KAZUAKI TAGUCHI

Last Updated :2025/07/18

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
E-mail
taguakihiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2025/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Professor
  • 2021/04/01, 2025/03/31, Keio University, Associate Professor
  • 2018/04/01, 2021/03/31, Keio University, Senior Assistant Professor
  • 2013/04/01, 2018/03/31, Sojo University, Assistant Professor
  • 2011/04/01, 2013/03/31, Kumamoto University Hospital, Pharmacist

Educational Backgrounds

  • Kumamoto University, Ph.D, Japan, 2008/04, 2011/03
  • Kumamoto University, M.Sc., Japan, 2006/04, 2008/03
  • Kumamoto University, Pharmaceutical Science, Japan, 2002/04, 2006/03

In Charge of Primary Major Programs

  • Medicinal Sciences
  • Pharmaceutical Sciences

Research Fields

  • Interdisciplinary science and engineering;Nano / Micro science;Nanobioscience
  • Medicine,dentistry, and pharmacy;Pharmacy;Drug development chemistry
  • Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy

Affiliated Academic Societies

  • The Japan Society of Drug Delivery System
  • Japanese Society of Pharmaceutical Health Care and Sciences
  • Japanese Society of Chemotherapy
  • The Academy of Pharmaceutical Science and Technology, Japan
  • The Pharmaceutical Society of Japan
  • The Society of Blood Substitutes, Japan
  • The Japanese Society for the Study of Xenobiotics

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Research Practice A
  2. 2025, Undergraduate Education, Second Semester, Research Practice B
  3. 2025, Undergraduate Education, 1Term, Clinical Medicine and Pharmacotherapy I
  4. 2025, Undergraduate Education, 2Term, Pharmacoeconomics
  5. 2025, Undergraduate Education, 3Term, Clinical Evaluation
  6. 2025, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  7. 2025, Undergraduate Education, 3Term, Pharmacy Practice
  8. 2025, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  9. 2025, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  10. 2025, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  11. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  12. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  13. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  14. 2025, Graduate Education (Doctoral Program) , 4Term, Pharmacotherapeutic Research
  15. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Clinical Pharmacotherapy
  16. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Clinical Pharmacotherapy
  17. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Clinical Pharmacotherapy
  18. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Clinical Pharmacotherapy
  19. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Pharmacotherapy
  20. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Pharmacotherapy
  21. 2025, Graduate Education (Master's Program) , First Semester, Research on Pharmacotherpeutic Research
  22. 2025, Graduate Education (Master's Program) , Second Semester, Research on Pharmacotherpeutic Research

