YASUHIRO ISHIHARA

Last Updated :2022/11/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
ishiyasuhiroshima-u.ac.jp
Other Contact Details
1-7-1，Kagamiyama，Higashi-Hiroshima, Japan
TEL : (+81)82-424-6500 FAX : (+81)82-424-0759

Basic Information

Major Professional Backgrounds

  • 2006/04/01, 2007/03/31, Tokushima Bunri University, Research Associate
  • 2007/04/01, 2011/03/31, Tokushima Bunri University, Assistant Professor
  • 2011/04/01, 2019/03/31, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
  • 2012/07/30, 2012/09/28, University of California, Visiting Scientist
  • 2007/04/01, 2011/03/31, Part-Time Lecturer
  • 2017/03/17, 2018/03/16, University of California, Davis, Visiting Scientist
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor

Educational Backgrounds

  • Kwansei Gakuin University, School of Science, Department of Chemistry, Japan, 1997/04, 2001/03
  • Osaka University, Graduate School of Science, Department of Biological Sciences, Japan, 2001/04, 2006/03

Academic Degrees

  • Doctor of Science, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Life Sciences
  • Integrated Arts and Sciences

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • PM2.5
  • Glia
  • Environmental Chemicals
  • Oxidative Stress
  • Ischemia

Affiliated Academic Societies

  • The Japanese Society for Alternatives to Animal Experiments, 2021
  • The Japanese Pharmacological Society, 2001
  • The Pharmaceutical Society of Japan, 2004
  • The Japanese Biochemical Society, 2004
  • The Society for Free Radical Research Japan, 2007
  • The Japanese Society of Toxicology, 2012
  • The American Society for Biochemistry and Molecular Biology, 2015
  • Society for Neuroscience, 2017

Educational Activity

Course in Charge

  1. 2022, Graduate Education (Master's Program) , 1Term, Exercises in Life and Environmental Sciences A
  2. 2022, Graduate Education (Master's Program) , 2Term, Exercises in Life and Environmental Sciences A
  3. 2022, Graduate Education (Master's Program) , 3Term, Exercises in Life and Environmental Sciences B
  4. 2022, Graduate Education (Master's Program) , 4Term, Exercises in Life and Environmental Sciences B
  5. 2022, Graduate Education (Master's Program) , Second Semester, Functional biochemistry
  6. 2022, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
  7. 2022, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  8. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  9. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  10. 2022, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  11. 2022, Graduate Education (Master's Program) , 1Term, Exercises in Biomedical Science A
  12. 2022, Graduate Education (Master's Program) , 2Term, Exercises in Biomedical Science A
  13. 2022, Graduate Education (Master's Program) , 3Term, Exercises in Biomedical Science B
  14. 2022, Graduate Education (Master's Program) , 4Term, Exercises in Biomedical Science B
  15. 2022, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  16. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  17. 2022, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  18. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  19. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
  20. 2022, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Chemistry I
  21. 2022, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Chemistry II
  22. 2022, Undergraduate Education, 2Term, Natural Sciences of Life and Environment
  23. 2022, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  24. 2022, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  25. 2022, Undergraduate Education, 2Term, Introduction to Life Sciences
  26. 2022, Undergraduate Education, 3Term, Functional Biochemistry II
  27. 2022, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  28. 2022, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  29. 2022, Undergraduate Education, 4Term, Functional Biochemistry III
  30. 2022, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
  31. 2022, Undergraduate Education, 1Term, Fundamentals of Biochemistry II
  32. 2022, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences

