Ryukichi Takagi

Last Updated :2021/05/31

Affiliations, Positions
Graduate School of Advanced Science and Engineering, Assistant Professor
E-mail
rtakagihiroshima-u.ac.jp
Self-introduction
My research is focused on development of synthetic methodology of organic chemistry.

Basic Information

Major Professional Backgrounds

  • 1998/04/01, 2007/03/31, Department of Chemistry, Graduate School of Science, Assiatant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Natural Science, 1995/04, 1998/03

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Educational Activity

  • 【Bachelor Degree Program】School of Science : Chemistry
  • 【Master's Program】Graduate School of Advanced Science and Engineering : Division of Advanced Science and Engineering : Basic Chemistry Program
  • 【Doctoral Program】Graduate School of Advanced Science and Engineering : Division of Advanced Science and Engineering : Basic Chemistry Program

Research Fields

  • Chemistry;Applied chemistry;Synthetic chemistry

Research Keywords

  • organic synthesis
  • stereoselectivity
  • natural product

Educational Activity

Course in Charge

  1. 2021, Undergraduate Education, Second Semester, Exercises in Organic Chemistry
  2. 2021, Undergraduate Education, First Semester, Chemical Experiments I
  3. 2021, Undergraduate Education, 3Term, Introduction to Chemistry B
  4. 2021, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  5. 2021, Undergraduate Education, Second Semester, Chemical Experiments II
  6. 2021, Graduate Education (Master's Program) , First Semester, Organic Reaction Chemistry (Seminar)
  7. 2021, Graduate Education (Master's Program) , Second Semester, Organic Reaction Chemistry (Seminar)
  8. 2021, Graduate Education (Doctoral Program) , First Semester, Seminar in Chemical
  9. 2021, Graduate Education (Doctoral Program) , Second Semester, Seminar in Chemical
  10. 2021, Graduate Education (Doctoral Program) , First Semester, Organic Reaction Chemistry (Seminar)
  11. 2021, Graduate Education (Doctoral Program) , Second Semester, Organic Reaction Chemistry (Seminar)
  12. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Chemistry A
  13. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Chemistry B
  14. 2021, Graduate Education (Master's Program) , Academic Year, Master's Thesis in Chemistry

