YUJIRO MAEOKA

Last Updated :2024/05/07

Affiliations, Positions
Hiroshima University Hospital(Medical), Assistant Professor
E-mail
ymaeokahiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, Internal Medicine II

Research Activities

Academic Papers

  1. ★, Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone, Hypertension, 79(7), 1423-1434, 202207
  2. ★, Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice, J Am Soc Nephrol, 33(3), 584-600, 202203
  3. ★, Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
    Link to Paper Search Results by DOI
  4. ★, NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, J Biol Chem ., 294(1), 101-115, 20190104
  5. Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells, J Am Soc Nephrol., 20240119
  6. ★, Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation, Am J Physiol Renal Physiol., 326(1), F39-F56, 20240101
  7. Renal effects of cullin 3 mutations causing familial hyperkalemic hypertension, Curr Opin Nephrol Hypertens, 20230413
  8. ★, CUL3 (Cullin 3) and Blood Pressure Regulation: Insights From Familial Hyperkalemic Hypertension, Hypertension, 20230302
  9. Mineralocorticoid receptor antagonists in patients with kidney disease, Japanese Journal of Nephrology, 65(1), 25-33, 202301
  10. Cullin 3 mutant causing Familial Hyperkalemic Hypertension lacks normal activity in kidney, Am J Physiol Renal Physiol, 323(5), F564-F576, 20221101
  11. Klotho overexpression protects against renal aging along with suppression of transforming growth factor-b1 signaling pathways, Am J Physiol Renal Physiol, 321(6), F799-F811, 20211201
  12. Molecular Mechanisms of Renal Magnesium Reabsorption, J Am Soc Nephrol, 32(9), 2125-2136, 202109
  13. A case report of adult-onset COQ8B nephropathy presenting focal segmental glomerulosclerosis with granular swollen podocytes, BMC Nephrology, 21(1), 376-376, 20200828
    Link to Paper Search Results by DOI
  14. NaCl cotransporter activity and Mg2+ handling by the distal convoluted tubule, Am J Physiol Renal Physiol., 319(6), F1043-F1053, 20201201
  15. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLoS One, 13(1), e0190407., 20180104
  16. Seasonal variation in hemodialysis initiation: A single-center retrospective analysis, PLoS One, 12(6), e0178967, 20170602
  17. Hemodialysis immediately after cardiac catheterization is a risk factor for intradialytic hypotension, Ther Apher Dial, 19(3), 245-249

