Term, Topics in Dental Research I
  10. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  11. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  12. 2025, Undergraduate Education, 2Term, International Future Dentistry with the Outcomes of Researches
  13. 2025, Undergraduate Education, 2Term, Cancer Biology
  14. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  15. 2025, Undergraduate Education, 4Term, Research Start-Up
  16. 2025, Undergraduate Education, 4Term, Research Start-Up
  17. 2025, Graduate Education (Master's Program) , First Semester, Seminar
  18. 2025, Graduate Education (Master's Program) , Second Semester, Seminar
  19. 2025, Graduate Education (Master's Program) , First Semester, Research
  20. 2025, Graduate Education (Master's Program) , Second Semester, Research
  21. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Genomic Oncology and Oral Medicine
  22. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Genomic Oncology and Oral Medicine
  23. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Genomic Oncology and Oral Medicine
  24. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Genomic Oncology and Oral Medicine

Research Activities

Academic Papers

  1. Proposal for Points of Consideration for Pluripotent Stem Cell Culture, In Vitro Cellular & Developmental Biology - Animal., 2024
  2. Microgravity alters growth and gene expression of malignant mesothelioma cells, The Journal of Hiroshima University Dental Society, 54(2), 78-88, 20221201
  3. The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications., J Biol Chem., 280(42067), 2005
  4. The bone morphogenetic protein type Ib receptor is a major mediator of glial differentiation and cell survival in adult hippocampal progenitor cell culture., Mol Biol Cell., 2004
  5. Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis., J Invest Dermatol., 123, 2004
  6. Amelioration of radiation-induced fibrosis: Inhibtion of transforming growth factor-beta signaling by halofuginone., J Biol Chem., 2004
  7. Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin., Am J Pathol., 2003
  8. Keratinocyte growth inhibition by high-dose epidermal growth factor is mediated by transforming growth factor beta autoinduction: a negative feedback mechanism for keratinocyte growth., J Invest Dermatol., 2003
  9. Smad protein and TGF-beta signaling in vascular smooth muscle cells., Int J Mol Med., 2003
  10. Bone morphogenetic protein signaling in articular chondrocyte differentiation., Biochem Biophys Res Commun., 301, 617, 2003
  11. Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells., Mol Cell Endocrinol., 193, 299, 2002
  12. Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor- in human umbilical vein endothelial cells., J Cell Physiol., 193, 299, 2002
  13. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation., Am J Pathol., 160, 1057, 2002
  14. cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7, Cytogenet Cell Genet., 95, 2001
  15. Ectopic expression of Smad7 inhibits transforming growth factor-beta responses in vascular smooth muscle cells., Life Sci., 69(2641), 2001
  16. Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction., J Cell Sci., 114, 1483, 2001
  17. Smad-mediated transcription is required for transforming growth factor-1-induced p57(Kip2) proteolysis in osteoblastic cells., J Biol Chem., 276, 2001
  18. A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interactionin cleidocranial dysplasia., Proc Natl Acad Sci USA, 97, 2000
  19. ★, Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation., Mol Biol Cell, 10, 3801, 1999
  20. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice., J Clin Invest., 104, 5, 1999
  21. Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA, J Biol Chem., 1998
  22. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK), EMBO J., 17, 2596, 1998
  23. BMP and activin membrane-bound inhibitor regulate connective tissue growth factor controlling mesothelioma cell proliferation, BMC CANCER, 22(1), 20220915
    Link to Paper Search Results by DOI
  24. ★, SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes., Molecular cell, 24(5), 2006
  25. Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells., Carcinogenesis, 30(7), 2009
  26. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation., The American journal of pathology, 160(3), 2002
  27. Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma., Cancer research, 69(23), 2009
  28. Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers., International journal of cancer, 127(9), 2010
  29. LATS2 is a tumor suppressor gene of malignant mesothelioma., Cancer research, 71(3), 2011
  30. Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis., The American journal of pathology, 178(4), 2011
  31. Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(7), 2011
  32. Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour., Gut, 61(3), 2012
  33. ★, TGF-beta synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth., The Journal of experimental medicine, 209(3), 2012
  34. Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma., Carcinogenesis, 33(7), 2012
  35. Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 7(5), 2012
  36. Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells., The Journal of biological chemistry, 287, 27396, 2012
  37. Exploration of a new drug that targets YAP., Journal of biochemistry, 152(3), 2012
  38. ★, Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGF-beta signaling and defects in the Hippo signaling cascade., Cell cycle (Georgetown, Tex.), 11(18), 1, 2012
  39. Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer., The Journal of surgical research, 179(1), 24-32, 2013
  40. Hepatitis virus infection affects DNA methylation in mice with humanized livers., Gastroenterology, 146(2), 2014
  41. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer., Lung cancer (Amsterdam, Netherlands), 83(1), 2014
  42. Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer., Oncotarget, 9(59), 2018
  43. PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-beta (TGF-beta) signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(13), 4966-4980, 20190329
    Link to Paper Search Results by DOI
  44. Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation, Sci Rep., 10, 4134, 20200305
  45. Elimination of Porphyromonas gingivalis inhibits liver fibrosis and inflammation in NASH, JOURNAL OF CLINICAL PERIODONTOLOGY, 48(10), 1367-1378, 202110
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Alteration of CTGF expression by PDGFR in malignant mesothelioma, Tomoya Suehiro, The 82nd Annual Meeting of The Japanese Cancer Association, 2023/09/21, Without Invitation, Japanese
  2. PDGFR regulates cell proliferation through CTGF expression, Tomoya Suehiro, Yuichi Mine, Makiko Fujii, The 81st Annual Meeting of the Japanese Cancer Association, 2022/09/29, Without Invitation, Japanese
  3. The activity of CTGF in cytoplasm in cancer cells, The 42nd Annual Meeting of the Biomolecular Biology Society of Japan, 2019/12/03, Without Invitation, Japanese
  4. Inhibitory effects of molecular targeting agents and signal transduction mechanism in malignant mesothelioma, 2019/11/18, Without Invitation, Japanese
  5. Therapeutic development based on personalized medicine for malignant mesothelioma, 2019/09/26, Without Invitation, Japanese
  6. CTGF plays an important role in the growth of malignant tumor originated from non-epithelial cells, Makiko Fujii,, Hirotaka Osada, Hayao Nakanishi, Yoshitaka Sekido, 2015/10/08, Without Invitation, English, Tomoki Naoe, International Conference Center, Nagoya
  7. The Role of CTGF in Cancer Cells, Nguyen Truong Duc Hoang, Yuichi Mine , Yoshitaka Sekido, Makiko Fujii, Japanese Cancer Association Conference, 2018/10/29, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Challenging Research (Pioneering)), 2022, 2023
  2. KAKENHI, 2016, 2017
  3. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2019, 2021

Social Activities

History as Committee Members

  1. a secretary， a councilor, 2019/04/01, 2021/03/31
  2. a secretary， a councilor, 2018/04/01, 2021/03/31

Organizing Academic Conferences, etc.

  1. 2022/07
  2. 第93回日本組織培養学会大会, 2021/
  3. 第79回日本癌学会総会, 2020/

History as Peer Reviews of Academic Papers

  1. 2022, Oncogene, Others