YASUHIRO ISHIHARA

Last Updated :2025/06/16

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Web Site
https://biomed.hiroshima-u.ac.jp/
E-mail
ishiyasuhiroshima-u.ac.jp
Other Contact Details
1-7-1, Kagamiyama, Higashi-Hiroshima, Hiroshima, Japan, Japan
TEL : (+81)82-424-6529 FAX : (+81)82-424-0759
Self-introduction
We investigate the effects of environmental chemicals on neuronal function, focusing on glial cells such as microglia and oligodendrocytes.

Basic Information

Major Professional Backgrounds

  • 2006/04/01, 2007/03/31, Tokushima Bunri University, Research Associate
  • 2007/04/01, 2011/03/31, Tokushima Bunri University, Assistant Professor
  • 2007/04/01, 2011/03/31, Part-Time Lecturer
  • 2011/04/01, 2019/03/31, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
  • 2012/07/30, 2012/09/28, University of California, Davis, Visiting Scientist
  • 2017/03/17, 2018/03/16, University of California, Davis, Visiting Scientist
  • 2019/04/01, 2023/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor
  • 2023/04/01, Hiroshima Univesrsity, Graduate School of Integrated Sciences for Life, Professor

Educational Backgrounds

  • Kwansei Gakuin University, School of Science, Department of Chemistry, Japan, 1997/04, 2001/03
  • Osaka University, Graduate School of Science, Department of Biological Sciences, Japan, 2001/04, 2006/03

Academic Degrees

  • Doctor of Science, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Humanities and Social Sciences : Division of Humanities and Social Sciences : Integrated Arts and Human Sciences Program
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

In Charge of Primary Major Programs

  • Life Sciences
  • Integrated Arts and Sciences

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • Neurodevelopmental disorders
  • PM2.5
  • Glia
  • Environmental Chemicals
  • Oxidative Stress
  • Ischemia

Affiliated Academic Societies

  • Society of Toxicology, 2024
  • The Society for Free Radical Research International, 2007
  • The Japanese Society of Child Neurology, 2025
  • Japanese Cosmetic Science Society, 2024
  • The Japanese Society for Alternatives to Animal Experiments, 2021
  • The Japanese Pharmacological Society, 2001
  • The Pharmaceutical Society of Japan, 2004
  • The Japanese Biochemical Society, 2004
  • The Society for Free Radical Research Japan, 2007
  • The Japanese Society of Toxicology, 2012

