YASUHIRO ISHIHARA
Last Updated :2023/09/06
- Affiliations, Positions
- Graduate School of Integrated Sciences for Life, Professor
- E-mail
- ishiyasu
hiroshima-u.ac.jp
- Other Contact Details
- 1-7-1,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)82-424-6500 FAX : (+81)82-424-0759
Basic Information
Major Professional Backgrounds
- 2006/04/01, 2007/03/31, Tokushima Bunri University, Research Associate
- 2007/04/01, 2011/03/31, Tokushima Bunri University, Assistant Professor
- 2007/04/01, 2011/03/31, Part-Time Lecturer
- 2011/04/01, 2019/03/31, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
- 2012/07/30, 2012/09/28, University of California, Davis, Visiting Scientist
- 2017/03/17, 2018/03/16, University of California, Davis, Visiting Scientist
- 2019/04/01, 2023/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor
- 2023/04/01, Hiroshima Univesrsity, Graduate School of Integrated Sciences for Life, Professor
Educational Backgrounds
- Kwansei Gakuin University, School of Science, Department of Chemistry, Japan, 1997/04, 2001/03
- Osaka University, Graduate School of Science, Department of Biological Sciences, Japan, 2001/04, 2006/03
Academic Degrees
- Doctor of Science, Osaka University
Educational Activity
- [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
- [Master's Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
- [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
- [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
- [Doctoral Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
- [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
- [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
In Charge of Primary Major Programs
- Life Sciences
- Integrated Arts and Sciences
Research Fields
- Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
- Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
- Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
- Agricultural sciences;Agricultural chemistry;Food science
Research Keywords
- PM2.5
- Glia
- Environmental Chemicals
- Oxidative Stress
- Ischemia
Affiliated Academic Societies
- The Japanese Society for Alternatives to Animal Experiments, 2021
- The Japanese Pharmacological Society, 2001
- The Pharmaceutical Society of Japan, 2004
- The Japanese Biochemical Society, 2004
- The Society for Free Radical Research Japan, 2007
- The Japanese Society of Toxicology, 2012
- The American Society for Biochemistry and Molecular Biology, 2015
- Society for Neuroscience, 2017
Educational Activity
Course in Charge
- 2023, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Chemistry I
- 2023, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Chemistry II
- 2023, Undergraduate Education, 2Term, Natural Sciences of Life and Environment
- 2023, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
- 2023, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
- 2023, Undergraduate Education, 2Term, Introduction to Life Sciences
- 2023, Undergraduate Education, First Semester, Fundamental Laboratory Work in Chemistry
- 2023, Undergraduate Education, First Semester, Fundamental Methodology in Chemistry
- 2023, Undergraduate Education, 3Term, Functional Biochemistry II
- 2023, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
- 2023, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
- 2023, Undergraduate Education, 4Term, Functional Biochemistry III
- 2023, Undergraduate Education, 1Term, Fundamentals of Life Science
- 2023, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
- 2023, Undergraduate Education, 1Term, Fundamentals of Biochemistry II
- 2023, Graduate Education (Master's Program) , 2Term, societal implementation of life science
- 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
- 2023, Graduate Education (Master's Program) , First Semester, Exercises in Life and Environmental Sciences A
- 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Life and Environmental Sciences B
- 2023, Graduate Education (Master's Program) , Second Semester, Functional biochemistry
- 2023, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
- 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
- 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
- 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
- 2023, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
- 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
- 2023, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
- 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
- 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
- 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
- 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
- 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
Research Activities
Academic Papers
- Complementary spectroscopy studies and potential activities of levan-type fructan produced by Bacillus paralicheniformis ND2, CARBOHYDRATE POLYMERS, 311, 20230701
- Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation, PARTICLE AND FIBRE TOXICOLOGY, 20(1), 20230216
- Associations between welding fume exposure and neurological function in Japanese male welders and non-welders, JOURNAL OF OCCUPATIONAL HEALTH, 65(1), 202301
- Chemokine expression in human 3-dimensional cultured epidermis exposed to PM2.5 collected by cyclonic separation, TOXICOLOGICAL RESEARCH, 39(1), 1-13, 202301
- Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
- Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
- Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
- Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
- Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
- De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
- Blood-brain barrier leakage is transiently induced by activity-dependent excessive nitric oxide production, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 185P-185P, 2013
- Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
- Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 2014
- Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 2015
- Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 2015
- Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 2015
- Critical role of exposure time to endogenous oxidative stress in hepatocyte apoptosis., Redox report : communications in free radical research, 12(6), 2007
- Sustained contraction and endothelial dysfunction induced by reactive oxygen species in porcine coronary artery., Biological & pharmaceutical bulletin, 31(9), 2008
- Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats., European journal of pharmacology, 611(1-3), 2009
- Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size., Journal of pharmacological sciences, 113(4), 2010
- Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., Journal of applied toxicology : JAT, 31(2), 2011
- Dual regulation of hepatocyte apoptosis by reactive oxygen species: Increases in transcriptional expression and decreases in proteasomal degradation of BimEL., Journal of cellular physiology, 226(4), 2011
- Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., The FEBS journal, 278(11), 2011
- Effects of sulfaphenazole after collagenase-induced experimental intracerebral hemorrhage in rats., Biological & pharmaceutical bulletin, 35(10), 2012
- Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine., Neuroscience letters, 708, 2019
- Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Scientific reports, 9(1), 2019
- Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p., Biological & pharmaceutical bulletin, 43(12), 2020
- Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke., Cells, 10(4), 2021
- Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring., Epilepsy & behavior : E&B, 121(Pt A), 2021
- Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter., The Journal of toxicological sciences, 47(5), 2022
- Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model., International journal of molecular sciences, 23(14), 2022
- Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice., International journal of molecular sciences, 23(14), 2022
- A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure., Journal of neuroinflammation, 19(1), 2022
- Less Invasive Management of Tissue Deficits for Deep Sternal Wound Infections., Plastic and reconstructive surgery. Global open, 8(4), 2020
- Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells., Journal of natural products, 83(10), 2020
- Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease., Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866(2), 2021
- Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development., Frontiers in immunology, 12, 2021
- DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells., International journal of molecular sciences, 22(6), 2021
- Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds., Phytochemistry, 191, 2021
- FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction., International journal of molecular sciences, 22(20), 2021
- Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats., Endocrine journal, 69(7), 2022
- Aryl Hydrocarbon Receptor Signaling Synergizes with TLR/NF-κB-Signaling for Induction of IL-22 Through Canonical and Non-Canonical AhR Pathways., Frontiers in toxicology, 3, 2021
- CaMK phosphatase (CaMKP/POPX2/PPM1F) inhibitors suppress the migration of human breast cancer MDA-MB-231 cells with loss of polarized morphology, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 639, 1-8, 20230108
- Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(14), 202207
- Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(14), 202207
- A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure, JOURNAL OF NEUROINFLAMMATION, 19(1), 20220729
- Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats, ENDOCRINE JOURNAL, 69(7), 797-807, 2022
- Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter, JOURNAL OF TOXICOLOGICAL SCIENCES, 47(5), 201-210, 2022
- Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
- Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 2012
- Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
- Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
- Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 527(1), 16-22, 2012
- Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
- De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
- Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 2013
- Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 2013
- An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
- Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase, BRAIN RESEARCH, 1530, 44-53, 2013
- Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., JOURNAL OF APPLIED TOXICOLOGY, 32(2), 173-178, 2011
- Dual regulation of hepatocyte apoptosis by reactive oxygen species: increases in transcriptional expression and decreases in proteasomal degradation of BimEL., JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1007-1016, 2011
- Increased expression of c-fos by ERK activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., FEBS JOURNAL, 278(11), 1873-1881, 2011
- Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
- Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 20140318
- Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, 201404
- Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 201501
- Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 343706, 201503
- Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 201505
- Beneficial Effects of Supplementation of the Rare Sugar D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice", JOURNAL OF FOOD SCIENCE, 80(7), H1619-H1626, 201507
- Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 201507
