YUJIRO MAEOKA

Last Updated :2026/06/03

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
ymaeokahiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2026, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2026, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2026, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2026, Undergraduate Education, First Semester, Internal Medicine II

Research Activities

Academic Papers

  1. C3 mutation-associated atypical hemolytic uremic syndrome with severe renal dysfunction and hypertensive emergency successfully treated with ravulizumab and sacubitril/valsartan: a case report, BMC NEPHROLOGY, 27(1), 20260212
    Link to Paper Search Results by DOI
  2. Relapsing peritoneal dialysis-associated peritonitis caused by Pseudomonas oryzihabitans with concurrent tunnel infection: a case report and literature review, CEN CASE REPORTS, 15(1), 20260106
    Link to Paper Search Results by DOI
  3. Hypomagnesaemia-associated hypokalaemia requires activation of both ENaC and ROMK, JOURNAL OF PHYSIOLOGY-LONDON, 603(22), 7365-7382, 202511
    Link to Paper Search Results by DOI
  4. Early use of renin-angiotensin-aldosterone system inhibitors and stable renal function in familial focal segmental glomerulosclerosis with ACTN4 mutation: a case report and literature review, BMC NEPHROLOGY, 26(1), 20250926
    Link to Paper Search Results by DOI
  5. Abemaciclib-associated acute interstitial nephritis successfully treated with glucocorticoids: a case report and literature review, BMC NEPHROLOGY, 26(1), 20250929
    Link to Paper Search Results by DOI
  6. Effect of haemodiafiltration versus haemodialysis on vascular access patency when starting haemodialysis, NEPHROLOGY DIALYSIS TRANSPLANTATION, 40(8), 1538-1549, 202508
    Link to Paper Search Results by DOI
  7. Targeting MLL1/WDR5-Mediated Epigenetic Regulation Mitigates Peritoneal Fibrosis by Reducing p16INK4a, FASEB JOURNAL, 39(8), 20250430
    Link to Paper Search Results by DOI
  8. Successful treatment of severe renal failure caused by malignant hypertension using a combination of renin-angiotensin-aldosterone system inhibitors: a case report, CEN CASE REPORTS, 14(2), 200-207, 202504
    Link to Paper Search Results by DOI
  9. Polycythemia secondary to bilaterally enlarged kidneys in T-Cell acute lymphoblastic leukemia: a case report and literature review, BMC NEPHROLOGY, 26(1), 20250306
    Link to Paper Search Results by DOI
  10. Peritoneal dialysis-associated polymicrobial peritonitis with slow onset after root canal treatment: the first case and review of the literature, BMC NEPHROLOGY, 26(1), 20250313
    Link to Paper Search Results by DOI
  11. Recent Advances and Perspectives on the Use of Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Chronic Kidney Disease: A Review, BIOMEDICINES, 13(1), 202501
    Link to Paper Search Results by DOI
  12. Peritoneal dialysis-associated peritonitis, caused by superior mesenteric artery thrombosis with intestinal necrosis: a case report, CEN CASE REPORTS, 14(1), 1-5, 202502
    Link to Paper Search Results by DOI
  13. Familial Hyperkalemic Hypertension, COMPREHENSIVE PHYSIOLOGY, 14(5), 5839-5874, 202412
    Link to Paper Search Results by DOI