Research Activities

Academic Papers

  1. Development and validation of a population pharmacokinetic model of vancomycin for patients of advanced age, Journal of Pharmaceutical Health Care and Sciences, 11(1), 20251201
  2. Shortening the interval between the first and the second dose of vancomycin facilitates rapid achievement of the target AUC without increasing the risk of acute kidney injury, provided the AUC on the second day is appropriately controlled: a multicenter retrospective study, Journal of Pharmaceutical Health Care and Sciences, 11(1), 20251201
  3. Combined dual β-lactams and diazabicyclooctane β-lactamase inhibitor is highly effective against Mycobacterium abscessus species in vitro, Journal of Global Antimicrobial Resistance, 42, 142-150, 20250501
  4. Methemoglobin-Encapsulating Liposome: A Low-Risk Intravascular Contrast Agent for Magnetic Resonance Imaging, ACS Applied Bio Materials, 8(4), 2838-2846, 20250421
  5. Direct comparison of the effects of first- and second-generation H1-receptor blockers on motor functions in mice, Pharmazie, 80(1), 24-28, 20250301
  6. Carbon monoxide alleviates endotoxin-induced acute lung injury via NADPH oxidase inhibition in macrophages and neutrophils, Biochemical Pharmacology, 233, 20250301
  7. Simulated achievement rate of β-lactams/nacubactam treatment in humans using instantaneous MIC-based PK/PD analysis, Journal of Antimicrobial Chemotherapy, 80(2), 547-553, 20250201
  8. Treatment success prediction in patients with methicillin-resistant coagulase-negative staphylococci infections, using vancomycin AUC24/MIC ratio: a multicentre retrospective cohort study, Journal of Antimicrobial Chemotherapy, 80(2), 538-546, 20250201
  9. Development of a pharmacokinetic/pharmacodynamic evaluation model for osteomyelitis and usefulness of tedizolid as an alternative to vancomycin against MRSA osteomyelitis, Journal of Pharmacy and Pharmacology, 77(2), 291-298, 20250201
  10. One-Step Maleimide-Based Dual Functionalization of Protein N-Termini, Angewandte Chemie International Edition, 64(5), 20250127
  11. Influence factors of metronidazole-related CNS disorders: an analysis of the Japan adverse drug event report and FDA adverse event reporting system, Expert Opinion on Drug Safety, 20250101
  12. SARS-CoV-2 mRNA vaccine-related myocarditis and pericarditis: An analysis of the Japanese Adverse Drug Event Report database, Journal of Infection and Chemotherapy, 31(1), 20250101
  13. Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice, Journal of Pharmaceutical Health Care and Sciences, 10(1), 20241201
  14. Identification of Patients Who Require Two-Point Blood Sampling for the Peak and Trough Values Rather Than One-Point Blood Sampling for the Trough Value for the Evaluation of AUC of Vancomycin Using Bayesian Estimation, Pharmaceutical Research, 41(11), 2161-2171, 20241101
  15. Hydrosulphide-methaemoglobin-albumin cluster: a hydrogen sulphide donor, Journal of Materials Chemistry B, 12(44), 11515-11522, 20241014
  16. T-cell immunosuppression in sepsis is augmented by sciatic denervation-induced skeletal muscle atrophy, FEBS Letters, 598(20), 2581-2591, 20241001
  17. Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation, Redox Biology, 76, 20241001
  18. Carbon monoxide-loaded cell therapy as an exercise mimetic for sarcopenia treatment, Free Radical Biology and Medicine, 220, 67-77, 20240801
  19. Antimicrobial Stewardship of Oral Third-Generation Cephalosporins in Community Pharmacy: A Single-Center Quasi-Experimental Study, Biological and Pharmaceutical Bulletin, 47(8), 1447-1451, 20240801
  20. Predictive Value of Vancomycin AUC24/MIC Ratio for 30-day Mortality in Patients with Severe or Complicated Methicillin-Resistant Staphylococcus aureus Infections: A Multicenter Retrospective Study, Pharmaceutical Research, 41(7), 1381-1389, 20240701
  21. Relationship between nephrotoxicity and area under the concentration-time curve of vancomycin in critically ill patients: a multicenter retrospective study, Microbiology Spectrum, 12(7), 20240701
  22. Anti-edematous effects of epinastine, cetirizine and its enantiomers in λ-carrageenan-induced edema in rat hind paw, Pharmazie, 79(6), 98-100, 20240601
  23. Dual delivery of carbon monoxide and doxorubicin using haemoglobin-albumin cluster: proof of concept for well-tolerated cancer therapy, Journal of Materials Chemistry B, 12(23), 5600-5608, 20240507
  24. Direct comparison of anti-inflammatory effects of 14-, 15-, and 16-membered macrolide antibiotics in experimental inflammation model induced by carrageenan in rats, Pharmazie, 79(3-5), 64-66, 20240501