Research Activities

Academic Papers

  1. Enantioselective Michael Reaction of Cyclic beta-Ketoesters with Morita-Baylis-Hillman Derivatives Using a Phase-Transfer Catalyst, JOURNAL OF ORGANIC CHEMISTRY, 83(18), 11191-11203, 20180921
  2. Photochemical [2+2] cycloaddition reaction of enone derivatives with 2-siloxy-1H-pyrrole derivatives, ARKIVOC, 192-204, 2018
  3. Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities, JOURNAL OF NATURAL PRODUCTS, 80(12), 3173-3179, 201712
  4. Two ring opened oxetane taxoids containing a C-20 benzoyloxy group from the roots of Taxus wallichiana Zucc., TETRAHEDRON LETTERS, 58(40), 3897-3900, 20171004
  5. Paterno-Buchi photochemical [2+2] cycloaddition of aromatic carbonyl compounds with 2-siloxy-1H-pyrrole derivatives(dagger), JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 30(4), 201704
  6. Formation of Isomerized E,Z-Configured 1,3-Dienes in Construction of Macrocyclic Trienes by Diene-Ene RCM, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88(1), 146-148, 20150115
  7. A novel non-metathetic behavior of Grubbs catalyst: Ruthenium-mediated intramolecular [3+2] cycloaddition of bis-1,3-dienes, JOURNAL OF ORGANOMETALLIC CHEMISTRY, 723, 171-175, 20130101
  8. Concentration and Temperature Dependency of Regio- and Stereoselectivity in a Photochemical [2+2] Cycloaddition Reaction (the Paterno Buchi Reaction): Origin of the Hydroxy-Group Directivity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(8), 2592-2604, 20110302
  9. Stereochemical deuterium-labeling study on the denitrogenation of 7,7-diethoxy-2, 3-diazabicyclo[2.2.1]hept-2-ene, JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 24(10), 894-901, 201110
  10. Zirconium-catalyzed chemoselective methylalumination of ethers, amines, and sulfides bearing two terminal alkenyl groups, JOURNAL OF ORGANOMETALLIC CHEMISTRY, 696(8), 1556-1564, 20110415
  11. Alkylalumination of arylacetylene catalyzed by zirconocene catalysts supported on solid materials, Journal of Molecular Catalysis A: Chemical, 321, 71-76, 20100401
  12. Computational study on the cyclopropanation reaction of ylides generated from -pyridiniumacetates, HETEROCYCLES, 81(11), 2479-2495, 20101101
  13. Late acceleration of phosphoric acid-catalyzed Diels-Alder reaction by internal hydrogen-bonding of adjacent hydroxy group, JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 278(1-2), 120-126, 20071214
  14. Stereochemical investigation on the construction of poly-functionalized bicyclo[3.3.1]nonenones by successive Michael reactions of 2-cyclohexenones, ORGANIC & BIOMOLECULAR CHEMISTRY, 5(2), 286-300, 2007
  15. ★, Stereoselective total synthesis of (+)-scyphostatin via a pi-facially selective Diels-Alder reaction, JOURNAL OF ORGANIC CHEMISTRY, 72(11), 4117-4125, 20070525
  16. One-pot synthesis of adamantane derivatives by domino Michael reactions from ethyl 2,4-dioxocyclohexanecarboxylate, JOURNAL OF ORGANIC CHEMISTRY, 70(21), 8587-8589, 20051014
  17. Synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative via epoxide ring opening, 1,3-carbonyl transposition and epoxide ring regeneration: a synthetic study on a scyphostatin analogue, Organic & Biomolecular Chemistry, 3, 2031-2036, 20050401
  18. Facial Selectivity in Nucleophilic Epoxidation of 3-Aryl-2-phosphonoacrylates Induced by the (-)-8-Phenylmenthyl Moiety as a Chiral Auxiliary, Heterocycles, 62, 251-262, 20040401
  19. Influence of polymerization degree of poly-l-leucine catalyst and substituent effect on the Julia-Colonna asymmetric epoxidation of benzalacetophenones, HETEROCYCLES, 64, 129-141, 20041231
  20. Stereoselective Synthesis of the hydophobic side chain of Scyphostatin, Australian Journal of Chemistry, 57, 439-447, 20040401
  21. Stereoselectivity control by oxaspiro rings during Diels-Alder cycloadditions to cross-conjugated cyclohexadienones: The syn oxygen phenomenon, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(51), 16783-16792, 20041229
  22. Synthetic study of an analogue of the hydrophilic moiety of Scyphostatin via p-facial selective Diels-Alder reaction, Heterocycles, 64, 75-91, 20040401
  23. Computational study of base-induced skeletal conversion via a spirocyclic intermediate in dibenzodithiocinium derivatives by ab initio MO calculations, JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 16(5), 271-278, 200305
  24. pi-Facial selectivity in Diels-Alder reactions of cross-conjugated ketones bearing an oxa-spiro-ring with sterically undemanding dienes, HETEROCYCLES, 60(4), 785-790, 20030401
  25. Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high ?-facial selectivit, Chemical Communications, 2096-2097, 20020401
  26. Stereochemical considerations on the stereoselective cyclopropanation reactions of 3-aryl-2-phosphonoacrylates induced by the (-)-8-phenylmenthyl group as a chiral auxiliary, Journal of the Chemical Society= Perkin Transactions 1, 179-190, 20020101
