Masaru Ueno

Last Updated :2025/02/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
scmuenohiroshima-u.ac.jp
Self-introduction
I study about chromosome stability and function to apply them for prevent and cure cancer. I use genetics, molecular biology, cell biology.I want to understand the system of nuclear functions that regulate gene expression and maintain chromosome stability at molecular lebel. I use fluorescence live cell imaging of biomolecure that function inside the nucleus to quantitate the 3 dimention positions and movements of biomolecules. These data are analysed mathmatically to know the function of biomolecule and to find new biological phenomina.

Basic Information

Academic Degrees

  • Ph.D., Kyoto Institute of Technology
  • Master of Engineering, Osaka Prefecture University

Research Fields

  • Biology;Basic biology;Genetics / Chromosome dynamics
  • Agricultural sciences;Boundary agriculture;Applied molecular and cellular biology

Research Keywords

  • Yeast
  • Chromosome
  • Telomere

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 4Term, Basic life science
  2. 2024, Undergraduate Education, First Semester, Training of Biotechnology I
  3. 2024, Undergraduate Education, 2Term, Molecular biology II
  4. 2024, Undergraduate Education, Year, Graduation Thesis
  5. 2024, Graduate Education (Master's Program) , 1Term, Integrated Genome Science A
  6. 2024, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  7. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  8. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  9. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  10. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  11. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  12. 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  13. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  14. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  15. 2024, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  16. 2024, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  17. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  18. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  19. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  20. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  21. 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  22. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  23. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Award of Education