  25. Flowchart for predicting achieving the target area under the concentration-time curve of vancomycin in critically ill Japanese patients: A multicenter retrospective study, Journal of Infection and Chemotherapy, 30(4), 329-336, 20240401
  26. Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin, Chemical and Pharmaceutical Bulletin, 72(1), 21-27, 20240101
  27. Carbon Monoxide Alleviates Post-ischemia–reperfusion Skeletal Muscle Injury and Systemic Inflammation, Biological and Pharmaceutical Bulletin, 47(4), 868-871, 20240101
  28. Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver, Xenobiotica, 54(9), 624-628, 20240101
  29. Polyoxazoline-Conjugated l-Asparaginase: An Antibody-Production-Free Therapeutic Agent for Acute Lymphoblastic Leukemia, ACS Applied Bio Materials, 6(12), 5789-5797, 20231218
  30. Elucidating the binding properties of methemoglobin in red blood cell to cyanide, hydrosulfide, and azide ions using artificial red blood cell, Toxicology and Applied Pharmacology, 481, 20231215
  31. Oral teicoplanin administration suppresses recurrence of Clostridioides difficile infection: Proof of concept, Anaerobe, 84, 20231201
  32. Polysarcosine-Coated liposomes attenuating immune response induction and prolonging blood circulation, Journal of Colloid and Interface Science, 651, 273-283, 20231201
  33. Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs, Scientific Reports, 13(1), 20231201
  34. The anti-inflammatory effect of tedizolid on carrageenan-induced footpad edema rat model, Journal of Infection and Chemotherapy, 29(11), 1088-1090, 20231101
  35. Pharmaceutical stability of methemoglobin-albumin cluster as an antidote for hydrogen sulfide poisoning after one-year storage in freeze-dried form, International Journal of Pharmaceutics, 645, 20231015
  36. A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease, FASEB Bioadvances, 5(10), 377-394, 20231001
  37. In vivo Pharmacokinetic/Pharmacodynamic Analysis of the Efficacy of the Cefepime/Nacubactam Combination Against β-Lactamase-Producing Enterobacterales based on the Instantaneous MIC Concept, Pharmaceutical Research, 40(10), 2423-2431, 20231001
  38. Carbon Monoxide-Loaded Red Blood Cell Prevents the Onset of Cisplatin-Induced Acute Kidney Injury, Antioxidants, 12(9), 20230901
  39. Antimicrobial Efficacy Evaluations of Metronidazole against Clostridioides difficile Infection using Fecal Pharmacokinetic and Pharmacodynamic Analyses, Pharmaceutical Research, 40(7), 1799-1806, 20230701
  40. In vivo Pharmacokinetics/Pharmacodynamics Profiles for Appropriate Doses of Cefditoren pivoxil against S. pneumoniae in Murine Lung-Infection Model, Pharmaceutical Research, 40(7), 1789-1797, 20230701
  41. Anti-inflammatory actions of expectorants in a rat carrageenan-induced footpad edema model, Pharmazie, 78(6-7), 86-88, 20230701
  42. Pharmaceutical Integrity of Lyophilized Methemoglobin-Albumin Clusters after Reconstitution, ACS Omega, 8(25), 22589-22595, 20230627
  43. Optimal therapeutic recommendation for Clostridioides difficile infection in pediatric and adolescent populations: a systematic review and meta-analysis, European Journal of Pediatrics, 182(6), 2673-2681, 20230601
  44. Fecal pharmacokinetics/pharmacodynamics characteristics of fidaxomicin and vancomycin against Clostridioides difficile infection elucidated by in vivo feces-based infectious evaluation models, Clinical Microbiology and Infection, 29(5), 616-622, 20230501
  45. Methemoglobin-albumin clusters for cyanide detoxification, Toxicology and Applied Pharmacology, 466, 20230501
  46. Comparison of the efficacy and safety of standard- and high-dose daptomycin: A systematic review and meta-analysis, British Journal of Clinical Pharmacology, 89(4), 1291-1303, 20230401
  47. Development of an optimized and practical pharmacokinetics/pharmacodynamics analysis method for aztreonam/nacubactam against carbapenemase-producing K. pneumoniae, Journal of Antimicrobial Chemotherapy, 78(4), 991-999, 20230401
  48. SCIATIC DENERVATION-INDUCED SKELETAL MUSCLE ATROPHY IS ASSOCIATED WITH PERSISTENT INFLAMMATION AND INCREASED MORTALITY DURING SEPSIS, Shock, 59(3), 417-425, 20230301
  49. The G protein-coupled receptor ligand apelin-13 ameliorates skeletal muscle atrophy induced by chronic kidney disease, Journal of Cachexia Sarcopenia and Muscle, 14(1), 553-564, 20230201
  50. Differences in Pharmacokinetic/Pharmacodynamic Parameters of Tedizolid Against VRE and MRSA, Pharmaceutical Research, 40(1), 187-196, 20230101
