KENICHI KAWANO

Last Updated :2025/11/07

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor
E-mail
kawano0623hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D., Kyoto University

Research Keywords

  • peptide
  • membrane curvature
  • lipid packing
  • Extracellular vesicles
  • drug delivery
  • membrane proteins
  • fluorescence imaging

Affiliated Academic Societies

  • The Membrane Society of Japan, 2019/07, 9999
  • Division of Biofunctional Chemistry, The chemical Society of Japan, 2017/06, 9999
  • The Japanese Peptide Society, 2016/04, 9999
  • THE PHARMACEUTICAL SOCIETY OF JAPAN, 2011/10, 9999
  • THE BIOPHYSICAL SOCIETY OF JAPAN, 2018/08, 2021/03

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  2. 2025, Undergraduate Education, Second Semester, Training of Physical Chemistry

Research Activities

Academic Papers

  1. Biomembrane research utilizing functional peptides: Stoichiometric analysis of oligomeric states of membrane proteins and sensing analysis of membrane curvature of extracellular vesicles, Accounts in Peptide Science Japan, 36(1), 22-32, 20251001
  2. Applied Research on Extracellular Vesicles Based on Membrane Curvature Sensing Technology, Membrane, 50(5), 222-228, 20250929
  3. Steady dimer formation by the S31N mutant of influenza A virus M2 protein in living cell membranes, BBA - Biomembranes, 1867(8), 184456, 20250909
  4. Curvature-sensing peptide functions as a membrane interfactant that glues small extracellular vesicles to cell membranes and enhances vesicle cellular uptake, bioRxiv, 20250808
  5. Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease, npj Parkinson's Disease, 11(1), 224, 20250731
  6. Structural Changes of Amyloid β-Protein Fibrils on Neuronal Cells, ACS Chemical Neuroscience, 16(13), 2387-2394, 20250610
  7. Skeletal ciliopathy variants of dynein-2 DYNC2LI1 subunitimpair osteogenic differentiation of mesenchymal stem cells, Journal of Cell Science, 138, jcs263737, 20250521
  8. Rapid screening and identification of genes involved in bacterial extracellular membrane vesicle production using a curvature-sensing peptide, Journal of Bacteriology, 207(5), e0049724, 20250404
  9. Helicene–Fluorescein Hybrids: A Reversible Base-triggered (Chir)optical Switch with Sign Inversion of Circularly Polarized Luminescence, Chemistry - A European Journal, e202500335, 20250130
  10. Development of Simple Methods for Detecting and Isolating Extracellular Vesicles using Curvature-sensing Peptides, Membrane, 49(6), 316-321, 20241204
  11. Stable and minimum-size solubilization of membrane proteins with cocktails of phospholipid analogs, ACS Applied Materials & Interfaces, 16(46), 63358-63367, 20241120
  12. Amyloid fibril formation on neuronal cells in the coexistence of Aβ40 and Aβ42, ChemBioChem, e202400603, 20240925
  13. Extracellular-vesicle catch-and-release isolation system using a net-charge invertible curvature-sensing peptide, Analytical Chemistry, 96(9), 3754-3762, 20240305
  14. Elucidation of the Curved Membrane–binding Mechanism of Curvature–sensing Peptides that Enable Highly Sensitive Detection of Extracellular Vesicles, Membrane, 48(4), 178-183, 20230802
  15. Structural factors governing binding of curvature-sensing peptides to bacterial extracellular vesicles covered with hydrophilic polysaccharide chains, Biophysical Chemistry, 299, 107039-107039, 20230518
  16. Structural Dissection of Epsin-1 N-Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating Membrane Curvature, Chemistry - A European Journal, 29(29), e202300129, 20230306
  17. Development of antimicrobial peptide-antibiotic conjugates to improve the outer membrane permeability of antibiotics against Gram-negative bacteria, ACS Infectious Diseases, 8(11), 2339-2347, 20221018
  18. Hemopexin as a Potential Binding Partner of Arginine-Rich Cell-Penetrating Peptides in Serum, ACS Pharmacology & Translational Science, 5(8), 603-615, 20220720
  19. Split luciferase-based estimation of cytosolic cargo concentration delivered intracellularly via attenuated cationic amphiphilic lytic peptides, Bioorganic & Medicinal Chemistry Letters, 72, 128875, 20220704
  20. Synthesis and Properties of V-Shaped Xanthene Dyes with Tunable and Predictable Absorption and Emission Wavelengths, The Journal of Organic Chemistry, 87(5), 2336-2344, 20220112
