KAZUAKI TAGUCHI

Last Updated :2025/06/14

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
taguakihiroshima-u.ac.jp

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Research Practice A
  2. 2025, Undergraduate Education, Second Semester, Research Practice B
  3. 2025, Undergraduate Education, 1Term, Clinical Medicine and Pharmacotherapy I
  4. 2025, Undergraduate Education, 2Term, Pharmacoeconomics
  5. 2025, Undergraduate Education, 3Term, Clinical Evaluation
  6. 2025, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  7. 2025, Undergraduate Education, 3Term, Pharmacy Practice
  8. 2025, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  9. 2025, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  10. 2025, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  11. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  12. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  13. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  14. 2025, Graduate Education (Doctoral Program) , 4Term, Pharmacotherapeutic Research
  15. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Clinical Pharmacotherapy
  16. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Clinical Pharmacotherapy
  17. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Clinical Pharmacotherapy
  18. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Clinical Pharmacotherapy
  19. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacotherapy
  20. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacotherapy
  21. 2025, Graduate Education (Master's Program) , First Semester, Research on Pharmacotherpeutic Research
  22. 2025, Graduate Education (Master's Program) , Second Semester, Research on Pharmacotherpeutic Research

Research Activities

Academic Papers

  1. Development and validation of a population pharmacokinetic model of vancomycin for patients of advanced age, Journal of Pharmaceutical Health Care and Sciences, 11(1), 20251201
  2. Combined dual β-lactams and diazabicyclooctane β-lactamase inhibitor is highly effective against Mycobacterium abscessus species in vitro, Journal of Global Antimicrobial Resistance, 42, 142-150, 20250501
  3. Influence factors of metronidazole-related CNS disorders: an analysis of the Japan adverse drug event report and FDA adverse event reporting system, Expert Opinion on Drug Safety, 20250101
  4. Direct comparison of the effects of first- and second-generation H1-receptor blockers on motor functions in mice, Pharmazie, 80(1), 24-28, 20250301
  5. Methemoglobin-Encapsulating Liposome: A Low-Risk Intravascular Contrast Agent for Magnetic Resonance Imaging, ACS Applied Bio Materials, 8(4), 2838-2846, 20250421
  6. Shortening the interval between the first and the second dose of vancomycin facilitates rapid achievement of the target AUC without increasing the risk of acute kidney injury, provided the AUC on the second day is appropriately controlled: a multicenter retrospective study, Journal of Pharmaceutical Health Care and Sciences, 11(1), 20251201
  7. Carbon monoxide-loaded cell therapy as an exercise mimetic for sarcopenia treatment, Free Radical Biology and Medicine, 220, 67-77, 20240801
  8. Predictive Value of Vancomycin AUC24/MIC Ratio for 30-day Mortality in Patients with Severe or Complicated Methicillin-Resistant Staphylococcus aureus Infections: A Multicenter Retrospective Study, Pharmaceutical Research, 41(7), 1381-1389, 20240701
  9. Relationship between nephrotoxicity and area under the concentration-time curve of vancomycin in critically ill patients: a multicenter retrospective study, Microbiology Spectrum, 12(7), 20240701
  10. SARS-CoV-2 mRNA vaccine-related myocarditis and pericarditis: An analysis of the Japanese Adverse Drug Event Report database, Journal of Infection and Chemotherapy, 31(1), 20250101
  11. T-cell immunosuppression in sepsis is augmented by sciatic denervation-induced skeletal muscle atrophy, FEBS Letters, 598(20), 2581-2591, 20241001