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, Second Semester, Chemistry and human being
  2. 2025, Undergraduate Education, 1Term, Natural Sciences of Life and Environment
  3. 2025, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  4. 2025, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  5. 2025, Undergraduate Education, 3Term, Seminar in English for Life Sciences
  6. 2025, Undergraduate Education, 2Term, Introduction to Life Sciences
  7. 2025, Undergraduate Education, First Semester, Fundamental Laboratory Work in Chemistry
  8. 2025, Undergraduate Education, First Semester, Fundamental Methodology in Chemistry
  9. 2025, Undergraduate Education, 2Term, Functional Biochemistry I
  10. 2025, Undergraduate Education, 3Term, Functional Biochemistry II
  11. 2025, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  12. 2025, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  13. 2025, Undergraduate Education, 1Term, Fundamentals of Life Science
  14. 2025, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
  15. 2025, Undergraduate Education, 1Term, Fundamentals of Biochemistry II
  16. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  17. 2025, Graduate Education (Master's Program) , First Semester, Exercises in Life and Environmental Sciences A
  18. 2025, Graduate Education (Master's Program) , Second Semester, Exercises in Life and Environmental Sciences B
  19. 2025, Graduate Education (Doctoral Program) , Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  20. 2025, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  21. 2025, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  22. 2025, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  23. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Biomedial Science
  24. 2025, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  25. 2025, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  26. 2025, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  27. 2025, Graduate Education (Doctoral Program) , Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  28. 2025, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  29. 2025, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Effects of urban particulate matter on the secondary structure of albumin, ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 27(4), 892-900, 20250416
    Link to Paper Search Results by DOI
  2. Design, Synthesis, and Biological Evaluation of BODIPY-Caged Resiquimod as a Dual-Acting Phototherapeutic, JOURNAL OF MEDICINAL CHEMISTRY, 68(4), 4561-4581, 20250217
    Link to Paper Search Results by DOI
  3. Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice, JOURNAL OF TOXICOLOGICAL SCIENCES, 50(3), 147-159, 2025
  4. Impact of Artificial Sunlight Aging on the Respiratory Effects of Polyethylene Terephthalate Microplastics through Degradation-Mediated Terephthalic Acid Release in Male Mice, TOXICOLOGICAL SCIENCES, 203(2), 242-252, 20241212
    Link to Paper Search Results by DOI
  5. Mice deficient in the phosphatase activity of sEH show decreased levels of the endocannabinoid 2-AG in the olfactory bulb and depressive-like behavior, FEBS LETTERS, 598(24), 2980-2994, 202412
    Link to Paper Search Results by DOI
  6. Ribosomal Protein S4 X-Linked as a Novel Modulator of MDM2 Stability by Suppressing MDM2 Auto-Ubiquitination and SCF Complex-Mediated Ubiquitination, BIOMOLECULES, 14(8), 202408
    Link to Paper Search Results by DOI
  7. Enhancement of keratinocyte survival and migration elicited by interleukin 24 upregulation in dermal microvascular endothelium upon welding-fume exposure, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 87(19), 792-810, 20241001
    Link to Paper Search Results by DOI
  8. Isolation of Fluorescent Benzoxazines with Neuroprotective Activity from the Olive Weevil Pimelocerus perforatus, JOURNAL OF NATURAL PRODUCTS, 85(12), 2740-2745, 20221021
    Link to Paper Search Results by DOI
  9. Numerical simulation of IL-8-based relative inflammation potentials of aerosol particles from vehicle exhaust and non-exhaust emission sources in Japan, ATMOSPHERIC ENVIRONMENT-X, 21, 202401
    Link to Paper Search Results by DOI
  10. Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder, JOURNAL OF LIPID RESEARCH, 64(11), 202311
    Link to Paper Search Results by DOI
  11. Suppressive Effects of Docosahexaenoic Acid Intake on Increased Seizure Susceptibility after Growth Due to Febrile Seizures in Infancy, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46(9), 1184-1193, 202309
  12. Airborne hydrophilic microplastics in cloud water at high altitudes and their role in cloud formation, ENVIRONMENTAL CHEMISTRY LETTERS, 21(6), 3055-3062, 202312
    Link to Paper Search Results by DOI
  13. Microglial inflammatory reactions regulated by oxidative stress, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 72(1), 23-27, 2023
    Link to Paper Search Results by DOI
  14. The effect of mask fit test on the association between the concentration of metals in biological samples and the results of time-weighted average personal exposure: A study on Japanese male welders, JOURNAL OF OCCUPATIONAL HEALTH, 65(1), 202301
    Link to Paper Search Results by DOI