- ★, Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, 20150911
- Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy, APPLIED SCIENCES-BASEL, 6(3), 201603
- Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3(2), 63-65, 2016
- Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4), 820-825, 20160902
- Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures, STEROIDS, 113, 71-77, 201609
- Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice, BRAIN RESEARCH, 1652, 1-13, 20161201
- Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 20161101
- Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells, Scientific Reports, 7, 20170202
- ★, Potentiation of 17 beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid, SCIENTIFIC REPORTS, 7, 20170724
- Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 582-587, 20180205
- Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 642, 75-80, 20180315
- Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin, JOURNAL OF TOXICOLOGICAL SCIENCES, 43(1-3), 25-31, 2018
- Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory, ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 23(1), 20180619
- The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS), ENVIRONMENTAL RESEARCH, 166, 562-569, 201810
- Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 2016
- Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children, EUROPEAN JOURNAL OF MEDICAL RESEARCH, 23, 20181226
- Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, COMMUNICATIONS BIOLOGY, 1, 2018
- Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
- Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages., Toxicol Sci., 170(2), 404-414, 201905
- A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth, Cancers (Basel)., 11(5), E589, 201904
- Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study., J Epidemiol, 201901
- Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children's Study (JECS), ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24(1), 20190607
- A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth, CANCERS, 11(5), 201905
- Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(11), 20190601
- Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 20190824
- Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus, SCIENTIFIC REPORTS, 9, 20190925
- Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 193, 201910
- Interleukin 33 Expression Induced by Aryl Hydrocarbon Receptor in Macrophages, TOXICOLOGICAL SCIENCES, 170(2), 404-414, 201908
- Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study, JOURNAL OF EPIDEMIOLOGY, 29(12), 478-486, 201912
- Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol, 193, 105421, 2019
- Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Sci Rep, 9, 13899, 2019
- Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
- Measurement of the estradiol concentration in cerebrospinal fluid from infants and its correlation with serum estradiol and exosomal microRNA-126-5p., Biol. Pharm. Bull., 2020
- Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
- Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells, JOURNAL OF NATURAL PRODUCTS, 83(10), 3050-3057, 20201023
- Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43(12), 1966-1968, 202012
- Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1866(2), 202102
- Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development, FRONTIERS IN IMMUNOLOGY, 12, 20210308
- Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke, CELLS, 10(4), 202104
- DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6), 202103
- Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring, EPILEPSY & BEHAVIOR, 121, 202108
- Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds, PHYTOCHEMISTRY, 191, 202111
- FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 202110
Publications such as books
- 2014, Fifty Years of Cytochrome P450 Research, Neurosteroids: regional steroidogenesis., Springer Japan, 2014, Scholarly Book, Joint work, Yamazaki T, Ishihara Y
Invited Lecture, Oral Presentation, Poster Presentation
- Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter., 2022/06/30, Without Invitation, Japanese
- Airborne Microplastics and Health Impact., Okochi H, Yoshida N, Fujikawa M, Zhao H, Tani Y, Hayami H, Takeuchi M, Sorimachi A, Fujii Y, Takenaka N, Kajino M, Adachi K, Ishihara Y, Iwamoto Y, Aiyazaki A, Katsumi N, Niida Y, Kobayashi H, Urayama N, Hagino H, Iso E, Miura T, Taira E, Akao K, Yamamoto M, Takami T, Itaya Y., Joint Usage/Joint Research Symposium on Integrated Environmental Studies., 2021/12/01, Without Invitation, Japanese
- Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinsons disease, Oguro A, Ishihara Y, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases (IECBM2020), 2020/12/01, Without Invitation, English
- Activated microglia in ischemic stroke aggravate brain edema in
Mice, Tanaka M, Fujikawa M, Itoh K, Ishihara Y, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
- Activation of microglia and excitation-inhibition imbalances in the developing hippocampus of mice prenatally treated with valproate, Ishihara Y, Itoh K, Tominaga T, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
- Developmental microglial activation and postgrowth abnormal behavior induced by prenatal exposure of chemicals, Ishihara Y, The 35th Annual Meeting of KSOT/KEMS, 2019, With Invitation, English
- A role of AhR in microglial polarization., 2017/06/23, With Invitation, English, Center for the health and environment, University of California, Davis.
- Role of astrogliosis elicited by methylmercury in neuroprotection, Prenatal Programming and Toxicity V., 2016/11/16, With Invitation, English
Social Activities
History as Committee Members
- Editorial Board, 2015, Fundamental Toxicological Sciences