  12. Flowchart for predicting achieving the target area under the concentration-time curve of vancomycin in critically ill Japanese patients: A multicenter retrospective study, Journal of Infection and Chemotherapy, 30(4), 329-336, 20240401
  13. Oral teicoplanin administration suppresses recurrence of Clostridioides difficile infection: Proof of concept, Anaerobe, 84, 20231201
  14. Polysarcosine-Coated liposomes attenuating immune response induction and prolonging blood circulation, Journal of Colloid and Interface Science, 651, 273-283, 20231201
  15. Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs, Scientific Reports, 13(1), 20231201
  16. The anti-inflammatory effect of tedizolid on carrageenan-induced footpad edema rat model, Journal of Infection and Chemotherapy, 29(11), 1088-1090, 20231101
  17. Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation, Redox Biology, 76, 20241001
  18. Pharmaceutical stability of methemoglobin-albumin cluster as an antidote for hydrogen sulfide poisoning after one-year storage in freeze-dried form, International Journal of Pharmaceutics, 645, 20231015
  19. Antimicrobial Stewardship of Oral Third-Generation Cephalosporins in Community Pharmacy: A Single-Center Quasi-Experimental Study, Biological and Pharmaceutical Bulletin, 47(8), 1447-1451, 20240801
  20. Identification of Patients Who Require Two-Point Blood Sampling for the Peak and Trough Values Rather Than One-Point Blood Sampling for the Trough Value for the Evaluation of AUC of Vancomycin Using Bayesian Estimation, Pharmaceutical Research, 41(11), 2161-2171, 20241101
  21. Hydrosulphide-methaemoglobin-albumin cluster: a hydrogen sulphide donor, Journal of Materials Chemistry B, 12(44), 11515-11522, 20241014
  22. Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice, Journal of Pharmaceutical Health Care and Sciences, 10(1), 20241201
  23. One-Step Maleimide-Based Dual Functionalization of Protein N-Termini, Angewandte Chemie International Edition, 64(5), 20250127
  24. Simulated achievement rate of β-lactams/nacubactam treatment in humans using instantaneous MIC-based PK/PD analysis, Journal of Antimicrobial Chemotherapy, 80(2), 547-553, 20250201
  25. Treatment success prediction in patients with methicillin-resistant coagulase-negative staphylococci infections, using vancomycin AUC24/MIC ratio: a multicentre retrospective cohort study, Journal of Antimicrobial Chemotherapy, 80(2), 538-546, 20250201
  26. Development of a pharmacokinetic/pharmacodynamic evaluation model for osteomyelitis and usefulness of tedizolid as an alternative to vancomycin against MRSA osteomyelitis, Journal of Pharmacy and Pharmacology, 77(2), 291-298, 20250201
  27. Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model, Life Sciences, 91(11-12), 420-428, 20121005
  28. Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats, Life Sciences, 91(25-26), 1304-1308, 20121217
  29. A reduced linezolid dosage maintains favorable efficacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureus-infected patient with renal insufficiency, Scandinavian Journal of Infectious Diseases, 45(1), 77-80, 20130101
  30. Carbon monoxide-bound red blood cells protect red blood cell transfusion-induced hepatic cytochrome P450 impairment in hemorrhagic-shock rats, Drug Metabolism and Disposition, 41(1), 141-148, 20130101
  31. A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease, FASEB Bioadvances, 5(10), 377-394, 20231001
  32. Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen g-chain dodecapeptide as a synthetic platelet substitutes, Drug Metabolism and Disposition, 41(8), 1584-1591, 20130801
  33. Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model, Journal of Pharmaceutical Sciences, 102(10), 3852-3859, 20130101
  34. Effect of albumin on transthyretin and amyloidogenic transthyretin Val30Met disposition and tissue deposition in familial amyloidotic polyneuropathy, Life Sciences, 93(25-26), 1017-1022, 20131218
  35. Fecal pharmacokinetics/pharmacodynamics characteristics of fidaxomicin and vancomycin against Clostridioides difficile infection elucidated by in vivo feces-based infectious evaluation models, Clinical Microbiology and Infection, 29(5), 616-622, 20230501