  1. 2011/.1
  2. 2016/12/27

Research Activities

Academic Papers

  1. A Double Mutant between Fission Yeast Telomerase and RecQ Helicase Is Sensitive to Thiabendazole, an Anti-Microtubule Drug, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76(2), 264-269, 201202
    Link to Paper Search Results by DOI
  2. APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage, CELL DIVISION, 7, 20120209
    Link to Paper Search Results by DOI
  3. Fission Yeast RecQ Helicase Rqh1 Is Required for the Maintenance of Circular Chromosomes, MOLECULAR AND CELLULAR BIOLOGY, 33(6), 1175-1187, 201303
    Link to Paper Search Results by DOI
  4. ★, Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss., Molecular Biology of the Cell, 18(6), 2378-2387, 20070601
  5. ★, Fission yeast Dna2 is required for generation of the telomeric single-strand overhang., Molecular and Cellular Biology, 24(21), 9557-9567, 20041101
  6. Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase, Genes to Cells, 11(12), 1367-1379, 20061201
  7. TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients, The EMBO Journal, 25(16), 3832-3842, 20060801
  8. A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe, Current Genetics, 49(6), 403-413, 20060321
  9. Dual DNA recognition codes of a short peptide derived from the basic leucine zipper protein EmBP1, Bioorganic & Medicinal Chemistry, 13(9), 3107-3116, 20050501
  10. Sequence-Specific Binding of the Schizosaccharomyces pombe His1 Protein to Fission Yeast Telomeric DNA, Chemistry & Biodiversity, 1(9), 1344-1353, 20040923
  11. Fission yeast Arp6 is required for telomere silencing, but functions independently of Swi6, Nucleic Acids Research, 32(2), 736-741, 20040201
  12. Synthesis and crystal structures of metal complexes with 4,5-imidazole-dicarboxylate chelates: self-assembled structures via NHOC intermolecular hydrogen bonds, Inorganic Chemistry Communications, 7(11), 1191-1194, 20041101
  13. The roles of DNA replication and rcombination factors in telomere maintenance, Seikagaku, 79(9), 868, 20070925
  14. Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation., Mol. Cell. Biol, 31, 495-506, 20110201
  15. A novel method of screening cell-cycle blockers as candidates for anti-tumor reagents by using yeast as a screening tool, Biosci. Biotech. Biochem., 74(2), 411-414, 20100201
  16. Expression of mutant RPA in human cancer cells causes telomere shortening., Bioscience Biotechnology and Biochemistry, 74(2), 382-385, 20100201
  17. Rpd3/HDAC complex is present at the URS1 cis-element with hyperacetylated histone H3, Biosci. Biotechnol. Biochem, 73(2), 378-384, 20090201
  18. Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation., Mol. Cell. Biol., 31, 495-506, 20110501
  19. Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss, MOLECULAR BIOLOGY OF THE CELL, 18(6), 2378-2387, 200706
    Link to Paper Search Results by DOI
  20. The Rpd3/HDAC Complex Is Present at the URS1 cis-Element with Hyperacetylated Histone H3, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73(2), 378-384, 200902
    Link to Paper Search Results by DOI
  21. Roles of DNA Repair Proteins in Telomere Maintenance, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(1), 1-6, 201001
    Link to Paper Search Results by DOI
  22. Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(2), 382-385, 201002
    Link to Paper Search Results by DOI
  23. Fission Yeast Pot1 and RecQ Helicase Are Required for Efficient Chromosome Segregation, MOLECULAR AND CELLULAR BIOLOGY, 31(3), 495-506, 201102
    Link to Paper Search Results by DOI
  24. Genetic and Metabolomic Dissection of the Ergothioneine and Selenoneine Biosynthetic Pathway in the Fission Yeast, S. pombe, and Construction of an Overproduction System, PLOS ONE, 9(5), 20140314
    Link to Paper Search Results by DOI
  25. Rad51-Dependent Aberrant Chromosome Structures at Telomeres and Ribosomal DNA Activate the Spindle Assembly Checkpoint, MOLECULAR AND CELLULAR BIOLOGY, 34(8), 1389-1397, 201404
    Link to Paper Search Results by DOI
  26. SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(16), 5950-5955, 20140422
    Link to Paper Search Results by DOI
  27. 3,6-Epidioxy-1,10-bisaboladiene inhibits G(1)-specific transcription through Swi4/Swi6 and Mbp1/Swi6 via the Hog1 stress pathway in yeast, FEBS JOURNAL, 281(20), 4612-4621, 201410
    Link to Paper Search Results by DOI
  28. RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae, PLOS ONE, 10(6), 20150618
    Link to Paper Search Results by DOI
  29. The yeast chromatin remodeler Rsc1-RSC complex is required for transcriptional activation of autophagy-related genes and inhibition of the TORC1 pathway in response to nitrogen starvation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(4), 1248-1253, 20150904
    Link to Paper Search Results by DOI
  30. Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(1), 140-146, 20150814
    Link to Paper Search Results by DOI
  31. The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts, YEAST, 32(9), 607-614, 201509
    Link to Paper Search Results by DOI
  32. Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres, PLOS ONE, 10(10), 20151014
    Link to Paper Search Results by DOI
  33. A diffusion model for the coordination of DNA replication in Schizosaccharomyces pombe, SCIENTIFIC REPORTS, 6, 20160105
    Link to Paper Search Results by DOI
  34. Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine, PLOS ONE, 12(11), 20171109
    Link to Paper Search Results by DOI
  35. Chromosome passenger complex is required for the survival of cells with ring chromosomes in fission yeast, PLOS ONE, 13(1), 20180103
    Link to Paper Search Results by DOI
  36. Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(4), 1284-1290, 20180219
    Link to Paper Search Results by DOI
  37. Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells, SCIENTIFIC REPORTS, 8, 20181004
    Link to Paper Search Results by DOI
  38. Spindle pole body movement is affected by glucose and ammonium chloride in fission yeast, Biochem Biophys Res Commun., 115(4), 820-825, 20190416
  39. Reliable imaging of ATP in living budding and fission yeast, Journal of Cell Science, 132, 1-11, 20190417