  15. Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer, CELLS, 12(10), 20230520
    Link to Paper Search Results by DOI
  16. Complementary spectroscopy studies and potential activities of levan-type fructan produced by Bacillus paralicheniformis ND2, CARBOHYDRATE POLYMERS, 311, 20230701
    Link to Paper Search Results by DOI
  17. Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation, PARTICLE AND FIBRE TOXICOLOGY, 20(1), 20230216
    Link to Paper Search Results by DOI
  18. Associations between welding fume exposure and neurological function in Japanese male welders and non-welders, JOURNAL OF OCCUPATIONAL HEALTH, 65(1), 202301
    Link to Paper Search Results by DOI
  19. Chemokine expression in human 3-dimensional cultured epidermis exposed to PM2.5 collected by cyclonic separation, TOXICOLOGICAL RESEARCH, 39(1), 1-13, 202301
    Link to Paper Search Results by DOI
  20. Antioxidant properties of rare sugar D-allose: Effects on mitochondrial reactive oxygen species production in Neuro2A cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(6), 638-642, 2011
  21. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
  22. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
  23. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
  24. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
  25. Blood-brain barrier leakage is transiently induced by activity-dependent excessive nitric oxide production, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 185P-185P, 2013
  26. Enhancement of Quinone Hepatotoxicity by Cytochrome P450 Inhibition, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 133(8), 873-878, 2013
  27. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 2015
  28. CaMK phosphatase (CaMKP/POPX2/PPM1F) inhibitors suppress the migration of human breast cancer MDA-MB-231 cells with loss of polarized morphology, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 639, 1-8, 20230108
    Link to Paper Search Results by DOI
  29. Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(14), 202207
    Link to Paper Search Results by DOI
  30. Regulation of Inflammation-Related Genes through Fosl1 Suppression in a Levetiracetam-Treated Pilocarpine-Induced Status Epilepticus Mouse Model, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(14), 202207
    Link to Paper Search Results by DOI
  31. A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure, JOURNAL OF NEUROINFLAMMATION, 19(1), 20220729
    Link to Paper Search Results by DOI
  32. Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats, ENDOCRINE JOURNAL, 69(7), 797-807, 2022
    Link to Paper Search Results by DOI
  33. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter, JOURNAL OF TOXICOLOGICAL SCIENCES, 47(5), 201-210, 2022
  34. Contribution of Reductase Activity to Quinone Toxicity in Three Kinds of Hepatic Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(4), 634-638, 2012
    Link to Paper Search Results by DOI
  35. Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures, NEUROCHEMISTRY INTERNATIONAL, 60(8), 782-790, 2012
    Link to Paper Search Results by DOI
  36. Sulfaphenazole Attenuates Myocardial Cell Apoptosis Accompanied With Cardiac Ischemia-Reperfusion by Suppressing the Expression of BimEL and Noxa, JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 251-259, 2012
    Link to Paper Search Results by DOI
  37. Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10), 1849-1853, 2012
    Link to Paper Search Results by DOI
  38. Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 527(1), 16-22, 2012
    Link to Paper Search Results by DOI
  39. Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging, MAGNETIC RESONANCE IMAGING, 31(1), 130-138, 2013
    Link to Paper Search Results by DOI
  40. De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices, PLOS ONE, 8(2), 2013
    Link to Paper Search Results by DOI
  41. Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 135, 1-6, 2013
    Link to Paper Search Results by DOI
  42. Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Noninvasive measurement of the brain redox state by magnetic resonance imaging, FREE RADICAL RESEARCH, 47(9), 731-739, 2013
    Link to Paper Search Results by DOI
  43. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
    Link to Paper Search Results by DOI
  44. Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase, BRAIN RESEARCH, 1530, 44-53, 2013
    Link to Paper Search Results by DOI
  45. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats., JOURNAL OF APPLIED TOXICOLOGY, 32(2), 173-178, 2011
  46. Dual regulation of hepatocyte apoptosis by reactive oxygen species: increases in transcriptional expression and decreases in proteasomal degradation of BimEL., JOURNAL OF CELLULAR PHYSIOLOGY, 226(4), 1007-1016, 2011
  47. Suppressive effects of 17 beta-estradiol on tributyltin-induced neuronal injury via Akt activation and subsequent attenuation of oxidative stress, LIFE SCIENCES, 99(1-2), 24-30, 20140318
    Link to Paper Search Results by DOI
  48. Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, NATURE COMMUNICATIONS, 5, 201404
    Link to Paper Search Results by DOI
  49. Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 85-93, 201501
    Link to Paper Search Results by DOI
