SYUNSUKE IZUMI

Last Updated :2024/02/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
shunhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Research Fields

  • Chemistry;Applied chemistry;Bio-related chemistry

Research Keywords

  • Mass Spectrometry
  • Plant cells
  • Dynamics
  • Biotrans formation
  • Proteomics

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 2Term, Modern Chemistry
  2. 2023, Undergraduate Education, 4Term, Advanced Chemistry
  3. 2023, Undergraduate Education, 2Term, Systembiology
  4. 2023, Undergraduate Education, First Semester, Special Study for Graduation
  5. 2023, Undergraduate Education, Second Semester, Special Study for Graduation
  6. 2023, Undergraduate Education, 4Term, Chemistry of Biological Compounds
  7. 2023, Undergraduate Education, 3Term, Biological Chemistry
  8. 2023, Undergraduate Education, First Semester, Introducution to Science Communication A
  9. 2023, Undergraduate Education, First Semester, Science Literacy
  10. 2023, Undergraduate Education, First Semester, Organic Chemistry in Natural Products
  11. 2023, Graduate Education (Master's Program) , 1Term, Introduction to Life Science
  12. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
  13. 2023, Graduate Education (Master's Program) , 2Term, Theory and Experiment of Proteomics
  14. 2023, Graduate Education (Master's Program) , 1Term, Biological Chemistry A
  15. 2023, Graduate Education (Master's Program) , 2Term, Special Lecture on Mathematical and Life Sciences C
  16. 2023, Graduate Education (Master's Program) , 2Term, Topical Seminar in Life Science A
  17. 2023, Graduate Education (Master's Program) , 4Term, Topical Seminar in Life Science B
  18. 2023, Graduate Education (Master's Program) , First Semester, Exercises in Life Science A
  19. 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Life Science B
  20. 2023, Graduate Education (Doctoral Program) , 2Term, Special Lecture on Mathematical and Life Sciences G

