HIDENORI AIZAWA

Last Updated :2024/02/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
E-mail
haizawahiroshima-u.ac.jp
Self-introduction
Our lab works for the brain machinery underlying the mental and neurological disorders such as depression and migraine. Our interests include the molecular mechanism of the neural network in regulation of the cognitive functions such as learning, memory and emotion.

Basic Information

Major Professional Backgrounds

  • 2011/04/01, 2015/05/31, Tokyo Medical and Dental University, Associate Professor
  • 2015/06/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor
  • 2007/06/01, 2011/03/31, RIKEN Brain Science Institute, Deputy lab head

Academic Degrees

  • MD, PhD, Chiba University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Biological Sciences;Neuroscience;Neurophysiology / General neuroscience

Research Keywords

  • habenula, depression, monoamines, stress, coping, lateralization, asymmetry, zebrafih

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 3Term, Anatomy for understanding human being I
  2. 2023, Liberal Arts Education Program1, 4Term, Anatomy for understanding human being II
  3. 2023, Liberal Arts Education Program1, 2Term, Cell Science
  4. 2023, Undergraduate Education, 2Term, Introduction for medical research
  5. 2023, Undergraduate Education, 4Term, Medical Neuroscience I
  6. 2023, Undergraduate Education, Intensive, Medical Neuroscience II
  7. 2023, Undergraduate Education, Year, Medical Neuroscience III
  8. 2023, Undergraduate Education, Intensive, Practice for medical research
  9. 2023, Undergraduate Education, First Semester, Structure of human body
  10. 2023, Graduate Education (Master's Program) , First Semester, Seminar
  11. 2023, Graduate Education (Master's Program) , Second Semester, Seminar
  12. 2023, Graduate Education (Master's Program) , First Semester, Research
  13. 2023, Graduate Education (Master's Program) , Second Semester, Research
  14. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  15. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  16. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  17. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  18. 2023, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  19. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Neurobiology
  20. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Neurobiology
  21. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Neurobiology
  22. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Neurobiology