Research Activities

Academic Papers

  1. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
  2. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
  3. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
  4. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  5. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  6. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  7. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  8. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  9. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  10. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  11. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  12. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  13. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  14. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  15. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  16. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
  17. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
  18. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
  19. Blood-brain barrier leakage is transiently induced by activity-dependent excessive nitric oxide production, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 185P-185P, 2013
  20. Blood-brain barrier leakage is transiently induced by activity-dependent excessive nitric oxide production, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 185P-185P, 2013
  21. Blood-brain barrier leakage is transiently induced by activity-dependent excessive nitric oxide production, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 185P-185P, 2013
  22. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  23. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  24. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  25. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 2014
  26. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 2014
  27. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 2014
  28. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 2015
  29. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 2015
  30. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 2015
  31. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 2015
  32. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 2015
  33. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 2015
  34. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 2015
  35. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 2015
  36. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 2015
  37. Critical role of exposure time to endogenous oxidative stress in hepatocyte apoptosis., Redox report : communications in free radical research, 12(6), 2007
  38. Sustained contraction and endothelial dysfunction induced by reactive oxygen species in porcine coronary artery., Biological & pharmaceutical bulletin, 31(9), 2008
  39. Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats., European journal of pharmacology, 611(1-3), 2009
  40. Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size., Journal of pharmacological sciences, 113(4), 2010
  41. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., Journal of applied toxicology : JAT, 31(2), 2011
  42. Dual regulation of hepatocyte apoptosis by reactive oxygen species: Increases in transcriptional expression and decreases in proteasomal degradation of BimEL., Journal of cellular physiology, 226(4), 2011
  43. Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., The FEBS journal, 278(11), 2011
  44. Effects of sulfaphenazole after collagenase-induced experimental intracerebral hemorrhage in rats., Biological & pharmaceutical bulletin, 35(10), 2012
  45. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine., Neuroscience letters, 708, 2019
  46. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Scientific reports, 9(1), 2019
  47. Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p., Biological & pharmaceutical bulletin, 43(12), 2020
  48. Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke., Cells, 10(4), 2021
  49. Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring., Epilepsy & behavior : E&B, 121(Pt A), 2021
  50. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter., The Journal of toxicological sciences, 47(5), 2022
  51. Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model., International journal of molecular sciences, 23(14), 2022
  52. Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice., International journal of molecular sciences, 23(14), 2022
  53. A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure., Journal of neuroinflammation, 19(1), 2022
  54. Less Invasive Management of Tissue Deficits for Deep Sternal Wound Infections., Plastic and reconstructive surgery. Global open, 8(4), 2020
  55. Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells., Journal of natural products, 83(10), 2020
  56. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease., Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866(2), 2021
  57. Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development., Frontiers in immunology, 12, 2021
  58. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells., International journal of molecular sciences, 22(6), 2021
  59. Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds., Phytochemistry, 191, 2021
  60. FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction., International journal of molecular sciences, 22(20), 2021
  61. Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats., Endocrine journal, 69(7), 2022
  62. Aryl Hydrocarbon Receptor Signaling Synergizes with TLR/NF-κB-Signaling for Induction of IL-22 Through Canonical and Non-Canonical AhR Pathways., Frontiers in toxicology, 3, 2021
  63. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
    Link to Paper Search Results by DOI
  64. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 2012
    Link to Paper Search Results by DOI
  65. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
    Link to Paper Search Results by DOI
  66. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
    Link to Paper Search Results by DOI
  67. Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 527(1), 16-22, 2012
    Link to Paper Search Results by DOI
  68. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
    Link to Paper Search Results by DOI
  69. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
    Link to Paper Search Results by DOI
  70. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 2013
    Link to Paper Search Results by DOI
  71. Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 2013
    Link to Paper Search Results by DOI
  72. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
    Link to Paper Search Results by DOI
  73. Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase, BRAIN RESEARCH, 1530, 44-53, 2013
    Link to Paper Search Results by DOI
  74. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., JOURNAL OF APPLIED TOXICOLOGY, 32(2), 173-178, 2011
  75. Dual regulation of hepatocyte apoptosis by reactive oxygen species: increases in transcriptional expression and decreases in proteasomal degradation of BimEL., JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1007-1016, 2011
  76. Increased expression of c-fos by ERK activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., FEBS JOURNAL, 278(11), 1873-1881, 2011
  77. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
    Link to Paper Search Results by DOI
  78. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 20140318
    Link to Paper Search Results by DOI
  79. Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, 201404
    Link to Paper Search Results by DOI
  80. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 201501
    Link to Paper Search Results by DOI
  81. Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 343706, 201503
    Link to Paper Search Results by DOI
  82. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 201505
    Link to Paper Search Results by DOI
  83. Beneficial Effects of Supplementation of the Rare Sugar D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice", JOURNAL OF FOOD SCIENCE, 80(7), H1619-H1626, 201507
    Link to Paper Search Results by DOI
  84. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 201507
    Link to Paper Search Results by DOI
  85. ★, Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, 20150911
    Link to Paper Search Results by DOI
  86. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy, APPLIED SCIENCES-BASEL, 6(3), 201603
    Link to Paper Search Results by DOI
  87. Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3(2), 63-65, 2016
  88. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4), 820-825, 20160902
    Link to Paper Search Results by DOI
  89. Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures, STEROIDS, 113, 71-77, 201609
    Link to Paper Search Results by DOI
  90. Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice, BRAIN RESEARCH, 1652, 1-13, 20161201
    Link to Paper Search Results by DOI
  91. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 20161101
    Link to Paper Search Results by DOI
  92. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells, Scientific Reports, 7, 20170202
    Link to Paper Search Results by DOI
  93. ★, Potentiation of 17 beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid, SCIENTIFIC REPORTS, 7, 20170724
    Link to Paper Search Results by DOI
  94. Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 582-587, 20180205
    Link to Paper Search Results by DOI
  95. Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 642, 75-80, 20180315
    Link to Paper Search Results by DOI
  96. Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin, JOURNAL OF TOXICOLOGICAL SCIENCES, 43(1-3), 25-31, 2018
  97. Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory, ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 23(1), 20180619
    Link to Paper Search Results by DOI
  98. The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS), ENVIRONMENTAL RESEARCH, 166, 562-569, 201810
    Link to Paper Search Results by DOI
  99. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 2016
  100. Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children, EUROPEAN JOURNAL OF MEDICAL RESEARCH, 23, 20181226
    Link to Paper Search Results by DOI
  101. Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, COMMUNICATIONS BIOLOGY, 1, 2018
    Link to Paper Search Results by DOI
  102. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  103. Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages., Toxicol Sci., 170(2), 404-414, 201905
  104. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study., J Epidemiol, 201901
  105. Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children's Study (JECS), ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24(1), 20190607
    Link to Paper Search Results by DOI
  106. A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth, CANCERS, 11(5), 201905
    Link to Paper Search Results by DOI
  107. Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(11), 20190601
    Link to Paper Search Results by DOI
  108. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 20190824
    Link to Paper Search Results by DOI
  109. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus, SCIENTIFIC REPORTS, 9, 20190925
    Link to Paper Search Results by DOI
  110. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 193, 201910
    Link to Paper Search Results by DOI
  111. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol, 193, 105421, 2019
  112. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Sci Rep, 9, 13899, 2019
  113. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
  114. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
  115. Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells, JOURNAL OF NATURAL PRODUCTS, 83(10), 3050-3057, 20201023
    Link to Paper Search Results by DOI
  116. Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43(12), 1966-1968, 202012
    Link to Paper Search Results by DOI
  117. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1866(2), 202102
    Link to Paper Search Results by DOI