  51. Analysis of Risk Factors for Developing Tuberculosis in Patients Who Received Prophylactic Latent Tuberculosis Infection Treatment with Experience of Biologic Medications, Biological and Pharmaceutical Bulletin, 46(12), 1832-1837, 20230101
  52. Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis, BMC Pharmacology and Toxicology, 23(1), 20221201
  53. Analysis of adverse drug events in pulmonary Mycobacterium avium complex disease using spontaneous reporting system, BMC Infectious Diseases, 22(1), 20221201
  54. Ceftazidime encephalopathy developed without the elevation of cerebrospinal fluid concentration of ceftazidime: A case report of two cases, Journal of Infection and Chemotherapy, 28(12), 1667-1671, 20221201
  55. In vitro effects of diazabicyclooctane β-lactamase inhibitors relebactam and nacubactam against three subspecies of Mycobacterium abscessus complex, International Journal of Antimicrobial Agents, 60(5-6), 20221101
  56. Oral fidaxomicin versus vancomycin for the treatment of Clostridioides difficile infection: A systematic review and meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 28(11), 1536-1545, 20221101
  57. Efficacy of surgical skin preparation with chlorhexidine in alcohol according to the concentration required to prevent surgical site infection: Meta-Analysis, Bjs Open, 6(5), 20221001
  58. Methemoglobin-albumin clusters for the treatment of hydrogen sulfide intoxication, Journal of Controlled Release, 349, 304-314, 20220901
  59. Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning, Toxicology and Applied Pharmacology, 450, 20220901
  60. Exploring the Factors Affecting the Transferability of Vancomycin to Cerebrospinal Fluid in Postoperative Neurosurgical Patients with Bacterial Meningitis, Biological and Pharmaceutical Bulletin, 45(9), 1398-1402, 20220901
  61. Single-Step N-Terminal Modification of Proteins via a Bio-Inspired Copper(II)-Mediated Aldol Reaction, Chemistry A European Journal, 28(47), 20220822
  62. Trimethoxy Trityl Groups as a Potent Substituent for Anti-cancer Cytidine Analog Prodrugs, Journal of Pharmaceutical Sciences, 111(8), 2201-2209, 20220801
  63. Influences of protein levels on the cerebrospinal fluid distribution of ceftazidime & ceftriaxone in the cerebrospinal fluid of patients with inflamed meningitis, Journal of Infection and Chemotherapy, 28(8), 1216-1219, 20220801
  64. A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease, Redox Biology, 54, 20220801
  65. Target Therapeutic Ranges of Anti-MRSA Drugs, Linezolid, Tedizolid and Daptomycin, and the Necessity of TDM, Biological and Pharmaceutical Bulletin, 45(7), 824-833, 20220701
  66. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats, Drug Metabolism and Disposition, 50(6), 822-826, 20220601
  67. Oxidized liposomal artificial red blood cells rescue azide-poisoned mice from lethal toxidrome by recovering cytochrome c oxidase activity, Journal of Drug Delivery Science and Technology, 71, 20220501
  68. Incidence of elevated creatine phosphokinase between daptomycin alone and concomitant daptomycin and statins: A systematic review and meta-analysis, British Journal of Clinical Pharmacology, 88(5), 1985-1998, 20220501
  69. Efficacy and Safety of Daptomycin versus Vancomycin for Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus with Vancomycin Minimum Inhibitory Concentration > 1 µg/mL: A Systematic Review and Meta-Analysis, Pharmaceutics, 14(4), 20220401
  70. In Vitro and In Vivo Assessment of Atemoya Fruit (Annona atemoya) for Food–Drug Interactions, European Journal of Drug Metabolism and Pharmacokinetics, 47(2), 177-185, 20220301
  71. Neurotoxicity associated with colistin methanesulfonate treatment is enhanced by concomitant sevoflurane inhalation, Toxicology Reports, 9, 1255-1260, 20220101
  72. An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins, Journal of Pharmacy and Pharmacology, 74(1), 88-93, 20220101
  73. Bioinspired carbon monoxide delivery using artificial blood attenuates the progression of obliterative bronchiolitis via suppression of macrophage activation by IL-17A, European Journal of Pharmaceutics and Biopharmaceutics, 170, 43-51, 20220101
  74. Liposomal artificial red blood cell-based carbon monoxide donor is a potent renoprotectant against cisplatin-induced acute kidney injury, Pharmaceutics, 14(1), 20220101
