Takemasa Sakaguchi

Last Updated :2022/11/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
tsakahiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan, Japan
TEL : (+81)82-257-5157 FAX : (+81)82-257-5159
Self-introduction
I have been working in the field of virology for 35 years. I have been doing basic research on RNA viruses, mainly paramyxoviruses and influenza viruses, and hepatitis B virus, and more recently applied research on disinfectants and antiviral agents. Currently, we are working hard to combat the novel coronavirus. (April 20, 2021)

Basic Information

Major Professional Backgrounds

  • 1987/04/01, 1996/08/31, Hiroshima University, Research Associate
  • 1993/10/23, 1996/02/28, Northwestern University, Postdoctrol fellow
  • 1996/09/01, 1998/04/30, Hiroshima University, Assistant Professor
  • 1998/05/01, 2007/03/31, Hiroshima University, Associate Professor
  • 2007/04/01, 2009/03/31, Hiroshima University, Associate Professor
  • 2009/04/01, 2019/03/31, Hiroshima University, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Nagoya University, Faculty of Medicine, School of Medicine, Japan, 1979/04, 1985/03
  • Nagoya University, Graduate School of Medical Sciences, Laboratory of Molecular Pathogenesis, Japan, 1986/04, 1987/03

Academic Degrees

  • Doctor of Medicine, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology

Research Keywords

  • Sendai virus (HVJ)
  • SARS-CoV-2
  • influenza virus
  • hepatitis B virus
  • Protein three dimensional structure
  • morphogenesis
  • interferon
  • accessory protein
  • anti-virus
  • persimmon tannin