  21. Design of the N-terminus Substituted Curvature-sensing Peptides that Exhibit Highly Sensitive Detection Ability of Bacterial Extracellular Vesicles, Chemical and Pharmaceutical Bulletin, 69(11), 1075-1082, 20211101
  22. 細胞外膜小胞の高感度検出を基軸とした曲率認識ペプチドの創製研究, Peptide Newsletter Japan, 121, 1-5, 20210730
  23. Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides, Amino Acids, 53, 1033-1049, 20210525
  24. Membrane anchoring of a curvature-inducing peptide, EpN18, promotes membrane translocation of octaarginine, Bioorganic & Medicinal Chemistry Letters, 43, 128103, 20210510
  25. Metal complex lipids for fluid–fluid phase separation in co-assembled phospholipid membranes, Angewandte Chemie International Edition, 60, 13603-13608, 20210315
  26. Development of a Microwave Resonator and Effects of Electric and Magnetic Fields on Cultured Cancer Cells, Thermal Medicine, 37(1), 15-24, 202103
  27. Development of a Simple and Rapid Method for In Situ Vesicle Detection in Cultured Media, Journal of Molecular Biology, 432, 5876-5888, 20200912
  28. Pseudo‐membrane jackets: Two‐dimensional coordination polymers achieving visible phase separation in cell membrane, Angewandte Chemie International Edition, 59(41), 17931-17937, 20200630
  29. Optimizing charge switching in membrane lytic peptides for endosomal release of biomacromolecules, Angewandte Chemie International Edition, 59, 19990-19998, 20200618
  30. Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules, Molecular Pharmaceutics, 17(6), 2175-2185, 202004
  31. Enhancing the Activity of Membrane Remodeling Epsin-Peptide by Trimerization, Bioorganic & Medicinal Chemistry Letters, 30, 127190, 202004
  32. Loosening of Lipid Packing by Cell Surface Recruitment of Amphiphilic Peptides by Coiled-coil Tethering, ChemBioChem, 20(16), 2151-2159, 201908
  33. Development of a membrane curvature-sensing peptide based on a structure–activity correlation study., Chemical & Pharmaceutical Bulletin, 67(10), 1131-1138, 201907
  34. Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine., Bioconjugate chemistry, 30(2), 454-460, 201902
  35. Development of xanthene dyes containing arylacetylenes: The role of acetylene linker and substituents on the aryl group, Tetrahedron, 74(27), 3608-3615, 20180705
  36. Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides, Molecular Pharmaceutics, 15(3), 1332-1340, 20180305
  37. Syntheses and properties of second-generation V-shaped xanthene dyes with piperidino groups, Tetrahedron, 73(50), 7061-7066, 201712
  38. Stoichiometric analysis of oligomeric states of three class-A GPCRs, chemokine-CXCR4, dopamine-D2, and prostaglandin-EP1 receptors, on living cells, Journal of Peptide Science, 23(7-8), 650-658, 201707
  39. Loosening of Lipid Packing Promotes Oligoarginine Entry into Cells, Angewandte Chemie International Edition, 56(26), 7644-7647, 201706
  40. A pH-dependent charge reversal peptide for cancer targeting, European Biophysical Journal, 46(2), 121-127, 201703
  41. The 3G Condiments, Garlic, Ginger, and Green Onion, Exhibit Synergistic Antibacterial effects, ELCAS Journal, 1, 58-62, 201603
  42. Oligomerization-function relationship of EGFR on living cells detected by the coiled-coil labeling and FRET microscopy, Biochimica et Biophysica Acta - Biomembranes, 1848(6), 1359-1366, 2015
  43. A Dimer Is the Minimal Proton-Conducting Unit of the Influenza A Virus M2 Channel, Journal of Molecular Biology, 426(14), 2679-2691, 201407
  44. A visualization tool for oligomerization and internalization of membrane proteins in living cells: Coiled-coil labeling method, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 134(4), 501-506, 2014
  45. Stoichiometric analysis of oligomerization of membrane proteins using coiled-coil labeling and in-cell spectroscopy, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 134(9), 931-937, 2014
  46. Stoichiometric analysis of oligomerization of membrane proteins on living cells using coiled-coil labeling and spectral imaging, Analytical Chemistry, 85(6), 3454-3461, 20130319
  47. Coiled-Coil Tag–Probe Labeling Methods for Live-Cell Imaging of Membrane Receptors, Methods Enzymology, 504, 355-370, 2012