  36. Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis, Biomaterials, 35(24), 6553-6562, 20140101
  37. Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats, Journal of Pharmaceutical Sciences, 103(7), 2199-2206, 20140101
  38. An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta, Natural Product Research, 28(23), 2211-2213, 20141205
  39. Comparison of the efficacy and safety of standard- and high-dose daptomycin: A systematic review and meta-analysis, British Journal of Clinical Pharmacology, 89(4), 1291-1303, 20230401
  40. Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models, Journal of Pharmacology and Experimental Therapeutics, 352(2), 244-257, 20150101
  41. Cross-linked human serum albumin dimer has the potential for use as a plasma-retaining agent for the fatty acid-conjugated antidiabetic drugs, Journal of Pharmacy and Pharmacology, 67(2), 255-263, 20150101
  42. The G protein-coupled receptor ligand apelin-13 ameliorates skeletal muscle atrophy induced by chronic kidney disease, Journal of Cachexia Sarcopenia and Muscle, 14(1), 553-564, 20230201
  43. False tacrolimus concentrations measured by antibody-conjugated magnetic immunoassay in liver transplant patient: 2 case reports and literature review, Experimental and Clinical Transplantation, 12(5), 474-478, 20141001
  44. Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia, Molecular Pharmaceutics, 11(11), 4238-4248, 20140925
  45. Antioxidant and renoprotective activity of 2-hydroxypropyl-β-cyclodextrin in nephrectomized rats, Journal of Pharmacy and Pharmacology, 68(5), 608-614, 20160501
  46. Differences in Pharmacokinetic/Pharmacodynamic Parameters of Tedizolid Against VRE and MRSA, Pharmaceutical Research, 40(1), 187-196, 20230101
  47. Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants, Life Sciences, 134(1), 36-41, 20150101
  48. Direct radical scavenging activity of benzbromarone provides beneficial antioxidant properties for hyperuricemia treatment, Biological and Pharmaceutical Bulletin, 38(3), 487-492, 20150301
  49. SCIATIC DENERVATION-INDUCED SKELETAL MUSCLE ATROPHY IS ASSOCIATED WITH PERSISTENT INFLAMMATION AND INCREASED MORTALITY DURING SEPSIS, Shock, 59(3), 417-425, 20230301
  50. Safety Evaluation of Hemoglobin-Albumin Cluster "HemoAct" as a Red Blood Cell Substitute, Scientific Reports, 5, 20150729
  51. Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model, Journal of Pharmaceutical Sciences, 104(9), 3084-3091, 20150901
  52. Potential use of biological proteins for liver failure therapy, Pharmaceutics, 7(3), 255-274, 20150831
  53. Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis, BMC Pharmacology and Toxicology, 23(1), 20221201
  54. Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock, Biochemical Pharmacology, 97(3), 310-319, 20151001
  55. Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia, Journal of Pharmaceutical Sciences, 104(11), 3968-3976, 20151101
  56. Analysis of adverse drug events in pulmonary Mycobacterium avium complex disease using spontaneous reporting system, BMC Infectious Diseases, 22(1), 20221201
  57. Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model, Scientific Reports, 5, 20151016
  58. Biological responsiveness and metabolic performance of liposome-encapsulated hemoglobin (hemoglobin-vesicles) in apolipoprotein E-deficient mice after massive intravenous injection, Biological and Pharmaceutical Bulletin, 38(10), 1606-1616, 20151001
  59. Ceftazidime encephalopathy developed without the elevation of cerebrospinal fluid concentration of ceftazidime: A case report of two cases, Journal of Infection and Chemotherapy, 28(12), 1667-1671, 20221201
  60. Establishment of a model of acetaminophen-induced hepatotoxicity in different weekly-aged ICR mice, Laboratory Animals, 49(4), 294-301, 20151001
  61. In vitro effects of diazabicyclooctane β-lactamase inhibitors relebactam and nacubactam against three subspecies of Mycobacterium abscessus complex, International Journal of Antimicrobial Agents, 60(5-6), 20221101