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Biological Responses
  2. 2022, Undergraduate Education, 2Term, Introduction for medical research
  3. 2022, Undergraduate Education, Intensive, Practice for medical research
  4. 2022, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  5. 2022, Undergraduate Education, 4Term, Microbiology II
  6. 2022, Graduate Education (Doctoral Program) , 1Term, Advanced Lecture on Methods in biomedical sciences
  7. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  8. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  9. 2022, Graduate Education (Master's Program) , First Semester, Research
  10. 2022, Graduate Education (Master's Program) , Second Semester, Research
  11. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  12. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  13. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  14. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  15. 2022, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense
  16. 2022, Graduate Education (Master's Program) , 1Term, Seminar on Health Policy & Global Health
  17. 2022, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  18. 2022, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  19. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Virology
  20. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Virology
  21. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Virology
  22. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Virology
  23. 2022, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. Complex formation of potassium salt of highly fatty acid with hemagglutinin protein in influenza virus via exothermic interaction, BIOCHEMISTRY AND BIOPHYSICS REPORTS, 31, 20220901
  2. Duration of infectious viral shedding in patients with mild to moderate COVID-19 treated with REGN-CoV2?, JOURNAL OF INFECTION AND CHEMOTHERAPY, 28(7), 912-917, 20220701
  3. Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor, PROTEIN SCIENCE, 31(6), 20220601
  4. In vitro Suppression of SARS-CoV-2 Infection by Existing Kampo Formulas and Crude Constituent Drugs Used for Treatment of Common Cold Respiratory Symptoms, FRONTIERS IN PHARMACOLOGY, 13, 20220329
  5. Sequential dynamics of virological and serological changes in the serum of SARS-CoV-2 infected patients, JOURNAL OF MEDICAL VIROLOGY, 94(4), 1734-1737, 20220401
  6. Crystal structure of O-ureidoserine racemase found in the d-cycloserine biosynthetic pathway, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 90(4), 912-918, 20220401
  7. Novel Coronavirus Variants, Hiroshima Igaku, 75(2), 56-60, 20220228
  8. Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan, SCIENTIFIC REPORTS, 12(1), 20220214
  9. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation, NATURE, 602(7896), 300-+, 20220210
  10. Duration of infectious virus shedding in patients with severe coronavirus disease 2019 who required mechanical ventilation, JOURNAL OF INFECTION AND CHEMOTHERAPY, 28(1), 19-23, 20220101
  11. Exopolysaccharide Produced by Plant-Derived Lactobacillus plantarum SN35N Exhibits Antiviral Activity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44(12), 1886-1890, 20211201
  12. Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding, JOURNAL OF VIROLOGY, 95(19), 20211001
  13. ★, Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target, SCIENTIFIC REPORTS, 11(1), 18581, 20210917
  14. Ethanol Susceptibility of SARS-CoV-2 and Other Enveloped Viruses, BIOCONTROL SCIENCE, 26(3), 177-180, 20210910
  15. The Association between Wearing a Mask and COVID-19, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(17), 9131, 20210901
  16. Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal, SCIENTIFIC REPORTS, 11(1), 16629, 20210817
  17. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 221, 112239, 20210801
  18. Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination, AMERICAN JOURNAL OF INFECTION CONTROL, 49(3), 299-301, 20210301
  19. Effect of intermittent irradiation and dose-response of 222 nm ultraviolet light on SARS-CoV-2 contamination., Photodiagnosis and Photodynamic Therapy, 33, 102184, 20210301
  20. Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan, PLOS ONE, 16(2), 20210205
  21. Efficacy of photodynamic antimicrobial chemotherapy on Acanthamoeba keratitis in vivo., Lasers in Surgery and Medicine, 20201201
  22. Development of an Oncolytic Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA, ANTICANCER RESEARCH, 40(11), 6319-6325, 20201101
  23. Characterization of a unique Sendai virus isolate and its potential as an effective vaccine adjuvant., BIO Clinica, 35(2), 78-81, 20200201
  24. Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus Replication In Vitro: Suppression of Viral Protein Synthesis by Glycyrrhizae Radix, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 20191203
  25. Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 28, 166-171, 20191201