Publications such as books

  1. 2014, Fifty Years of Cytochrome P450 Research, Neurosteroids: regional steroidogenesis., Springer Japan, 2014, Scholarly Book, Joint work, Yamazaki T, Ishihara Y

Invited Lecture, Oral Presentation, Poster Presentation

  1. Airborne Microplastics and Health Impact., Okochi H, Yoshida N, Fujikawa M, Zhao H, Tani Y, Hayami H, Takeuchi M, Sorimachi A, Fujii Y, Takenaka N, Kajino M, Adachi K, Ishihara Y, Iwamoto Y, Aiyazaki A, Katsumi N, Niida Y, Kobayashi H, Urayama N, Hagino H, Iso E, Miura T, Taira E, Akao K, Yamamoto M, Takami T, Itaya Y., Joint Usage/Joint Research Symposium on Integrated Environmental Studies., 2021/12/01, Without Invitation, Japanese
  2. Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinsons disease, Oguro A, Ishihara Y, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases (IECBM2020), 2020/12/01, Without Invitation, English
  3. Activated microglia in ischemic stroke aggravate brain edema in Mice, Tanaka M, Fujikawa M, Itoh K, Ishihara Y, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  4. Activation of microglia and excitation-inhibition imbalances in the developing hippocampus of mice prenatally treated with valproate, Ishihara Y, Itoh K, Tominaga T, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  5. Developmental microglial activation and postgrowth abnormal behavior induced by prenatal exposure of chemicals, Ishihara Y, The 35th Annual Meeting of KSOT/KEMS, 2019, With Invitation, English
  6. A role of AhR in microglial polarization., 2017/06/23, With Invitation, English, Center for the health and environment, University of California, Davis.
  7. Role of astrogliosis elicited by methylmercury in neuroprotection, Prenatal Programming and Toxicity V., 2016/11/16, With Invitation, English

Social Activities

History as Committee Members

  1. Editorial Board, 2015, Fundamental Toxicological Sciences