  27. Stereoselective cyclopropanation of 3-aryl-2-phosphonoacrylates induced by the (-)-8-phenylmenthyl group as a chiral auxiliary, TETRAHEDRON LETTERS, 42(34), 5891-5895, 20010820
  28. Stereoselective Formation of 2,5-Disubstituted Tetrahydropyrans by Intramolecular Hetero-Michael Addition and a Computational Study at AM1 Level, Bulletin of the Chemical Society of Japan, 74(10), 1901-1907, 20011001
  29. Stereoselectivity in the Darzens Condensation of Cyclohexanone Derivatives with a-Haloacetate, Heterocycles, 55(1), 9-12, 20010101
  30. The Julia Colonna Asymmetric Epoxidation Reaction by Soluble Oligo-L-leucine Containing an a-Aminobutylic Acid Residue; Importance of Helical Structure of the Catalyst on the Asymmetric Induction, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 73(4), 2115-2121, 20000401
  31. The Julia-Colonna type asymmetric epoxidation reaction catalyzed by soluble oligo-L-leucines containing an alpha-aminoisobutyric acid residue: Importance of helical structure of the catalyst on asymmetric induction, CHEMISTRY LETTERS, 366-367, 20000405
  32. Stereoselective Synthesis of (+)-Rhopaloic Acid A and (-)-ent- and (+-)-rac-Rhopaloic Acid A, Journal of the Chemical Society= Perkin Transactions 1, -(5), 925-934, 19980301
  33. (-)-Loliolide and other Germination Inhibitory Active Constituents in Equisetum arvense, Natural Product Letters, 10(1), 181-186, 19970101
  34. Excellent Z-selective olefin formation using pentacoordinate pirophosphoranes and aldehydes. Wittig type reaction via hexacoordinate intermediates, Journal of Amnerican Chemical Society, 119(25), 5970-5971, 19970601
  35. Selective Conversion of Bromo-oxirane into Tetrahydropyranylacrylate by Epoxide ring Opening, Chemical Communications, 875-876, 19970501
  36. Stereoselectivity in the Formation of 2,5-Disubstituted Tetrahydropyrans by Intramolecular Hetero-Michael Addition, Heterocycles, 45(12), 2313-2316, 19971201
  37. Synthesis of Norsesterterpene rac- and ent-Rhopaloic Acid A, Chemical Communications, 1887-1889, 19971001
  38. Asymmetric Darzens Condensation of Ketones with a-Chloroacetates by Means of (-)-8-Phenylmenthyl Auxiliary, Chemical Communications, 2411-2412, 19961101
  39. Monomeric 10-Sb-5 Pentacoordinate Organoantimony Monohalides and Their Permutational Behavior, Chemistry Letters, 857-858, 19950401
  40. Organocatalytic asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones via an intermolecular Diels-Alder reaction, ORGANIC & BIOMOLECULAR CHEMISTRY, 13(45), 11039-11045, 2015
  41. Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high pi-facial selectivity: a synthetic study towards scyphostatin., Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high pi-facial selectivity: a synthetic study towards scyphostatin., 2002
  42. Stereoselectivity control by oxaspiro rings during Diels-Alder cycloadditions to cross-conjugated cyclohexadienones: the syn oxygen phenomenon., Stereoselectivity control by oxaspiro rings during Diels-Alder cycloadditions to cross-conjugated cyclohexadienones: the syn oxygen phenomenon., 126(51), 2004
  43. One-pot synthesis of adamantane derivatives by domino Michael reactions from ethyl 2,4-dioxocyclohexanecarboxylate., One-pot synthesis of adamantane derivatives by domino Michael reactions from ethyl 2,4-dioxocyclohexanecarboxylate., 70(21), 2005
  44. Stereoselective total synthesis of (+)-Scyphostatin via a pi-facially selective Diels-Alder reaction., Stereoselective total synthesis of (+)-Scyphostatin via a pi-facially selective Diels-Alder reaction., 72(11), 2007
  45. Construction of the adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols., Construction of the adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols., 73(23), 2008
  46. Computational study on the cyclopropanation reaction of ylides generated from α-pyridiniumacetates, Heterocycles, 81(11), 2479-2495, 20101101
  47. ★, Organocatalytic asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones via an intermolecular Diels–Alder reaction, Organic & Biomolecular Chemistry, 13, 11039-11045, 2015
  48. Design and Synthesis of a 4‑Nitrobromobenzene Derivative Bearing an Ethylene Glycol Tetraacetic Acid Unit for a New Generation of Caged Calcium Compounds with Two-Photon Absorption Properties in the Near-IR Region and Their Application in Vivo., ACS Omega, 1, 193-201, 2016
  49. Paternò–Büchi photochemical [2+2] cycloaddition of aromatic carbonyl compounds with 2-siloxy-1H-pyrrole derivatives., J. Phys. Org. Chem., 30, e3632, 2017
  50. Two ring opened oxetane taxoids containing a C-20 benzoyloxy group from the roots of Taxus wallichiana Zucc., Tetrahderon Lett., 58, 3897-3900, 2017
  51. Artocarmins G-M, prenylated 4-chromenones from the stems of Artocarpus rigida and their tyrosinase Inhibitory activities., Journal of Natural Products, 80, 3172-3178, 2017