  26. Development of new concept viral vectors exerting both vaccine and adjuvant activities., IMPACT, 2019(7), 9-11, 20190801
  27. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi, LASERS IN MEDICAL SCIENCE, 34(4), 743-747, 20190601
  28. Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice, JOURNAL OF ORTHOPAEDIC RESEARCH, 37(5), 1192-1201, 20190501
  29. Current Status and Prospects of Viral Vector Vaccines, BIO Clinica, 34(2), 107-111, 20190201
  30. How Sendai virus counteracts interferon, 50, 7-12, 20190101
  31. Inactivation of human and avian influenza viruses by potassium oleate of natural soap component through exothermic interaction, PLOS ONE, 13(9), 20180927
  32. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction, PLOS ONE, 13(5), 20180521
  33. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, LASERS IN MEDICAL SCIENCE, 33(7), 1455-1460, 20180901
  34. Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma, JOURNAL OF ORTHOPAEDIC RESEARCH, 36(9), 2562-2569, 20180901
  35. Eligibility of Feline Calicivirus for a Surrogate of Human Norovirus in Comparison with Murine Norovirus, Poliovirus and Coxsackievirus, BIOCONTROL SCIENCE, 23(3), 145-149, 20180901
  36. A Single Amino Acid Substitution within the Paramyxovirus Sendai Virus Nucleoprotein Is a Critical Determinant for Production of Interferon-Beta-Inducing Copyback-Type Defective Interfering Genomes, JOURNAL OF VIROLOGY, 92(5), 20180501
  37. Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(48), 19752-19766, 20171201
  38. Inactivation of the influenza virus by a supplemental fermented plant product (Manda Koso)., Hiroshima Journal of Medical Sciences, 66(4), 97-101, 20171201
  39. High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120, MARINE BIOTECHNOLOGY, 18(2), 215-231, 20160401
  40. Nonstructural protein p39 of feline calicivirus suppresses host innate immune response by preventing IRF-3 activation, VETERINARY MICROBIOLOGY, 185, 62-67, 20160101
  41. High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120 (vol 18, pg 144, 2016), MARINE BIOTECHNOLOGY, 18(3), 448-448, 20160101
  42. Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12), 20160101
  43. Airborne virus detection by a sensing system using a disposable integrated impaction device, JOURNAL OF BREATH RESEARCH, 10(3), 20160101
  44. ★, Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, Journal of Virology, 89(22), 11487-11499, 20151115
  45. Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy., Molecular Vision, 21, 532-537, 20150502
  46. Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro., Lasers in Medical Science, 30(1), 383-387, 20150101
  47. Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin, MARINE DRUGS, 13(6), 3454-3465, 20150101
  48. IFN-beta-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner, FRONTIERS IN MICROBIOLOGY, 6, 20150101
  49. Sendai virus C proteins regulate viral genome and antigenome synthesis to dictate the negative genome polarity., Journal of Virology, 88(1), 690-698, 20140101
  50. Clustered basic amino acids of the small Sendai virus C protein Y1 are critical to its Ran GTPase-mediated nuclear localization., PLoS One, 8(8), 20130809
  51. The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer., International Journal of Molecular Medicine, 31(2), 299-306, 20130201
  52. ★, Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses., PLoS One, 8(1), 20130125
  53. Passage of a Sendai virus recombinant in embryonated chicken eggs leads to markedly rapid accumulation of U-to-C transitions in a limited region of the viral genome., PLoS One, 7(11), 20121121
  54. Inhibition of virus-like particle release of Sendai virus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2., Hiroshima Journal of Medical Sciences, 61(3), 59-67, 20120901
  55. Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein., Journal of Virology, 86(13), 7136-7145, 20120701
  56. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation., Neuroscience Letters, 505(3), 279-281, 20111121
  57. Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5., Microbiology and Immunology, 55(11), 760-767, 20111101
  58. Decreased expression in nuclear factor-kB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency., Journal of Clinical Immunology, 31(5), 762-772, 20111001
  59. Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth., Journal of Orthopaedic Research, 29(5), 795-800, 20110501
  60. Paramyxovirus assembly and budding: building particles that transmit infections., The International Journal of Biochemistry & Cell Biology, 42(9), 1416-1429, 20100901
  61. Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection., Virology, 405(2), 334-341, 20100901
  62. Conserved charged amino acids within Sendai virus C protein play multiple roles in the evasion of innate immune responses., PLoS ONE, 5(5), e10719, 20100501