Research Activities

Academic Papers

  1. ★, Deep ultraviolet fluorescence microscopy of three-dimensional structures in the mouse brain, Scientific reports, 13(1), 8553, 20230526
  2. Genetic deletion of translocator protein exacerbates post-sepsis syndrome with activation of the C1q pathway in septic mouse model, Shock, 59, 82-90, 2022
  3. Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine, BRAIN COMMUNICATIONS, 3(4), 20211001
  4. ★, Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae, J Ethnopharmacol, 284, 114763, 20211021
  5. ★, Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum, J Neurophysiol, 126(6), 1934-1942, 20211201
  6. ★, Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix, NEUROPSYCHOPHARMACOLOGY, 46(2), 442-454, 202101
  7. ★, Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model, SHOCK, 56(1), 142-149, 202107
  8. ★, A novel microcontroller-based system for the wheel-running activity in mice, eNeuro, 20210910
  9. ★, Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress, NEUROPHARMACOLOGY, 162, 20200101
  10. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 20200512
  11. ★, Glial glutamate transporter GLT-1 determines susceptibility to spreading depression in the mouse cerebral cortex., GLIA, 20200625
  12. ★, Dopaminergic signaling in the nucleus accumbens modulates stress-coping strategies during inescapable stress., The Journal of neuroscience : the official journal of the Society for Neuroscience, 20200916
  13. Microglial translocator protein and stressor-related disorder, NEUROCHEMISTRY INTERNATIONAL, 140, 202011
  14. Toward an understanding of the habenula's various roles in human depression, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 73(10), 607-612, 201910
  15. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice, NEUROCHEMISTRY INTERNATIONAL, 131, 201912
  16. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice, BRAIN RESEARCH, 1680, 13-38, 20180201
  17. Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice, GLIA, 66(4), 777-788, 201804
  18. Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice., Hum Mol Genet., 26(16), 3094-3104, 2017
  19. Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ, BMC GENOMICS, 17, 20161128
  20. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice, HUMAN MOLECULAR GENETICS, 25(20), 4507-4517, 20161015
  21. Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice, NEUROPSYCHOPHARMACOLOGY, 40(7), 1569-1579, 2015
  22. Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits, JOURNAL OF NEUROSCIENCE, 35(36), 12432-12445, 20150909
  23. Fear and anxiety : choice of adaptive behaviors to overcome them, 66(1), 29-32, 201501
  24. Role of the habenula in pathophysiology of the depression, 65(1), 12-15, 201401
  25. Habenula and the asymmetric development of the vertebrate brain, 88(1), 1-9, 2013
  26. Habenula and the Asymmetric Development of the Vertebrate Brain, 87(3), 57-58, 20120901
  27. Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish, Development, growth & differentiation, 50, S167-S175, 2008
  28. Development of zebrafish brain asymmetry, Cell technology., 27(6), 576-582, 200806
  29. Visualization and manipulation of the emotional neural circuits in the zebrafish brain: study of mechanisms and roles for the asymmetry in the habenulo-interpeduncular projection, Protein, nucleic acid and enzyme, 53(4), 475-481, 200803
  30. Activation of distinct neural ensemble in zebrafish telencephalon following the go/no-go rule change in the goal directed active avoidance learning, NEUROSCIENCE RESEARCH, 68, E68-E68, 2010
  31. Identification of the Zebrafish Ventral Habenula As a Homolog of the Mammalian Lateral Habenula, JOURNAL OF NEUROSCIENCE, 30(4), 1566-1574, 2010
  32. The habenula is crucial for experience-dependent modification of fear responses in zebrafish, NATURE NEUROSCIENCE, 13(11), 1354-1356, 2010
  33. Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety, DEVELOPMENTAL NEUROBIOLOGY, 72(3), 386-394, 2012
  34. Genetic manipulation of mammalian lateral and medial habenula homolog in zebrafish: Toward functional analysis of the habenula, NEUROSCIENCE RESEARCH, 71, E271-E271, 2011
  35. Fear and Anxiety Regulation by Conserved Affective Circuits, NEURON, 78(3), 411-413, 2013
  36. Molecular characterization of the subnuclei in rat habenula, JOURNAL OF COMPARATIVE NEUROLOGY, 520(18), 4051-4066, 2012
  37. ★, The Synchronous Activity of Lateral Habenular Neurons Is Essential for Regulating Hippocampal Theta Oscillation, JOURNAL OF NEUROSCIENCE, 33(20), 8909-+, 2013
  38. Reward-Modulated Motor Information in Identified Striatum Neurons, JOURNAL OF NEUROSCIENCE, 33(25), 10209-10220, 2013
  39. Hyperactivation of the habenula as a link between depression and sleep disturbance, FRONTIERS IN HUMAN NEUROSCIENCE, 7, 2013
  40. The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger, NEURON, 84(5), 1034-1048, 2014
  41. ★, Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance, JOURNAL OF NEUROSCIENCE, 34(49), 16273-16285, 2014
  42. Imaging of Neural Ensemble for the Retrieval of a Learned Behavioral Program, NEURON, 78(5), 881-894, 2013
  43. Phylogeny and ontogeny of the habenular structure, FRONTIERS IN NEUROSCIENCE, 5, 2011
  44. Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures, DEVELOPMENTAL CELL, 12(1), 87-98, 2007
  45. Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems, DEVELOPMENTAL DYNAMICS, 236(3), 706-718, 2007
  46. Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish, JOURNAL OF NEUROSCIENCE, 27(20), 5271-5279, 2007
  47. Development of the mouse amygdala as revealed by labeling with EGFP gene transfer and molecular markers, NEUROSCIENCE RESEARCH, 58, S38-S38, 2007
  48. Development of the Mouse Amygdala as Revealed by Enhanced Green Fluorescent Protein Gene Transfer by Means of In Utero Electroporation, JOURNAL OF COMPARATIVE NEUROLOGY, 513(1), 113-128, 2009
  49. Genetic inactivation of the habenulo-interpeduncular projection enhances the conditioned fear response in zebrafish, NEUROSCIENCE RESEARCH, 65, S66-S66, 2009
  50. Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements, NATURE NEUROSCIENCE, 12(12), 1586-U140, 2009
  51. Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae, JOURNAL OF ETHNOPHARMACOLOGY, 284, 20220210
  52. A Novel Microcontroller-Based System for the Wheel-Running Activity in Mice, ENEURO, 8(6), 2021
  53. Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum, JOURNAL OF NEUROPHYSIOLOGY, 126(6), 1934-1942, 202112

