Takemasa Sakaguchi

Last Updated :2021/10/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Other Contact Details
1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan, Japan
TEL : (+81)82-257-5157 FAX : (+81)82-257-5159
I have been working in the field of virology for 35 years. I have been doing basic research on RNA viruses, mainly paramyxoviruses and influenza viruses, and hepatitis B virus, and more recently applied research on disinfectants and antiviral agents. Currently, we are working hard to combat the novel coronavirus. (April 20, 2021)

Basic Information

Major Professional Backgrounds

  • 1987/04/01, 1996/08/31, Hiroshima University, Research Associate
  • 1993/10/23, 1996/02/28, Northwestern University, Postdoctrol fellow
  • 1996/09/01, 1998/04/30, Hiroshima University, Assistant Professor
  • 1998/05/01, 2007/03/31, Hiroshima University, Associate Professor
  • 2007/04/01, 2009/03/31, Hiroshima University, Associate Professor
  • 2009/04/01, 2019/03/31, Hiroshima University, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Nagoya University, Faculty of Medicine, School of Medicine, Japan, 1979/04, 1985/03
  • Nagoya University, Graduate School of Medical Sciences, Laboratory of Molecular Pathogenesis, Japan, 1986/04, 1987/03

Academic Degrees

  • Doctor of Medicine, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology

Research Keywords

  • Sendai virus (HVJ)
  • SARS-CoV-2
  • influenza virus
  • hepatitis B virus
  • Protein three dimensional structure
  • morphogenesis
  • interferon
  • accessory protein
  • anti-virus
  • persimmon tannin