  62. Influence of molecular structure on O2-binding properties and blood circulation of hemoglobin?albumin clusters, Plos One, 11(2), 20160201
  63. Oral fidaxomicin versus vancomycin for the treatment of Clostridioides difficile infection: A systematic review and meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 28(11), 1536-1545, 20221101
  64. Carbamazepine-imatinib interaction in a child with chronic myeloid leukemia, Pediatrics International, 56(4), e33-e36, 20140101
  65. Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations, Journal of Pharmaceutical Sciences, 105(3), 1043-1049, 20160301
  66. Efficacy of surgical skin preparation with chlorhexidine in alcohol according to the concentration required to prevent surgical site infection: Meta-Analysis, Bjs Open, 6(5), 20221001
  67. Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis, Journal of Controlled Release, 234, 49-58, 20160728
  68. Tyrosine411 and Arginine410 of Human Serum Albumin Play an Important Role in the Binding of Sodium 4-Phenylbutyrate to Site II, Journal of Pharmaceutical Sciences, 105(6), 1987-1994, 20160601
  69. Methemoglobin-albumin clusters for the treatment of hydrogen sulfide intoxication, Journal of Controlled Release, 349, 304-314, 20220901
  70. Long-term stored hemoglobin-vesicles, a cellular type of hemoglobin-based oxygen carrier, has resuscitative effects comparable to that for fresh red blood cells in a rat model with massive hemorrhage without post-transfusion lung injury, Plos One, 11(10), 20161001
  71. Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties, International Journal of Nanomedicine, 11, 5611-5620, 20161027
  72. Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning, Toxicology and Applied Pharmacology, 450, 20220901
  73. Locational analysis of glutathione in liposomes by using small-angle X-ray scattering, Chemistry Letters, 46(2), 185-187, 20170101
  74. The binding of silibinin, the main constituent of silymarin, to site i on human serum albumin, Biological and Pharmaceutical Bulletin, 40(3), 310-317, 20170101
  75. Structural and biological characterization of Fe3O4-loaded spherical and tubular liposomes for use in drug delivery systems, Japanese Journal of Applied Physics, 56(5), 20170501
  76. Exploring the Factors Affecting the Transferability of Vancomycin to Cerebrospinal Fluid in Postoperative Neurosurgical Patients with Bacterial Meningitis, Biological and Pharmaceutical Bulletin, 45(9), 1398-1402, 20220901
  77. Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin, Journal of Pharmaceutical Sciences, 106(9), 2860-2867, 20170901
  78. The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders, Journal of Pharmaceutical Sciences, 106(9), 2392-2400, 20170901
  79. Single-Step N-Terminal Modification of Proteins via a Bio-Inspired Copper(II)-Mediated Aldol Reaction, Chemistry A European Journal, 28(47), 20220822
  80. Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin, Plos One, 12(6), 20170601
  81. Albumin-Encapsulated Liposomes: A Novel Drug Delivery Carrier With Hydrophobic Drugs Encapsulated in the Inner Aqueous Core, Journal of Pharmaceutical Sciences, 107(1), 436-445, 20180101
  82. Recombinant human serum albumin containing 3 copies of domain I, Has significant in vitro antioxidative capacity compared to the wild-type, Biological and Pharmaceutical Bulletin, 40(10), 1813-1817, 20170101
  83. Pharmacokinetics studies of 4′-cyano-2′-deoxyguanosine, a potent inhibitor of the hepatitis B virus, in rats, Journal of Pharmacy and Pharmacology, 70(6), 723-731, 20180601
  84. Preparation and in vitro analysis of human serum albumin nanoparticles loaded with anthracycline derivatives, Chemical and Pharmaceutical Bulletin, 66(4), 382-390, 20180101
  85. Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites, Biochemistry and Biophysics Reports, 14, 155-160, 20180701
  86. Pharmacokinetic properties of a novel inosine analog, 40-cyano-20-deoxyinosine, after oral administration in rats, Plos One, 13(6), 20180601
