Masashi Yukawa
Last Updated :2021/01/11
- Affiliations, Positions
- Graduate School of Integrated Sciences for Life, Assistant Professor
- Web Site
- E-mail
- myukawa
hiroshima-u.ac.jp
Basic Information
Academic Degrees
- Doctor of Engineering, Hiroshima University
- Master of Engineering, Hiroshima University
Educational Activity
- 【Bachelor Degree Program】School of Engineering : Cluster 3(Applied Chemistry, Biotechnology and Chemical Engineering)
- 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
- 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
- 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
- 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
Research Fields
- Agricultural sciences;Agricultural chemistry;Applied biochemistry
Research Keywords
- Exploring the molecular mechanisms of mitotic spindle assembly critical for chromosome segregation
Affiliated Academic Societies
- Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA)
- The Molecular Biology Society of Japan (MBSJ)
- Yeast Genetics Society of Japan
Educational Activity
Course in Charge
- 2020, Undergraduate Education, Second Semester, Basic Experiments in Chemistry
- 2020, Undergraduate Education, Second Semester, Experiments on Biotechnology II
- 2020, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Biotechnology
- 2020, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Biotechnology
- 2020, Graduate Education (Doctoral Program) , 1Term, Research Plans in Life Science
- 2020, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
- 2020, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
- 2020, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
- 2020, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
- 2020, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
- 2020, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
- 2020, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
- 2020, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
- 2020, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
- 2020, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
- 2020, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
Research Activities
Academic Papers
- How essential kinesin-5 becomes non-essential in
fission yeast: Force balance and microtubule
dynamics matter, Cells, 9, 1154, 20200507
- Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells, BIOORGANIC & MEDICINAL CHEMISTRY, 28(1), 20200101
- Two XMAP215/TOG microtubule polymerases, Alp14 and Dis1, play non-exchangeable, distinct roles in microtubule organisation in fission yeast., International Journal of Molecular Sciences, 20(20), 5108-5125, 20191015
- Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast, Scientific Reports, 9(1), 7336, 20190514
- Generation of temperature sensitive mutations with error-prone PCR in agene encoding acomponent of the spindle pole body in fission yeast., BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1-4, 20190501
- ★, Suppressor analysis uncovers that MAPs and microtubule dynamics balance with the Cut7/Kinesin-5 motor for mitotic spindle assembly in Schizosaccharomyces pombe., G3: GENES GENOMES GENETICS, 9(1), 269-280, 20190109
- ★, Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors, FUNGAL GENETICS AND BIOLOGY, 116, 33-41, 201807
- ★, Two spatially distinct Kinesin-14 Pkl1 and Klp2 generate collaborative inward forces against Kinesin-5 Cut7 in S. pombe., JOURNAL OF CELL SCIENCE, 20170104
- ★, A microtubule polymerase cooperates with the Kinesin-6 motor and a microtubule crosslinker to promote bipolar spindle assembly in the absence of Kinesin-5 and Kinesin-14 in fission yeast., MOLECULAR BIOLOGY OF THE CELL, 28(25), 3647-3659, 20171201
- An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation, JOURNAL OF CELL SCIENCE, 129(24), 4592-4606, 20161215
- ★, The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies, JOURNAL OF CELL BIOLOGY, 209(4), 549-562, 20150525
- The yeast chromatin remodeler Rsc1-RSC complex is required for transcriptional activation of autophagy-related genes and inhibition of the TORC1 pathway in response to nitrogen starvation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(4), 1248-1253, 20150904
- RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae, PLOS ONE, 10(6), 20150618
- Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres., PLoS One, 10(10), e0140456, 20151014
- Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(1), 140-146, 20150814
- 3,6-Epidioxy-1,10-bisaboladiene inhibits G(1)-specific transcription through Swi4/Swi6 and Mbp1/Swi6 via the Hog1 stress pathway in yeast, FEBS JOURNAL, 281(20), 4612-4621, 201410
- Rad51-Dependent Aberrant Chromosome Structures at Telomeres and Ribosomal DNA Activate the Spindle Assembly Checkpoint, MOLECULAR AND CELLULAR BIOLOGY, 34(8), 1389-1397, 201404
- Fission yeast MOZART1/Mzt1 is an essential gamma-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly, MOLECULAR BIOLOGY OF THE CELL, 24(18), 2894-2906, 20130915