  63. Studies on the paramyxovirus accessory genes by reverse genetics in the Sendai virus?mouse system., Proceedings of the Japan Academy, Series B-Physical and Biological Sciences, 84(10), 439-451, 20090105
  64. Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles., Virology, 374(2), 495-505, 20080501
  65. Contribution of the leader sequence to homologous viral interference among Sendai virus strains., Virology, 372(1), 64-71, 20080301
  66. Recruitment of Alix/AIP1 to the plasma membrane by Sendai virus C protein facilitates budding of virus-like particles., Virology, 371(1), 108-120, 20080101
  67. Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus., Journal of Biological Chemistry, 282(37), 27383-27391, 20070914
  68. Paramyxovirus budding, Virus, 57(1), 1-7, 20070601
  69. The YLDL sequence within Sendai virus m protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein., Journal of Virology, 81(5), 2263-2273, 20070401
  70. Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice., Virology, 359(1), 82-91, 20070301
  71. Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet., Hypertension Research, 30(1), 85-91, 20070101
  72. Suppression of interferon-related promoter activation by hepatitis C virus proteins expressed in cultured cells., Hiroshima Journal of Medical Sciences, 55(3), 71-77, 20060901
  73. Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors., Microbiology and Immunology, 49(9), 835-844, 20050901
  74. ★, AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding., Journal of Virology, 79(14), 8933-8941, 20050715
  75. Generation of Sendai virus nucleocapsid-like particles in yeast., Virus Research, 108(1-2), 221-224, 20050301
  76. Characterization of the amino acid residues of Sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation., Journal of Virology, 78(14), 7443-7454, 20040701
  77. Paramyxovirus Sendai virus-like particle formation by expression multiple viral proteins and acceleration of its release by C protein., Virology, 325(1), 1-10, 20040701
  78. Masking of the contribution of V protein to Sendai virus pathogenesis in an infection model with a highly virulent field isolate., Virology, 313(2), 581-587, 20030901
  79. Safety and growth suppressive effect of intra-hepatic arterial injection of AdCMV p53 combine with CDDP to Rat liver metastatic tumors., Journal of Experimental & Clinical Cancer Research, 22(3), 339-406, 20030901
  80. Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage., Virus Genes, 25(2), 189-193, 20021001
  81. Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA., Journal of Virology, 76(17), 8540-8547, 20020901
  82. Mutational analysis of the Sendai virus V protein: Importance of the conserved residues for Zn binding, virus pathogenesis, and efficient RNA editing., Virology, 299(2), 172-181, 20020801
  83. Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein., Cancer Gene Therapy, 9(8), 655-664, 20020801
  84. Alteration of Sendai virus morphogenesis and nucleocapsid incorporation due to mutation of cystein residues of the matrix protein., Journal of Virology, 76(4), 1682-1690, 20020201
  85. Molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the nationwide outbreak of 1995 in Japan., Journal of Clinical Microbiology, 40(1), 140-145, 20020101
  86. Matrix proteins of envelope viruses., Virus, 51(1), 11-19, 20010601
  87. Attenuation of a field Sendai virus isolate through egg-passages is associated with an impediment of viral genome replication in mouse respiratory cells., Archives of Virology, 146(5), 893-908, 20010501
  88. Differential expression of CD45 isoforms in tolerant and rejecting rat liver transplant recipients., Transplantation Proceedings, 33(1-2), 544, 20010301
  89. Emergence of anti-inflammatory monocytes in long-term surviving hosts of IL-10-transduced liver allografts., Cytokine, 13(3), 183-187, 20010201
  90. Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames., Virus Genes, 22(1), 47-52, 20010101
  91. Adenovirus-mediated interleukin-10 overexpression: Comparison between intraportal and intramuscular gene transfer., Transplantation Proceedings, 32(7), 2006, 20001101
  92. Involvement of the zinc-binding capacity of Sendai virus V protein in viral pathogenesis., Journal of Virology, 74(17), 7834-7841, 20000901
  93. Adenovirus-mediated interleukin-10 overexpression: Comparison between intraportal and intramuscular gene transfer., Transplantation Proceedings, 32(7), 2006, 20000401
  94. p53 gene therapy for rat liver tumor by intrahepatic arterial injection of AdCMV-p53 in combination with CDDP., Molecular Therapy, 1(5), S326, 20000401
  95. Effects of adenovirus-mediated IL-10 gene transfer on liver transplantation., Molecular Therapy, 1(5), 176-177, 20000401
  96. Adenovirus-mediated allograft transduction of Interleukin-10: Role in the induction phase of liver allograft acceptance., Transplantation Proceedings, 32, 247-248, 20000301