  87. In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers, Journal of Drug Delivery Science and Technology, 47, 62-66, 20181001
  88. Trimethoxy Trityl Groups as a Potent Substituent for Anti-cancer Cytidine Analog Prodrugs, Journal of Pharmaceutical Sciences, 111(8), 2201-2209, 20220801
  89. Oral vancomycin versus metronidazole for the treatment of Clostridioides difficile infection: Meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 24(11), 907-914, 20181101
  90. Development of kupffer cell targeting type-i interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions, Drug Delivery, 25(1), 1067-1077, 20180424
  91. Influences of protein levels on the cerebrospinal fluid distribution of ceftazidime & ceftriaxone in the cerebrospinal fluid of patients with inflamed meningitis, Journal of Infection and Chemotherapy, 28(8), 1216-1219, 20220801
  92. Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity, Drug Delivery, 25(1), 1266-1274, 20180101
  93. Safety of nanoparticles based on albumin-polymer conjugates as a carrier of nucleotides for pancreatic cancer therapy, Journal of Materials Chemistry B, 6(39), 6278-6287, 20180101
  94. A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease, Redox Biology, 54, 20220801
  95. Benzbromarone attenuates oxidative stress in angiotensin II- and salt-induced hypertensive model rats, Oxidative Medicine and Cellular Longevity, 2018, 20180101
  96. Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure, ACS Omega, 3(10), 13790-13797, 20181022
  97. Target Therapeutic Ranges of Anti-MRSA Drugs, Linezolid, Tedizolid and Daptomycin, and the Necessity of TDM, Biological and Pharmaceutical Bulletin, 45(7), 824-833, 20220701
  98. Safety evaluation of cellular-type artificial blood based on pharmacokinetic analysis and its use in medical gas delivery, Yakugaku Zasshi, 138(11), 1381-1389, 20180101
  99. Pharmacokinetic and pharmacodynamic studies of pregabalin suppositories based on pharmacological research, Journal of Pharmacy and Pharmacology, 71(5), 746-752, 20190501
  100. Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin, Journal of Pharmaceutical Sciences, 108(5), 1890-1895, 20190501
  101. Investigation of anti-tumor effect of doxorubicin-loaded human serum albumin nanoparticles prepared by a desolvation technique, Cancer Chemotherapy and Pharmacology, 83(6), 1113-1120, 20190601
  102. Evaluation for optimal dosing of vancomycin in patients with different physical types, Journal of Infection and Chemotherapy, 25(9), 735-737, 20190901
  103. Preparation, Characterization, and in Vitro/in Vivo Evaluation of Paclitaxel-Bound Albumin-Encapsulated Liposomes for the Treatment of Pancreatic Cancer, ACS Omega, 4(5), 8693-8700, 20190517
  104. Experimental verification of factors influencing calcium salt formation based on a survey of the development of ceftriaxone-induced gallstone-related disorder, Journal of Infection and Chemotherapy, 25(12), 972-978, 20191201
  105. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats, Drug Metabolism and Disposition, 50(6), 822-826, 20220601
  106. α1-Acid Glycoprotein Has the Potential to Serve as a Biomimetic Drug Delivery Carrier for Anticancer Agents, Journal of Pharmaceutical Sciences, 108(11), 3592-3598, 20191101
  107. Age-associated theophylline metabolic activity corresponds to the ratio of 1,3-dimethyluric acid to theophylline in mice, Biological and Pharmaceutical Bulletin, 42(8), 1423-1427, 20190101
  108. Oxidized liposomal artificial red blood cells rescue azide-poisoned mice from lethal toxidrome by recovering cytochrome c oxidase activity, Journal of Drug Delivery Science and Technology, 71, 20220501
  109. Enhanced dissolution and oral bioavailability of praziquantel by emulsification with human serum albumin followed by spray drying, European Journal of Pharmaceutical Sciences, 139, 20191101
  110. Evaluation of the expression time of ganciclovir-induced adverse events using JADER and FAERS, Biological and Pharmaceutical Bulletin, 42(11), 1799-1804, 20190101