Publications such as books

  1. 2021/03/19, 中分子創薬研究のフロンティア －生体分子を標的とした機能性ペプチドの創製, 中分子創薬研究のフロンティア －生体分子を標的とした機能性ペプチドの創製, jpn, 河野健一; 中瀬生彦
  2. 2020/03/18, 中分子創薬研究のフロンティア:~ 生体分子の反応集積場としての膜曲率の役割~, 中分子創薬研究のフロンティア:~ 生体分子の反応集積場としての膜曲率の役割~, jpn, 河野健一; 中瀬生彦
  3. 2017/10/30, 細胞膜透過性（医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―）, 細胞膜透過性（医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―）, jpn, 二木史朗; 秋柴美沙穂; 河野健一

Invited Lecture, Oral Presentation, Poster Presentation

  1. Multiple applications of extracellular vesicles using curvature-sensing peptides, Kenichi Kawano, Pacifichem 2025 (Symposium: Advances in Peptide Therapeutics and Peptidomimetics: Navigating the Future of Precision Medicine), 2025/12
  2. Development of a simple drug-loading system onto small extracellular vesicles using a curvature- sensing peptide that enhances cellular uptake of the vesicles, Kenichi Kawano; Kenta Hosokawa; Aoi Taniguchi; Yuuto Oosugi; Yuki Kuzuama; Katsumi Matsuzaki, The 62nd Japanese Peptide Symposium, 2025/10/21
  3. Development of extracellular vesicle destruction technology for inhibiting cell-cell communication using a curved membrane-disrupting peptide, Shintaro Sakaue; Kenichi Kawano, The 62nd Japanese Peptide Symposium, 2025/10/21
  4. Stoichiometric analysis of oligomeric states of membrane proteins and sensing analysis of membrane curvature of extracellular vesicles, Kenichi Kawano, The 28th Korean Peptide and Protein Society (KPPS) Annual Symposium, 2025/06/24
  5. Exploration of immunostimulatory molecules in extracellular vesicles secreted from a horse mackerel intestinal bacterium, Koichi Yoshio; Jun Kawamoto; Tatsuo Kurihara; Kenichi Kawano, The 28th Korean Peptide and Protein Society (KPPS) Annual Symposium, 2025/06/23
  6. Application of Extracellular-Vesicle Catch and Release Isolation System Using a Newly Designed Net-Charge Invertible Curvature-Sensing Peptide, Yuuto Oosugi; Katsumi Matsuzaki; Kenichi Kawano, The 28th Korean Peptide and Protein Society (KPPS) Annual Symposium, 2025/06/23
  7. Applied research on extracellular vesicles based on membrane curvature-sensing technology., K. Kawano, 2025/06/05
  8. Exploration of immunostimulatory molecules in extracellular vesicles secreted from a horse mackerel intestinal bacterium., K. Yoshio; J. Kawamoto; T. Kurihara; K. Kawano, 2025/06
  9. Optimization of extracellular-vesicle catch-and-release isolation system using a net-charge invertible curvature-sensing peptide, 2025/03/22
  10. BIOMEMBRANE RESEARCH UTILIZING FUNCTIONAL PEPTIDES, Kenichi Kawano, The 61st Japanese Peptide Symposium（奨励賞受賞講演）, 2024/10/31
  11. SELECTIVE ANTICANCER ACTIVITIES OF LOW PH-RESPONSIVE PEPTIDES AND ACTIVITY ENHANCEMENT BY ANTICANCER DRUG CONJUGATION AND CATIONIC LIPOSOMES, Aoi Taniguchi; Kenichi Kawano; Katsumi Matsuzaki, The 61st Japanese Peptide Symposium, 2024/10/29
  12. ALANINE SCANNING REVEALED THE KEY CHARGED AMINO ACID RESIDUES OF Aβ40 AFFECTING ITS FIBRIL FORMATION AND CYTOTOXICITY, Atsushi Tanaka; Kenichi Kawano; Katsumi Matsuzaki, The 61st Japanese Peptide Symposium, 2024/10/29
