YASUHIRO ISHIHARA

Last Updated :2024/06/05

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
ishiyasuhiroshima-u.ac.jp
Other Contact Details
1-7-1,Kagamiyama,Higashi-Hiroshima, Japan
TEL : (+81)82-424-6500 FAX : (+81)82-424-0759

Basic Information

Major Professional Backgrounds

  • 2006/04/01, 2007/03/31, Tokushima Bunri University, Research Associate
  • 2007/04/01, 2011/03/31, Tokushima Bunri University, Assistant Professor
  • 2007/04/01, 2011/03/31, Part-Time Lecturer
  • 2011/04/01, 2019/03/31, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
  • 2012/07/30, 2012/09/28, University of California, Davis, Visiting Scientist
  • 2017/03/17, 2018/03/16, University of California, Davis, Visiting Scientist
  • 2019/04/01, 2023/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor
  • 2023/04/01, Hiroshima Univesrsity, Graduate School of Integrated Sciences for Life, Professor

Educational Backgrounds

  • Kwansei Gakuin University, School of Science, Department of Chemistry, Japan, 1997/04, 2001/03
  • Osaka University, Graduate School of Science, Department of Biological Sciences, Japan, 2001/04, 2006/03

Academic Degrees

  • Doctor of Science, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Life Sciences
  • Integrated Arts and Sciences

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • PM2.5
  • Glia
  • Environmental Chemicals
  • Oxidative Stress
  • Ischemia

Affiliated Academic Societies

  • The Japanese Society for Alternatives to Animal Experiments, 2021
  • The Japanese Pharmacological Society, 2001
  • The Pharmaceutical Society of Japan, 2004
  • The Japanese Biochemical Society, 2004
  • The Society for Free Radical Research Japan, 2007
  • The Japanese Society of Toxicology, 2012
  • The American Society for Biochemistry and Molecular Biology, 2015
  • Society for Neuroscience, 2017