  111. Incidence of elevated creatine phosphokinase between daptomycin alone and concomitant daptomycin and statins: A systematic review and meta-analysis, British Journal of Clinical Pharmacology, 88(5), 1985-1998, 20220501
  112. Cell uptake and anti-tumor effect of liposomes containing encapsulated paclitaxel-bound albumin against breast cancer cells in 2D and 3D cultured models, Journal of Drug Delivery Science and Technology, 55, 20200201
  113. Support for fungal infection treatment mediated by pharmacist-led antifungal stewardship activities, Journal of Infection and Chemotherapy, 26(3), 272-279, 20200301
  114. Processing grapefruit juice with γ-cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity, Journal of Pharmacy and Pharmacology, 72(3), 356-363, 20200301
  115. Efficacy and Safety of Daptomycin versus Vancomycin for Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus with Vancomycin Minimum Inhibitory Concentration > 1 µg/mL: A Systematic Review and Meta-Analysis, Pharmaceutics, 14(4), 20220401
  116. The charm of protein for drug development, Yakugaku Zasshi, 140(2), 139-140, 20200201
  117. Strategy of drug development based on the bioactive gas-carrying capacity of hemoglobin, Yakugaku Zasshi, 140(2), 141-146, 20200201
  118. In Vitro and In Vivo Assessment of Atemoya Fruit (Annona atemoya) for Food–Drug Interactions, European Journal of Drug Metabolism and Pharmacokinetics, 47(2), 177-185, 20220301
  119. Carbon monoxide rescues the developmental lethality of experimental rat models of rhabdomyolysis-induced acute kidney injury, Journal of Pharmacology and Experimental Therapeutics, 372(3), 355-365, 20200301
  120. Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes, Journal of Controlled Release, 322, 209-216, 20200610
  121. Effects of arterial hemorrhage speed on the blood coagulation/fibrinolysis system and hemodynamics in rats, Blood Coagulation and Fibrinolysis, 31(3), 198-206, 20200401
  122. Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications, Current Medicinal Chemistry, 27(18), 2949-2963, 20200101
  123. Methemoglobin-albumin clusters for cyanide detoxification, Toxicology and Applied Pharmacology, 466, 20230501
  124. In vivo evaluation of drug dialyzability in a rat model of hemodialysis, Plos One, 15(6), 20200601
  125. Echinocandins versus non-echinocandins for the treatment of invasive candidiasis: A meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 26(11), 1164-1176, 20201101
  126. Neurotoxicity associated with colistin methanesulfonate treatment is enhanced by concomitant sevoflurane inhalation, Toxicology Reports, 9, 1255-1260, 20220101
  127. Characterization of the Interaction of Daptomycin With Site II on Human Serum Albumin, Journal of Pharmaceutical Sciences, 109(9), 2919-2924, 20200901
  128. Concurrent administration with multivalent metal cation preparations or polycationic polymer preparations inhibits the absorption of raltegravir via its chelation, Journal of Pharmacy and Pharmacology, 72(10), 1361-1369, 20201001
  129. An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins, Journal of Pharmacy and Pharmacology, 74(1), 88-93, 20220101
  130. Characterization of bovine lactoferrin nanoparticle prepared by desolvation technique, Chemical and Pharmaceutical Bulletin, 68(8), 766-772, 20200101
  131. Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats, Drug Metabolism and Pharmacokinetics, 35(5), 425-431, 20201001
  132. Bioinspired carbon monoxide delivery using artificial blood attenuates the progression of obliterative bronchiolitis via suppression of macrophage activation by IL-17A, European Journal of Pharmaceutics and Biopharmaceutics, 170, 43-51, 20220101
  133. Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles, Drug Metabolism and Pharmacokinetics, 35(5), 417-424, 20201001
  134. Azoles versus conventional amphotericin B for the treatment of candidemia: A meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 26(11), 1232-1236, 20201101
