HIRONOBU HAMADA
Last Updated :2025/02/04
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Health Sciences), Professor
- E-mail
- hirohamada
hiroshima-u.ac.jp
- Self-introduction
- I performed basic and clinical researches for refractory pulmonary diseases such as interstitial pneumonia and lung cancer. In addition, I performed clinical researches for pulmonary rehabilitation collaborated with several hospitals.
Basic Information
Academic Degrees
- Doctor of Philosophy in Medical Science, Ehime University
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Health Sciences : Physical Therapy
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences
Research Fields
- Complex systems;Biomedical engineering;Rehabilitation science / Welfare engineering
Educational Activity
Course in Charge
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
- 2024, Graduate Education (Master's Program) , First Semester, Lecture on Physical Analysis and Therapeutic Sciences
- 2024, Graduate Education (Master's Program) , First Semester, Seminar on Physical Analysis and Therapeutic Sciences
- 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Physical Analysis and Therapeutic Sciences
- 2024, Graduate Education (Master's Program) , Year, Research on Physical Analysis and Therapeutic Sciences
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Physical Analysis and Therapeutic Sciences
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physical Analysis and Therapeutic Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physical Analysis and Therapeutic Sciences
- 2024, Liberal Arts Education Program1, 4Term, Human health and the society
- 2024, Undergraduate Education, Intensive, Practice of Medicine I
- 2024, Undergraduate Education, Intensive, Practice of Medicine II
- 2024, Undergraduate Education, Second Semester, Graduation Theses
- 2024, Undergraduate Education, First Semester, Internal medicine Ⅰ
- 2024, Undergraduate Education, Second Semester, Internal medicine II
- 2024, Undergraduate Education, First Semester, Rehabilitation for internal disorders
- 2024, Undergraduate Education, Second Semester, Practice in rehabilitation for internal disorders
- 2024, Undergraduate Education, 2Term, Introduction to Rehabilitation Science
- 2024, Undergraduate Education, 2Term, Introduction to Rehabilitation Science
- 2024, Undergraduate Education, 1Term, Sports Medicine
- 2024, Undergraduate Education, First Semester, Internal medicine Ⅰ
- 2024, Undergraduate Education, Second Semester, Internal medicine II
- 2024, Undergraduate Education, First Semester, Rehabilitation for internal disorders
- 2024, Graduate Education (Doctoral Program) , Year, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
- 2024, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
- 2024, Graduate Education (Master's Program) , First Semester, Advanced Lecture on Health Science 3(Experiment Research)
Research Activities
Academic Papers
- Intestinal overgrowth of Candida albicans exacerbates bleomycin-induced pulmonary fibrosis in mice with dysbiosis, JOURNAL OF PATHOLOGY, 261(2), 227-237, 202310
- Hypoxia-inducible factor 1ホア modulates interstitial pneumonia-mediated lung cancer progression, JOURNAL OF TRANSLATIONAL MEDICINE, 21(1), 20231127
- Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells, CELL COMMUNICATION AND SIGNALING, 21(1), 20230921
- Exhaled Nitric Oxide and Olfactory Dysfunction in Patients with Asthma: Association with Chronic Rhinosinusitis, MEDICINA-LITHUANIA, 59(10), 202310
- Effect of Dupilumab in a Patient With Severe Asthma Complicated With Recurrent Anaphylaxis: A Case Report, JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 33(3), 230-232, 2023
- Clinical characteristics of extrapulmonary nontuberculous mycobacteria infections in comparison with pulmonary infections: A single-center, retrospective study in Japan, JOURNAL OF INFECTION AND CHEMOTHERAPY, 29(9), 875-881, 202309
- Serum and bronchoalveolar lavage fluid levels of soluble B7H3 in patients with interstitial lung diseases, RESPIRATORY MEDICINE, 212, 202306
- Predictive value of serum high-mobility group box 1 levels for checkpoint inhibitor pneumonitis, RESPIROLOGY, 28(4), 380-388, 202304