Research Activities

Academic Papers

  1. Allosteric inhibition of rat neuronal nitric-oxide synthase caused by interference with the binding of calmodulin to the enzyme, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(2), 231-240, 200702
  2. Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons, JOURNAL OF NEUROCHEMISTRY, 100(4), 950-967, 200702
  3. A sensitive method based on fluorescence-detected circular dichroism for protein local structure analysis, ANALYTICAL BIOCHEMISTRY, 430(2), 179-184, 20121115
  4. Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase, Nucleic Acids Research, 32(17), 5291-5302, 20040801
  5. Mass spectrometry on hydrogen/deuterium exchange of dihydrofolate reductase: Effects of ligand binding., The Journal of Biochemistry, 135(6), 663-671, 20040601
  6. Mass spectrometry of hydrogen/deuterium exchange of Escherichia coli dihydrofolate reductase: Effects of loop mutations., Journal of Biochemistry (Tokyo= Japan), 135(4), 487-494, 20040401
  7. Identification of a novel rat microsomal vitamin D3 25-hydroxylase., The Journal of Biological Chemistry, 279(22), 22848-22856, 20040401
  8. Mass spectrometry on segment-specific hydrogen exchange of dihydrofolate reductase., Journal of Biochemistry (Tokyo= Japan), 135(1), 17-24, 20040101
  9. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans, Molecular Microbiology, 50(4), 1125-1139, 20030901
  10. Membrane Topology of Guinea Pig Cytochrome P450 17a Revealed by a Combination of Chemical Modifications and Mass Spectrometry., Bio chemistry, 42(49), 14663-14669, 20030801
  11. A novel reductase participating in the hydrogenation of an exocyclic C-C double bond of enones from Nicotiana tabacum., Bulletin of the Chemical Society of Japan, 75(4), 813-816, 20020601
  12. Proteome analysis of cellular responses to radiation in Jurkat cells, 79(特集号), 263-266, 20041201
  13. Radiation-induced apoptosis and dephosphorylation of acidic ribosomal protein P2, 59(4), 370-372, 20060401
  14. Secretion of Allelochemicals from the Cultured Suspension Cells of {\it Marchantia polymorpha}, Chemistry Letters, 1996, 205-206, 19960401
  15. Hydrolysis of isoprenyl diphosphates with the acid phosphatase from {\it Cinnamomum camphora}, Experientia, 52, 81-84, 19960401
  16. Novel Reductase Participating in the {\it syn}-Addition of Hydrogen to the C=C Bond of Enones in the Cultured Cells of {\it Nicotiana tabacum}, Journal of Chemical Society= Perkin Trans. 1, 1996, 355-358, 19960401
  17. Lipid Constituents of Oil Bodies in the Cultured Shoot Primordia of {\it Matricaria chamomilla}, Phytochemistry, 41, 1275-1279, 19960401
  18. Mr 33k Oil Body Associated Protein in the Cultured Shoot Primordia of {\it Matricaria chamomilla}, Phytochemistry, 42, 309-312, 19960401
  19. Enantioselective Glucosylation of ({\it RS})-1-Phenylethanol by the Cultured Suspension Cells of Higher Plants, Chemistry Letters, 1996, 719-720, 19960401
  20. Secretion of 112 kDa Phosphatase from the Cultured Suspension Cells of Liverworts, Chemistry Letters, 1996, 807-808, 19960401
  21. Volatile Constituents of {\it Stachys obliqua} L. (Lamiaceae) from Turkey, Flavour and Fragrance Journal, 12(3), 211-214, 19970401
  22. The volatile Constituents of {\it Stachys recta} and {\it Stachys balansae} from Turkey, Flavour and Fragrance Journal, 12(3), 215-218, 19970401
  23. Asymmetric Hydrolyses of 1,2- and 1,3-Diacetoxycyclohexanes with the Cultured Suspension Cells of {\it Marchantia polymorpha}, Chirality, 9, 250-253, 19970401
  24. A facile Synthesis of ({\it S})- and ({\it R})-[6-$H^{2}$H]Carvones and ({\it S})- and ({\it R})-[2-$H^{2}$H] Limonenes, Journal of Labelled Compounds and Radiopharmaceuticals, 39(4), 285-290, 19970401
  25. Monoterpenoids, Potent Inducers of Apoptosis in the Cells of {\it Marchantia polymorpha}, Chemistry Letters, 1997, 837-838, 19970401
  26. Asymmetric Hydrolysis of $\alpha$-Alkylated Cyclohexanone Enol Acetates by the Cultured Cells of {\it Marchantia polymorpha}, Tetrahedron; Asymmetry, 8, 2671-2673, 19970401
  27. Signal Transduction Against the Terpenoids-Stimulation in the Liverwort Cells, Chemistry Letters, 1997, 1117-1118, 19970401
  28. Asymmetric Hydrolysis of Enol-Acetates with the Cultured Cells of {\it Marchantia polymorpha}, Journal of Molecular Catalysis B; Enzymatic, 5, 143-147, 19980401
  29. Glucosylation of Benzyl Alcohols by the Cultured Suspension Cells of {\it Nicotiana tabacum} and {\it Catharanthus roseus}, Journal of Molecular Catalysis B; Enzymatic, 6, 67-73, 19990401
  30. Geraniol Is a Potent Inducer of Apoptosis-like Cell Death in the Cultured Shoot Primordia of {\it Matricaria chamomilla}, Biochemical and Biophysical Research Communications, 259, 519-522, 19990401
  31. A 20-kDa Protein with the GTP-Binding and Trypsin Inhibitory Activities from {\it Glycine max}, Bioscience= Biotechnology and Biochemistry, 63(10), 1816-1818, 19990401
  32. The volatile constituents of {\it Stacys athorecalyx} C. Koch. from Turkey, Flavour and Fragrance Journal, 14, 12-14, 19990401
  33. Facile Syntheses of [8,9-$H^{2}$H$H_{2}O$]- and [8-$H^{2}$H]-Digeranyl, Journal of Labelled Compounds and Radiopharmacuticals, 43, 1301-1309, 20000401
