shinichi tate
Last Updated :2024/09/02
- Affiliations, Positions
- Graduate School of Integrated Sciences for Life, Professor
- Web Site
- E-mail
- tatehiroshima-u.ac.jp
Basic Information
Major Professional Backgrounds
- 1999/04/01, 2002/03/31, Japan Advanced Institute of Science and Technology, New Material Center, Associate Professor
- 2006/04/01, 2021/03/31, Hiroshima University, Graduate School of Science, Professor
- 1989/04/01, 1992/12/31, Tokyo Metropolitan Institute of Medical Science, Laboratory for Biologically Active Molecules, Researcher
- 1993/01/01, 1999/03/31, Tokyo Metropolitan University, Department of Chemistry, Faculty of Science, Assistant Professor
- 2002/04/01, 2005/09/30, Biomolecular Engineering Research Institute, Department of Functional Regulation, Director
- 2005/10/01, 2008/03/31, Japan Science and Technology Agency, Researcher
- 1997/07/01, 1997/11/31, NIH, NIDDK, Chemical Physics, Visiting Scientist
- 1996/06/01, 1996/09/30, ETH, Institute of Molecular Biology & Biophysics, Visiting Scientist
Educational Backgrounds
- The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Japan, 1987/04, 1989/03
- The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Japan, 1985/04, 1987/03
- The University of Tokyo, Faculty of Pharmaceutical Science, Japan, 1981/04, 1985/03
Academic Degrees
- Doctor of Philosophy in Pharmaceutical Science, The University of Tokyo
- Master of Pharmaceutical Science, The University of Tokyo
Research Fields
- Biology;Biological Science;Structural biochemistry
Research Keywords
- Protein structure
- Protein structural dynamics
- Anisotropic spin interaction
- Nuclear spin relaxation
- NMR
Educational Activity
Course in Charge
- 2024, Liberal Arts Education Program1, 2Term, Modern Chemistry
- 2024, Undergraduate Education, First Semester, Special Study for Graduation
- 2024, Undergraduate Education, Second Semester, Special Study for Graduation
- 2024, Undergraduate Education, 4Term, Biopolymer Chemistry
- 2024, Graduate Education (Master's Program) , 1Term, Introduction to Life Science
- 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
- 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
- 2024, Graduate Education (Master's Program) , 1Term, Molecular Biophysics
- 2024, Graduate Education (Master's Program) , 2Term, Topical Seminar in Life Science C
- 2024, Graduate Education (Master's Program) , 4Term, Topical Seminar in Life Science D
- 2024, Graduate Education (Master's Program) , First Semester, Exercises in Life Science A
- 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Life Science B
- 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
- 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
- 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
- 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
- 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
- 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
Research Activities
Academic Papers
- Sequential backbone resonance assignments of the E.coli dihydrofolate reductase Gly67Val mutant: folate complex, Biomolecular NMR Assignments, 1-5, 20151019
- Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPlase, BIOCHEMISTRY, 54(33), 5242-5253, 20150825
- Coating the outer surface of glass nanopipette with chlorobenzene-terminated polysiloxane, e-Journal of Surface Science and Nanotechnology, 13, 79-84, 20150307
- The C113D Mutation in Human Pin1 Causes Allosteric Structural Changes in the Phosphate Binding Pocket of the PPIase Domain through the Tug of War in the Dual-Histidine Motif, BIOCHEMISTRY, 53(34), 5568-5578, 20140902