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Chemistry I
  2. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Chemistry II
  3. 2024, Undergraduate Education, 2Term, Natural Sciences of Life and Environment
  4. 2024, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  5. 2024, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  6. 2024, Undergraduate Education, 3Term, Seminar in English for Life Sciences
  7. 2024, Undergraduate Education, 2Term, Introduction to Life Sciences
  8. 2024, Undergraduate Education, First Semester, Fundamental Laboratory Work in Chemistry
  9. 2024, Undergraduate Education, First Semester, Fundamental Methodology in Chemistry
  10. 2024, Undergraduate Education, 2Term, Functional Biochemistry I
  11. 2024, Undergraduate Education, 3Term, Functional Biochemistry II
  12. 2024, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  13. 2024, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  14. 2024, Undergraduate Education, 4Term, Functional Biochemistry III
  15. 2024, Undergraduate Education, 1Term, Fundamentals of Life Science
  16. 2024, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
  17. 2024, Undergraduate Education, 1Term, Fundamentals of Biochemistry II
  18. 2024, Graduate Education (Master's Program) , 2Term, societal implementation of life science
  19. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  20. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Life and Environmental Sciences A
  21. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Life and Environmental Sciences B
  22. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  23. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  24. 2024, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  25. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  26. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  27. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  28. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  29. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  30. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Complementary spectroscopy studies and potential activities of levan-type fructan produced by Bacillus paralicheniformis ND2, CARBOHYDRATE POLYMERS, 311, 20230701
  2. Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation, PARTICLE AND FIBRE TOXICOLOGY, 20(1), 20230216
  3. Associations between welding fume exposure and neurological function in Japanese male welders and non-welders, JOURNAL OF OCCUPATIONAL HEALTH, 65(1), 202301
  4. Chemokine expression in human 3-dimensional cultured epidermis exposed to PM2.5 collected by cyclonic separation, TOXICOLOGICAL RESEARCH, 39(1), 1-13, 202301
  5. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
  6. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  7. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  8. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  9. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  10. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
  11. Blood-brain barrier leakage is transiently induced by activity-dependent excessive nitric oxide production, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 185P-185P, 2013
  12. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  13. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 2014
  14. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 2015
  15. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 2015
  16. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 2015
  17. Critical role of exposure time to endogenous oxidative stress in hepatocyte apoptosis., Redox report : communications in free radical research, 12(6), 2007
  18. Sustained contraction and endothelial dysfunction induced by reactive oxygen species in porcine coronary artery., Biological & pharmaceutical bulletin, 31(9), 2008
  19. Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats., European journal of pharmacology, 611(1-3), 2009
  20. Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size., Journal of pharmacological sciences, 113(4), 2010
  21. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., Journal of applied toxicology : JAT, 31(2), 2011
  22. Dual regulation of hepatocyte apoptosis by reactive oxygen species: Increases in transcriptional expression and decreases in proteasomal degradation of BimEL., Journal of cellular physiology, 226(4), 2011
  23. Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., The FEBS journal, 278(11), 2011
  24. Effects of sulfaphenazole after collagenase-induced experimental intracerebral hemorrhage in rats., Biological & pharmaceutical bulletin, 35(10), 2012
  25. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine., Neuroscience letters, 708, 2019
  26. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Scientific reports, 9(1), 2019
  27. Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p., Biological & pharmaceutical bulletin, 43(12), 2020
  28. Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke., Cells, 10(4), 2021
  29. Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring., Epilepsy & behavior : E&B, 121(Pt A), 2021
  30. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter., The Journal of toxicological sciences, 47(5), 2022
  31. Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model., International journal of molecular sciences, 23(14), 2022
  32. Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice., International journal of molecular sciences, 23(14), 2022
  33. A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure., Journal of neuroinflammation, 19(1), 2022
  34. Less Invasive Management of Tissue Deficits for Deep Sternal Wound Infections., Plastic and reconstructive surgery. Global open, 8(4), 2020
  35. Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells., Journal of natural products, 83(10), 2020
  36. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease., Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866(2), 2021
  37. Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development., Frontiers in immunology, 12, 2021
  38. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells., International journal of molecular sciences, 22(6), 2021
  39. Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds., Phytochemistry, 191, 2021
  40. FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction., International journal of molecular sciences, 22(20), 2021
  41. Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats., Endocrine journal, 69(7), 2022
  42. Aryl Hydrocarbon Receptor Signaling Synergizes with TLR/NF-κB-Signaling for Induction of IL-22 Through Canonical and Non-Canonical AhR Pathways., Frontiers in toxicology, 3, 2021
  43. CaMK phosphatase (CaMKP/POPX2/PPM1F) inhibitors suppress the migration of human breast cancer MDA-MB-231 cells with loss of polarized morphology, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 639, 1-8, 20230108
  44. Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(14), 202207
  45. Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(14), 202207
  46. A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure, JOURNAL OF NEUROINFLAMMATION, 19(1), 20220729
  47. Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats, ENDOCRINE JOURNAL, 69(7), 797-807, 2022
  48. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter, JOURNAL OF TOXICOLOGICAL SCIENCES, 47(5), 201-210, 2022
  49. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  50. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 2012
  51. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  52. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  53. Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 527(1), 16-22, 2012
  54. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  55. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
  56. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 2013
  57. Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 2013
  58. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
  59. Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase, BRAIN RESEARCH, 1530, 44-53, 2013
  60. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., JOURNAL OF APPLIED TOXICOLOGY, 32(2), 173-178, 2011
  61. Dual regulation of hepatocyte apoptosis by reactive oxygen species: increases in transcriptional expression and decreases in proteasomal degradation of BimEL., JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1007-1016, 2011
  62. Increased expression of c-fos by ERK activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis., FEBS JOURNAL, 278(11), 1873-1881, 2011
  63. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
  64. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 20140318
  65. Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, 201404
  66. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 201501
  67. Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 343706, 201503
  68. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 201505
  69. Beneficial Effects of Supplementation of the Rare Sugar D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice", JOURNAL OF FOOD SCIENCE, 80(7), H1619-H1626, 201507
  70. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 201507
  71. ★, Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, 20150911
  72. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy, APPLIED SCIENCES-BASEL, 6(3), 201603
  73. Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3(2), 63-65, 2016
  74. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4), 820-825, 20160902
  75. Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures, STEROIDS, 113, 71-77, 201609
  76. Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice, BRAIN RESEARCH, 1652, 1-13, 20161201
  77. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 20161101
  78. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells, Scientific Reports, 7, 20170202
  79. ★, Potentiation of 17 beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid, SCIENTIFIC REPORTS, 7, 20170724
  80. Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 582-587, 20180205
  81. Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 642, 75-80, 20180315
  82. Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin, JOURNAL OF TOXICOLOGICAL SCIENCES, 43(1-3), 25-31, 2018
  83. Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory, ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 23(1), 20180619
  84. The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS), ENVIRONMENTAL RESEARCH, 166, 562-569, 201810
  85. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 2016
  86. Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children, EUROPEAN JOURNAL OF MEDICAL RESEARCH, 23, 20181226
  87. Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, COMMUNICATIONS BIOLOGY, 1, 2018
  88. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  89. Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages., Toxicol Sci., 170(2), 404-414, 201905
  90. A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth, Cancers (Basel)., 11(5), E589, 201904
  91. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study., J Epidemiol, 201901
  92. Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children's Study (JECS), ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24(1), 20190607
  93. A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth, CANCERS, 11(5), 201905
  94. Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(11), 20190601
  95. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 20190824
  96. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus, SCIENTIFIC REPORTS, 9, 20190925
  97. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 193, 201910
  98. Interleukin 33 Expression Induced by Aryl Hydrocarbon Receptor in Macrophages, TOXICOLOGICAL SCIENCES, 170(2), 404-414, 201908
  99. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study, JOURNAL OF EPIDEMIOLOGY, 29(12), 478-486, 201912
  100. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol, 193, 105421, 2019
  101. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Sci Rep, 9, 13899, 2019
  102. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
  103. Measurement of the estradiol concentration in cerebrospinal fluid from infants and its correlation with serum estradiol and exosomal microRNA-126-5p., Biol. Pharm. Bull., 2020
  104. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: a comparative study of levetiracetam, valproate and carbamazepine., Neurosci Lett., 708, 134363, 2019
  105. Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells, JOURNAL OF NATURAL PRODUCTS, 83(10), 3050-3057, 20201023
  106. Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43(12), 1966-1968, 202012
  107. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1866(2), 202102
  108. Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development, FRONTIERS IN IMMUNOLOGY, 12, 20210308
  109. Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke, CELLS, 10(4), 202104
  110. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6), 202103
  111. Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring, EPILEPSY & BEHAVIOR, 121, 202108
  112. Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds, PHYTOCHEMISTRY, 191, 202111
  113. FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 202110