  14. Selective activation of PPARα by pemafibrate mitigates peritoneal inflammation and fibrosis through suppression of NLRP3 inflammasome and modulation of inflammation, SCIENTIFIC REPORTS, 14(1), 20241011
    Link to Paper Search Results by DOI
  15. Comparison between the 0-and 30-s balloon dilation time in percutaneous transluminal angioplasty for restenosed arteriovenous fistula among hemodialysis patients: a multicenter, prospective, randomized trial (CARP study), CLINICAL AND EXPERIMENTAL NEPHROLOGY, 28(7), 647-655, 202407
    Link to Paper Search Results by DOI
  16. ★, Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone, Hypertension, 79(7), 1423-1434, 202207
  17. ★, Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice, J Am Soc Nephrol, 33(3), 584-600, 202203
  18. ★, Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
    Link to Paper Search Results by DOI
  19. ★, NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, J Biol Chem ., 294(1), 101-115, 20190104
  20. Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells, J Am Soc Nephrol., 20240119
  21. ★, Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation, Am J Physiol Renal Physiol., 326(1), F39-F56, 20240101
  22. Comparison between the 0- and 30-s balloon dilation time in percutaneous transluminal angioplasty for restenosed arteriovenous fistula among hemodialysis patients: a multicenter, prospective, randomized trial (CARP study), Clin Exp Nephrol, 28(7), 647-655, 202407
    Link to Paper Search Results by DOI
  23. Peritoneal dialysis-associated peritonitis, caused by superior mesenteric artery thrombosis with intestinal necrosis: a case report, CEN Case Rep, 202406
    Link to Paper Search Results by DOI
  24. Renal effects of cullin 3 mutations causing familial hyperkalemic hypertension, Curr Opin Nephrol Hypertens, 20230413
  25. ★, CUL3 (Cullin 3) and Blood Pressure Regulation: Insights From Familial Hyperkalemic Hypertension, Hypertension, 20230302
  26. Mineralocorticoid receptor antagonists in patients with kidney disease, Japanese Journal of Nephrology, 65(1), 25-33, 202301
  27. Cullin 3 mutant causing Familial Hyperkalemic Hypertension lacks normal activity in kidney, Am J Physiol Renal Physiol, 323(5), F564-F576, 20221101
  28. Klotho overexpression protects against renal aging along with suppression of transforming growth factor-b1 signaling pathways, Am J Physiol Renal Physiol, 321(6), F799-F811, 20211201
  29. Molecular Mechanisms of Renal Magnesium Reabsorption, J Am Soc Nephrol, 32(9), 2125-2136, 202109
  30. A case report of adult-onset COQ8B nephropathy presenting focal segmental glomerulosclerosis with granular swollen podocytes, BMC Nephrology, 21(1), 376-376, 20200828
    Link to Paper Search Results by DOI
  31. NaCl cotransporter activity and Mg2+ handling by the distal convoluted tubule, Am J Physiol Renal Physiol., 319(6), F1043-F1053, 20201201
  32. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLoS One, 13(1), e0190407., 20180104
  33. Seasonal variation in hemodialysis initiation: A single-center retrospective analysis, PLoS One, 12(6), e0178967, 20170602
  34. Hemodialysis immediately after cardiac catheterization is a risk factor for intradialytic hypotension, Ther Apher Dial, 19(3), 245-249