  75. Impact of rifampicin on the pharmacokinetics of clarithromycin and 14-hydroxy clarithromycin in patients with multidrug combination therapy for pulmonary Mycobacterium avium complex infection, Journal of Infection and Chemotherapy, 28(1), 61-66, 20220101
  76. Research of storable and ready-to-use artificial red blood cells (hemoglobin vesicles) for emergency medicine and other clinical applications, Frontiers in Medical Technology, 4, 20220101
  77. Long-term pharmaceutical stability of liposome-encapsulated methemoglobin as an antidote for cyanide poisoning, International Journal of Pharmaceutics, 610, 20211215
  78. The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing, BMC Infectious Diseases, 21(1), 20211201
  79. Identification of Risk Factors for Daptomycin-Associated Creatine Phosphokinase Elevation and Development of a Risk Prediction Model for Incidence Probability, Open Forum Infectious Diseases, 8(12), 20211201
  80. Rational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses, Equine Veterinary Journal, 53(6), 1239-1249, 20211101
  81. Population pharmacokinetic analysis and dosing optimization of prophylactic fluconazole in japanese patients with hematological malignancy, Journal of Fungi, 7(11), 20211101
  82. Cefmetazole as an Alternative to Carbapenems Against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections Based on In Vitro and In Vivo Pharmacokinetics/Pharmacodynamics Experiments, Pharmaceutical Research, 38(11), 1839-1846, 20211101
  83. Retrospective study of the efficacy and safety of metronidazole and vancomycin for Clostridioides difficile infection, Journal of Infection and Chemotherapy, 27(10), 1407-1412, 20211001
  84. Liposome-encapsulated methemoglobin as an antidote against cyanide poisoning, Journal of Controlled Release, 337, 59-70, 20210910
  85. Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis, International Journal of Infectious Diseases, 110, 382-384, 20210901
  86. Species distribution of candidemia and their susceptibility in a single japanese university hospital: Prior micafungin use affects the appearance of candida parapsilosis and elevation of micafungin mics in non‐parapsilosis candida species, Journal of Fungi, 7(8), 20210801
  87. Pharmacokinetics of 4′-cyano-2′-deoxyguanosine, a novel nucleoside analog inhibitor of the resistant hepatitis B virus, in a rat model of chronic kidney disease, Journal of Infection and Chemotherapy, 27(5), 702-706, 20210501
  88. The optimal trough-guided monitoring of vancomycin in children: Systematic review and meta-analyses, Journal of Infection and Chemotherapy, 27(5), 781-785, 20210501
  89. Multivalent cation and polycation polymer preparations influence pharmacokinetics of dolutegravir via chelation-type drug interactions, Drug Metabolism and Pharmacokinetics, 37, 20210401
  90. When albumin meets liposomes: A feasible drug carrier for biomedical applications, Pharmaceuticals, 14(4), 20210401
  91. Remdesivir for the treatment of coronavirus COVID-19: A meta-analysis of randomised controlled trials, Journal of Global Antimicrobial Resistance, 24, 81-82, 20210301
  92. Stability of antimicrobial agents in an elastomeric infusion pump used for outpatient parenteral antimicrobial therapy, International Journal of Infectious Diseases, 103, 464-468, 20210201
  93. Possible role of electrolytes on the formation of precipitates during the infusion of nafamostat mesilate in hemodialysis, Biological and Pharmaceutical Bulletin, 44(2), 259-265, 20210201
  94. Use of an alternative signature peptide during development of a LC-MS/MS assay of plasma nivolumab levels applicable for multiple species, Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 1162, 20210101
  95. Pharmacokinetics/Pharmacodynamics Evaluation of Flomoxef against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli In Vitro and In Vivo in a Murine Thigh Infection Model, Pharmaceutical Research, 38(1), 27-35, 20210101
  96. Population Pharmacokinetic Analysis and Dosing Optimization Based on Unbound Daptomycin Concentration and Cystatin C in Nonobese Elderly Patients with Hypoalbuminemia and Chronic Kidney Disease, Pharmaceutical Research, 20210101
  97. Development of a bioactive gas delivery strategy based on biomimetic red blood cells for the treatment of intractable diseases 13th Young Scientist Award, Japan Society of DDS, Drug Delivery System, 36(4), 300-306, 20210101
  98. Pharmaceutical technology innovation strategy based on the function of blood transport proteins as DDS carriers for the treatment of intractable disorders and cancer, Biological and Pharmaceutical Bulletin, 43(12), 1815-1822, 20201201