  13. OPTIMIZATION OF EXTRACELLULAR-VESICLE CATCH-AND-RELEASE ISOLATION SYSTEM USING A NET-CHARGE INVERTIBLE CURVATURE-SENSING PEPTIDE, Yuuto Oosugi; Kenichi Kawano; Katsumi Matsuzaki, The 61st Japanese Peptide Symposium, 2024/10/29
  14. ANALYSIS OF THE HYPER-VESICULATING MECHANISM OF SHEWANELLA VESICULOSA HM13 USING A CURVATURE-SENSING PEPTIDE, Hiromu Inoue; Kenichi Kawano; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara, 14th International Congress on Extremophiles, 2024/09
  15. Development of extracellular-vesicle catch-and-release isolation system using a net-charge invertible curvature-sensing peptide, The 18th Symposium on Biorelevant Chemistry, 2024/09/12
  16. Extracellular-vesicle catch-and-release isolation system using a net-charge invertible curvature-sensing peptide, Kenichi Kawano; Yuki Kuzuma; Koichi Yoshio; Kenta Hosokawa; Yuuto Oosugi; Takahiro Fujiwara; Fumiaki Yokoyama; Katsumi Matsuzaki, The 37th EPS and 14th IPS Symposia, 2024/08/26
  17. Surface Functionalization For Marker Independent EV Capture And Profiling, Hugues Martin; Andreas Wallucks; Andy Ng; Molly Shen; Kenichi Kawano; David Juncker, ISEV2024 Annual Meeting, 2024/05
  18. Functional evaluation of extracellular vesicles isolated by a novel EV-isolation method using a curvature-sensing peptide, Kenichi Kawano; Yuki Kuzuma; Koichi Yoshio; Kenta Hosokawa; Yuuto Oosugi; Takahiro Fujiwara; Fumiaki Yokoyama; Katsumi Matsuzaki, The 144th Annual Meeting of the Pharmaceutical Society of Japan, 2024/03/31
  19. 曲率認識ぺプチドによるエクソソーム膜へのアルギニンペプチド修飾と細胞内導入促進, 中坊 美穂; 河野 健一; 藤原 大佑; 道上 雅孝; 松崎 勝巳; 藤井 郁雄; 中瀬 生彦, The 144th Annual Meeting of the Pharmaceutical Society of Japan, 2024/03/30
  20. Selective anticancer activities of low pH-responsive anticancer peptides and a peptide−anticancer drug conjugate, The 144th Annual Meeting of the Pharmaceutical Society of Japan, 2024/03/30
  21. Evaluation of Ligand Binding Ability of GPCRs Sollubilized with Novel Phospholipid Derivatives, The 144th Annual Meeting of the Pharmaceutical Society of Japan, 2024/03/30
  22. A simple method to modify the surface of extracellular vesicle-mimicking liposomes using curvature-sensing peptides, Kenta Hosokawa; Kenichi Kawano; Katsumi Matsuzaki, The 60th Japanese Peptide Symposium, 2023/11/09
  23. Extracellular-vesicle catch-and-release isolation system using a ph-dependent EV-binding curvature-sensing peptide, Kenichi Kawano; Yuki Kuzuma; Takahiro Fujiwara; Fumiaki Yokoyama; Katsumi Matsuzaki, The 60th Japanese Peptide Symposium, 2023/11/09
  24. Importance of the structural flexibility of curvature-sensing peptides that enable highly sensitive detection of extracellular vesicles, Kenichi Kawano, Biological Chemistry on Membranes - Understanding and Engineering -, 2023/08/28
  25. Development of dimerized curvature-sensing peptides for detection of extracellular vesicles from bacteria with low EV-secretion levels, Kenichi Kawano; Yuki Kuzuma; Yosuke Yamaoka; Kiyosei Takasu; Katsumi Matsuzaki, The 143rd Annual Meeting of the Pharmaceutical Society of Japan, 2023/03/28
  26. Design of a novel pH-responsive curvature-sensing peptide for isolation of extracellular vesicles, Yuki Kuzuma; Kenichi Kawano; Katsumi Matsuzaki, The 143rd Annual Meeting of the Pharmaceutical Society of Japan, 2023/03/28