  97. Double-layered membrane vesicles released from mamalian cells infected with Sendai virus expressing the matrix protein of vesicular stomotitis virus., Virology, 263(1), 230-243, 19991001
  98. Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation., Gene Therapy, 6(5), 816-822, 19990501
  99. The genome nucleotide sequence of a contemporary wild strain of measles virus and its comparison with the classical Edmonston strain genome., Virology, 256(2), 340-350, 19990401
  100. Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases., Microbiology and Immunology, 43(2), 133-140, 19990201
  101. Infulenza virus M2 ion channel-two functions for virus replication., Experimental Medicine, 15(19), 114-118, 19971201
  102. Viral ion channel : structure and function of the infuluenza virus M2 protein., Virus, 47(2), 177-186, 19971201
  103. Structure and function of the influenza virus M2 ion channel protein., Japanese Journal of Clinical Medicine, 55(10), 89-94, 19971001
  104. ★, The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer., Proc. Natl. Acad. Sci. USA, 94(10), 5000-5005, 19970501
  105. ★, Phosphorylation of the Sendai virus M protein is not essential for virus replication either in vitro or in vivo., Virology, 235(2), 360-366, 19970401
  106. Protection of mice from respiratory Sendai virus infections by recombinant vaccinia viruses., Journal of Virology, 71(1), 832-838, 19970101
  107. HLA-DR8 subtyping by polymerase chain reaction (PCR)-DNA conformation polymorphism(DCP) analysis; a simple and practical genotyping method., Hiroshima J. Med. Sci., 45(3), 85-92, 19960901
  108. ★, The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus., Journal of Cell Biology, 133(4), 733-747, 19960501
  109. Correlation of proteolytic cleavage of paramyxovirus F protein precursors with expression of the fur, PACE4 and PC6 genes in mammalian cells., Journal of General Virology, 75(10), 2821-2827, 19941001
  110. Monitoring for rejection and engraftment by means of the polymerase chain reaction after rat orthotopic liver transplantation., Transplantation, 58(6), 745-748, 19940901
  111. Monitoring for engraftment following rat orthotopic liver transplantation by the polymerase chain reaction., Transplantation Proceedings, 26(2), 902-903, 19940401
  112. Sequence specificity of furin, a proprotein processing endoprotease, for the Hemagglutinin of a virulent avian influenza virus., Journal of Virology, 68(2), 1213-1218, 19940201
  113. A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains., Arhieves of Virology, 135(1-2), 159-164, 19940101
  114. Fo-containing noninfectious Sendai virus can initiate replication in mouse lungs but requires a relatively long incubation period., Journal of Virology, 67(12), 7618-7622, 19931201
  115. Expression of the HN, F, NP and M proteins of Sendai virus by recombinant vaccinia viruses and their contribution to protective immunity against Sendai virus infections in mice., Journal of General Virology, 74, 479-484, 19930301
  116. Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus., Virology, 190(1), 278-289, 19920901
  117. Detection of cytomegalovirus in urine samples by an enzyme-linked immunosorbent assay using a monoclonal antibody against the viral 150-kilodalton protein., Journal of Clinical Microbiology, 30(3), 685-690, 19920301
  118. Distribution and substrate specificity of intracellular proteolytic processing enzyme(s) for paramyxovirus fusion glycoproteins., Journal of General Virology, 73(3), 583-590, 19920301
  119. ★, Identification of endoprotease activity in the trans Golgi membranes of rat liver cells that specifically processes in vitro the fusion glycoprotein precursor of virulent Newcastle disease virus., Virology, 184(2), 504-512, 19911001
  120. Immediate protection of mice from lethal wild-type Sendai virus (HVJ) infections by a temperature-sensitive mutant, HVJpi, possessing homologous intefering capacity., Virology, 177(1), 65-74, 19900701
  121. Endoproteolytic activiation of Newcastle disease virus fusion proteins requires an intracellular acidic environment., Virology, 170(2), 571-574, 19890601
  122. Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene., Virology, 169(2), 260-272, 19890401
  123. Newcastle disease virus evolution. II. Lack of gene recombination in generating virulent and avirulent strains., Virology, 169(2), 273-282, 19890401
  124. Identification of amino acids relevant to three antigenic determinants on the fusion protein of Newcastle disease virus that are involved in fusion inhibition and neutralization., Journal of Virology, 62(11), 4427-4430, 19881101
  125. Structural features unique to each of the three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus., Virology, 163(1), 174-182, 19880301
  126. Structural comparison of the cleavage-activation site of the fusion glycoprotein between virulent and avirulent strains of Newcastle disease virus., Virology, 158(1), 242-247, 19870501