KIYOMI NIGORIKAWA

Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
E-mail
knigohiroshima-u.ac.jp
Self-introduction
I investigate the roles of phosphoinositides in innate immune cell functions.

Basic Information

Major Professional Backgrounds

  • 1995/10/01, 2002/03/31, Hiroshima University, Faculty of Medicine
  • 2002/04/01, 2004/03/31, Hiroshima University, Faculty of Medicine
  • 2004/04/01, 2007/03/31, Hiroshima University, Technical Center
  • 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Biophere Sciences, Japan

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences

In Charge of Primary Major Programs

  • Pharmaceutical Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Research Keywords

  • neutrophil
  • NADPH oxidase
  • mast cell
  • PI3-kinase
  • macrophage
  • phagocytosis

Affiliated Academic Societies

  • The Pharmaceutical Society of Japan

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, 1Term, Biological Chemistry III
  2. 2022, Undergraduate Education, 2Term, Physiological Chemistry
  3. 2022, Undergraduate Education, Second Semester, Experiments of Biological Chemistry
  4. 2022, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  5. 2022, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  6. 2022, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  7. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  8. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  9. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  10. 2022, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  11. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physiological Chemistry
  12. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physiological Chemistry
  13. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Physiological Chemistry
  14. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Physiological Chemistry
  15. 2022, Graduate Education (Master's Program) , First Semester, Seminar on Mechanisms of Signal Transduction
  16. 2022, Graduate Education (Master's Program) , Second Semester, Seminar on Mechanisms of Signal Transduction
  17. 2022, Graduate Education (Master's Program) , First Semester, Research on Mechanisms of Signal Transduction
  18. 2022, Graduate Education (Master's Program) , Second Semester, Research on Mechanisms of Signal Transduction

Research Activities

Academic Papers

  1. C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase, JOURNAL OF BIOCHEMISTRY, 149(3), 265-274, 201103
  2. Phosphoinositide 3-Kinasec Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages, PLOS ONE, 6(10), 20111028
  3. Pervanadate activates NADPH oxidase via protein kinase C-independent phosphorylation of p47-phox, Arch. Biochem. Biophys., 361(1), 1-6, 19990101
  4. Role of phosphoinositide 3-kinase in innate immunity, Biol Pharm Bull, 30(9), 1617-1623, 20070901
  5. Inhibition of PTEN and activation of Akt by menadione, Biochim Biophys Acta, 1770(4), 687-693, 20070401
  6. Protein kinase C{delta} binds TIRAP/Mal to participate in TLR signaling, Mol Immunol, 44(9), 2257-2264, 20070301
  7. A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases, Mol Pharmacol, 70(3), 1143-1149, 20060901
  8. Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase., Mol Pharmacol, 69(5), 1717-1724, 20060501
  9. The effect of anionic amphiphiles on the recruitment of Rac in neutrophils, J Biochem, 136(4), 463-470, 20041001
  10. Specific role of phosphoinositide 3-kinase p110{alpha} in the regulation of phagocytosis and pinocytosis in macrophages, Biochem J, 423(1), 99-108, 20090914
  11. Negative regulation of class IA phosphoinositide 3-kinase by protein kinase C{delta}l limits Fc{gamma} receptor-mediated phagocytosis in macrophages, J Biochem, 145(1), 87-94, 20090101
  12. Critical roles of the p110{beta} subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells, J Immunol, 180(4), 2054-2061, 20080215
  13. Protein kinase C delta binds TIRAP/Mal to participate in TLR signaling, MOLECULAR IMMUNOLOGY, 44(9), 2257-2264, 200703
  14. Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C Limits Fc Receptor-Mediated Phagocytosis in Macrophages, JOURNAL OF BIOCHEMISTRY, 145(1), 87-94, 200901
  15. Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics, FEBS LETTERS, 586(22), 4010-4015, 20121116
  16. Class-IA Phosphoinositide 3-Kinase p110 beta Triggers GPCR-Induced Superoxide Production in p110 gamma-Deficient Murine Neutrophils, JOURNAL OF PHARMACOLOGICAL SCIENCES, 120(4), 270-279, 201212
  17. PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses, PLOS ONE, 8(9), 20130909
  18. Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20, BIOCHEMICAL JOURNAL, 464, 365-375, 20141215
  19. Involvement of Class II Phosphoinositide 3-Kinase alpha-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells, PLOS ONE, 9(10), 20141030
  20. Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns (3,4)P-2, PLOS ONE, 10(11), 20151104
  21. Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model, INNATE IMMUNITY, 22(6), 444-451, 201608
  22. Inhibitory receptor FcRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a, INNATE IMMUNITY, 23(4), 401-409, 201705
  23. Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages, EXPERIMENTAL CELL RESEARCH, 357(2), 252-259, 20170815
  24. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis, JOURNAL OF CELL SCIENCE, 131(5), 201803
  25. A SELECTIVE ORGANIC VAPOR SENSOR-BASED ON SIMULTANEOUS MEASUREMENTS OF CHANGES OF MASS AND RESISTANCE OF A POLY(PYRROLE) THIN-FILM, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 873-874, 19940407
  26. A SELECTIVE GAS SENSOR USING A POLYPYRROLE THIN-FILM AS A SENSITIVE MATRIX ON A PIEZOELECTRIC CRYSTAL, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 396(1-2), 563-567, 19951031
  27. PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel, JOURNAL OF BIOCHEMISTRY, 165(1), 75-84, 201901
  28. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages, GENES TO CELLS, 24(5), 366-376, 201905
  29. Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(6), 923-928, 201906
  30. Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning, JOURNAL OF BIOCHEMISTRY, 166(2), 175-185, 201908