  27. Screening and functional prediction of genes related to membrane vesicle production of Shewanella vesiculosa HM13 using a curvature-sensing peptide, Hiromu INOUE; Kenichi KAWANO; Jun KAWAMOTO; Takuya OGAWA; Tatsuo KURIHARA, The 2023 Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), 2023/03
  28. Binding characteristics of a curvature-sensing peptide recognizing bacterial extracellular membrane vesicles, Daiki Sakamoto; Hiromu Inoue; Kenichi Kawano; Tomoya Imai; Jun Kawamoto; Takuya Ogawa; Atsushi Kurata; Tatsuo Kurihara, The 2023 Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), 2023/03
  29. STRUCTURAL FACTORS GOVERNING VESICLE DETECTION OF CURVATURE-SENSING PEPTIDES, Kenichi Kawano; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Katsumi Matsuzaki, The 59th Japanese Peptide Symposium, 2022/10/27
  30. DEVELOPMENT OF PH-RESPONSIVE ANTICANCER PEPTIDES, Aoi Taniguchi; Kenichi Kawano; Katsumi Matsuzaki, The 59th Japanese Peptide Symposium, 2022/10/26
  31. Development of curvature-sensing peptides for highly sensitive detection of extracellular vesicles, KAWANO, Kenichi; KUZUMA, Yuki; YOKOYAMA, Fumiaki; KAMASAKA, Kouhei; OGAWA, Takuya; KAWAMOTO, Jun; KURIHARA, Tatsuo; MATSUZAKI, Katsumi, The 16th Symposium on Biorelevant Chemistry, 2022/09/11
  32. Highly sensitive detection of extracellular vesicles with N-terminus-substituted curvature-sensing peptides, Kenichi Kawano; Yuki Kuzuma; Fumiaki Yokoyama; Kouhei Kamasaka; Takuya Ogawa; Jun Kawamoto; Tatsuo Kurihara; Shiroh Futaki; Katsumi Matsuzaki, The 142 Annual Meeting of The Pharmaceutical Society of Japan, 2022/03/26
  33. Search for genes related to bacterial extracellular membrane vesicle production by high-throughput screening using curvature-sensing peptide, 井上宙夢; 河野健一; 川本純; 小川拓哉; 栗原達夫, The 2022 Annual Meetings of The Japanese Society for Bioscience, Biotechnology and Agrochemistry (JSBBA), 2022/03/18
  34. A novel detection tool of extracellular membrane vesicles of bacterial cells in cultured medium using a curvature-sensing peptide, Kenichi Kawano; Fumiaki Yokoyama; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki, EMBO BMVs Workshop, 2021/11/24
  35. 曲率認識ペプチドを用いたShewanella vesiculosa HM13の細胞外膜小胞生産関連遺伝子の探索, 井上宙夢; 河野健一; 川本 純; 小川 拓哉; 栗原 達夫, 極限環境生物学会2021年度（第22回）年会, 2021/11/20
  36. DESIGN OF CURVATURE-SENSING PEPTIDES FOR HIGHLY SENSITIVE DETECTION OF BACTERIAL EXTRACELLULAR VESICLES, Kenichi Kawano; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki, The 58th Japanese Peptide Symposium, 2021/10/21
  37. DEVELOPMENT OF ANTIMICROBIAL PEPTIDE–ANTIBIOTIC CONJUGATES FOR IMPROVED ANTIMICROBIAL ACTIVITY, Ruka Yamauchi; Kenichi Kawano; Daigo Kajiwara; Yousuke Yamaoka; Yoshiaki Yano; Kiyosei Takasu; Katsumi Matsuzaki, The 58th Japanese Peptide Symposium, 2021/10/20
  38. 曲率認識ペプチドを用いた細菌の菌体外膜小胞のハイスループット検出法の開発, 河野 健一; 小川 拓哉, 京都大学化学研究所 第120回化学研究所研究発表会, 2020/12/11
  39. CURVATURE-SENSING PEPTIDES TO DISTINGUISH BACTERIAL EXTRACELLULAR MEMBRANE VESICLES FROM CELLS IN CULTURED MEDIUM, K. Kawano; F. Yokoyama; J. Kawamoto; T. Ogawa; T. Kurihara; S. Futaki, The 57th Japanese Peptide Symposium, 2020/11/11
