MASATAKA NAGAO

Last Updated :2024/06/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
nagaohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1990/04, 1992/03, Hokkaido University, Research Associate
  • 1992/04, 1995/10, The University of Tokyo, Lecturer
  • 1995/11, 1997/03, The University of Tokyo, Associate Professor
  • 1997/04, 1999/04, The University of Tokyo, Associate Professor
  • 1999/05, 2002/03, Nagoya City University, Professor
  • 2002/04, 2007/03, Nagoya City University, Professor
  • 2007/04, 2007/12, Nagoya City University, Professor
  • 2008/01/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • HOKKAIDO UNIVERSITY, Japan, 1986/04, 1990/03
  • Kumamoto University, Japan, 1980/04, 1986/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, HOKKAIDO UNIVERSITY

Research Fields

  • Medicine,dentistry, and pharmacy;Society medicine;Legal medicine
  • Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy
  • Medicine,dentistry, and pharmacy;Society medicine;Hygiene and public health

Research Keywords

  • Noncholinergic mechanism of nerve agent
  • Rat having acquired resistance to paraquat
  • Analysis of paraquat resistant rat having head dysplasia
  • Medical toxicant immunoassay
  • Clinical forensic medicine

Affiliated Academic Societies

  • Japanese Society of Legal Medicine
  • Japanese Association of Forensic Toxicology
  • The Japanese Biochemical Society
  • Japanese Society for Prevention of Child Abuse and Neglect
  • American Chemical Society

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, Peace Messages from "Kasumi Campus"
  2. 2024, Undergraduate Education, Intensive, Social Medicine
  3. 2024, Undergraduate Education, 2Term, Introduction for medical research
  4. 2024, Undergraduate Education, Intensive, Practice for medical research
  5. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  6. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  7. 2024, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
  8. 2024, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
  9. 2024, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
  10. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  11. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  12. 2024, Graduate Education (Master's Program) , First Semester, Research
  13. 2024, Graduate Education (Master's Program) , Second Semester, Research
  14. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  15. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  16. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  17. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  18. 2024, Graduate Education (Master's Program) , First Semester, Research on Public Health (Social and BehaviOral Sciences)
  19. 2024, Graduate Education (Master's Program) , Second Semester, Research on Public Health (Social and BehaviOral Sciences)
  20. 2024, Graduate Education (Master's Program) , First Semester, Lecture on Clinical Forensic Medicine
  21. 2024, Graduate Education (Doctoral Program) , 1Term, Cause of Death Investigation
  22. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on forensic Medicine
  23. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on forensic Medicine
  24. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on forensic Medicine
  25. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on forensic Medicine
  26. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cause of Death investigation
  27. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cause of Death investigation
  28. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on forensic Dentistry
  29. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on forensic Dentistry
  30. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on forensic Dentistry
  31. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on forensic Dentistry