Invited Lecture, Oral Presentation, Poster Presentation

  1. A case of sporadic Karyomegalic Interstitial Nephritis with a novel FAN1 gene mutation: the first report in East Asia., Maria Yoshida, Yujiro Maeoka, Yasunao Kamikawa, Toshinori Ueno, Takayuki Naito, Takeshi Ike, Michio Nagata, Kandai Nozu, Eri Okada, Takayasu Mori, Shinichi Uchida, Takao Masaki, World Congress of Nephrology 2026, 2026/03/28, Without Invitation, English, Yokohama
  2. Association between remission of hematuria and subsequent renal outcomes in biopsy-proven IgA nephropathy, Aiko Okubo, Maria Yoshida, Akira Takahashi, Naoki Ishiuchi, Yosuke Osaki, Yujiro Maeoka, Kensuke Sasaki, Takao Masaki, World Congress of Nephrology 2026, 2026/03/30, Without Invitation, English, Yokohama
  3. Targeting Necroptosis as a Novel Strategy to Prevent Peritoneal Dysfunction, Kenji Fujii, Yosuke Osaki, Shiro Muraoka, Yujiro Maeoka, Naoki Ishiuchi, Kensuke Sasaki, Takao Masaki, World Congress of Nephrology 2026, 2026/03/30, Without Invitation, English, Yokohama
  4. Regulation of NKCC2 Phosphorylation by Hypokalemia through the PKA–DARPP-32–PP1 Pathway in the Renal Medulla, Wataru Harada, Yujiro Maeoka, Naoki Ishiuchi, Yosuke Osaki, Kensuke Sasaki, James A. McCormick, Takao Masaki, World Congress of Nephrology 2026, 2026/03/28, Without Invitation, English, Yokohama
  5. Hypokalemia-Induced NKCC2 Dephosphorylation via the PKA-DARPP-32-PP1 Pathway in the Renal Medulla, Wataru Harada, Yujiro Maeoka, Naoki Ishiuchi, Yosuke Osaki, Kensuke Sasaki, James A McCormick, Takao Masaki, ASN kidney week 2025, 2025/11/08, Without Invitation, English, Houston TX
  6. Myeloid IRF4 Deficiency Attenuates Peritoneal Fibrosis by Suppressing Macrophage Migration, Kensuke Sasaki, Keiko Onoue, Takeshi Ike, Yosuke Osaki, Naoki Ishiuchi, Yujiro Maeoka, Takao Masaki, ASN kidney week 2025, 2025/11/08, Without Invitation, English, Houston TX
  7. Peroxisome Proliferator-Activated Receptor a Modulator Pemafibrate Ameliorates Salt-Sensitive Hypertension and Hypertensive Organ Damage After Ischemia-Reperfusion Injury in Rats, Kensuke Sasaki, Takeshi Ike, Yosuke Osaki, Naoki Ishiuchi, Yujiro Maeoka, Takao Masaki, ASN kidney week 2025, 2025/11/06, Without Invitation, English, Houston TX
  8. Magnesium Protects Against CKD Progression by Reducing DNA Damage, Makoto Matsubara, Kensuke Sasaki, Naoki Ishiuchi, Yosuke Osaki, Yujiro Maeoka, Takao Masaki, Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT, 2024/09/14, Without Invitation, English, Kyoto
  9. Recovered Maternal Rhabdomyolysis Programs Renal Dysfunction in Adult Offspring, Hebert JF, Munhall AC, Nickerson MN, Maeoka Y, McCormick J, Hutchens MP, 2025 Military Health System Research Symposium, 2025/08/05, Without Invitation, English, Kissimmee, FL
  10. Recovered Parental Acute Kidney Injury Programs Renal Dysfunction in Adult Offspring, Jessica Hebert, Adam Munhall, Nickerson, Yujiro Maeoka, James A McCormick, Michael Hutchens, American Physiology Summit 2025 Meeting, 2025/04/26, Without Invitation, English, Baltimore, Maryland
  11. Dietary potassium restriction reprograms the distal convoluted tubule (DCT) and induces proliferative DCT populations, Xiao-Tong Su, Jeremiah V Reyes, Anne E Lackey, Hasan Demirci, Sebastian Bachmann, Yujiro Maeoka, Ryan J Cornelius, James A McCormick, Chao-Ling Yang, Hyun Jun Jung, Paul A Welling, Jonathan W Nelson, David H Ellison, American Physiology Summit 2025 Meeting, 2025/04/26, Without Invitation, English, Baltimore, Maryland
  12. Renal Kallikrein-1 Contributes to Cleavage of Gamma-Epithelial Sodium Channel (ENaC) in Response to a Short-Term, Low-Sodium, High-Potassium Diet, Joshua N. Curry, Xiao-Tong Su, Yujiro Maeoka, Chao-Ling Yang, Eric J. Delpire, Paul A.Welling, David H. Ellison, ASN kidney week 2024, 2024/10/25, Without Invitation, English, San Diego, CA
  13. Renal kallikrein-1 is not essential in adaptation to an overnight potassium load, Josh Curry, Xiao-tong Su, Yujiro Maeoka, Chao-Ling Yang, Eric Delpire, Paul Welling, David Ellison, Hypertension Scientific Sessions 2024, 2024/09/05, Without Invitation, English, Chicago, Illinois