  40. Improvement of membrane curvature-inducing ability of the EpN18 peptide by membrane anchoring, Kakeru Kuroki; Takayuki Sakai; Kenichi Kawano; Shiroh Futaki, The 56th Japanese Peptide Symposium, 2020/11/10
  41. Rational design of cytosolic macromolecular delivery peptide with enhanced endosomolytic activity, Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Kenichi Kawano; Shiroh Futaki, The 56th Japanese Peptide Symposium, 2020/11/09
  42. Frontier research in membrane curvature on roles as molecular reaction sites, Kenichi Kawano, Ikuhiko Nakase, The 140th Annual Meeting of the Pharmaceutical Society of Japan, 2020/03/27
  43. 膜曲率誘導による膜透過性ペプチドの細胞内送達促進, 河野健一, IRCCS The 5th Symposium, 2019/11/18
  44. Improving the activity of L17E by endowing pH-sensitive membrane destabilizing activity, Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Kenichi Kawano; Shiroh Futaki, The 56th Japanese Peptide Symposium, 2019/10/25
  45. Loosening of lipid packing by recruitment of amphiphilic peptides onto cell surface, Takayuki Sakai; Kenichi Kawano; Miki Imanishi; Shiroh Futaki, The 56th Japanese Peptide Symposium, 2019/10/24
  46. Structural parameters contributing to the ability of amphipathic peptides to induce membrane curvature, Motoki Nishimura; Toshihiro Masuda; Sergii Afonin; Kenichi Kawano; Anne S. Ulrich; Shiroh Futaki, The 56th Japanese Peptide Symposium, 2019/10/23
  47. DEVELOPMENT OF A MEMBRANE CURVATURE-SENSING PEPTIDE BASED ON A STRUCTURE–ACTIVITY CORRELATION STUDY, Kenichi Kawano, Masaya Ogushi, Toshihiro Masuda, and Shiroh Futaki, The 56th Japanese Peptide Symposium, 2019/10/23
  48. Induction and reversible control of phase separation on living cell membranes, Kenichi KAWANO; Yasufumi TAKAHASHI; Ryo OHTANI; Masanao KINOSHITA; Shiroh FUTAKI, The 57th Annual Meeting of The Biophysical Society of Japan, 2019/09/24
  49. 両親媒性ペプチドの細胞膜集積化とその膜 相互作用の増強, 阪井貴之; 河野健一; 飯野真丈; 武内敏秀; 今西未来; 二木史朗, 第17回次世代を担う若手のためのフィジカル•ファーマフォーラム（PPF2019）, 2019/09/03
  50. 生細胞膜上における相分離の誘発と可逆的制御, 河野健一; 高橋康史; 大谷亮; 木下祥尚; 二木史朗, 第17回次世代を担う若手のためのフィジカル•ファーマフォーラム（PPF2019）, 2019/09/03
  51. Improving Endosomolytic Activity of L17E, Kentarou Sakamoto; Misao Akishiba; Kenichi Kawano; Shiroh Futaki, The 55th Japanese Peptide Symposium / The 10th IPS, 2018/12/06
  52. Identified Macropinocytosis-inducing Peptide and Its Mode-of-Action, Jan Vincent-V. Arafiles; Kenichi Kawano; Shiroh Futaki, The 55th Japanese Peptide Symposium / The 10th IPS, 2018/12/05
  53. Detecting Highly Curved Membranes by Amphipathic Peptides, Masaya Ogushi; Toshihiro Masuda; Kenichi Kawano; Shiroh Futaki, The 55th Japanese Peptide Symposium / The 10th IPS, 2018/12/04
  54. Promoting Accumulation of Curvature-inducing Peptides on Cell Membranes, Takayuki Sakai; Kenichi Kawano; Shiroh Futaki, The 55th Japanese Peptide Symposium / The 10th IPS, 2018/12/04
  55. Structural Determinants of Membrane Curvature Inducing Peptide, Motoki Nishimura; Toshihiro Masuda; Kenichi Kawano; Shiroh Futaki, The 55th Japanese Peptide Symposium / The 10th IPS, 2018/12/04