Research Activities

Academic Papers

  1. Extraction of amphetamines and methylenedioxyamphetamines from urine using a monolithic silica disk-packed spin column and high-performance liquid chromatography-diode array detection, JOURNAL OF CHROMATOGRAPHY A, 1208(1-2), 71-75, 20081024
  2. Simultaneous determination of dibucaine and naphazoline in human serum by monolithic silica spin column extraction and liquid chromatography-mass spectrometry, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 872(1-2), 186-190, 20080901
  3. Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown eye color in the Japanese population, CELL BIOCHEMISTRY AND FUNCTION, 27(5), 323-327, 200907
  4. Monolithic silica spin column extraction and simultaneous derivatization of amphetamines and 3,4-methylenedioxyamphetamines in human urine for gas chromatographic-mass spectrometric detection, ANALYTICA CHIMICA ACTA, 661(1), 42-46, 20100219
  5. Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review, FORENSIC TOXICOLOGY, 29(1), 1-24, 201101
  6. Monolithic Spin Column: A New Extraction Device for Analysis of Drugs in Urine and Serum by GC/MS and HPLC/MS, JOURNAL OF AOAC INTERNATIONAL, 94(3), 765-774, 2011
  7. Confirmation that SNPs in the high mobility group-A2 gene (HMGA2) are associated with adult height in the Japanese population; wide-ranging population survey of height-related SNPs in HMGA2, ELECTROPHORESIS, 32(14), 1844-1851, 201107
  8. Simultaneous extraction of acidic and basic drugs from urine using mixed-mode monolithic silica spin column bonded with octadecyl and cation-exchange group, JOURNAL OF SEPARATION SCIENCE, 34(16-17), 2232-2239, 201109
  9. Replication study of the association of SNPs in the LHX3-QSOX2 and IGF1 loci with adult height in the Japanese population; wide-ranging comparison of each SNP genotype distribution, LEGAL MEDICINE, 14(4), 205-208, 201207
  10. Sequential extraction of inorganic arsenic compounds and methyl arsenate in human urine using mixed-mode monolithic silica spin column coupled with gas chromatography-mass spectrometry, JOURNAL OF SEPARATION SCIENCE, 35(18), 2506-2513, 201209
  11. Acute Intoxication Caused by Overdose of Flunitrazepam and Triazolam High Concentration of Metabolites Detected at Autopsy Examination, AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY, 33(4), 293-296, 201212
  12. Sequential extraction of amphetamines, opiates, and 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid from a limited volume of urine using a monolithic silica spin column coupled with gas chromatography-mass spectrometry, FORENSIC TOXICOLOGY, 31(2), 312-321, 201307
  13. A fatal case of 3,4-methylenedioxypyrovalerone poisoning: coexistence of alpha-pyrrolidinobutiophenone and alpha-pyrrolidinovalerophenone in blood and/or hair, FORENSIC TOXICOLOGY, 31(2), 338-343, 201307
  14. ★, Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats, TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(1), 61-66, 20131001
  15. A Fatal Case of Hypermagnesemia Caused by Ingesting Magnesium Chloride as a Folk Remedy, JOURNAL OF FORENSIC SCIENCES, 58(6), 1673-1675, 201311
  16. Simple segmental hair analysis for alpha-pyrrolidinophenone-type designer drugs by MonoSpin extraction for evaluation of abuse history, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 942, 15-20, 20131230
  17. Time-course profile of urinary excretion of intravenously administered alpha-pyrrolidinovalerophenone and alpha-pyrrolidinobutiophenone in a human, FORENSIC TOXICOLOGY, 32(1), 68-74, 201401
  18. 5-hydroxytryptamine- and dopamine-releasing effects of ring-substituted amphetamines on rat brain: A comparative study using in vivo microdialysis, EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24(8), 1362-1370, 201408
  19. Detection of abused drugs in human blood by using the on-site drug-screening device Oratect (R) III, LEGAL MEDICINE, 16(5), 308-313, 201409
  20. Comprehensive review of the detection methods for synthetic cannabinoids and cathinones, FORENSIC TOXICOLOGY, 33(2), 175-194, 201507
  21. Extraction of amphetamines and methylenedioxyamphetamines from urine using a monolithic silica disk-packed spin column and high-performance liquid chromatography-diode array detection., J Chromatogr A., 71-75, 20081024
  22. Preliminary screening method for the determination of inorganic arsenic in urine., Leg Med, 11(2), 80-82, 200903
  23. Comparison of four immunoassay screening devices for detection of benzodiazepine and its metabolites in urine: mainly detection of etizolam, thienodiazepine and its metabolites., The Japanese Journal of Clinical Toxicology, 24(1), 27-34, 201103
  24. Gender differences in D-aspartic acid content in skull bone., Hiroshima J Med Sci, 61(4), 91-100, 201212
  25. Simple segmental hair analysis for α-pyrrolidinophenone-type designer drugs by MonoSpin extraction for evaluation of abuse history., Simple segmental hair analysis for α-pyrrolidinophenone-type designer drugs by MonoSpin extraction for evaluation of abuse history., 942-943, 2013
  26. Cross-reactivity of Instant-View M-1 for detection of benzodiazepine-related drugs and their metabolites in urine., The Japanese Journal of Clinical Toxicology, 27(1), 33-38, 201403
  27. Suppression of prostate cancer in a transgenic rat model via gamma-tocopherol activation of caspase signaling., Prostate, 69(6), 644-651, 20090501
  28. Molecular analysis of mitochondrial hypervariable region 1 in 394 Japanese individuals., Leg Med, 11(Suppl 1), S443-S445, 200904
  29. Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum., Am J Physiol Heart Circ Physiol, H121-H133, 200801
  30. A fatal case of acute hepatitis B developed in a toluene abuser., Clin J Gastroenterol, 1(2), 64-68, 200806
  31. Epithelial Na+ channel delta subunit mediates acid-induced ATP release in the human skin., Biochem Biophys Res Commun., 373(1), 155-158, 20080815
  32. Epithelial Na+ channel delta subunit is an acid sensor in the human oesophagus., Eur J Pharmacol, 600(1-3), 32-36, 20081214
  33. Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms, PLOS ONE, 11(1), 20160119
  34. The Sarin-like Organophosphorus Agent bis (isopropyl methyl)phosphonate Induces Apoptotic Cell Death and COX-2 Expression in SK-N-SH Cells, Hiroshima J. Med. Sci, 65(1), 1-8, 201603
  35. The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells., J Toxicol Sci, 41(5), 617-25, 201610
  36. The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(5), 617-625, 201610
  37. Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 153, 1-11, 201702
  38. Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle, NATURE COMMUNICATIONS, 8, 20170313
  39. Optimization and application of octadecyl-modified monolithic silica for solid-phase extraction of drugs in whole blood samples, JOURNAL OF CHROMATOGRAPHY A, 1517, 9-17, 20170929
  40. Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans, LEGAL MEDICINE, 30, 28-33, 201801