Invited Lecture, Oral Presentation, Poster Presentation

  1. Deciphering the heterogeneous symptoms of depression by the habenular pathways, Hidenori Aizawa, Neuro2019, 2019/07/27, With Invitation, English, Niigata
  2. Wide-field serial block-face fluorescence microscope using deep ultraviolet light for whole-brain imaging, Kasaragod Deepa Kamath, Zhu Meina, Takemoto Hidenori, Aizawa Hidenori, Neuro2020, 2020/07/31, Without Invitation, English, Kobe
  3. A novel microcontroller-based system for the wheel running activity in mice, Meina Zhu and Hidenori Aizawa, Neuro2020, 2020/07/29, Without Invitation, English, Kobe
  4. Dopamine metabolism and coping behaviors under the tail suspension stress, Hidenori. Aizawa, Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Takashi Nakano, Shigeki Kato, Kohichi Tanaka, Kazuto Kobayashi, Tadashi Isa, Neuro2017, 2017/07/21, Without Invitation, English, The Japan Neuroscience Society, Chiba
  5. Effect of TSPO-targeting compound ONO-2952 on the mouse behaviors under the chronic social defeat stress, Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Takahiro Kato, Takashi Kitajima, Seishi Katsumata, Yousuke Yamawaki, Shigeto Yamawaki, Hidenori Aizawa, Neuro2018, 2018/07/28, Without Invitation, English, Japan Neuroscience Society, Kobe
  6. Anatomical proximity and concordance of laterality in the organs of developing zebrafish, Kei Taguchi, Masahi Akieda, Haruhi Terai, Hidenori Aizawa, The 41st Annual Meeting of the Japan Neuroscience Society (Neuroscience 2018), 2018/07/27, Without Invitation, English, Japan Neuroscience Society, Kobe
  7. TSPO-targeting compound ameliorates the abnormal behaviors of mice received social defeat stress, Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Yosuke Yamawaki, Takashi Kitajima, Seishi Katsumata, Shigeto Yamawaki, Takahiro Kato, Hidenori Aizawa, 9th Fedaration of the Asian and Oceanian Physiological Societies, 2019/03/29, Without Invitation, English, Asian and Oceanian Physiological Societies, Kobe

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Transformative Research Areas(A)), 2021, 2022
  2. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2021, 2023
  3. KAKENHI(Grant-in-Aid for Scientific Research on Innovative Areas), 2021, 2022
  4. KAKENHI, a Grant-in-Aid for Scientific Research on Innovative Areas, 2014, 2018
  5. KAKENHI, a Grant-in-Aid for Scientific Research (C), 2014, 2016
  6. KAKENHI, Grant-in-Aid for Scientific Research on Innovative Areas, 2014
  7. Mitsui Life Social Welfare Foundation, 2014
  8. Brain Science Foundation, 2014
  9. Inamori Foundation, 2014
  10. KAKENHI, 2015, 2019
  11. KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2017, 2019

Social Activities

History as Peer Reviews of Academic Papers

  1. 2015, Development, Growth and Differentiation, Others, Reviewer, 1
  2. 2015, Journal of Physiology, Others, Reviewer, 1