- Fission Yeast RecQ Helicase Rqh1 Is Required for the Maintenance of Circular Chromosomes, MOLECULAR AND CELLULAR BIOLOGY, 33(6), 1175-1187, 201303
- A Double Mutant between Fission Yeast Telomerase and RecQ Helicase Is Sensitive to Thiabendazole, an Anti-Microtubule Drug, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76(2), 264-269, 201202
- Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation., Mol. Cell. Biol, 31, 495-506, 20110201
- Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening, Biosci. Biotechnol. Biochem, 74(2), 382-385, 20100201
- A novel method of screening cell-cycle blockers as candidates for anti-tumor reagents by using yeast as a screening tool, Biosci. Biotech. Biochem., 74(2), 411-414, 20100201
- ★, The Rpd3/HDAC Complex Is Present at the URS1 cis-Element with Hyperacetylated Histone H3, Agricultural and Biological Chemistry, 73(2), 378-384, 2009
- ★, Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis., Mol. Cell. Biol., 27(4), 1254-1263, 2007
- Evaluation of image processing programs for accurate measurement of budding and fission yeast morphology., Curr Genet., 49(4), 237-247, 2006
- High-dimensional and large-scale phenotyping of yeast mutants., Proc Natl Acad Sci USA, 102(52), 19015-19020, 20051227
- Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae., Biosci. Biotech. Biochem., 69(11), 2213-2218, 2005
- Data mining tools for the Saccharomyces cerevisiae morphological database., Nucleic Acids Res., 33(Web Server issue), W753-W757, 20050701
- Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases., J Biol Chem., 280(2), 1613-1624, 2005
- Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae., Nat Cell Biol., 6(9), 861-871, 2004
- SCMD: Saccharomyces cerevisiae Morphological Database., Nucleic Acids Res., 32(Database issue), D319-D322, 2004
- Functional differences between RSC1 and RSC2, components of growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process, FEMS Yeast Research, 2(2), 87-91, 2002
- Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae, JOURNAL OF ANTIBIOTICS, 54(1), 84-90, 2001
- ★, Nps1/Sth1p, a component of an essential chromatin-remodeling complex of Saccharomyces cerevisiae is required for the maximal expression of early-meiotic genes, Genes Cells, 4(2), 99-110, 1999
Invited Lecture, Oral Presentation, Poster Presentation
- Interplay between two mitotic kinesins and the microtubule crosslinker drives spindle elongation during anaphase B, 10th International Fission Yeast Meeting, 2019/07/15, Without Invitation, English, International Fission Yeast Meeting
- Kinesin 6 Klp9 promotes microtubule elongation during anaphase B through motor-dependent and -independent manners, Joint Annual Meeting of 71st JSCB and 19th PSSJ, 2019/06/24, Without Invitation, English
- Exploring the molecular pathways leading to bipolar spindle formation, Joint Annual Meeting of 51st JSDB and 70th JSCB, 2018/06/07, Without Invitation, English
- Screening for anti-tumor compounds using HSET-overproduction fission yeast and isolated kolavenic acid analog from Solidago altissima, International Symposium on Innovative Agriculture and Fishery, 2018/05, Without Invitation, English
- Assembly of mitotic bipolar spindle in the absence of kinesin-5 Cut7, Masashi Yukawa, Masaki Okazaki, Yusuke Yamada, Tomoaki Yamauchi, Tomoki Kawakami, Takashi Toda, Pombe2017:9th International Fission Yeast Meeting, 2017/05/16, Without Invitation, English, International Fission Yeast Meeting, Banff
- Exploring the molecular mechanism of mitotic spindle assembly and chromosome segregation, 14th International Congress on Yeasts, 2016/09/14, With Invitation, English, International Commission on Yeasts; ICY, Awaji
- Molecular mechanisms of microtubule anchoring to the spindle pole, 2016/03/29, Without Invitation, Japanese
- The Msd1-Wdr8-Pkl1 complex anchors the minus ends of spindle microtubules to mitotic SPBs, Masashi Yukawa, Takashi Toda, Pombe2015/8th International Fission Yeast Meeting, 2015/06, Without Invitation, English, International Fission Yeast Meeting, Kobe
- The molecular mechanism of anchoring mitotic spindle microtubules to the spindle pole body in fission yeast, Masashi Yukawa, 2014/11/04, Without Invitation, English, University of Lausanne
- The molecular mechanism of anchoring mitotic spindle microtubules to the spindle pole body in fission yeast, Masashi Yukawa, Chiho Ikebe, Takashi Toda, EMBO Conference:Centrosomes and spindle pole bodies, 2014/10/02, Without Invitation, English, EMBO Conference, Lisbon
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, 2019, 2022
- KAKENHI, 2016, 2018
- KAKENHI, Analysis of histone deacetylase function in yeast meiosis and sporulation, 2010, 2012
- KAKENHI, Analysis of the essential role of chromatin remodeling factor in control of meiotic progression, 2007, 2008
- KAKENHI, 2006, 2007