HIDEHIKO TAKIGAWA

Last Updated :2024/07/15

Affiliations, Positions
Hiroshima University Hospital(Department of Endoscopy), Assistant Professor
E-mail
hidehikohiroshima-u.ac.jp
Self-introduction
May main research interests are as following, cancer-stromal interactions, Non-helicobacter pylori Helicobacters (NHPHs) infection, and gastrointestinal MALT lymphoma.

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship
  2. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2024, Undergraduate Education, First Semester, Internal Medicine I

Research Activities

Academic Papers

  1. Clinical usefulness and acceptability of small-bowel capsule endoscopy with panoramic imaging compared with axial imaging in Japanese patients., DEN open, 5(1), 2025
  2. Long-term prognosis after endoscopic submucosal dissection for esophageal cancer in older adult patients, BMC GASTROENTEROLOGY, 24(1), 20240514
  3. ★, Analysis of anti-tumor effect and mechanism of GLS1 inhibitor CB-839 in colorectal cancer using a stroma-abundant tumor model., Experimental and molecular pathology, 137, 20240503
  4. Clinical factors associated with stable treatment of chronic constipation in Japanese patients, BMC GASTROENTEROLOGY, 24(1), 20240129
  5. Can underwater endoscopic mucosal resection be an alternative to conventional endoscopic mucosal resection for superficial non-ampullary duodenal epithelial tumors?, DEN OPEN, 4(1), 202404
  6. Clinicopathological and genomic features of superficial esophageal squamous cell carcinomas in nondrinker, nonsmoker females, CANCER MEDICINE, 13(4), 202402
  7. Predictive factors for esophageal stenosis in patients receiving prophylactic steroid therapy after endoscopic submucosal dissection for esophageal squamous cell carcinoma., BMC gastroenterology, 24(1), 2024
  8. Clinicopathological and genomic features of superficial esophageal squamous cell carcinomas in nondrinker, nonsmoker females., Cancer medicine, 13(4), 2024
  9. Long-term prognosis after endoscopic submucosal dissection for esophageal cancer in older adult patients., BMC gastroenterology, 24(1), 2024
  10. Usefulness and Educational Benefit of a Virtual Scale Endoscope in Measuring Colorectal Polyp Size., Digestion, 2024
  11. Long-term outcomes of patients with obscure gastrointestinal bleeding after negative capsule endoscopy., Journal of gastroenterology and hepatology, 2024
  12. Hybrid endoscopic submucosal dissection as a salvage option for difficult colorectal conventional endoscopic submucosal dissection., Surgical endoscopy, 2024
  13. ★, No significant association between non-Helicobacter pylori Helicobacter infection with gastritis-related indices and gastric cancer, AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 366(6), 421-429, 202312
  14. ★, The Anti-Tumor Effect of the Newly Developed LAT1 Inhibitor JPH203 in Colorectal Carcinoma, According to a Comprehensive Analysis, CANCERS, 15(5), 202303
  15. ★, Comprehensive Analysis of Gene Expression Profiling to Explore Predictive Markers for Eradication Therapy Efficacy against Helicobacter pylori-Negative Gastric MALT Lymphoma, CANCERS, 15(4), 202302
  16. ★, Diagnostic performance of the normal range of gastrin calculated using strict criteria based on a combination of serum markers and pathological evaluation for detecting gastritis: a retrospective study., BMC gastroenterology, 23(1), 2023
  17. ★, Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient., Clinical journal of gastroenterology, 2023
  18. Anti-tumor necrosis factor-alpha monoclonal antibody suppresses colorectal cancer growth in an orthotopic transplant mouse model., PloS one, 18(3), 2023
  19. Efficacy of the specialized scissor-type knife for gastric endoscopic submucosal dissection: a propensity score matched retrospective study., Endoscopy international open, 11(4), 2023
  20. Endoscopic findings suggestive of a high risk of non-radical cure after definitive chemoradiotherapy for cT1bN0M0 esophageal squamous cell carcinoma., Esophagus : official journal of the Japan Esophageal Society, 20(3), 2023
  21. Disease surveillance evaluation of primary small-bowel follicular lymphoma using capsule endoscopy images based on a deep convolutional neural network (with video)., Gastrointestinal endoscopy, 98(6), 2023