  56. 高曲率小胞指向性を有する曲率感知ペプチドの開発, 河野健一; 小串正哉; 益田俊博; 二木史朗, 第2回統合物質創製化学研究推進機構(IRCCS)若手の会, 2018/06/15
  57. 脂質小胞を感知する曲率センターペプチドの開発, 河野健一; 小串正哉; 益田俊博; 二木史朗, 第65回日本生化学会近畿支部例会, 2018/05/26
  58. Lipid packing loosening plays a key role in the direct membrane translocation of octaarginine, Tomo Murayama; ◯Kenichi Kawano; Shiroh Futaki, The Second International Symposium on Biofunctional Chemistry 2017, 2017/12/14
  59. Novel macropinocytosis-inducing cell penetrating peptides, Jan Vincent-V. Arafiles; Kenichi Kawano; Shiroh Futaki, The 54th Japanese Peptide Symposium, 2017/11/21
  60. Histidines in L17E endosome-destabilizing peptide, Kentarou Sakamoto; Misao Akishiba; Kenichi Kawano; Shiroh Futaki, The 54th Japanese Peptide Symposium, 2017/11/20
  61. Modification of Lipid Packing State by Amphipathic Peptides with Curvature Inducibility., Tomo Murayama; ◯Kenichi Kawano; Shiroh Futaki, 2017/10/30
  62. Membrane-Remodeling Amphipathic Peptides Facilitate Direct Penetration of Octaarginine (R8), 2017/03/25
  63. STOICHIOMETRIC ANALYSIS OF OLIGOMERIC STATES OF THREE CLASS-A GPCRS, CHEMOKINE-CXCR4, DOPAMINE-D2, AND PROSTAGLANDIN-EP1 RECEPTORS, ON LIVING CELLS, ◯Kenichi Kawano; Tetsuya Yagi; Yoshiaki Yano; Katsumi Matsuzaki, The 53th Japanese Peptide Symposium, 2016/10/27
  64. Cell penetration of dipicolylamine-modified R8 facilitated by metal complex formation, Shoko Ise; Yoshimasa Kawaguchi; Toshihide Takeuchi; ○Kenichi Kawano; Shiroh Futaki, 34th European Peptide Symposium and 8th International Peptide Symposium, 2016/09/08
  65. Facilitated cell penetration of dipicolylamine-modified R8 by metal complex formation, Shoko Ise; Yoshimasa Kawaguchi; Toshihide Takeuchi; ◯Kenichi Kawano; Shiroh Futaki, The 14th Chinese International Peptide Symposium & the 5th Asia-pacific International Peptide Symposium, 2016/07/05
  66. THE AMANTADINE-RESISTANT S31N MUTANT OF INFLUENZA A VIRUS M2 PROTEIN STABLY FORMS A DIMER ON THE LIVING CELLS, Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki, 58th Annual Meeting Biophysical Society, 2014/02/16
  67. Dimer is a minimal functional unit for influenza a virus m2 channel on biomembrane, Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki, The 50th Japanese Peptide Symposium / The 4th APIPS, 2013/11/06
  68. Dimer is a minimal functional unit for influenza A virus M2 channel on biomembrane, ◯Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki, 4th Asia-Pacific International Peptide Symposium, 2013/11/06
  69. OLIGOMERIC STATES OF FULL LENGTH INFLUENZA A VIRUS M2 PROTEINS ON BIOLOGICAL MEMBRANES, Ken-ichi Kawano; Sayaka Matsuzaki; Kaoru Oomae; Yoshiaki Yano; Katsumi Matsuzaki, 57th Annual Meeting Biophysical Society, 2013/02/04
  70. Mechanism of antiviral Amantadine resistance of influenza A virus M2 proton channel, ◯Kenichi Kawano; Sayaka Matsuzaki; Kaoru Oomae; Yoshiaki Yano; Katsumi Matsuzaki, 49th Japanese Peptide Symposium, 2012/11/07
  71. Stoichiometric analysis of oligomerization of membrane proteins on living cell surface, ◯Kenichi Kawano; Kaoru Oomae; Sayaka Matsuzaki; Yoshiaki Yano; Katsumi Matsuzaki, The 7th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists, 2012/05/24