Educational Activity

Course in Charge

  1. 2021, Undergraduate Education, Intensive, Practice for medical research
  2. 2021, Undergraduate Education, Year, Biological Responses
  3. 2021, Undergraduate Education, 2Term, Introduction for medical research
  4. 2021, Undergraduate Education, 4Term, Microbiology II
  5. 2021, Graduate Education (Doctoral Program) , 1Term, Advanced Lecture on Methods in biomedical sciences
  6. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  7. 2021, Graduate Education (Master's Program) , First Semester, Seminar
  8. 2021, Graduate Education (Master's Program) , Second Semester, Seminar
  9. 2021, Graduate Education (Master's Program) , First Semester, Research
  10. 2021, Graduate Education (Master's Program) , Second Semester, Research
  11. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  12. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  13. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  14. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  15. 2021, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense
  16. 2021, Graduate Education (Master's Program) , 1Term, Seminar on Health Policy & Global Health
  17. 2021, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  18. 2021, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  19. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Virology
  20. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Virology
  21. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Virology
  22. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Virology
  23. 2021, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, implicating the role of Pin1 inhibitors as potential therapeutic agents against COVID-19., Scientific Reports, 11, 18581, 20210917
  2. Ethanol susceptibility of SARS-CoV-2 and other enveloped viruses., Biocontrol Science, 26(3), 177-180, 20210910
  3. Structural insight into the interaction of the Sendai virus C protein with Alix stimulating the viral budding., Journal of Virology, 95(19), e0081521, 20210909
  4. The association between wearing a mask and COVID19., International Journal of Environmental Research of Public Health, 18, 9131, 20210830
  5. Inhibiting SARS-CoV-2 infection by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal. Scientific Reports., Scientific Reports, 11(1), 16629, 20210817
  6. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue., Journal of Photochemistry & Photobiology, B: Biology, 221, 112239, 20210601
  7. Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination, AMERICAN JOURNAL OF INFECTION CONTROL, 49(3), 299-301, 20210301
  8. Effect of intermittent irradiation and dose-response of 222 nm ultraviolet light on SARS-CoV-2 contamination., Photodiagnosis and Photodynamic Therapy, 33, 102184, 20210301
  9. Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan, PLOS ONE, 16(2), 20210205
  10. Efficacy of photodynamic antimicrobial chemotherapy on Acanthamoeba keratitis in vivo., Lasers in Surgery and Medicine, 20201201
  11. Development of an Oncolytic Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA, ANTICANCER RESEARCH, 40(11), 6319-6325, 20201101
  12. Characterization of a unique Sendai virus isolate and its potential as an effective vaccine adjuvant., BIO Clinica, 35(2), 78-81, 20200201
  13. Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus Replication In Vitro: Suppression of Viral Protein Synthesis by Glycyrrhizae Radix, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 20191203
  14. Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 28, 166-171, 201912
  15. Development of new concept viral vectors exerting both vaccine and adjuvant activities., IMPACT, 2019(7), 9-11, 201908
  16. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi, LASERS IN MEDICAL SCIENCE, 34(4), 743-747, 201906
  17. Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice, JOURNAL OF ORTHOPAEDIC RESEARCH, 37(5), 1192-1201, 201905
  18. Inactivation of human and avian influenza viruses by potassium oleate of natural soap component through exothermic interaction, PLOS ONE, 13(9), 20180927
  19. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, LASERS IN MEDICAL SCIENCE, 33(7), 1455-1460, 201809
  20. Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma, JOURNAL OF ORTHOPAEDIC RESEARCH, 36(9), 2562-2569, 201809
  21. Eligibility of Feline Calicivirus for a Surrogate of Human Norovirus in Comparison with Murine Norovirus, Poliovirus and Coxsackievirus, BIOCONTROL SCIENCE, 23(3), 145-149, 201809
  22. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction, PLOS ONE, 13(5), 20180521
  23. A Single Amino Acid Substitution within the Paramyxovirus Sendai Virus Nucleoprotein Is a Critical Determinant for Production of Interferon-Beta-Inducing Copyback-Type Defective Interfering Genomes, JOURNAL OF VIROLOGY, 92(5), 201805
  24. Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(48), 19752-19766, 20171201
  25. Inactivation of the influenza virus by a supplemental fermented plant product (Manda Koso)., Hiroshima Journal of Medical Sciences, 66(4), 97-101, 201712
  26. High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120, MARINE BIOTECHNOLOGY, 18(2), 215-231, 201604
  27. Nonstructural protein p39 of feline calicivirus suppresses host innate immune response by preventing IRF-3 activation, VETERINARY MICROBIOLOGY, 185, 62-67, 2016
  28. High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120 (vol 18, pg 144, 2016), MARINE BIOTECHNOLOGY, 18(3), 448-448, 2016
  29. Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12), 2016
  30. Airborne virus detection by a sensing system using a disposable integrated impaction device, JOURNAL OF BREATH RESEARCH, 10(3), 2016
  31. ★, Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, Journal of Virology, 89(22), 11487-11499, 20151115
  32. Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy., Molecular Vision, 21, 532-537, 20150502
  33. Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro., Lasers in Medical Science, 30(1), 383-387, 20150101
  34. Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin, MARINE DRUGS, 13(6), 3454-3465, 2015