  34. Enantioselective Hydrolysis of $\alpha$-Methylated Cyclohexyl Acetates with the Cultured Cells of {\it Marchantia polymorpha}, Journal of Molecular Catalysis B; Enzymatic, 11(4-6), 439-443, 20010401
  35. An eudesmanolide and a carotane from {\it Ferula sinaica}, Phytochemistry, 57, 512-515, 20010401
  36. Enantioselectivity in the Hydrolysis by Lipase. A Study of MALDI TOF-MS Analysis, Chemistry Letters, 2001, 892-893, 20010401
  37. Characterization of rat and human CYP2J enzymes as vitamin D 25-hydroxylases, Steroid, 71, 849-856, 20060601
  38. Allosteric inhibition of rat neuronal nitric-oxide synthase caused by interference with the binding of calmodulin to the enzyme., Biochem. Biophys. Acta, 1770, 231-240, 20070405
  39. Nucleotide excision repair and homologous recombination systems commit differentially to the repair of DNA-protein cross-links, Molecular Cell, 28, 147-158, 20071012
  40. ★, Selective detection of 2-nitrobenzenesulfenyl-labeled peptides by matrix-assisted laser desorption/ionization-time of flight mass spectrometry using a novel matrix., Proteomics, 6(7), 2042-2049, 20060701
  41. Mass spectrometry of hydrogen/deuterium exchange in 70S ribosomal proteins from E. coli, FEBS Letters, 580(15), 3638-3642, 20060626
  42. High glucose concentration induces elevated expression of anti-oxidant and proteolytic enzymes in cultured human retinal pigment epithelial cells., Experimental Eye Research, 83(3), 602-609, 20060901
  43. The interaction of cytochrome P450 17.alpha. with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry., Biochimica et Biophysica Acta, 1764(6), 1126-1131, 20060601
  44. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein, Biochimica et Biophysica Acta, 1764(10), 1561-1567, 20061001
  45. High glucose concentration induces elevated expression of anti-oxidant and proteolytic enzymes in cultured human retinal pigment epithelial cells., Experimental Eye Research, 83(3), 602-609, 20060501
  46. Mass spectroscopic approach to amino acids formation processes by UV irradiation to simple organic molecules in aqueous solution, Analytical Science, 21(9), 1085-1090, 20050901
  47. Topological study of membrane proteins by mass spectrometry, J. Mass Spectrom. Soc. Jpn., 55(3), 221, 20070601
  48. Proline-rich domain in dynamin-2 has a low microtubule-binding activity: how is this activity controlled during mitosis in HeLa cells?, J Biochem, 148(5), 533-8, 20101101
  49. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development., Mech Dev., 127(3-4), 235-245, 20100401
  50. Facile syntheses of [8,9-H-2(2)]- and [8-H-2]-digeranyl, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 43(13), 1301-1309, 200011
  51. Enantioselective hydrolyses of alpha-methylated cyclohexyl acetates by the cultured cells of Marchantia polymorpha, JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 11(4-6), 439-443, 20010122
  52. An eudesmanolide and a carotane from Ferula sinaica, PHYTOCHEMISTRY, 57(4), 513-515, 200106
  53. Effects of high magnetic field on Euglena gracilis, INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS, 14(1-4), 311-316, 2001
  54. Enantioselectivity in the hydrolysis by lipase: A study of MALDI TOF-MS analysis, CHEMISTRY LETTERS, 892-893, 20010905
  55. A novel reductase participating in the hydrogenation of an exocyclic C-C double bond of enones from Nicotiana tabacum, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 75(4), 813-816, 200204
  56. Asymmetric epoxidation of digeranyl by cultured cells of Nicotiana tabacum, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 46(5), 401-409, 200304
  57. Chemical composition and antifungal properties of essential oils of three Pistacia species, FITOTERAPIA, 74(1-2), 170-176, 200302
  58. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans, MOLECULAR MICROBIOLOGY, 50(4), 1125-1139, 200311
  59. Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry, BIOCHEMISTRY, 42(49), 14663-14669, 20031216
  60. Composition and antifungal activity of essential oils isolated from Hypericum hyssopifolium and Hypericum heterophyllum, FLAVOUR AND FRAGRANCE JOURNAL, 19(1), 62-68, 2004
  61. Mass Spectrometry on segment-specific hydrogen exchange of dihydrofolate reductase, JOURNAL OF BIOCHEMISTRY, 135(1), 17-24, 200401
  62. Mass spectrometry of hydrogen/deuterium exchange of Escherichia coli dihydrofolate reductase: Effects of loop mutations, JOURNAL OF BIOCHEMISTRY, 135(4), 487-494, 200404
  63. Identification of a novel rat microsomal vitamin D-3 25-hydroxylase, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(22), 22848-22856, 20040528
  64. Mass Spectrometry on hydrogen/deuterium exchange of dihydrofolate reductase: Effects of ligand binding, JOURNAL OF BIOCHEMISTRY, 135(6), 663-671, 200406
  65. Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase, NUCLEIC ACIDS RESEARCH, 32(17), 5291-5302, 2004
  66. Studies on substantially increased proteins in follicular fluid of bovine ovarian follicular cysts using 2-D PAGE and MALDI-TOF MS, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 3, 20050608
  67. Mass spectroscopic approach to amino acids formation processes by UV irradiation to simple organic molecules in aqueous solution, ANALYTICAL SCIENCES, 21(9), 1085-1090, 200509