  99. Echinocandins versus non-echinocandins for the treatment of invasive candidiasis: A meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 26(11), 1164-1176, 20201101
  100. Azoles versus conventional amphotericin B for the treatment of candidemia: A meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 26(11), 1232-1236, 20201101
  101. Hepatic Cytochrome P450 Profiles in Hemorrhagic Shock Model Rats After Transfusion With Stored Red Blood Cells, Journal of Pharmaceutical Sciences, 109(11), 3490-3495, 20201101
  102. Concurrent administration with multivalent metal cation preparations or polycationic polymer preparations inhibits the absorption of raltegravir via its chelation, Journal of Pharmacy and Pharmacology, 72(10), 1361-1369, 20201001
  103. Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats, Drug Metabolism and Pharmacokinetics, 35(5), 425-431, 20201001
  104. Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles, Drug Metabolism and Pharmacokinetics, 35(5), 417-424, 20201001
  105. Characterization of the Interaction of Daptomycin With Site II on Human Serum Albumin, Journal of Pharmaceutical Sciences, 109(9), 2919-2924, 20200901
  106. Pharmacokinetic properties of orally administered 4′-Cyano-2′-deoxyguanosine, a novel nucleoside analog inhibitor of the hepatitis B virus, in viral liver injury model rats, Biological and Pharmaceutical Bulletin, 43(9), 1426-1429, 20200901
  107. Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes, Journal of Controlled Release, 322, 209-216, 20200610
  108. In vivo evaluation of drug dialyzability in a rat model of hemodialysis, Plos One, 15(6), 20200601
  109. Effects of arterial hemorrhage speed on the blood coagulation/fibrinolysis system and hemodynamics in rats, Blood Coagulation and Fibrinolysis, 31(3), 198-206, 20200401
  110. Support for fungal infection treatment mediated by pharmacist-led antifungal stewardship activities, Journal of Infection and Chemotherapy, 26(3), 272-279, 20200301
  111. Processing grapefruit juice with γ-cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity, Journal of Pharmacy and Pharmacology, 72(3), 356-363, 20200301
  112. Carbon monoxide rescues the developmental lethality of experimental rat models of rhabdomyolysis-induced acute kidney injury, Journal of Pharmacology and Experimental Therapeutics, 372(3), 355-365, 20200301
  113. Cell uptake and anti-tumor effect of liposomes containing encapsulated paclitaxel-bound albumin against breast cancer cells in 2D and 3D cultured models, Journal of Drug Delivery Science and Technology, 55, 20200201
  114. The charm of protein for drug development, Yakugaku Zasshi, 140(2), 139-140, 20200201
  115. Strategy of drug development based on the bioactive gas-carrying capacity of hemoglobin, Yakugaku Zasshi, 140(2), 141-146, 20200201
  116. Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications, Current Medicinal Chemistry, 27(18), 2949-2963, 20200101
  117. Characterization of bovine lactoferrin nanoparticle prepared by desolvation technique, Chemical and Pharmaceutical Bulletin, 68(8), 766-772, 20200101
  118. Experimental verification of factors influencing calcium salt formation based on a survey of the development of ceftriaxone-induced gallstone-related disorder, Journal of Infection and Chemotherapy, 25(12), 972-978, 20191201
  119. α1-Acid Glycoprotein Has the Potential to Serve as a Biomimetic Drug Delivery Carrier for Anticancer Agents, Journal of Pharmaceutical Sciences, 108(11), 3592-3598, 20191101
  120. Enhanced dissolution and oral bioavailability of praziquantel by emulsification with human serum albumin followed by spray drying, European Journal of Pharmaceutical Sciences, 139, 20191101
  121. Evaluation for optimal dosing of vancomycin in patients with different physical types, Journal of Infection and Chemotherapy, 25(9), 735-737, 20190901
  122. Investigation of anti-tumor effect of doxorubicin-loaded human serum albumin nanoparticles prepared by a desolvation technique, Cancer Chemotherapy and Pharmacology, 83(6), 1113-1120, 20190601
  123. Preparation, Characterization, and in Vitro/in Vivo Evaluation of Paclitaxel-Bound Albumin-Encapsulated Liposomes for the Treatment of Pancreatic Cancer, ACS Omega, 4(5), 8693-8700, 20190517
  124. Pharmacokinetic and pharmacodynamic studies of pregabalin suppositories based on pharmacological research, Journal of Pharmacy and Pharmacology, 71(5), 746-752, 20190501
  125. Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin, Journal of Pharmaceutical Sciences, 108(5), 1890-1895, 20190501