  35. IFN-beta-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner, FRONTIERS IN MICROBIOLOGY, 6, 2015
  36. Sendai virus C proteins regulate viral genome and antigenome synthesis to dictate the negative genome polarity., Journal of Virology, 88(1), 690-698, 20140101
  37. Clustered basic amino acids of the small Sendai virus C protein Y1 are critical to its Ran GTPase-mediated nuclear localization., PLoS One, 8(8), 20130809
  38. The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer., International Journal of Molecular Medicine, 31(2), 299-306, 20130201
  39. Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses., PLoS One, 8(1), 20130125
  40. Passage of a Sendai virus recombinant in embryonated chicken eggs leads to markedly rapid accumulation of U-to-C transitions in a limited region of the viral genome., PLoS One, 7(11), 20121121
  41. Inhibition of virus-like particle release of Sendai virus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2., Hiroshima Journal of Medical Sciences, 61(3), 59-67, 20120901
  42. Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein., Journal of Virology, 86(13), 7136-7145, 20120701
  43. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation., Neuroscience Letters, 505(3), 279-281, 20111121
  44. Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5., Microbiology and Immunology, 55(11), 760-767, 20111101
  45. Decreased expression in nuclear factor-kB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency., Journal of Clinical Immunology, 31(5), 762-772, 20111001
  46. Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth., Journal of Orthopaedic Research, 29(5), 795-800, 20110501
  47. Paramyxovirus assembly and budding: building particles that transmit infections., The International Journal of Biochemistry & Cell Biology, 42(9), 1416-1429, 20100901
  48. Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection., Virology, 405(2), 334-341, 20100901
  49. Conserved charged amino acids within Sendai virus C protein play multiple roles in the evasion of innate immune responses., PLoS ONE, 5(5), e10719, 20100501
  50. Studies on the paramyxovirus accessory genes by reverse genetics in the Sendai virus?mouse system., Proceedings of the Japan Academy, Series B-Physical and Biological Sciences, 84(10), 439-451, 20090105
  51. Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles., Virology, 374(2), 495-505, 20080501
  52. Contribution of the leader sequence to homologous viral interference among Sendai virus strains., Virology, 372(1), 64-71, 20080301
  53. Recruitment of Alix/AIP1 to the plasma membrane by Sendai virus C protein facilitates budding of virus-like particles., Virology, 371(1), 108-120, 20080101
  54. Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus., Journal of Biological Chemistry, 282(37), 27383-27391, 20070914
  55. Paramyxovirus budding, Virus, 57(1), 1-7, 20070601
  56. The YLDL sequence within Sendai virus m protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein., Journal of Virology, 81(5), 2263-2273, 20070401
  57. Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice., Virology, 359(1), 82-91, 20070301
  58. Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet., Hypertension Research, 30(1), 85-91, 20070101
  59. Suppression of interferon-related promoter activation by hepatitis C virus proteins expressed in cultured cells., Hiroshima Journal of Medical Sciences, 55(3), 71-77, 20060901
  60. Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors., Microbiology and Immunology, 49(9), 835-844, 20050901
  61. ★, AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding., Journal of Virology, 79(14), 8933-8941, 20050715
  62. Generation of Sendai virus nucleocapsid-like particles in yeast., Virus Research, 108(1-2), 221-224, 20050301
  63. Characterization of the amino acid residues of Sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation., Journal of Virology, 78(14), 7443-7454, 20040701
  64. Paramyxovirus Sendai virus-like particle formation by expression multiple viral proteins and acceleration of its release by C protein., Virology, 325(1), 1-10, 20040701
  65. Masking of the contribution of V protein to Sendai virus pathogenesis in an infection model with a highly virulent field isolate., Virology, 313(2), 581-587, 20030901
  66. Safety and growth suppressive effect of intra-hepatic arterial injection of AdCMV p53 combine with CDDP to Rat liver metastatic tumors., Journal of Experimental & Clinical Cancer Research, 22(3), 339-406, 20030901
  67. Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage., Virus Genes, 25(2), 189-193, 20021001
  68. Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA., Journal of Virology, 76(17), 8540-8547, 20020901
  69. Mutational analysis of the Sendai virus V protein: Importance of the conserved residues for Zn binding, virus pathogenesis, and efficient RNA editing., Virology, 299(2), 172-181, 20020801
  70. Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein., Cancer Gene Therapy, 9(8), 655-664, 20020801
  71. Alteration of Sendai virus morphogenesis and nucleocapsid incorporation due to mutation of cystein residues of the matrix protein., Journal of Virology, 76(4), 1682-1690, 20020201
  72. Molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the nationwide outbreak of 1995 in Japan., Journal of Clinical Microbiology, 40(1), 140-145, 20020101
  73. Matrix proteins of envelope viruses., Virus, 51(1), 11-19, 20010601
  74. Attenuation of a field Sendai virus isolate through egg-passages is associated with an impediment of viral genome replication in mouse respiratory cells., Archives of Virology, 146(5), 893-908, 20010501
  75. Differential expression of CD45 isoforms in tolerant and rejecting rat liver transplant recipients., Transplantation Proceedings, 33(1-2), 544, 20010301
  76. Emergence of anti-inflammatory monocytes in long-term surviving hosts of IL-10-transduced liver allografts., Cytokine, 13(3), 183-187, 20010201
  77. Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames., Virus Genes, 22(1), 47-52, 20010101