  68. Morphological behavior of lipid bilayers induced by melittin near the phase transition temperature, BIOPHYSICAL JOURNAL, 89(5), 3214-3222, 200511
  69. Selective detection of 2-nitrobenzenesulfenyl-labeled peptides by matrix-assisted laser desorption/ionization-time of flight mass spectrometry using a novel matrix, PROTEOMICS, 6(7), 2042-2049, 200604
  70. Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling, BIOCHEMICAL JOURNAL, 402, 515-523, 20070315
  71. Mass spectrometry of hydrogen/deuterium exchange in 70S ribosomal proteins from E-coli, FEBS LETTERS, 580(15), 3638-3642, 20060626
  72. The interaction of cytochrome P450 17 alpha with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1764(6), 1126-1131, 200606
  73. High glucose concentration induces elevated expression of anti-oxidant and proteolytic enzymes in cultured human retinal pigment epithelial cells, EXPERIMENTAL EYE RESEARCH, 83(3), 602-609, 200609
  74. Characterization of rat and human CYP2J enzymes as vitamin D 25-hydroxylases, STEROIDS, 71(10), 849-856, 200610
  75. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1764(10), 1561-1567, 200610
  76. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics, MOLECULAR AND CELLULAR BIOLOGY, 27(20), 7028-7040, 200710
  77. Nucleotide excision repair and homologous recombination systems commit differentially to the repair of DNA-Protein crosslinks, MOLECULAR CELL, 28(1), 147-158, 20071012
  78. GSK-3 beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5, JOURNAL OF BIOLOGICAL CHEMISTRY, 283(19), 12981-12991, 20080509
  79. Stereospecific hydrogenation of the C=C double bond of enones by Escherichia coli overexpressing an enone reductase of Nicotiana tabacum, JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 59(1-3), 158-162, 200907
  80. RNA interference-mediated suppression of xanthine dehydrogenase reveals the role of purine metabolism in drought tolerance in Arabidopsis, FEBS LETTERS, 584(6), 1181-1186, 20100319
  81. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development, MECHANISMS OF DEVELOPMENT, 127(3-4), 235-245, 2010
  82. Topology and dynamics of melittin within the liposome revealed by a combination of mass spectrometry and chemical modification, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 397(1), 1-4, 20100618
  83. Proline-rich domain in dynamin-2 has a low microtubule-binding activity: how is this activity controlled during mitosis in HeLa cells?, JOURNAL OF BIOCHEMISTRY, 148(5), 533-538, 201011
  84. Localized Bioconvection of Euglena Caused by Phototaxis in the Lateral Direction, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 80(6), 201106
  85. Mode Change in the Self-Motion of a Benzoquinone Disk Coupled with a NADPH System, CHEMPHYSCHEM, 13(2), 520-524, 201202
  86. Alkylated Dihydroxybenzoic Acid as a MALDI Matrix Additive for Hydrophobic Peptide Analysis, ANALYTICAL CHEMISTRY, 84(9), 4237-4243, 20120501
  87. Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation, MOLECULAR CELL, 47(5), 694-706, 20120914
  88. Potential of radical scavenging reagents as a matrix additive in the direct detection of S-nitrosylated peptides with UV-MALDI MS, INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 333, 67-+, 20130101
  89. Reciprocating Motion of a Self-Propelled Object on a Molecular Layer, CHEMPHYSCHEM, 13(18), 4129-4133, 20121221
  90. Reciprocating Motion of a Self-Propelled Object on a Molecular Layer with a Local Minimum and a Local Maximum Isotherm, JOURNAL OF PHYSICAL CHEMISTRY C, 117(12), 6346-6352, 20130328
  91. A possible means of realizing a sacrifice-free three component separation of lignocellulose from wood biomass using an amino acid ionic liquid, GREEN CHEMISTRY, 15(7), 1863-1868, 2013
  92. Alkylated Trihydroxyacetophenone as a MALDI Matrix for Hydrophobic Peptides, ANALYTICAL CHEMISTRY, 85(20), 9444-9448, 20131015
  93. Localized Bioconvection Patterns and Their Initial State Dependency in Euglena gracilis Suspensions in an Annular Container, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 83(4), 201404
  94. Self-propelled Motor Driven by a Glucose Engine, CHEMISTRY LETTERS, 43(4), 453-455, 20140405
  95. In vitro and in vivo evidence for oxalate oxidase activity of a germin-like protein from azalea, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 458(3), 536-542, 20150313
  96. Marangoni flow around a camphor disk regenerated by the interaction between camphor and sodium dodecyl sulfate molecules, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 466, 40-44, 20150205
  97. A unique mechanism of successful fertilization in a domestic bird, SCIENTIFIC REPORTS, 5, 20150109
  98. A topological measurement of protein compressibility, JAPAN JOURNAL OF INDUSTRIAL AND APPLIED MATHEMATICS, 32(1), 1-17, 201503
  99. Dual selective nitration in Arabidopsis: Almost exclusive nitration of PsbO and PsbP, and highly susceptible nitration of four non-PSII proteins, including peroxiredoxin II E, ELECTROPHORESIS, 36(20), 2569-2578, 201510
  100. Membrane Protein Analyses Using Alkylated Trihydroxyacetophenone (ATHAP) as a MALDI Matrix, ANALYTICAL CHEMISTRY, 88(3), 1688-1695, 20160202
  101. Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule, JOURNAL OF RADIATION RESEARCH, 57(2), 142-149, 201603

Patented

  1. Patent, 5706597, 2015/03/06