- Solvent environments significantly affect the enzymatic function of Escherichia coli dihydrofolate reductase: Comparison of wild-type protein and active-site mutant D27E, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834(12), 2782-2794, 20131213
- Redox-sensitive structural change in the A-domain of HMGB1 and its implication for the binding to cisplatin modified DNA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(4), 701-706, 20131129
- Preferential domain orientation of HMGB2 determined by the weak intramolecular interactions mediated by the interdomain linker, CHEMICAL PHYSICS, 419, 212-223, 20130620
- Phosphorylation-Coupled Intramolecular Dynamics of Unstructured Regions in Chromatin Remodeler FACT, BIOPHYSICAL JOURNAL, 104(10), 2222-2234, 20130521
- Nucleosome structural changes induced by binding of non-histone chromosomal proteins HMGN1 and HMGN2, FEBS OPEN BIO, 3, 184-191, 20130320
- Structural implication for the impaired binding of W150A mutant LOX-1 to oxidized low density lipoprotein, OxLDL, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1824(5), 739-749, 20120512
- Secondary-structure analysis of alcohol-denatured proteins by vacuum-ultraviolet circular dichroism spectroscopy, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 80(1), 281-293, 20120112
- Complementary use of NMR to X-ray crystallography for the analysis of protein morphological change in solution, Current Trends in X-ray Crystallography (Ed. Chandrasekaran, A.), 409-436, 20111201
- The NMR Structure of FliK, the Trigger for the Switch of Substrate Specificity in the Flagellar Type III Secretion Apparatus, JOURNAL OF MOLECULAR BIOLOGY, 409(4), 558-573, 20110617
- Surface plasmon resonance study on functional significance of clustered organization of lectin-like oxidized LDL receptor (LOX-1), BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1814(2), 345-354, 20110201
- Coupling effects of distal loops on structural stability and enzymatic activity of Escherichia coli dihydrofolate reductase revealed by deletion mutants, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804(4), 846-855, 20100410
- Cloning and characterization of dihydrofolate reductases from deep-sea bacteria, JOURNAL OF BIOCHEMISTRY, 147(4), 591-599, 20100410
- Pressure dependence of activity and stability of dihydrofolate reductases of the deep-sea bacterium Moritella profunda and Escherichia coli, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1824(3), 511-519, 20100301
- Proline cis/trans-Isomerase Pin1 Regulates Peroxisome Proliferator-activated Receptor gamma Activity through the Direct Binding to the Activation Function-1 Domain, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(5), 3126-3132, 20100129
- Comprehensive secondary-structure analysis of disulfide variants of lysozyme by synchrotron-radiation vacuum-ultraviolet circular dichroism, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 77(1), 191-201, 20091009
- Phosphorylated Intrinsically Disordered Region of FACT Masks Its Nucleosomal DNA Binding Elements, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(36), 24610-24621, 20090904
- Anisotropic nuclear spin interactions for the morphology analysis of proteins in solution by NMR spectroscopy, Anal.Sci., 24, 39-50, 20080110
- Anisotropic nuclear spin interactions for the morphology analysis of proteins in solution by NMR spectroscopy, ANALYTICAL SCIENCES, 24(1), 39-50, 20080101
- Chimeric structural stabilities in the coiled-coil structure of the NECK domain in human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1), JOURNAL OF BIOCHEMISTRY, 141(6), 855-866, 20070607
