KIYOMI NIGORIKAWA
Last Updated :2023/09/06
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
- E-mail
- knigo
hiroshima-u.ac.jp
- Self-introduction
- I investigate the roles of phosphoinositides in innate immune cell functions.
Basic Information
Major Professional Backgrounds
- 1995/10/01, 2002/03/31, Hiroshima University, Faculty of Medicine
- 2002/04/01, 2004/03/31, Hiroshima University, Faculty of Medicine
- 2004/04/01, 2007/03/31, Hiroshima University, Technical Center
- 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
- 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
- 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
Educational Backgrounds
- Hiroshima University, Graduate School, Division of Biophere Sciences, Japan
Academic Degrees
- Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
- Master, Hiroshima University
Educational Activity
- [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
- [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences
In Charge of Primary Major Programs
Research Fields
- Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
Research Keywords
- neutrophil
- NADPH oxidase
- mast cell
- PI3-kinase
- macrophage
- phagocytosis
Affiliated Academic Societies
- The Pharmaceutical Society of Japan
Educational Activity
Course in Charge
- 2023, Undergraduate Education, 1Term, Biological Chemistry III
- 2023, Undergraduate Education, 2Term, Physiological Chemistry
- 2023, Undergraduate Education, Second Semester, Experiments of Biological Chemistry
- 2023, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
- 2023, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
- 2023, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
- 2023, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
- 2023, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
- 2023, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physiological Chemistry
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physiological Chemistry
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Physiological Chemistry
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Physiological Chemistry
- 2023, Graduate Education (Master's Program) , 3Term, Lecture on Mechanisms of Signal Transduction
- 2023, Graduate Education (Master's Program) , First Semester, Seminar on Mechanisms of Signal Transduction
- 2023, Graduate Education (Master's Program) , Second Semester, Seminar on Mechanisms of Signal Transduction
- 2023, Graduate Education (Master's Program) , First Semester, Research on Mechanisms of Signal Transduction
- 2023, Graduate Education (Master's Program) , Second Semester, Research on Mechanisms of Signal Transduction
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physiological Chemistry for Medicinal Sciences
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physiological Chemistry for Medicinal Sciences
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Physiological Chemistry for Medicinal Sciences
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Physiological Chemistry for Medicinal Sciences
Research Activities
Academic Papers
- Cas9-Geminin and Cdt1-fused anti-CRISPR protein synergistically increase editing accuracy, FEBS LETTERS, 597(7), 985-994, 202304
- PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel, JOURNAL OF BIOCHEMISTRY, 165(1), 75-84, 201901
- Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages, GENES TO CELLS, 24(5), 366-376, 201905
- Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(6), 923-928, 201906
- Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning, JOURNAL OF BIOCHEMISTRY, 166(2), 175-185, 201908
- TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis, JOURNAL OF CELL SCIENCE, 131(5), 201803
- Inhibitory receptor FcRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a, INNATE IMMUNITY, 23(4), 401-409, 201705
- Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages, EXPERIMENTAL CELL RESEARCH, 357(2), 252-259, 20170815
- Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model, INNATE IMMUNITY, 22(6), 444-451, 201608
- Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns (3,4)P-2, PLOS ONE, 10(11), 20151104
- Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20, BIOCHEMICAL JOURNAL, 464, 365-375, 20141215
- Involvement of Class II Phosphoinositide 3-Kinase alpha-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells, PLOS ONE, 9(10), 20141030
- PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses, PLOS ONE, 8(9), 20130909
- Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics, FEBS LETTERS, 586(22), 4010-4015, 20121116
- Class-IA Phosphoinositide 3-Kinase p110 beta Triggers GPCR-Induced Superoxide Production in p110 gamma-Deficient Murine Neutrophils, JOURNAL OF PHARMACOLOGICAL SCIENCES, 120(4), 270-279, 201212
- C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase, JOURNAL OF BIOCHEMISTRY, 149(3), 265-274, 201103
- Phosphoinositide 3-Kinasec Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages, PLOS ONE, 6(10), 20111028
- Specific role of phosphoinositide 3-kinase p110{alpha} in the regulation of phagocytosis and pinocytosis in macrophages, Biochem J, 423(1), 99-108, 20090914
- Negative regulation of class IA phosphoinositide 3-kinase by protein kinase C{delta}l limits Fc{gamma} receptor-mediated phagocytosis in macrophages, J Biochem, 145(1), 87-94, 20090101
- Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C Limits Fc Receptor-Mediated Phagocytosis in Macrophages, JOURNAL OF BIOCHEMISTRY, 145(1), 87-94, 200901
- Critical roles of the p110{beta} subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells, J Immunol, 180(4), 2054-2061, 20080215
- Role of phosphoinositide 3-kinase in innate immunity, Biol Pharm Bull, 30(9), 1617-1623, 20070901
- Inhibition of PTEN and activation of Akt by menadione, Biochim Biophys Acta, 1770(4), 687-693, 20070401
- Protein kinase C{delta} binds TIRAP/Mal to participate in TLR signaling, Mol Immunol, 44(9), 2257-2264, 20070301
- Protein kinase C delta binds TIRAP/Mal to participate in TLR signaling, MOLECULAR IMMUNOLOGY, 44(9), 2257-2264, 200703
- A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases, Mol Pharmacol, 70(3), 1143-1149, 20060901
- Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase., Mol Pharmacol, 69(5), 1717-1724, 20060501
- The effect of anionic amphiphiles on the recruitment of Rac in neutrophils, J Biochem, 136(4), 463-470, 20041001
- Pervanadate activates NADPH oxidase via protein kinase C-independent phosphorylation of p47-phox, Arch. Biochem. Biophys., 361(1), 1-6, 19990101
- A SELECTIVE GAS SENSOR USING A POLYPYRROLE THIN-FILM AS A SENSITIVE MATRIX ON A PIEZOELECTRIC CRYSTAL, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 396(1-2), 563-567, 19951031
- A SELECTIVE ORGANIC VAPOR SENSOR-BASED ON SIMULTANEOUS MEASUREMENTS OF CHANGES OF MASS AND RESISTANCE OF A POLY(PYRROLE) THIN-FILM, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 873-874, 19940407