Awards

  1. 2024/10, Young Investigator Award, The Japanese Peptide Society
  2. 2016/07, Poster Prize, The 5th Asia-pacific International Peptide Symposium

External Funds

Acceptance Results of Competitive Funds

  1. 2026/04, 2029/03
  2. 2024/08, 2029/03
  3. 2025/04, 2028/03
  4. 2025/04, 2027/12
  5. 2025/09, 2027/08
  6. 2025/04, 2027/03
  7. 2024/04, 2027/03
  8. 2021/04/01, 2025/03/31
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  9. Grants-in-Aid for Scientific Research, 新規リン脂質誘導体可溶化剤を用いた革新的膜タンパク質研究プラットホームの構築, 2023/06, 2025/03
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  10. Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), In-cell分光法によるアミロイドβ産生制御機構・構造変化の解明と創薬, 2021/04, 2025/03
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  11. 2023/12, 2024/12
  12. 2023/08, 2024/07
  13. Grants-in-Aid for Scientific Research, Exploration of adjuvant-active substances derived from extracellular membrane vesicles, 2021/04, 2024/03
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  14. 2022/04, 2023/03
  15. 2021/04, 2022/03
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  16. 2018 Pharmaceutical Research Grants, Development of peptide-based diagnostic agents targeting exosomes from cancers, 2018/08, 2021/05
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  17. 2019/07, 2020/07
  18. Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Elucidation of the mechanism underlying the influx point of cell-penetrating peptides using artificial lipid domains, 2018/04, 2020/03
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  19. 2018/04, 2019/03
  20. JSPS Research Fellowship for Young Sciensists, Cell entry mechanism of anthrax toxin: Elucidation of cooperation mechanism of actin membrane skeleton and raft by single molecule method, 2016/04, 2019/03
  21. Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), New strategy for intracellular delivery of biomacropharmaceuticals, 2015/04, 2018/03
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  22. Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Development of a novel fluorescent labeling method for detecting heterooligomers of membrane proteins on living cells, 2015/04, 2018/03
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  23. Grants-in-Aid for Scientific Research, Structural analysis of Am-resistant M2-S31N mutant using a novel detergent and solution NMR, 2014/08, 2016/03
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