  50. Protective Actions of 17 beta-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 343706, 201503
    Link to Paper Search Results by DOI
  51. Prevention of status epilepticus-induced brain edema and neuronal cell loss by repeated treatment with high-dose levetiracetam, BRAIN RESEARCH, 1608, 225-234, 201505
    Link to Paper Search Results by DOI
  52. Beneficial Effects of Supplementation of the Rare Sugar D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice", JOURNAL OF FOOD SCIENCE, 80(7), H1619-H1626, 201507
    Link to Paper Search Results by DOI
  53. Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40(1), 199-205, 201507
    Link to Paper Search Results by DOI
  54. ★, Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia OXIDATIVE STRESS TOLERANCE AND CONVERGENCE OF INFLAMMATORY RESPONSES, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(37), 22805-22817, 20150911
    Link to Paper Search Results by DOI
  55. Transcription factor activation in rat primary astrocytes exposed to methylmercury., Fundam. Toxicol. Sci., 3(2), 63-65, 2016
  56. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4), 820-825, 20160902
    Link to Paper Search Results by DOI
  57. Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures, STEROIDS, 113, 71-77, 201609
    Link to Paper Search Results by DOI
  58. Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice, BRAIN RESEARCH, 1652, 1-13, 20161201
    Link to Paper Search Results by DOI
  59. Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(3), 182-190, 20161101
    Link to Paper Search Results by DOI
  60. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells, Scientific Reports, 7, 20170202
    Link to Paper Search Results by DOI
  61. ★, Potentiation of 17 beta-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid, SCIENTIFIC REPORTS, 7, 20170724
    Link to Paper Search Results by DOI
  62. Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 496(2), 582-587, 20180205
    Link to Paper Search Results by DOI
  63. Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 642, 75-80, 20180315
    Link to Paper Search Results by DOI
  64. Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin, JOURNAL OF TOXICOLOGICAL SCIENCES, 43(1-3), 25-31, 2018
  65. Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory, ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 23(1), 20180619
    Link to Paper Search Results by DOI
  66. The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS), ENVIRONMENTAL RESEARCH, 166, 562-569, 201810
    Link to Paper Search Results by DOI
  67. Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children, EUROPEAN JOURNAL OF MEDICAL RESEARCH, 23, 20181226
    Link to Paper Search Results by DOI
  68. Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, COMMUNICATIONS BIOLOGY, 1, 2018
    Link to Paper Search Results by DOI
  69. Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children's Study (JECS), ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24(1), 20190607
    Link to Paper Search Results by DOI
  70. A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth, CANCERS, 11(5), 201905
    Link to Paper Search Results by DOI
  71. Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(11), 20190601
    Link to Paper Search Results by DOI
  72. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 20190824
    Link to Paper Search Results by DOI
  73. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus, SCIENTIFIC REPORTS, 9, 20190925
    Link to Paper Search Results by DOI
  74. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 193, 201910
    Link to Paper Search Results by DOI
  75. Interleukin 33 Expression Induced by Aryl Hydrocarbon Receptor in Macrophages, TOXICOLOGICAL SCIENCES, 170(2), 404-414, 201908
    Link to Paper Search Results by DOI
  76. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study, JOURNAL OF EPIDEMIOLOGY, 29(12), 478-486, 201912
    Link to Paper Search Results by DOI
  77. Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells, JOURNAL OF NATURAL PRODUCTS, 83(10), 3050-3057, 20201023
    Link to Paper Search Results by DOI
  78. Measurement of the Estradiol Concentration in Cerebrospinal Fluid from Infants and Its Correlation with Serum Estradiol and Exosomal MicroRNA-126-5p, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43(12), 1966-1968, 202012
    Link to Paper Search Results by DOI
  79. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1866(2), 202102
    Link to Paper Search Results by DOI
  80. Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development, FRONTIERS IN IMMUNOLOGY, 12, 20210308
    Link to Paper Search Results by DOI
  81. Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke, CELLS, 10(4), 202104
    Link to Paper Search Results by DOI
  82. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6), 202103
    Link to Paper Search Results by DOI
  83. Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring, EPILEPSY & BEHAVIOR, 121, 202108
    Link to Paper Search Results by DOI
  84. Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds, PHYTOCHEMISTRY, 191, 202111
    Link to Paper Search Results by DOI
  85. FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 202110
    Link to Paper Search Results by DOI