  126. Age-associated theophylline metabolic activity corresponds to the ratio of 1,3-dimethyluric acid to theophylline in mice, Biological and Pharmaceutical Bulletin, 42(8), 1423-1427, 20190101
  127. Evaluation of the expression time of ganciclovir-induced adverse events using JADER and FAERS, Biological and Pharmaceutical Bulletin, 42(11), 1799-1804, 20190101
  128. Oral vancomycin versus metronidazole for the treatment of Clostridioides difficile infection: Meta-analysis of randomized controlled trials, Journal of Infection and Chemotherapy, 24(11), 907-914, 20181101
  129. Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure, ACS Omega, 3(10), 13790-13797, 20181022
  130. In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers, Journal of Drug Delivery Science and Technology, 47, 62-66, 20181001
  131. Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites, Biochemistry and Biophysics Reports, 14, 155-160, 20180701
  132. Pharmacokinetics studies of 4′-cyano-2′-deoxyguanosine, a potent inhibitor of the hepatitis B virus, in rats, Journal of Pharmacy and Pharmacology, 70(6), 723-731, 20180601
  133. Pharmacokinetic properties of a novel inosine analog, 40-cyano-20-deoxyinosine, after oral administration in rats, Plos One, 13(6), 20180601
  134. Development of kupffer cell targeting type-i interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions, Drug Delivery, 25(1), 1067-1077, 20180424
  135. Albumin-Encapsulated Liposomes: A Novel Drug Delivery Carrier With Hydrophobic Drugs Encapsulated in the Inner Aqueous Core, Journal of Pharmaceutical Sciences, 107(1), 436-445, 20180101
  136. Preparation and in vitro analysis of human serum albumin nanoparticles loaded with anthracycline derivatives, Chemical and Pharmaceutical Bulletin, 66(4), 382-390, 20180101
  137. Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity, Drug Delivery, 25(1), 1266-1274, 20180101
  138. Safety of nanoparticles based on albumin-polymer conjugates as a carrier of nucleotides for pancreatic cancer therapy, Journal of Materials Chemistry B, 6(39), 6278-6287, 20180101
  139. Benzbromarone attenuates oxidative stress in angiotensin II- and salt-induced hypertensive model rats, Oxidative Medicine and Cellular Longevity, 2018, 20180101
  140. Safety evaluation of cellular-type artificial blood based on pharmacokinetic analysis and its use in medical gas delivery, Yakugaku Zasshi, 138(11), 1381-1389, 20180101
  141. Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin, Journal of Pharmaceutical Sciences, 106(9), 2860-2867, 20170901
  142. The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders, Journal of Pharmaceutical Sciences, 106(9), 2392-2400, 20170901
  143. Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin, Plos One, 12(6), 20170601
  144. Structural and biological characterization of Fe3O4-loaded spherical and tubular liposomes for use in drug delivery systems, Japanese Journal of Applied Physics, 56(5), 20170501
  145. Locational analysis of glutathione in liposomes by using small-angle X-ray scattering, Chemistry Letters, 46(2), 185-187, 20170101
  146. The binding of silibinin, the main constituent of silymarin, to site i on human serum albumin, Biological and Pharmaceutical Bulletin, 40(3), 310-317, 20170101
  147. Recombinant human serum albumin containing 3 copies of domain I, Has significant in vitro antioxidative capacity compared to the wild-type, Biological and Pharmaceutical Bulletin, 40(10), 1813-1817, 20170101
  148. Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties, International Journal of Nanomedicine, 11, 5611-5620, 20161027
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Publications such as books

  1. Nanobiotherapeutic Based Blood Substitutes, Carbon monoxide-bound Hemoglobin-vesicles: Current facts and potential medical applications, World Scientific Publishing Co. Ltd., 2021, Taguchi K, Matsumoto K, Sakai H, Maruyama T, Otagiri M
  2. Human Serum Albumin (HSA): Functional Structure, Synthesis and Therapeutic Uses, Pharmacokinetically modified human serum albumin based therapeutic design and development, Nova Science Publishers, Inc., 2015, Taguchi K, Chuang VTG, Yamasaki K, Otagiri M
  3. HUMAN SERUM ALBUMIN, Albumin dialysis, Sojo University publisher, 2013, Taguchi K, Chuang VTG, Otagiri M
  4. Acute Phase Proteins, Molecular aspects of human alpha-1 acid glycoprotein — Structure and function, Intech Open Ltd., 2013, Taguchi K, Nishi K, Chuang VTG, Maruyama T, Otagiri M

Patented

  1. Patent, JP第6523842号