  22. Investigating the Role of Tumor-Infiltrating Lymphocytes as Predictors of Lymph Node Metastasis in Deep Submucosal Invasive Colorectal Cancer: A Retrospective Cross-Sectional Study., Cancers, 15(21), 2023
  23. Outcomes of endoscopic submucosal dissection in patients who develop metachronous superficial esophageal squamous cell carcinoma close to a post-endoscopic submucosal dissection scar., Esophagus : official journal of the Japan Esophageal Society, 20220802
  24. Predictive factors for the progression of primary localized stage small-bowel follicular lymphoma., Journal of gastroenterology, 20220713
  25. Investigation of endoscopic findings in nine cases of Helicobacter suis-infected gastritis complicated by gastric mucosa-associated lymphoid tissue lymphoma., Helicobacter, 20220627
  26. ★, Identification of Helicobacter pylori-related gastric cancer risk using serological gastritis markers and endoscopic findings: a large-scale retrospective cohort study., BMC gastroenterology, 22(1), 20220620
  27. Promoting mechanism of serum amyloid a family expression in mouse intestinal epithelial cells., PloS one, 17(3), 20220318
  28. ★, Serum Gastrin and Pepsinogen Levels after Administration of Acid Secretion Inhibitors for Ulcers due to Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer., Gastroenterology research and practice, 2022, 20220128
  29. Anti-Programmed Cell Death-1 Antibody and Dasatinib Combination Therapy Exhibits Efficacy in Metastatic Colorectal Cancer Mouse Models., Cancers, 14(24), 2022
  30. Characteristics and Treatment Outcomes of Small-bowel Angioectasia in Systemic Sclerosis Patients: A Retrospective Observational Study., Internal medicine (Tokyo, Japan), 20210824
  31. Role of tumor-associated macrophages at the invasive front in human colorectal cancer progression, Cancer Science, 112(7), 2692-2704, 20210701
  32. ★, Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALT lymphoma pathogenesis and efficacy of eradication therapy, Gastric Cancer, 24(4), 937-945, 20210701
  33. Mesenchymal stem cells induce tumor stroma formation and epithelial-mesenchymal transition through SPARC expression in colorectal cancer, Oncology Reports, 45(6), 20210601
  34. Gastric mucosa-associated lymphoid tissue lymphoma in conjunction with multiple lymphomatous polyposis in the context of Helicobacter pylori and Helicobacter suis superinfection, Clinical Journal of Gastroenterology, 14(2), 478-483, 20210401
  35. Stromal reaction inhibitor and immune-checkpoint inhibitor combination therapy attenuates excluded-type colorectal cancer in a mouse model, Cancer Letters, 498, 111-120, 20210201
  36. Association between Helicobacter suis infection and the pathogenesis of gastric mucosa-associated lymphoid tissue lymphoma, Hiroshima Journal of Medical Sciences, 69(2), 33-37, 20200601
  37. Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission, BMC Gastroenterology, 20(1), 20200403
  38. ★, Helicobacter suis infection is associated with nodular gastritis-like appearance of gastric mucosa-associated lymphoid tissue lymphoma, Cancer Medicine, 8(9), 4370-4379, 20190801
  39. Unusual complication of frailty: Superior mesenteric artery syndrome, Internal Medicine, 58(14), 2119-2120, 20190101
  40. Watch-and-wait policy versus rituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma, Journal of Gastroenterology and Hepatology (Australia), 33(8), 1461-1468, 20180801
  41. Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer, Translational Oncology, 11(3), 575-584, 20180601
  42. ★, Mesenchymal Stem Cells Induce Epithelial to Mesenchymal Transition in Colon Cancer Cells through Direct Cell-to-Cell Contact, Neoplasia (United States), 19(5), 429-438, 20170501
  43. ★, Multikinase inhibitor regorafenib inhibits the growth and metastasis of colon cancer with abundant stroma, Cancer Science, 107(5), 601-608, 20160501
  44. A case of primary peritoneal carcinoma with gastric metastasis that was diagnosed by endosonography-guided fine needle aspiration, Gastroenterological Endoscopy, 55(11), 3562-3567, 20131101
  45. A case of acute hepatitis C with hepatitis C virus (HCV) genotype 3A -discussion of IL28-B-, Acta Hepatologica Japonica, 54(2), 120-127, 20130101

