YASUHIRO ISHIHARA

Last Updated :2022/08/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
ishiyasuhiroshima-u.ac.jp
Other Contact Details
1-7-1,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)82-424-6500 FAX : (+81)82-424-0759

Basic Information

Major Professional Backgrounds

  • 2006/04/01, 2007/03/31, Tokushima Bunri University, Research Associate
  • 2007/04/01, 2011/03/31, Tokushima Bunri University, Assistant Professor
  • 2011/04/01, 2019/03/31, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
  • 2012/07/30, 2012/09/28, University of California, Visiting Scientist
  • 2007/04/01, 2011/03/31, Part-Time Lecturer
  • 2017/03/17, 2018/03/16, University of California, Davis, Visiting Scientist
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor

Educational Backgrounds

  • Kwansei Gakuin University, School of Science, Department of Chemistry, Japan, 1997/04, 2001/03
  • Osaka University, Graduate School of Science, Department of Biological Sciences, Japan, 2001/04, 2006/03

Academic Degrees

  • Doctor of Science, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Life Sciences
  • Integrated Arts and Sciences

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • PM2.5
  • Glia
  • Environmental Chemicals
  • Oxidative Stress
  • Ischemia

Affiliated Academic Societies

  • The Japanese Society for Alternatives to Animal Experiments, 2021
  • The Japanese Pharmacological Society, 2001
  • The Pharmaceutical Society of Japan, 2004
  • The Japanese Biochemical Society, 2004
  • The Society for Free Radical Research Japan, 2007
  • The Japanese Society of Toxicology, 2012
  • The American Society for Biochemistry and Molecular Biology, 2015
  • Society for Neuroscience, 2017

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Chemistry I
  2. 2022, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Chemistry II
  3. 2022, Undergraduate Education, 2Term, Natural Sciences of Life and Environment
  4. 2022, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  5. 2022, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  6. 2022, Undergraduate Education, 2Term, Introduction to Life Sciences
  7. 2022, Undergraduate Education, 3Term, Functional Biochemistry II
  8. 2022, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  9. 2022, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  10. 2022, Undergraduate Education, 4Term, Functional Biochemistry III
  11. 2022, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
  12. 2022, Undergraduate Education, 1Term, Fundamentals of Biochemistry II
  13. 2022, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  14. 2022, Graduate Education (Master's Program) , 1Term, Exercises in Life and Environmental Sciences A
  15. 2022, Graduate Education (Master's Program) , 2Term, Exercises in Life and Environmental Sciences A
  16. 2022, Graduate Education (Master's Program) , 3Term, Exercises in Life and Environmental Sciences B
  17. 2022, Graduate Education (Master's Program) , 4Term, Exercises in Life and Environmental Sciences B
  18. 2022, Graduate Education (Master's Program) , Second Semester, Functional biochemistry
  19. 2022, Graduate Education (Doctoral Program) , 4Term, Exercises in Integrated Life Sciences
  20. 2022, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  21. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  22. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  23. 2022, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  24. 2022, Graduate Education (Master's Program) , 1Term, Exercises in Biomedical Science A
  25. 2022, Graduate Education (Master's Program) , 2Term, Exercises in Biomedical Science A
  26. 2022, Graduate Education (Master's Program) , 3Term, Exercises in Biomedical Science B
  27. 2022, Graduate Education (Master's Program) , 4Term, Exercises in Biomedical Science B
  28. 2022, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  29. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  30. 2022, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  31. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  32. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  2. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 2012
  3. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  4. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  5. Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 527(1), 16-22, 2012
  6. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  7. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
  8. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 2013
  9. Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 2013
  10. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
  11. Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase, BRAIN RESEARCH, 1530, 44-53, 2013
  12. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., JOURNAL OF APPLIED TOXICOLOGY, 32(2), 173-178, 2011
  13. Dual regulation of hepatocyte apoptosis by reactive oxygen species: increases in transcriptional expression and decreases in proteasomal degradation of BimEL., JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1007-1016, 2011
  14. Increased expression of c-fos by ERK activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., FEBS JOURNAL, 278(11), 1873-1881, 2011
  15. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
  16. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 20140318
  17. Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, 201404
  18. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 201501
  19. Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 343706, 201503
  20. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 201505
  21. Beneficial Effects of Supplementation of the Rare Sugar D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice", JOURNAL OF FOOD SCIENCE, 80(7), H1619-H1626, 201507
  22. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 201507
  23. ★, Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, 20150911
  24. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy, APPLIED SCIENCES-BASEL, 6(3), 201603
  25. Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3(2), 63-65, 2016
  26. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4), 820-825, 20160902
  27. Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures, STEROIDS, 113, 71-77, 201609
  28. Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice, BRAIN RESEARCH, 1652, 1-13, 20161201
  29. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 20161101
  30. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells, Scientific Reports, 7, 20170202
  31. ★, Potentiation of 17 beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid, SCIENTIFIC REPORTS, 7, 20170724
  32. Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 582-587, 20180205
  33. Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 642, 75-80, 20180315
  34. Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin, JOURNAL OF TOXICOLOGICAL SCIENCES, 43(1-3), 25-31, 2018
  35. Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory, ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 23(1), 20180619
  36. The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS), ENVIRONMENTAL RESEARCH, 166, 562-569, 201810
  37. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 2016
  38. Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children, EUROPEAN JOURNAL OF MEDICAL RESEARCH, 23, 20181226
  39. Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, COMMUNICATIONS BIOLOGY, 1, 2018
  40. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  41. Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages., Toxicol Sci., 170(2), 404-414, 201905
  42. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study., J Epidemiol, 201901
  43. Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children's Study (JECS), ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24(1), 20190607
  44. A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth, CANCERS, 11(5), 201905
  45. Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(11), 20190601
  46. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 20190824
  47. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus, SCIENTIFIC REPORTS, 9, 20190925
  48. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 193, 201910
  49. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol, 193, 105421, 2019
  50. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Sci Rep, 9, 13899, 2019
  51. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
  52. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
  53. Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells, JOURNAL OF NATURAL PRODUCTS, 83(10), 3050-3057, 20201023
  54. Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43(12), 1966-1968, 202012
  55. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1866(2), 202102