Publications such as books

  1. 2014, Fifty Years of Cytochrome P450 Research, Neurosteroids: regional steroidogenesis., Springer Japan, 2014, Scholarly Book, Joint work, Yamazaki T, Ishihara Y

Invited Lecture, Oral Presentation, Poster Presentation

  1. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter., 2022/06/30, Without Invitation, Japanese
  2. Airborne Microplastics and Health Impact., Okochi H, Yoshida N, Fujikawa M, Zhao H, Tani Y, Hayami H, Takeuchi M, Sorimachi A, Fujii Y, Takenaka N, Kajino M, Adachi K, Ishihara Y, Iwamoto Y, Aiyazaki A, Katsumi N, Niida Y, Kobayashi H, Urayama N, Hagino H, Iso E, Miura T, Taira E, Akao K, Yamamoto M, Takami T, Itaya Y., Joint Usage/Joint Research Symposium on Integrated Environmental Studies., 2021/12/01, Without Invitation, Japanese
  3. Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinsons disease, Oguro A, Ishihara Y, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases (IECBM2020), 2020/12/01, Without Invitation, English
  4. Activated microglia in ischemic stroke aggravate brain edema in Mice, Tanaka M, Fujikawa M, Itoh K, Ishihara Y, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  5. Activation of microglia and excitation-inhibition imbalances in the developing hippocampus of mice prenatally treated with valproate, Ishihara Y, Itoh K, Tominaga T, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  6. Developmental microglial activation and postgrowth abnormal behavior induced by prenatal exposure of chemicals, Ishihara Y, The 35th Annual Meeting of KSOT/KEMS, 2019, With Invitation, English
  7. A role of AhR in microglial polarization., 2017/06/23, With Invitation, English, Center for the health and environment, University of California, Davis.
  8. Role of astrogliosis elicited by methylmercury in neuroprotection, Prenatal Programming and Toxicity V., 2016/11/16, With Invitation, English

Social Activities

History as Committee Members

  1. Editorial Board, 2015, Fundamental Toxicological Sciences