Invited Lecture, Oral Presentation, Poster Presentation

  1. CLINICOPATHOLOGICAL FEATURES AND SERUM RISK MARKERS OF METACHRONOUS GASTRIC CANCER AFTER ERADICATION, Teshima H, Kotachi T, Takemoto H, Tamari H, Tsuboi A, Tanaka H, Yamashita K, Yuge R, Takigawa H, Urabe Y, Oka S, 31th United European Gastroenterology Week (UEGW) 2023, 2023/10/12, Without Invitation, Japanese
  2. LONG-TERM OUTCOMES OF PATIENTS WITH OBSCURE GASTROINTESTINAL BLEEDING AFTER NEGATIVE CAPSULE ENDOSCOPY​​​​, Hirata I, Tsuboi A, Matsubara Y, Sumioka A, Takasago T, Tanaka H, Yamashita K, Takigawa H, Kotachi T, Yuge R, Urabe Y, Oka S, 31th United European Gastroenterology Week (UEGW) 2023, 2023/10/12, Without Invitation, Japanese
  3. CLINICAL FEATURES AND PROGNOSIS OF SPORADIC NEOPLASIAS DETECTED IN ULCERATIVE COLITIS PATIENTS, Yamamoto N, Yamashita K, Takehara Y, Morimoto S, Tanino F, Kamigaichi Y, Tanaka H, Takigawa H, Yuge R, Urabe Y, Shimamoto F, Oka S, 31th United European Gastroenterology Week (UEGW) 2023, 2023/10/12, Without Invitation, Japanese
  4. OUTCOMES OF ESD IN EARLY GASTRIC CANCER PATIENTS WITH ADVANCED MALIGNANT TUMORS OF OTHER ORGANS, Takemoto H, Kotachi T, Teshima H, Tamari H, Tsuboi A, Tanaka H, Yamashita K, Takigawa H, Yuge R, Urabe Y, Oka S, 31th United European Gastroenterology Week (UEGW) 2023, 2023/10/12, Without Invitation, Japanese
  5. FOXP3+ T-CELLS AS PREDICTORS OF LYMPH NODE METASTASIS IN T1B COLORECTAL CANCER, Tamari H, Kitadai Y, Tanaka H, Tsuboi A, Yamashita K, Kotachi T, Takigawa H, Yuge R, Urabe Y, Oka S, 31th United European Gastroenterology Week (UEGW) 2023, 2023/10/12, Without Invitation, Japanese
  6. EVALUATION FOR DISEASE SURVEILLANCE OF PRIMARY SMALL-BOWEL FOLLICULAR LYMPHOMA IN CAPSULE ENDOSCOPY IMAGES BASED ON A DEEp CONVOLUTIONAL NEURAL NETWORK: A PILOT STUDY, Sumioka A, Tsuboi A, Matsubara Y, Hirata I, Takigawa H, Yuge R, Tada T, Oka S, 31th United European Gastroenterology Week (UEGW) 2023, 2023/10/12, Without Invitation, Japanese
  7. EFFECTS OF THE NEWLY DEVELOPED LARGE NEUTRAL AMINO ACID TRANSPORTER1 INHIBITOR, JPH203 ON TUMOR MICROENVIRONMENT IN COLORECTAL CANCER, Otani R, Takigawa H, Ariyoshi M, Shimizu D, Miyamoto R, Hiyama Y, Yuge R, Urabe Y, Ishikawa A, Kitadai Y, Oka S, 31th United European Gastroenterology Week (UEGW) 2023, 2023/10/12, Without Invitation, Japanese
  8. Clinicopathological features of metachronous gastric cancer after eradication, Teshima H, Kotachi T, Oka S, Takemoto H, Tamari H, Tanaka H, Tsuboi A, Hiyama Y, Yamashita K, Takigawa H, Yuge R, Hayashi R, Urabe Y, Oue N, Tanaka S, International Gastric Cancer Congress (IGCC) 2023, 2023/06/14, Without Invitation, Japanese
  9. CLINICOPATHOLOGICAL CHARACTERISTICS OF EARLY GASTRIC CANCER DISCOVERED AFTER HELICOBACTER PYLORI ERADICATION IN RELATION TO THE PERIOD AFTER ERADICATION AND HISTOLOGICAL TYPE, Teshima H, Kotachi T, Oka S, Mizuno J, Tamari H, Fukuhara M, Abudwaili M, Tanaka H, Tsuboi A, Yamashita K, Takigawa H, Yuge R, Hayashi R, Urabe Y, Ito M, Kitadai Y, Arihiro K, Tanaka S., American Society for Gastrointestinal Endoscopy (ASGE), DDW2022, 2022/05/21, Without Invitation, Japanese