Invited Lecture, Oral Presentation, Poster Presentation

  1. Dysregulation of the WNK4-SPAK/OxSR1 pathway has a mild effect on NKCC2 activity, Yujiro Maeoka, Luan Nguyen, Avika Sharma, Xiao-Tong Su, Hector Carbajal-Contreras, Maria Castaneda-Bueno, Gerardo Gamba, James McCormick, American Physiology Summit 2023 Meeting, 2023/04/21, Without Invitation, English, Long beach
  2. DISTAL NEPHRON ROLE IN LETHAL CRUSH SYNDROME HYPERKALEMIA MAY HAVE TREATMENT IMPLICATIONS, Karen G. Minoza, Lydia Buzzard, Moqing Liu, Samantha Durbin, Marissa Beiling, Adam Munhall, Joseph Garay, Mahaba B. Eiwaz, Yujiro Maeoka, James A. McCormick, Martin Schreiber, Michael Hutchens, 82nd Annual Meeting of AAST & Clinical Congress of Acute Care Surgery, 2023/09/21, Without Invitation, English
  3. Magnesium Protects Against CKD Progression by Reducing DNA Damage, Makoto Matsubara, Kensuke Sasaki, Naoki Ishiuchi, Akira Takahashi, Yosuke Osaki, Yujiro Maeoka, Takao Masaki, ASN kidney week 2023, 2023/11/03, Without Invitation, English, Philadelphia
  4. PPARa Modulator Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis, Yutaka Shinkai, Ryo Tamura, Naoki Ishiuchi, Yosuke Osaki, Yujiro Maeoka, Kensuke Sasaki, Takao Masaki, ASN kidney week 2023, 2023/11/03, Without Invitation, English, Philadelphia
  5. Distal Convoluted Tubule-Specific Disruption of the COP9 Signalosome and CUL3 Activates the WNK4-SPAK-NCC Pathway, Ryan J. Cornelius, Yujiro Maeoka1,Tanner Bradford, Xiao-Tong Su, Chao-Ling Yang, David H. Ellison, James A McCormick, ASN kidney week 2023, 2023/11/03, Without Invitation, English, Philadelphia
  6. Mineralocorticoid receptor antagonists cause natriuresis in the absence of Aldosterone, Yujiro Maeoka, Xiao-Tong Su, Avika Sharma, Wen-Hui Wang, Xin-Peng Duan, Na Li, Olivier Staub, James A McCormick, and David H Ellison, 9th LeDucq Meeting, 2022/06/10, Without Invitation, English
  7. Dietary Mg restriction reduces ENaC activity, Yujiro Maeoka, Avika Sharma, Luan Nguyen, and James A. McCormick, ASN kidney week 2022, 2022/11/03, Without Invitation, English, Orland (USA)
  8. Combined Kelch-like 3 and Cullin 3 degradation is a central mechanism in familial hyperkalemic hypertension, Yujiro Maeoka, Mohammed Z. Ferdaus, Avika Sharma, Ryan J. Cornelius, Xiao-Tong Su, Joshua A. Robertson, Susan B. Gurley, David H. Ellison, James A. McCormick., The 58th Japanese SHR Meeting, 2022/10/16, Without Invitation, Japanese, Kyoto
  9. Eplerenone-induced natriuresis and hyperkalemia in mice lacking aldosterone results from aldosterone-independent mineralocorticoid receptor occupancy, Maeoka Y, Su X-T, Sharma A, Wang W-H, Duan X-P, Li N, Staub O, McCormick JA, Ellison DH, Experimental Biology 2022, 2022/04/04, Without Invitation, English, Philadelphia (USA)
  10. Activation of the Distal Convoluted Tubule Enhances Sodium Excretion Through Rapid Dephosphorylation of the Sodium-Chloride Cotransporter, Martz KJ, Su X-T, Maeoka Y, Sharma A, McCormick JA, Ellison DH, Nelson JW, American Society of Nephrology Kidney Week 2021, 2021/11/04, Without Invitation, English, San Diego (USA)
  11. Mechanistic importance of reduced KLHL3 and CUL3 expression in CUL3-D9-mediated familial hyperkalemic hypertension, Maeoka Y, Ferdaus MZ, Cornelius RJ, Sharma A, Su X-T, Robertson JA, Gurley SB, Ellison DH, McCormick JA, American Society of Nephrology Kidney Week 2021, 2021/11/04, Without Invitation, English, American Society of Nephrology, San Diego (USA)
  12. MR occupancy without aldosterone, Yujiro Maeoka, James A McCormick, David H Ellison, 7th LeDucq Meeting, 2021/06/29, Without Invitation, English

Awards

  1. 2022/11/04, Best of ASN Journals 2022, American Society of Nephrology, Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice
  2. 2023/12/11, Best of Hypertension Award 2022, American Heart Association, Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone

External Funds

Acceptance Results of Competitive Funds

  1. Grant-in-Aid for Research Activity Start-up, Elucidation of the mechanism by which hypomagnesemia causes hypokalemia, 2023, 2024
  2. Tsuchiya Memorial Foundation, Elucidation of the mechanism of antihypertensive effects of MR antagonists, 2023, 2024
  3. N. L. Tartar Trust Fellowship, Dietary Mg restriction reduces ENaC activity, 2022/07, 2023/06
  4. N. L. Tartar Trust Fellowship, Mechanistic importance of reduced KLHL3 and CUL3 expression in CUL3-D9-mediated familial hyperkalemic hypertension, 2021/07, 2022/06
  5. Uehara Memorial Foundation (postdoctoral fellowship), 2020/04, 2022/03

Social Activities

History as Peer Reviews of Academic Papers

  1. 2022, Kidney 360, Others, assistant of reviewer, 1
  2. 2022, Journal of the American Heart Association, Others, assistant of reviewer, 1
  3. 2023, Frontiers, Others, reviewer, 1
  4. 2022, Frontiers, Others, reviewer, 1
  5. 2021, American Journal of Physiology-Cell Physiology, Others, assistant of reviewer, 1
  6. 2021, American Journal of Physiology-Renal Physiology, Others, assistant of reviewer, 1
  7. 2021, American Journal of Kidney Diseases, Others, assistant of reviewer, 1
  8. 2021, Journal of the American Society of Nephrology, Others, assistant of reviewer, 1
  9. 2021, Kidney International, Others, Assistant of reviewer, 1
  10. 2020, American Journal of Physiology-Renal Physiology, Others, assistant of reviewer, 1
  11. 2020, Kidney 360, Others, assistant of reviewer, 1
  12. 2020, Journal of the American Society of Nephrology, Others, assistant of reviewer, 2
  13. 2020, Cells, Others, assistant of reviewer, 1
  14. 2020, Kidney International, Others, assistant of reviewer, 2
  15. 2020, Hypertension, Others, assistant of reviewer, 1