  78. Adenovirus-mediated interleukin-10 overexpression: Comparison between intraportal and intramuscular gene transfer., Transplantation Proceedings, 32(7), 2006, 20001101
  79. Involvement of the zinc-binding capacity of Sendai virus V protein in viral pathogenesis., Journal of Virology, 74(17), 7834-7841, 20000901
  80. Adenovirus-mediated interleukin-10 overexpression: Comparison between intraportal and intramuscular gene transfer., Transplantation Proceedings, 32(7), 2006, 20000401
  81. p53 gene therapy for rat liver tumor by intrahepatic arterial injection of AdCMV-p53 in combination with CDDP., Molecular Therapy, 1(5), S326, 20000401
  82. Effects of adenovirus-mediated IL-10 gene transfer on liver transplantation., Molecular Therapy, 1(5), 176-177, 20000401
  83. Adenovirus-mediated allograft transduction of Interleukin-10: Role in the induction phase of liver allograft acceptance., Transplantation Proceedings, 32, 247-248, 20000301
  84. Double-layered membrane vesicles released from mamalian cells infected with Sendai virus expressing the matrix protein of vesicular stomotitis virus., Virology, 263(1), 230-243, 19991001
  85. Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation., Gene Therapy, 6(5), 816-822, 19990501
  86. Double-layered membrane vesicles released from mammalian cells infected with Sendai virus expressing the matrix protein of vesicular stomatitis virus., Virology, 263(1), 230-243, 19990401
  87. The genome nucleotide sequence of a contemporary wild strain of measles virus and its comparison with the classical Edmonston strain genome., Virology, 256(2), 340-350, 19990401
  88. Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases., Microbiology and Immunology, 43(2), 133-140, 19990201
  89. Infulenza virus M2 ion channel-two functions for virus replication., Experimental Medicine, 15(19), 114-118, 19971201
  90. Viral ion channel : structure and function of the infuluenza virus M2 protein., Virus, 47(2), 177-186, 19971201
  91. Structure and function of the influenza virus M2 ion channel protein., Japanese Journal of Clinical Medicine, 55(10), 89-94, 19971001
  92. ★, The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer., Proc. Natl. Acad. Sci. USA, 94(10), 5000-5005, 19970501
  93. ★, Phosphorylation of the Sendai virus M protein is not essential for virus replication either in vitro or in vivo., Virology, 235(2), 360-366, 19970401
  94. Protection of mice from respiratory Sendai virus infections by recombinant vaccinia viruses., Journal of Virology, 71(1), 832-838, 19970101
  95. HLA-DR8 subtyping by polymerase chain reaction (PCR)-DNA conformation polymorphism(DCP) analysis; a simple and practical genotyping method., Hiroshima J. Med. Sci., 45(3), 85-92, 19960901
  96. ★, The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus., Journal of Cell Biology, 133(4), 733-747, 19960501
  97. Correlation of proteolytic cleavage of paramyxovirus F protein precursors with expression of the fur, PACE4 and PC6 genes in mammalian cells., Journal of General Virology, 75(10), 2821-2827, 19941001
  98. Monitoring for rejection and engraftment by means of the polymerase chain reaction after rat orthotopic liver transplantation., Transplantation, 58(6), 745-748, 19940901
  99. Monitoring for engraftment following rat orthotopic liver transplantation by the polymerase chain reaction., Transplantation Proceedings, 26(2), 902-903, 19940401
  100. Sequence specificity of furin, a proprotein processing endoprotease, for the Hemagglutinin of a virulent avian influenza virus., Journal of Virology, 68(2), 1213-1218, 19940201
  101. A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains., Arhieves of Virology, 135(1-2), 159-164, 19940101
  102. Fo-containing noninfectious Sendai virus can initiate replication in mouse lungs but requires a relatively long incubation period., Journal of Virology, 67(12), 7618-7622, 19931201
  103. Expression of the HN, F, NP and M proteins of Sendai virus by recombinant vaccinia viruses and their contribution to protective immunity against Sendai virus infections in mice., Journal of General Virology, 74, 479-484, 19930301
  104. Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus., Virology, 190(1), 278-289, 19920901
  105. Detection of cytomegalovirus in urine samples by an enzyme-linked immunosorbent assay using a monoclonal antibody against the viral 150-kilodalton protein., Journal of Clinical Microbiology, 30(3), 685-690, 19920301
  106. Distribution and substrate specificity of intracellular proteolytic processing enzyme(s) for paramyxovirus fusion glycoproteins., Journal of General Virology, 73(3), 583-590, 19920301
  107. ★, Identification of endoprotease activity in the trans Golgi membranes of rat liver cells that specifically processes in vitro the fusion glycoprotein precursor of virulent Newcastle disease virus., Virology, 184(2), 504-512, 19911001
  108. Immediate protection of mice from lethal wild-type Sendai virus (HVJ) infections by a temperature-sensitive mutant, HVJpi, possessing homologous intefering capacity., Virology, 177(1), 65-74, 19900701
  109. Endoproteolytic activiation of Newcastle disease virus fusion proteins requires an intracellular acidic environment., Virology, 170(2), 571-574, 19890601
  110. Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene., Virology, 169(2), 260-272, 19890401
  111. Newcastle disease virus evolution. II. Lack of gene recombination in generating virulent and avirulent strains., Virology, 169(2), 273-282, 19890401
  112. Identification of amino acids relevant to three antigenic determinants on the fusion protein of Newcastle disease virus that are involved in fusion inhibition and neutralization., Journal of Virology, 62(11), 4427-4430, 19881101
  113. Structural features unique to each of the three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus., Virology, 163(1), 174-182, 19880301
  114. Structural comparison of the cleavage-activation site of the fusion glycoprotein between virulent and avirulent strains of Newcastle disease virus., Virology, 158(1), 242-247, 19870501