  10. INDICATIONS OF A DENTAL FLOSS CLIP TRACTION DURING GASTRIC ENDOSCOPIC SUBMUCOSAL DISSECTION PERFORMED BY LESS-EXPERIENCED ENDOSCOPISTS, Tamari H, Oka S, Kotachi T, Teshima H, Tanaka H, Tsuboi A, Yamashita K, Takigawa H, Yuge R, Urabe Y, Tanaka S., American Society for Gastrointestinal Endoscopy (ASGE), DDW2022, 2022/05/21, Without Invitation, Japanese
  11. Evaluation of therapeutic efficacy of primary small-bowel follicular lymphoma using artificial intelligence system of capsule endoscopy: a pilot study, Sumioka A, Oka S, Tsuboi A, Hirata I, Iio S, Takigawa H, Yuge R, Tada T, Tanaka S., ENDO2022 (The 3rd World Congress of GI Endoscopy), 2022/05/13, Without Invitation, Japanese
  12. Efficacy of scissor type knife specialized for gastric endoscopic submucosal dissection, Tamari H, Oka S, Kotachi T, Teshima H, Tanaka H, Tsuboi A, Yamashita K, Takigawa H, Yuge R, Urabe Y, Arihiro K, Tanaka S., ENDO2022 (The 3rd World Congress of GI Endoscopy), 2022/05/13, Without Invitation, Japanese
  13. Predictive factors for esophageal stenosis in patients with the preventive administered steroids after endoscopic submucosal resection for esophageal squamous cell carcinoma, Mizuno J, Urabe Y, Oka S, Fukuhara M, Tanaka H, Tsuboi A, Yamashita K, Hiyama Y, Kotachi T, Takigawa H, Yuge R, Hayashi R, Tanaka S., ENDO2022 (The 3rd World Congress of GI Endoscopy), 2022/05/13, Without Invitation, Japanese
  14. Outcomes of Endoscopic Polidocanol Injection Therapy for Small-bowel Angioectasia in Systemic Sclerosis Patients, Iio S, Oka S, Sumioka A, Tsuboi A, Hiyama Y, Yamashita K, Kotachi T, Takigawa H, Yuge R, Urabe Y, Tanaka S., Asian Pacific Digestive Week (APDW) 2021, 2021/08/19, Without Invitation, English
  15. Expression of SPARC is associated with poor prognosis in human colorectal cancer, Toshikatsu Naito, Yasuhiko Kitadai, Hidehiko Takigawa, Ryo Yuge, Toshio Kuwai, Wataru Yasui, Shinji Tanaka, Kazuaki Chayama, Annual meeting of the Japanese Cancer Association, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2024/04/01, 2027/03/31
  2. Nozomi H Foundation, subsidy for the promotion of cancer treatment research, Exploring the potential of oral diabetic drugs, SGLT family inhibitors, as anti-tumor agents, 2023/02/01, 2025/01/31
  3. 2021/04/01, 2024/03/31
  4. 2020/04/01, 2021/03/31

Social Activities

History as Peer Reviews of Academic Papers

  1. 2024, Cancer Science, Others, reviewer, 1
  2. 2023, Heliyon, Others, reviewer, 1
  3. 2023, Journal of Cancer Research and Clinical Oncology, Others, reviewer, 1
  4. 2023, Cancer Cell International, Others, reviewer, 1
  5. 2023, Cancer Medicine, Others, reviewer, 2
  6. 2023, Cancers, Others, reviewer, 2
  7. 2023, Diagnostics, Others, reviewer, 2
  8. 2023, International Journal of Molecular Sciences, Others, reviewer, 2
  9. 2022, Internal Medicine, Others, reviewer, 1
  10. 2022, Diagnostics, Others, reviewer, 2
  11. 2022, Cancers, Others, reviewer, 2
  12. 2022, Cancers, Others, reviewer, 1
  13. 2022, Cancers, Others, reviewer, 2
  14. 2021, International Journal of Hematology, Others, reviewer, 1