Publications such as books

  1. 2012/03/10, NEW ESSENTIALS OF FORENSIC MEDICINE, Ishiyaku Publishers, Inc., 2012, 3, Scholarly Book, Compilation, 9784263207963
  2. 2018/05/20, A Color Atlas of Clinical Forensic Medicine, CHUGAI-IGAKUSHA, 2018, 5, Scholarly Book, Joint work

Invited Lecture, Oral Presentation, Poster Presentation

  1. A sarin-like reagent induces apoptosis on human astrocytoma derived cells through the endoplasmic reticulum (ER) stress stimulated signaling pathways., Shiraishi H, Arima Y, Namera A, Yoshimoto K, Nagao M., The 9th International Symposium on Advances in legal medicine (ISALM), 2014/06/17, Without Invitation, English, Fukuoka
  2. Optimization of silica monolith in MonoSpin for the extraction of drugs in whole blood., Namera A, Saito T, Ota S, Oikawa H, Miyazaki S, Shiraishi H, Nagao M., The 9th International Symposium on Advances in legal medicine (ISALM), 2014/06/17, Without Invitation, English, Fukuoka
  3. Comparative Evaluation of Triage TOX and Triage DOA Using Chromatography and Mass Spectrometry., Arima Y, Namera A, Fukuda S, Shiraishi H, Nagao M., The 9th International Symposium on Advances in legal medicine (ISALM)., 2014/06/18, Without Invitation, English, Fukuoka
  4. D-Aspartic acid, but not L-Aspartic acid, modulates osteoblast marker gene expression in MC3T3E-1 osteoblasts., Arima Y, Yoshiko Y, Namera A, Nagao M, The 2nd International Conference of D- Amino Acid Research (IDAR 2014), 2014/09/02, Without Invitation, English, Utsunomiya, Tochigi
  5. The sarin-like nerve agent BIMP induces apoptosis and inflammatory responses in SK-N-SH cells., Arima Y, Yoshimoto K, Namera A, Nagao M, 2015/06/11, Without Invitation, English
  6. The effect of a sarin-like organophosphorus agent on human neuroblastoma cell line SK-N-SH., Yamada K, Shiraishi H, Namera A, Arima Y, Nagao M, Yamada Y., 25th Meeting of the International Society for Neurochemistry and 13th the Asian Pacific Society for Neurochemistry, 2015/08/25, Without Invitation, English, Cairns, Australia
  7. A sarin-like organophosphate induces non-cholinergic cell death via an inflammatory response in SK-N-SH cells., Y. ARIMA, A. NAMERA, K. YOSHIMOTO, K. MURATA, M. NAGAO., Neuroscience 2015 Society for Neuroscience, 2015/10/21, Without Invitation, English, Chicago, U.S.A.
  8. Alcohol-drinking and eating behaviors associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala of brain rewarding system., Miyagi N., Kuramoto R., Mori A., Murata K., Namera A., Nagao M., Yoshimoto K., 19th World Congress of International Society for Biomedical Research on Alcoholism, 2018/09/12, Without Invitation, English, Kyoto

Social Activities

History as Committee Members

  1. Editorial Board, 2010/04, Japanese Society for Prevention of Child Abuse and Neglect

Organizing Academic Conferences, etc.

  1. THE 34th Chugoku-Shikoku Dictrict Conference of the Japanese Society of Legal Medicine, 2016/10