  14. Hypomagnesemia-induced hypokalemia is associated with higher activities of ENaC and ROMK, Yujiro Maeoka, Xin-Peng Duan, Luan Nguyen, Avika Sharma, Marissa Gutierrez, Wen-Hui Wang, and James A. McCormick, American Physiology Summit 2023 Meeting, 2024/04/06, Without Invitation, English, Long beach
  15. Dysregulation of the WNK4-SPAK/OxSR1 pathway has a mild effect on NKCC2 activity, Yujiro Maeoka, Luan Nguyen, Avika Sharma, Xiao-Tong Su, Hector Carbajal-Contreras, Maria Castaneda-Bueno, Gerardo Gamba, James McCormick, American Physiology Summit 2023 Meeting, 2023/04/21, Without Invitation, English, Long beach
  16. PPARa Modulator Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis, Yutaka Shinkai, Ryo Tamura, Naoki Ishiuchi, Yosuke Osaki, Yujiro Maeoka, Kensuke Sasaki, Takao Masaki, ASN kidney week 2023, 2023/11/03, Without Invitation, English, Philadelphia
  17. Magnesium Protects Against CKD Progression by Reducing DNA Damage, Makoto Matsubara, Kensuke Sasaki, Naoki Ishiuchi, Akira Takahashi, Yosuke Osaki, Yujiro Maeoka, Takao Masaki, ASN kidney week 2023, 2023/11/03, Without Invitation, English, Philadelphia
  18. Distal Convoluted Tubule-Specific Disruption of the COP9 Signalosome and CUL3 Activates the WNK4-SPAK-NCC Pathway, Ryan J. Cornelius, Yujiro Maeoka1,Tanner Bradford, Xiao-Tong Su, Chao-Ling Yang, David H. Ellison, James A McCormick, ASN kidney week 2023, 2023/11/03, Without Invitation, English, Philadelphia
  19. Mineralocorticoid receptor antagonists cause natriuresis in the absence of Aldosterone, Yujiro Maeoka, Xiao-Tong Su, Avika Sharma, Wen-Hui Wang, Xin-Peng Duan, Na Li, Olivier Staub, James A McCormick, and David H Ellison, 9th LeDucq Meeting, 2022/06/10, Without Invitation, English
  20. DISTAL NEPHRON ROLE IN LETHAL CRUSH SYNDROME HYPERKALEMIA MAY HAVE TREATMENT IMPLICATIONS, Karen G. Minoza, Lydia Buzzard, Moqing Liu, Samantha Durbin, Marissa Beiling, Adam Munhall, Joseph Garay, Mahaba B. Eiwaz, Yujiro Maeoka, James A. McCormick, Martin Schreiber, Michael Hutchens, 82nd Annual Meeting of AAST & Clinical Congress of Acute Care Surgery, 2023/09/21, Without Invitation, English
  21. Dietary Mg restriction reduces ENaC activity, Yujiro Maeoka, Avika Sharma, Luan Nguyen, and James A. McCormick, ASN kidney week 2022, 2022/11/03, Without Invitation, English, Orland (USA)
  22. Combined Kelch-like 3 and Cullin 3 degradation is a central mechanism in familial hyperkalemic hypertension, Yujiro Maeoka, Mohammed Z. Ferdaus, Avika Sharma, Ryan J. Cornelius, Xiao-Tong Su, Joshua A. Robertson, Susan B. Gurley, David H. Ellison, James A. McCormick., The 58th Japanese SHR Meeting, 2022/10/16, Without Invitation, Japanese, Kyoto
  23. Eplerenone-induced natriuresis and hyperkalemia in mice lacking aldosterone results from aldosterone-independent mineralocorticoid receptor occupancy, Maeoka Y, Su X-T, Sharma A, Wang W-H, Duan X-P, Li N, Staub O, McCormick JA, Ellison DH, Experimental Biology 2022, 2022/04/04, Without Invitation, English, Philadelphia (USA)
  24. Activation of the Distal Convoluted Tubule Enhances Sodium Excretion Through Rapid Dephosphorylation of the Sodium-Chloride Cotransporter, Martz KJ, Su X-T, Maeoka Y, Sharma A, McCormick JA, Ellison DH, Nelson JW, American Society of Nephrology Kidney Week 2021, 2021/11/04, Without Invitation, English, San Diego (USA)
  25. Mechanistic importance of reduced KLHL3 and CUL3 expression in CUL3-D9-mediated familial hyperkalemic hypertension, Maeoka Y, Ferdaus MZ, Cornelius RJ, Sharma A, Su X-T, Robertson JA, Gurley SB, Ellison DH, McCormick JA, American Society of Nephrology Kidney Week 2021, 2021/11/04, Without Invitation, English, American Society of Nephrology, San Diego (USA)
  26. MR occupancy without aldosterone, Yujiro Maeoka, James A McCormick, David H Ellison, 7th LeDucq Meeting, 2021/06/29, Without Invitation, English