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role of nuclear membrane protein Bqt4 for the regulation of the nucleolus position and volume in fission yeast, Masaru Ueno, 2021/03/01, Without Invitation, Japanese
  2. Roles of telomere-tethering protein for the regulation of nuclear organization and dynamics, Masaru Ueno, 2019/12, With Invitation, Japanese
  3. TOR Signaling and TOR Complex Assembly, Ted Power, 2019/12, With Invitation, English
  4. Nucleolus dynamics is affected by different stresses and proteins that localize to nuclear membrane or telomere, Masaru Ueno, 10th International Pombe 2019 meeting, 2019/07, Without Invitation, English
  5. Analysis of chromosome stability and dynamics in fission yeast, Masaru Ueno, The International Symposium on Biofunctional Chemistry, 2019/04, With Invitation, English, Kyoto Uji
  6. Spindle pole body movement is affected by glucose concentration, medium, and DNA replication stress in fission yeast, Masaru Ueno, FASEB Yeast Chromosome Biology and Cell Cycle, 2018/07/15, Without Invitation, English, Steamboat Springs, Colorado USA
  7. Identification of factors affecting chromatin dynamics by live cell imaging and quantitative analysis in fission yeast, Masaru Ueno, 2018/03/21, Without Invitation, English
  8. Replication stress and chromosome instability, Jo Murray, 5th HiHA International Symposium, 2018/03/12, Without Invitation, English
  9. Different regulation of centromere and subtelomere movement by glucose, medium and DNA damage in fission yeast, Masaru Ueno, seminar at Friedrich Miescher Institute for Biomedical Research in Switzerland, 2017/05/18, With Invitation, English, Susan M. Gasser, Switzerland
  10. Different regulation of centromere and subtelomere movement by glucose, medium and DNA damage in fission yeast, Masaru Ueno, 4D Nucleome: The Cell Nucleus in Space and Time, 2017/05/15, Without Invitation, English, Krakow Poland
  11. The Smc5/6 complex and replication stress, Jo Murray, 4th HiHA International Symposium, 2017/03/10, With Invitation, English
  12. DNA repair pathway choice regulation by the small protein CYREN, Jan Karlseder, HiHA 4th International Symposium, 2017/03/10, With Invitation, Japanese
  13. modeling chromatin dynamics as a polymer fiber:what we learn from single molecule tracking, Susan Gasser, 5th International Symposium of the Mathematics on Chromatin Live Dynamics in March, 2017/03/09, With Invitation, English
  14. lattice light sheet microscopy: development and applications, Bi-Chang Chen, 5th International Symposium of the Mathematics on Chromatin Live Dynamics, 2017/03/09, With Invitation, English
  15. Different regulation of centromere and telomere movement by glucose, medium and DNA damage in fission yeast, Masaru Ueno, 5th International Symposium of the Mathematics on Chromatin Live Dynamics, 2017/03/09, Without Invitation, English
  16. Analysis of glucose-dependent chromosome dynamics in fission yeast, Masaru Ueno, 2016/11/30, With Invitation, English
  17. Using single particle trajectory statistics and polymer simulations to analyze and predict changes in chromatin structure, Andrew Seeber, 2016/11/28, With Invitation, English
  18. Analysis of glucose-dependent chromosome dynamics in fission yeast, Masaru Ueno, 2016/11/13, Without Invitation, English
  19. The Smc5/6 complex, regulation of recombination and replication fork stability, Jo Murray, HiHA国際シンポジウム, 2016/03, With Invitation, English, Higashi-hiroshima
  20. Identification of genes required for the formation or maintenance of circular chromosomes, Masaru Ueno, 2015/12, Without Invitation, Japanese, Kobe Japan
  21. Screening of novel factors involved in formation and maintenance of circular chromosome in S. pombe, Masaru Ueno, The 4th International Symposium of the Mathematics on Chromatin Live Dynamics, 2015/12, Without Invitation, Japanese
  22. Searching for cancer’s new weak points using fission yeast, 2015/11, With Invitation, Japanese
  23. Fission yeast exo1 and rqh1 contribute to degradation of uncapped telomere, Masaru Ueno, EMBO Conference on DNA Replication, Chromosome Segregation and Cell Division, 2015/07, Without Invitation, English, EMBO, Egham UK
  24. Fission yeast exo1 and rqh1 contribute to degradation of uncapped telomere, Masaru Ueno, The 8th international fission yeast meeting, 2015/06, Without Invitation, English, Kobe Japan
  25. Understanding the workings of the Schizosaccharomyces pombe genome in three dimensions, Justin O'Sullivan, The Collaborated Seminar by 5 Graduated Schools, 2015/06, With Invitation, English, Masaru Ueno, Higashi-Hiroshima

Social Activities

Organizing Academic Conferences, etc.

  1. 2006/01
  2. 2014/11
  3. 2014/09
  4. 2016/07, 2016/07