Publications such as books

  1. 2014, Fifty Years of Cytochrome P450 Research, Neurosteroids: regional steroidogenesis., Springer Japan, 2014, Scholarly Book, Joint work, Yamazaki T, Ishihara Y

Invited Lecture, Oral Presentation, Poster Presentation

  1. Airborne Microplastics and Health Impact., Okochi H, Yoshida N, Fujikawa M, Zhao H, Tani Y, Hayami H, Takeuchi M, Sorimachi A, Fujii Y, Takenaka N, Kajino M, Adachi K, Ishihara Y, Iwamoto Y, Aiyazaki A, Katsumi N, Niida Y, Kobayashi H, Urayama N, Hagino H, Iso E, Miura T, Taira E, Akao K, Yamamoto M, Takami T, Itaya Y., Joint Usage/Joint Research Symposium on Integrated Environmental Studies., 2021/12/01, Without Invitation, Japanese
  2. Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinsons disease, Oguro A, Ishihara Y, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases (IECBM2020), 2020/12/01, Without Invitation, English
  3. Activated microglia in ischemic stroke aggravate brain edema in Mice, Tanaka M, Fujikawa M, Itoh K, Ishihara Y, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  4. Activation of microglia and excitation-inhibition imbalances in the developing hippocampus of mice prenatally treated with valproate, Ishihara Y, Itoh K, Tominaga T, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  5. Developmental microglial activation and postgrowth abnormal behavior induced by prenatal exposure of chemicals, Ishihara Y, The 35th Annual Meeting of KSOT/KEMS, 2019, With Invitation, English
  6. A role of AhR in microglial polarization., 2017/06/23, With Invitation, English, Center for the health and environment, University of California, Davis.
  7. Role of astrogliosis elicited by methylmercury in neuroprotection, Prenatal Programming and Toxicity V., 2016/11/16, With Invitation, English

Social Activities

History as Committee Members

  1. Editorial Board, 2015, Fundamental Toxicological Sciences