  135. Pharmacokinetic properties of orally administered 4′-Cyano-2′-deoxyguanosine, a novel nucleoside analog inhibitor of the hepatitis B virus, in viral liver injury model rats, Biological and Pharmaceutical Bulletin, 43(9), 1426-1429, 20200901
  136. Liposomal artificial red blood cell-based carbon monoxide donor is a potent renoprotectant against cisplatin-induced acute kidney injury, Pharmaceutics, 14(1), 20220101
  137. Hepatic Cytochrome P450 Profiles in Hemorrhagic Shock Model Rats After Transfusion With Stored Red Blood Cells, Journal of Pharmaceutical Sciences, 109(11), 3490-3495, 20201101
  138. Pharmaceutical technology innovation strategy based on the function of blood transport proteins as DDS carriers for the treatment of intractable disorders and cancer, Biological and Pharmaceutical Bulletin, 43(12), 1815-1822, 20201201
  139. Remdesivir for the treatment of coronavirus COVID-19: A meta-analysis of randomised controlled trials, Journal of Global Antimicrobial Resistance, 24, 81-82, 20210301
  140. Impact of rifampicin on the pharmacokinetics of clarithromycin and 14-hydroxy clarithromycin in patients with multidrug combination therapy for pulmonary Mycobacterium avium complex infection, Journal of Infection and Chemotherapy, 28(1), 61-66, 20220101
  141. Use of an alternative signature peptide during development of a LC-MS/MS assay of plasma nivolumab levels applicable for multiple species, Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 1162, 20210101
  142. Pharmacokinetics of 4′-cyano-2′-deoxyguanosine, a novel nucleoside analog inhibitor of the resistant hepatitis B virus, in a rat model of chronic kidney disease, Journal of Infection and Chemotherapy, 27(5), 702-706, 20210501
  143. Long-term pharmaceutical stability of liposome-encapsulated methemoglobin as an antidote for cyanide poisoning, International Journal of Pharmaceutics, 610, 20211215
  144. Stability of antimicrobial agents in an elastomeric infusion pump used for outpatient parenteral antimicrobial therapy, International Journal of Infectious Diseases, 103, 464-468, 20210201
  145. Pharmacokinetics/Pharmacodynamics Evaluation of Flomoxef against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli In Vitro and In Vivo in a Murine Thigh Infection Model, Pharmaceutical Research, 38(1), 27-35, 20210101
  146. The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing, BMC Infectious Diseases, 21(1), 20211201
  147. Rational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses, Equine Veterinary Journal, 53(6), 1239-1249, 20211101
  148. Possible role of electrolytes on the formation of precipitates during the infusion of nafamostat mesilate in hemodialysis, Biological and Pharmaceutical Bulletin, 44(2), 259-265, 20210201
  149. Identification of Risk Factors for Daptomycin-Associated Creatine Phosphokinase Elevation and Development of a Risk Prediction Model for Incidence Probability, Open Forum Infectious Diseases, 8(12), 20211201
  150. Multivalent cation and polycation polymer preparations influence pharmacokinetics of dolutegravir via chelation-type drug interactions, Drug Metabolism and Pharmacokinetics, 37, 20210401
  151. The optimal trough-guided monitoring of vancomycin in children: Systematic review and meta-analyses, Journal of Infection and Chemotherapy, 27(5), 781-785, 20210501
  152. Population pharmacokinetic analysis and dosing optimization of prophylactic fluconazole in japanese patients with hematological malignancy, Journal of Fungi, 7(11), 20211101
  153. When albumin meets liposomes: A feasible drug carrier for biomedical applications, Pharmaceuticals, 14(4), 20210401
  154. Population Pharmacokinetic Analysis and Dosing Optimization Based on Unbound Daptomycin Concentration and Cystatin C in Nonobese Elderly Patients with Hypoalbuminemia and Chronic Kidney Disease, Pharmaceutical Research, 20210101
  155. Cefmetazole as an Alternative to Carbapenems Against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections Based on In Vitro and In Vivo Pharmacokinetics/Pharmacodynamics Experiments, Pharmaceutical Research, 38(11), 1839-1846, 20211101
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