Awards

  1. 2021/07, N. L. Tartar Trust Fellowship, Oregon Health & Science University, Mechanistic importance of reduced KLHL3 and CUL3 expression in CUL3-delta9-mediated familial hyperkalemic hypertension
  2. 2022/07, N. L. Tartar Trust Fellowship, Oregon Health & Science University, Dietary Mg restriction reduces ENaC activity
  3. 2022/11/04, Best of ASN Journals 2022, American Society of Nephrology, Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice
  4. 2023/12/11, Best of Hypertension Award 2022, American Heart Association, Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone

External Funds

Acceptance Results of Competitive Funds

  1. 2024
  2. 2024
  3. Grant-in-Aid for Early-Career Scientists, Elucidation of the mechanism by which mineralocorticoid receptor antagonists reduce blood pressure, 2024, 2027
  4. Grant-in-Aid for Research Activity Start-up, Elucidation of the mechanism by which hypomagnesemia causes hypokalemia, 2023, 2025
  5. Tsuchiya Memorial Foundation, Elucidation of the mechanism of antihypertensive effects of MR antagonists, 2023, 2024
  6. Uehara Memorial Foundation (postdoctoral fellowship), 2020/04, 2022/03

Social Activities

History as Peer Reviews of Academic Papers

  1. 2025, Sci Rep, Others, reviewer, 1
  2. 2025, Nephron, Others, reviewer, 1
  3. 2025, American Journal of Physiology-Renal Physiology, Others, reviewer, 1
  4. 2025, Renal Failure, Others, reviewer, 2
  5. 2024, BMJ Open, Others, reviewer, 1
  6. 2022, Kidney 360, Others, assistant of reviewer, 1
  7. 2022, Journal of the American Heart Association, Others, assistant of reviewer, 1
  8. 2023, Frontiers, Others, reviewer, 1
  9. 2022, Frontiers, Others, reviewer, 1
  10. 2021, American Journal of Physiology-Cell Physiology, Others, assistant of reviewer, 1
  11. 2021, American Journal of Physiology-Renal Physiology, Others, assistant of reviewer, 1
  12. 2021, American Journal of Kidney Diseases, Others, assistant of reviewer, 1
  13. 2021, Journal of the American Society of Nephrology, Others, assistant of reviewer, 1
  14. 2021, Kidney International, Others, Assistant of reviewer, 1
  15. 2020, American Journal of Physiology-Renal Physiology, Others, assistant of reviewer, 1
  16. 2020, Kidney 360, Others, assistant of reviewer, 1
  17. 2020, Journal of the American Society of Nephrology, Others, assistant of reviewer, 2
  18. 2020, Cells, Others, assistant of reviewer, 1
  19. 2020, Kidney International, Others, assistant of reviewer, 2
  20. 2020, Hypertension, Others, assistant of reviewer, 1