Publications such as books

  1. 2018/03/01, Simple Microbiology Ver. 6, D. Filoviridae, E. Bunyaviridae, F. Arenaviridae, Nankodo, 2018, 3, Textbook, Joint work, Japanese, Sakaguchi, T., 978-4-524-25483-5
  2. 2012/10/01, Review of Medical Microbiology and Immunology, Eleventh Edition, Warren Levinson, McGraw-Hill Medical (2010/5/19), ISBN: 978-0071700283, Chapter 39, RNA envelope viruses., Maruzen, 2012, 10, Textbook, Joint work, Japanese, Sakaguchi T., 462108562X, 704, 19, 268-286
  3. 2011/08/01, Negative Strand RNA virus, Paramyxovirus budding mechanisms., World Scientific Hackensack, NJ., 2011, 8, Scholarly Book, Joint work, English, Harrison MS, Sakaguchi T, Schmitt AP., 981-4317-22-5, 314, 26, 193-218
  4. 2011/04/01, Simple Microbiology Ver. 5, D. Filoviridae, E. Bunyaviridae, F. Arenaviridae., Nankoudo, 2011, 4, Textbook, Joint work, Japanese, Sakaguchi T., 978-4-524-26207-6, 436, 6, 297-302
  5. 2001/06/01, Recent Research Developments in Virology, Functional divergence of the Paramyxovirinae accessory proteins: the V and C proteins, Transworld Research Network, 2001, 6, Scholarly Book, Joint work, English, Sakaguchi T, Huang C, Kiyotani K, Yoshida T. , 81-86846-99-9, 386, 11, 341-348
  6. 1997/12/01, Medical aspects of proteases and protease inhibitors., Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease., IOS press, 1997, 12, Scholarly Book, Joint work, English, Nagamune H, Muramatsu K, Higashine M, Akamatsu T, Tamai Y, Yonetomi Y, Tsuji A, Izumi K, Sakaguchi T, Yoshida T, Matsuda Y., 978-90-5199-292-2, 206, 12, 22-33


  1. Patent, 2719358, 2017/10/24
  2. Patent, 9609872, 2017/04/04
  3. Patent, 9445605, 2016/09/20
  4. Patent, 10-1649387, 2016/08/11
  5. Patent, 9278107, 2016/03/08
  6. Patent, JP5593572, 2014/08/15
  7. Patent, KR:10-1426744, 2014/07/30
  8. Patent, JP5571577, 2014/07/04
  9. Patent, JP5421901, 2013/11/29
  10. Patent, CN:ZL201080016783.2, 2013/11/20
  11. Patent, RU:2491929, 2013/09/10
  12. Patent, JP4848484, 2011/10/28
  13. Patent, JP4830075, 2011/09/30