- Oxidized low-density lipoprotein receptor, LOX-1, on the endothelial cell - the receptor structure and functions of LOX-1 in atherogenesis, J.Biol.Macromol., 7(2), 11-22, 20070601
- Tautomerism of histidine 64 associated with proton transfer in catalysis of carbonic anhydrase, JOURNAL OF BIOCHEMISTRY, 282(13), 9649-9656, 20070330
- Structure and mode of ligand recognition of the oxidized LDL receptor, LOX-1, Functional and structural biology on the lipo-network, 179-198, 20060601
- Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA, JOURNAL OF BIOCHEMISTRY, 139(3), 503-515, 20060401
- Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I, MOLECULAR AND CELLULAR BIOLOGY, 25(23), 10639-10651, 20051205
- A genetic algorithm taking account of substructures for NMR three-dimensional protein protein structure determination, Evolutionary Computation, 2, 1761-1768, 20051001
- Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle, NUCLEIC ACIDS RESEARCH, 33(10), 3424-3434, 20050610
- Resonance assignments for the DNA binding domain of ERCC-1/XPF heterodimer, JOURNAL OF BIOMOLECULAR NMR, 32(2), 175-175, 20050605
- Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL, STRUCTURE, 13(6), 905-917, 20050605
- Purification, crystallization and preliminary X-ray analysis of the ligand-binding domain of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1), ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 61, 524-527, 20050505
- Solution structure of the HMG-box domain in the SSRP1 subunit of FACT, JOURNAL OF BIOMOLECULAR NMR, 32(1), 83-88, 20050505
- Molecular-orientation analysis based on alignment-induced TROSY chemical shift changes, JOURNAL OF MAGNETIC RESONANCE, 171(2), 284-292, 20041204
- Domain Architectures and characterization of an RNA-binding protein, TLS, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(43), 44834-44840, 20041022
- Measurement of N-15 chemical shift anisotropy in a protein dissolved in a dilute liquid crystalline medium with the application of magic angle sample spinning, JOURNAL OF MAGNETIC RESONANCE, 163(1), 163-173, 20030703
- Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 97(17), 9729-9734, 20000815
- The NMR structure of a DNA dodecamer in an aqueous dilute liquid crystalline phase, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 122(26), 6190-6200, 20000705
- Structural comparison between wild-type and P25S human cystatin A by NMR spectroscopy, JOURNAL OF STRUCTURAL AND FUNCTIONAL GENOMICS, 1(1), 26-42, 20000201
- Analysis of the relationship between enzyme activity and its internal motion using nuclear magnetic resonance: 15N relaxation studeis of wild-type and mutant lysozyme, JOURNAL OF MOLECULAR BIOLOGY, 286(5), 1547-1565, 19990401
- Mutational analysis of the reactive site loop of Streptomyces metalloproteinase inhibitor, SMPI, JOURNAL OF BIOCHEMISTRY, 125(1), 202-209, 19990101
- Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide, JOURNAL OF BIOMOLECULAR NMR, 13(1), 11-24, 19990101
- 31p NMR relaxation studies of the local conformational dynamics in a GNRA tetraloop, Nucleic acids symposium series, 39, 125-126, 19981201
- NMR structure of the Streptomyces metalloproteinase inhibitor, SMPI, isolated from Streptomyces nigrescens TK-23: Another example of an ancestral beta gamma-crystallin precursor structure, JOURNAL OF MOLECULAR BIOLOGY, 282(2), 421-433, 19980918
- Elucidation of the mode of interaction of thermolysin with a proteinaceous metalloproteinase inhibitor, SMPI, based on a model complex structure and a structural dynamics analysis, JOURNAL OF MOLECULAR BIOLOGY, 282(2), 435-446, 19980918