- Preserved ratio impaired spirometry with or without restrictive spirometric abnormality, SCIENTIFIC REPORTS, 13(1), 20230220
- Association between Plasminogen Activator Inhibitor-1 and Osimertinib Tolerance in EGFR-Mutated Lung Cancer via Epithelial-Mesenchymal Transition, CANCERS, 15(4), 202302
- Association of the RAGE/RAGE-ligand axis with interstitial lung disease and its acute exacerbation, RESPIRATORY INVESTIGATION, 60(4), 531-542, 202207
- Effects of L-Arginine on impaired blood fluidity after high-intensity exercise: An in vitro evaluation, Clinical Hemorheology and Microcirculation, 82(1), 1-12, 2022
- Association Between Patient Preference for Inhaler Medications and Asthma Outcomes, JOURNAL OF ASTHMA AND ALLERGY, 15, 1539-1547, 2022
- Predictive role of circulatory levels of high-mobility group box 1 for radiation pneumonitis in patients with non-small cell lung cancer treated with definitive thoracic radiotherapy, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27(11), 1698-1705, 202211
- Hochuekkito Combined with Pulmonary Rehabilitation in Apathetic Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Pilot Trial, JOURNAL OF CLINICAL MEDICINE, 11(19), 202210
- Possible Therapeutic Utility of anti-Cell Adhesion Molecule 1 Antibodies for Malignant Pleural Mesothelioma, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, 20220712
- Effects of soy protein isolate and soy peptide preload on gastric emptying rate and postprandial glycemic control in healthy humans, JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY, 41(1), 20220627
- Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer, BMC PULMONARY MEDICINE, 22(1), 20220630
- Role of Soluble Receptor for Advanced Glycation End Products in Postoperative Fibrotic Lung Injury, ANNALS OF THORACIC SURGERY, 113(5), 1617-1623, 202205
- Accelerated decline in lung function in adults with a history of remitted childhood asthma, EUROPEAN RESPIRATORY JOURNAL, 59(1), 20220101
- Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer, CANCER SCIENCE, 112(1), 369-379, 202101
- Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma, CLINICAL RESPIRATORY JOURNAL, 15(1), 48-55, 202101
- Concomitant emphysema might increase the false-negative rate of urinary antigen tests in patients with pneumococcal pneumonia: results from a retrospective study, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 40(4), 871-877, 202104
- Autoantibody Positivity Is a Risk Factor for Chemotherapy-induced Exacerbation of Interstitial Pneumonia in Lung Cancer, ANTICANCER RESEARCH, 41(3), 1497-1506, 202103
- Prognostic Significance of EGFR Gene Mutation in Patients With EGFR Mutated Non-small Cell Lung Cancer Who Received Best Supportive Care Alone, ANTICANCER RESEARCH, 41(5), 2661-2667, 202105
- Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients, SCIENTIFIC REPORTS, 11(1), 20210512
- Risk factors associated with increased discontinuation rate of trimethoprim-sulfamethoxazole used as a primary prophylaxis for Pneumocystis pneumonia: A retrospective cohort study, PULMONARY PHARMACOLOGY & THERAPEUTICS, 67, 202104
- A machine-learning based approach to quantify fine crackles in the diagnosis of interstitial pneumonia A proof-of-concept study, MEDICINE, 100(7), 20210219
- IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis, PLOS ONE, 16(6), 20210604
- Quantitative parameters of lymphocyte nuclear morphology in bronchoalveolar lavage fluid as novel biomarkers for sarcoidosis, ORPHANET JOURNAL OF RARE DISEASES, 16(1), 20210703
- Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity, STEM CELL RESEARCH & THERAPY, 12(1), 20210823
- Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis, STEM CELL RESEARCH & THERAPY, 12(1), 20210916
- Analysis of microRNA Expression in Liquid-Based Cytology Samples May Be Useful for Primary Lung Cancer Diagnosis, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 156(4), 644-652, 202110
- Association between glucose intolerance and chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 88(5), 857-865, 202111
- Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 25(1), 74-81, 202001
- Treatment rationale and design of the PROLONG study: safety and efficacy of pembrolizumab as first-line therapy for elderly patients with non-small cell lung cancer, JOURNAL OF THORACIC DISEASE, 12(3), 1079-1084, 202003
- Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25(3), 275-280, 202003
- Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21(1), 20200611
- Serum high-mobility group box 1 as a predictive marker for cytotoxic chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease, RESPIRATORY MEDICINE, 172, 202010
- Extent of pulmonary fibrosis on high-resolution computed tomography is a prognostic factor in patients with pleuroparenchymal fibroelastosis, RESPIRATORY INVESTIGATION, 58(6), 465-472, 202011
- Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers, JAMA NETWORK OPEN, 3(11), 20201112
- Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442, 31-39, 2019
- High preoperative C-reactive protein level is a risk factor for acute exacerbation of interstitial lung disease after non-pulmonary surgery, MEDICINE, 98(5), 201902
- Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma A case report, MEDICINE, 98(12), 201903
- L-cysteine improves blood fluidity impaired by acetaldehyde: In vitro evaluation, PLOS ONE, 14(3), 20190329
- Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 23(4), 2984-2994, 201904
- Performance Status Is a Risk Factor for Depression before the Diagnosis of Lung Cancer Patients, INTERNAL MEDICINE, 58(7), 915-920, 2019
- Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress, FREE RADICAL BIOLOGY AND MEDICINE, 136, 52-59, 20190520
- Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia, RESPIRATORY MEDICINE, 152, 44-50, 201906
- Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer, RESPIRATORY INVESTIGATION, 57(5), 451-459, 201909
- C-C Motif Chemokine Ligand 15 May Be a Useful Biomarker for Predicting the Prognosis of Patients with Chronic Hypersensitivity Pneumonitis, RESPIRATION, 98(3), 212-220, 201909
- Chemotherapy-associated Acute Exacerbation of Interstitial Lung Disease Shortens Survival Especially in Small Cell Lung Cancer, ANTICANCER RESEARCH, 39(10), 5725-5731, 201910
- Non-small Cell Lung Cancer Treated by an Anti-programmed Cell Death-1 Antibody without a Flare-up of Preexisting Granulomatosis with Polyangiitis, INTERNAL MEDICINE, 58(21), 3129-3132, 2019
- Baseline High-Resolution CT Findings Predict Acute Exacerbation of Idiopathic Pulmonary Fibrosis: German and Japanese Cohort Study, JOURNAL OF CLINICAL MEDICINE, 8(12), 201912
- The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81(1), 131-139, 201801
- Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119, 21-24, 201805
- Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51(5), 20180501
- Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32(5), 1155-1160, 2018
- Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18(8), 1215-1218, 201808
- Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 698-706, 20180907
- Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(4), 3070-3076, 201810
- Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9(5), 539-544, 201811
- Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(6), 5236-5242, 201812
- Posture and firmness changes in a pressure-relieving air mattress affect cough strength in elderly people with dysphagia, PLOS ONE, 13(12), 20181211
- Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97(49), 201812
- The effect of body weight support on predicted locomotive physical
activity, The Journal of Physical Therapy Science, 30, 759-763, 2018
- FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123, 105-109, 201702
- MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study, BMC CANCER, 17, 20170412
- Central command increases muscular oxygenation of the non-exercising arm at the early period of voluntary one-armed cranking, PHYSIOLOGICAL REPORTS, 5(7), 201704
- Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106, 1-9, 201705
- AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22(5), 965-971, 201707
- Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18, 20170818
- CLINICAL AND MOLECULAR FEATURES OF RAPIDLY PROGRESSIVE CHRONIC HYPERSENSITIVITY PNEUMONITIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 34(1), 48-57, 2017
- Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease, Oxidants and Antioxidants in Medical Science, 6, 19-24, 2017
- Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56(19), 2627-2631, 2017
- AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8(55), 94382-94392, 20171107
- Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56(24), 3327-3331, 2017
- Effect of Different Levels of Pressure Relieving Air-Mattress Firmness on Cough Strength, PLOS ONE, 11(1), 20160107
- Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11(2), 20160209
- Cardiac parasympathetic outflow during dynamic exercise in humans estimated from power spectral analysis of P-P interval variability, EXPERIMENTAL PHYSIOLOGY, 101(3), 397-409, 20160301
- The effect of exercise on blood fluidity: Use of the capillary model to assess the clogginess of blood, CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 61(4), 559-569, 2016
- Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
- Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28(8), 343-348, 201607
- Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76(11), 3285-3294, 20160601
- Oxidative stress induced by smoking and exercise., International Journal of Medical and Biological Frontiers, 22, 203-213, 2016
- Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients, DRUG DESIGN DEVELOPMENT AND THERAPY, 8, 1211-1219, 2014
- Phase II trial of S-1 as third-line or further chemotherapy in patients with advanced non-small-cell lung cancer, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 19(6), 1005-1010, 201412
- Phase-dependent modulation of corticospinal excitability during the observation of the initial phase of gait, SOMATOSENSORY AND MOTOR RESEARCH, 31(4), 209-213, 201412
- Cigarette smoking does not induce plasma or pulmonary oxidative stress
after moderate-intensity exercise., JOURNAL OF PHYSICAL THERAPY SCIENCE, 26, 413-415, 2014
- Differential contribution of ACh-muscarinic and b-adrenergic receptors to vasodilatation in noncontracting muscle during voluntary one-legged excercise., PHYSIOLOGICAL REPORTS, 2, e12202, 2014
- Characteristics of Patients with Severe Heart Failure Exhibiting Exercise Oscillatory Ventilation, CLINICAL AND EXPERIMENTAL HYPERTENSION, 35(4), 267-272, 2013
- Evidence for centrally-induced cholinergic vasodilatation in skeletal muscle during voluntary one-legged cycling and motor imagery in humans, PHYSIOLOGICAL REPORTS, 1(4), 20130901
- EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy, CANCER CELL INTERNATIONAL, 13, 20130223
- Plasma oxidative stress is induced by single-sprint anaerobic exercise in young cigarette smokers, CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, 33(3), 241-244, 201305
- Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis, DRUG DESIGN DEVELOPMENT AND THERAPY, 7, 305-316, 2013
- Pulmonary Oxidative Stress Is Induced by Maximal Exercise in Young Cigarette Smokers, NICOTINE & TOBACCO RESEARCH, 14(2), 243-247, 201202
- Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer, INTERNATIONAL JOURNAL OF CANCER, 130(2), 377-387, 20120115
- The evaluation of the internal quality control of respiratory function tests, 37(3), 287-292, 20120601
- Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo, INTERNATIONAL JOURNAL OF ONCOLOGY, 41(2), 449-456, 201208
- Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma, INTERNATIONAL JOURNAL OF ONCOLOGY, 41(5), 1610-1618, 201211
- Attenuation of the Muscle Metaboreflex in Patients with Type 2 Diabetes, JOURNAL OF PHYSICAL THERAPY SCIENCE, 24(8), 721-724, 201209
- Antitussive effect of bakumondoto a fixed kampo medicine (six herbal components) for treatment of post-infectious prolonged cough: Controlled clinical pilot study with 19 patients, PHYTOMEDICINE, 18(8-9), 630-633, 20110615
- Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease, RESPIRATORY RESEARCH, 12, 20110726
Publications such as books
- 2014, Acute Lung Injury: Epidemiology, Health Effects and Therapeutic Treatment Strategies., Pharmacological therapies for acute respiratory distress syndrome., Nova Science Publishers, 2014, Scholarly Book, Single work, Hironobu Hamada
- 2013, Handbook on Reactive oxygen species (ROS): formation mechanisms, physiological roles and common harmful effects, Oxidative stress in lungs and blood induced by smoking and exercise, Nova Science Publishers, 2013, Scholarly Book, Joint work, Taito S, Hamada H