Publications such as books

  1. 2014, Fifty Years of Cytochrome P450 Research, Neurosteroids: regional steroidogenesis., Springer Japan, 2014, Scholarly Book, Joint work, Yamazaki T, Ishihara Y

Invited Lecture, Oral Presentation, Poster Presentation

  1. Distribution of Potentially Airborne Sub-100 um Marine Microplastics in the Surface Ocean Near Japan., Komatsu M, Okochi H, Tani Y, Onozuka Y, Oshimi M., Hayami H, Takeuchi M, Sorimachi A, Fujii Y, Takenaka N, Yamaguchi T, Katsumi N, Kajino M, Adachi K, Ishihara Y, Iwamoto Y, Niida Y, Nakajima R, Yabuki A, 2nd International Symposium on Plastic Pollution in Asian Waters - From land to the ocean., 2024/02/28, Without Invitation, English
  2. Impact of particulate matter 2.5 on skin conditions- Using a novel air-liquid interface exposure system., Kono M, Takaishi M, Kinoshita K, Ikeda H, Okuda T, Okano Y, Ishihara Y., IFSCC 2023 Congress., 2023/09/04, Without Invitation, English
  3. Occurrence, behavior, fate, and health impact of airborne microplastics (AMPs)(3)., Onozuka Y, Okochi H, Tani Y, Yoshida N, Hayami H, Takeuchi M, Sorimachi A, Fujii Y, Takenaka N, Yamaguchi T, Katsumi N, Matsuki A, Kajino M, Adachi K, Ishihara Y, Iwamoto Y, Niida Y., 10th International Conference on Acid Deposition., 2023/04/17, Without Invitation, English
  4. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter., 2022/06/30, Without Invitation, Japanese
  5. Airborne Microplastics and Health Impact., Okochi H, Yoshida N, Fujikawa M, Zhao H, Tani Y, Hayami H, Takeuchi M, Sorimachi A, Fujii Y, Takenaka N, Kajino M, Adachi K, Ishihara Y, Iwamoto Y, Aiyazaki A, Katsumi N, Niida Y, Kobayashi H, Urayama N, Hagino H, Iso E, Miura T, Taira E, Akao K, Yamamoto M, Takami T, Itaya Y., Joint Usage/Joint Research Symposium on Integrated Environmental Studies., 2021/12/01, Without Invitation, Japanese
  6. Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinsons disease, Oguro A, Ishihara Y, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases (IECBM2020), 2020/12/01, Without Invitation, English
  7. Activated microglia in ischemic stroke aggravate brain edema in Mice, Tanaka M, Fujikawa M, Itoh K, Ishihara Y, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  8. Activation of microglia and excitation-inhibition imbalances in the developing hippocampus of mice prenatally treated with valproate, Ishihara Y, Itoh K, Tominaga T, GLIA IN HEALTH & DISEASE Cold Spring Harbor Laboratory Meetings & Courses, 2020/07/15, Without Invitation, English
  9. Developmental microglial activation and postgrowth abnormal behavior induced by prenatal exposure of chemicals, Ishihara Y, The 35th Annual Meeting of KSOT/KEMS, 2019, With Invitation, English
  10. A role of AhR in microglial polarization., 2017/06/23, With Invitation, English, Center for the health and environment, University of California, Davis.
  11. Role of astrogliosis elicited by methylmercury in neuroprotection, Prenatal Programming and Toxicity V., 2016/11/16, With Invitation, English

Social Activities

History as Committee Members

  1. Editorial Board, 2015, Fundamental Toxicological Sciences