- Collision-induced dissociation spectra obtained by Fourier transform ion cyclotron resonance mass spectrometry using a C-13, N-15-doubly depleted protein, ANALYTICAL CHEMISTRY, 70(15), 3333-3336, 19980801
- NMR with C-13, N-15-doubly-labeled DNA: The Antennapedia homeodomain complex with a 14-mer DNA duplex, JOURNAL OF BIOMOLECULAR NMR, 12(1), 25-37, 19980701
- C5' methylene proton signal assignment of DNA/RNA oligomers labeled with C5'-monodeuterated nucleosides by H-1-P-31 HSQC spectroscopy, MAGNETIC RESONANCE IN CHEMISTRY, 34, S40-S46, 19971201
- Measurement of (3)J(C2'P) scalar couplings in a 17 kDa protein complex with C-13,N-15-Labeled DNA distinguishes the B-I and B-II phosphate conformations of the DNA, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 119(41), 9901-9902, 19971015
- Nmr spectroscopy of nucleic acids, FASEB JOURNAL, 11(9), A1122-A1122, 19970731
- Selective multiple labeling strategy to obtain accurate NMR parameters for nucleic acids. Conformational analysis around the glycosidic bond., Nucleic acids symposium series, 37, 75-76, 19961201
- Synthesis of stereoselectively 5'-monodeuterated nucleoside with defined S/R-ratios. An application to the assignment of 5'-methylene signals of DNA oligomers., Nucleic acids symposium series, 37, 35-36, 19961201
- Structural analysis of DNA by isotope-aided NMR: Application of 13C/2H-doubly labeled DNA oligomers, Nucleic acids symposium series, 35, 17-18, 19961201
- Synthesis of stereoselectively 13C/2H-doubly labeled DNA oligomers by the combined use of chemical and enzymatic reactions., Nucleic acids symposium series, 37, 73-73, 19961201
- NMR spectral and structural studies of an RNA hairpin by specific isotope labeling method, Nucleic acids symposium series, 35, 93-94, 19961201
- SOLUTION STRUCTURE OF A HUMAN CYSTATIN-A VARIANT, CYSTATIN-A(2-98) M65L, BY NMR-SPECTROSCOPY - A POSSIBLE ROLE OF THE INTERACTIONS BETWEEN THE N-TERMINI AND C-TERMINI TO MAINTAIN THE INHIBITORY ACTIVE FORM OF CYSTATIN-A, BIOCHEMISTRY, 34(45), 14637-14648, 19951114
- HUMAN CYSTATIN-A IS INACTIVATED BY ENGINEERED TRUNCATION - THE NH2-TERMINAL REGION OF THE CYSTEINE PROTEINASE-INHIBITOR IS ESSENTIAL FOR EXPRESSION OF ITS INHIBITORY ACTIVITY, BIOCHEMISTRY, 34(38), 12185-12192, 19950926
- SIGNIFICANCE OF THE HIGHLY CONSERVED GLY-4 RESIDUE IN HUMAN CYSTATIN-A, JOURNAL OF BIOCHEMISTRY, 118(3), 635-642, 19950901
- STEREOSPECIFIC MEASUREMENTS OF THE VICINAL H-1-P-31 COUPLING-CONSTANTS FOR THE DIASTEREOTOPIC C5' METHYLENE PROTONS IN A DNA DODECAMER WITH A C-13/H-2 DOUBLY LABELED RESIDUE - CONFORMATIONAL-ANALYSIS OF THE TORSION ANGLE-BETA, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 117(27), 7277-7278, 19950712
- TISSUE ACCUMULATION OF SULFATIDE AND G(M3) GANGLIOSIDE IN A PATIENT WITH VARIANT FARBER-DISEASE, CLINICA CHIMICA ACTA, 234, 23-36, 19950131
- SEQUENTIAL BACKBONE ASSIGNMENT IN C-13-LABELED DNA BY THE H-1, C-13, P-31 TRIPLE-RESONANCE EXPERIMENT, HCP-CCH-COSY, JOURNAL OF MAGNETIC RESONANCE SERIES B, 106(1), 89-91, 19950131
- New strategy for stable-isotope aided multi-dimensional NMR spectroscopy of DNA oligomer, Stable isotope applications in biomolecular structure and mechanisms, 127-144, 19941201
- Preparation of isotopically labeled DNA oligomers and their application to heteronuclear NMR spectroscopy, Nucleic acids symposium series, 31, 295-296, 19941201
- TERTIARY STRUCTURE OF ERABUTOXIN-B IN AQUEOUS-SOLUTION AS ELUCIDATED BY 2-DIMENSIONAL NUCLEAR-MAGNETIC-RESONANCE, JOURNAL OF MOLECULAR BIOLOGY, 240(2), 155-166, 19940708
- PREPARATION AND HETERONUCLEAR 2D NMR-SPECTROSCOPY OF A DNA DODECAMER CONTAINING A THYMIDINE RESIDUE WITH A UNIFORMLY C-13-LABELED DEOXYRIBOSE RING, JOURNAL OF BIOMOLECULAR NMR, 4(4), 581-586, 19940708
- AN ALTERNATIVE TRIPLE-RESONANCE METHOD FOR THE THROUGH-BOND CORRELATION OF INTRANUCLEOTIDE H1' AND H8 NMR SIGNALS OF PURINE NUCLEOTIDES - APPLICATION TO A DNA DODECAMER WITH FULLY C-13/N-15-LABELED DEOXYADENOSINE RESIDUES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116(13), 5977-5978, 19940629
- CRYSTALLIZATION AND X-RAY STUDIES OF THE DNA-BINDING DOMAIN OF OMPR PROTEIN, A POSITIVE REGULATOR INVOLVED IN ACTIVATION OF OSMOREGULATORY GENES IN ESCHERICHIA-COLI, JOURNAL OF MOLECULAR BIOLOGY, 235(2), 780-782, 19940114
- NOVEL GANGLIOSIDES CONTAINING THE SIALYL-LE(A) STRUCTURE FROM A HUMAN RECTAL ADENOCARCINOMA, JOURNAL OF BIOLOGICAL CHEMISTRY, 268(35), 26541-26545, 19931215
- NOVEL OLIGOSACCHARIDES WITH THE SIALYL-LE(A) STRUCTURE IN HUMAN-MILK, JOURNAL OF BIOCHEMISTRY, 114(4), 504-508, 19931001
- A NOVEL DIFUCOSYLATED NEUTRAL GLYCOSPHINGOLIPID FROM THE EGGS OF THE SEA-URCHIN, HEMICENTROTUS-PULCHERRIMUS .2. STRUCTURAL DETERMINATION BY 2-DIMENSIONAL NMR, JOURNAL OF BIOCHEMISTRY, 112(2), 286-289, 19930801
- A COMPARATIVE-STUDY OF THE SOLUTION STRUCTURES OF TACHYPLESIN-I AND A NOVEL ANTI-HIV SYNTHETIC PEPTIDE, T22 ([TYR(5,12), LYS(7)]-POLYPHEMUSIN-II), DETERMINED BY NUCLEAR-MAGNETIC-RESONANCE, BIOCHIMICA ET BIOPHYSICA ACTA, 1163(2), 209-216, 19930513
- NOVEL STRUCTURE OF THE N-ACETYLGALACTOSAMINE CONTAINING N-GLYCOSIDIC CARBOHYDRATE CHAIN OF BATROXOBIN, A THROMBIN-LIKE SNAKE-VENOM ENZYME, JOURNAL OF BIOCHEMISTRY, 112(1), 68-74, 19920701
- STABLE ISOTOPE AIDED NUCLEAR-MAGNETIC-RESONANCE STUDY TO INVESTIGATE THE RECEPTOR-BINDING SITE OF HUMAN INTERLEUKIN-1-BETA, BIOCHEMISTRY, 31(8), 2435-2442, 19920503
- A trisialoganglioside containing a sialyl alpha 2-6 N-acetylgalactosamine residue is a cholinergic-specific antigen, Chol-1 alpha, JOURNAL OF BIOCHEMISTRY, 111(3), 287-290, 19920401
- REDUCTION OF THE WATER HUMP USING A COMPOSITE REFOCUSING PULSE, JOURNAL OF MAGNETIC RESONANCE, 96(3), 635-643, 19920215
- A NOVEL N-15-LABELING METHOD TO SELECTIVELY OBSERVE (NH2)-N-15 RESONANCES OF PROTEINS IN H-1-DETECTED HETERONUCLEAR CORRELATION SPECTROSCOPY, FEBS LETTERS, 297, 39-42, 19920203
- Isolation and structural studies of human milk oligosaccharides that are reactive with a monoclonal antibody MSW 113, JOURNAL OF BIOCHEMISTRY, 110(4), 598-604, 19911101
- APPLICATION OF THE DEPT SEQUENCE TO THE SEPARATION OF (NH)-N-15 AND (NH2)-N-15 RESONANCES IN H-1-DETECTED N-15 SINGLE-QUANTUM COHERENCE SPECTROSCOPY, JOURNAL OF MAGNETIC RESONANCE, 94(3), 625-630, 19911001
- SPIN-LOCK PULSES FOR PURGING AND SHAPING THE WATER RESONANCE IN H-1 DETECTED N-15 SINGLE-QUANTUM-COHERENCE SPECTROSCOPY, JOURNAL OF MAGNETIC RESONANCE, 94(2), 394-400, 19910901
- TERTIARY STRUCTURE OF CONOTOXIN GIIIA IN AQUEOUS-SOLUTION, BIOCHEMISTRY, 30(28), 6908-6916, 19910716
- NOVEL OLIGOSACCHARIDES WITH THE SIALYL-LEA STRUCTURE IN HUMAN-MILK, BIOCHEMISTRY, 30(11), 2869-2876, 19910319
- LOCATION OF PHOSPHORYLATION SITE AND DNA-BINDING SITE OF A POSITIVE REGULATOR, OMPR, INVOLVED IN ACTIVATION OF THE OSMOREGULATORY GENES OF ESCHERICHIA-COLI, FEBS LETTERS, 249(2), 168-172, 19890605
- LOCATION OF DNA-BINDING SEGMENT OF A POSITIVE REGULATOR, OMPR, INVOLVED IN ACTIVATION OF THE OMPF AND OMPC GENES OF ESCHERICHIA-COLI, FEBS LETTERS, 242(1), 27-30, 19881219
- A Raman spectroscopic study on the sequence dependent conformations of DNA oligomers, Nucleic acids symposium series, 17, 195-198, 19851201
Publications such as books
- 2006/08, Functional and Structural Biology on the Lipo-network , 2006, 08, Scholarly Book, Compilation, 8178952327, 198
Awards
- 1998, Best Article Award, The Spectroscopical Society of Japan