TATSUYA MARUHASHI

Last Updated :2023/01/05

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
maru0512hiroshima-u.ac.jp
Self-introduction
I am interested in detecting atherosclerosis by using non-invasive vascular function tests.

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Affiliated Academic Societies

  • The Japanese Society of Internal Medicine
  • Japanese College of Cardiology
  • The Japanese Society of Hypertension
  • Japanese Atherosclerosis Society
  • Japanese Society of Clinical Physiology
  • Nitric Oxide Society of Japan
  • The Japanese Circulation Society

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2022, Undergraduate Education, Intensive, Practice for medical research

Research Activities

Academic Papers

  1. White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12(1), 20220517
  2. Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study, FRONTIERS IN CARDIOVASCULAR MEDICINE, 9, 20220428
  3. Relationship between hemoglobin A1c level and flow-mediated vasodilation in patients with type 2 diabetes mellitus receiving antidiabetic drugs, JOURNAL OF DIABETES INVESTIGATION, 13(4), 677-686, 202204
  4. Self-reported total sitting time on a non-working day is associated with blunted flow-mediated vasodilation and blunted nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12(1), 20220416
  5. Implantation of Hypoxia-Induced Mesenchymal Stem Cell Advances Therapeutic Angiogenesis, STEM CELLS INTERNATIONAL, 2022, 20220320
  6. Isolated diastolic hypertension is not associated with endothelial dysfunction, HYPERTENSION RESEARCH, 45(4), 698-707, 202204
  7. Poor tooth brushing behavior is associated with high risk of cardiovascular events: A prospective observational study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 350, 111-117, 20220301
  8. Inconvenient relationship of haemoglobin A1c level with endothelial function in type 2 diabetes in a cross-sectional study, BMJ OPEN, 11(6), 202106
  9. Interrelationships Among Flow-Mediated Vasodilation, Nitroglycerine-Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1), 201801
  10. Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery, INTERNATIONAL JOURNAL OF CARDIOLOGY, 260, 178-183, 20180601
  11. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women, INTERNATIONAL JOURNAL OF CARDIOLOGY, 261, 196-203, 20180615
  12. Assessment of endothelium-independent vasodilation: from methodology to clinical perspectives, JOURNAL OF HYPERTENSION, 36(7), 1460-1467, 201807
  13. New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement, INTERNATIONAL JOURNAL OF CARDIOLOGY, 265, 24-29, 20180815
  14. Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation, SCIENTIFIC REPORTS, 8, 20180618
  15. Dec1 and CLOCK Regulate Na+/K+-ATPase 1 Subunit Expression and Blood Pressure, HYPERTENSION, 72(3), 746-754, 201809
  16. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study., Atherosclerosis, 268, 92-98, 2018
  17. Documentation of early improvement of left ventricular function in tako-tsubo cardiomyopathy., Internal Journal of Cardiology, 114(2), E70-E72, 2007
  18. Tako-tsubo cardiomyopathy after automobile accident., Internal Journal of Cardiology, 118(1), e16-e18, 2007
  19. Variant form of tako-tsubo cardiomyopathy., Internal Journal of Cardiology, 119(2), e56-e58, 2008
  20. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism., Hypertension Research, 2018
  21. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A., Journal of the American Heart Association, 7(14), e008588, 2018
  22. Vascular Digit Injury in a College Baseball Player., Circulation Journal, 82(9), 2377-2377, 2018
  23. Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction., Internal Journal of Cardiology, 254, 284-290, 2018
  24. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension., European Journal of Nutrition, s00394-018-1611-s00394-018-1617, 2018
  25. Effects of Cerebral Blood Flow and Vessel Conditions on Speech Recognition in Patients With Postlingual Adult Cochlear Implant: Predictable Factors for the Efficacy of Cochlear Implant., Ear and Hearing, 39(3), 540-547, 2018
  26. Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals., Scientific Reports, 7(1), 8422, 2017
  27. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)., Hypertension, 70(4), 790-797, 2017
  28. Relation of the Bilateral Earlobe Crease to Endothelial Dysfunction., American Journal of Cardiology, 119(12), 1983-1988, 2017
  29. Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial., Cardiovascular Diabetology, 16(1), 48, 2017
  30. Decreased frequency and duration of tooth brushing is a risk factor for endothelial dysfunction., Internal Journal of Cardiology, 15(241), 30-34, 2017
  31. Development of an earlobe crease identification system to support diagnosis of arteriosclerosis., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society, 2374-2377, 2016
  32. Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women., Circulation Journal, 81(6), 862-869, 2017
  33. Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction., Internal Journal of Cardiology, 231, 181-187, 2017
  34. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study., Internal Journal of Cardiology, 230, 523-528, 2017
  35. Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow-Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events., Journal of the American Heart Association, 5(12), e004385, 2016
  36. Vascular Function and Intima-media Thickness of a Leg Artery in Peripheral Artery Disease: A Comparison of Buerger Disease and Atherosclerotic Peripheral Artery Disease., Journal of Atherosclerosis and Thrombosis, 23(11), 1261-1269, 2016
  37. Circulating level of pigment epithelium-derived factor is associated with vascular function and structure: A cross-sectional study., Internal Journal of Cardiology, 225, 91-95, 2016
  38. Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study., Cardiovascular Diabetology, 15(1), 134, 2016
  39. Nitroglycerine-induced vasodilation in coronary and brachial arteries in patients with suspected coronary artery disease., Internal Journal of Cardiology, 219, 312-316, 2016
  40. Relationship between serum triglyceride levels and endothelial function in a large community-based study., Atherosclerosis, 249, 70-75, 2016
  41. Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events., Hypertension, 67(5), 1045-1052, 2016
  42. Reduction in blood pressure improves impaired nitroglycerine-induced vasodilation in patients with essential hypertension., Hypertension Research, 38(12), 862-868, 2015
  43. Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome., Hypertension, 66(4), 892-899, 2015
  44. Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial., Hypertension Research, 38(7), 485-490, 2015
  45. Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism., Hypertension, 65(4), 841-848, 2015
  46. Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function., Diabetes Care, 38(1), 119-125, 2015
  47. Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells., PLoS One, 9(10), e109017, 2014
  48. Relationship between nitroglycerine-induced vasodilation and clinical severity of peripheral artery disease., Atherosclerosis, 235(1), 65-70, 2014
  49. Borderline ankle-brachial index value of 0.91-0.99 is associated with endothelial dysfunction., Circulation Journal, 78(7), 1740-1745, 2014
  50. Poor oral health, that is, decreased frequency of tooth brushing, is associated with endothelial dysfunction., Circulation Journal, 78(4), 950-954, 2014
  51. Rho-associated kinase activity is a predictor of cardiovascular outcomes., Hypertension, 63(4), 856-864, 2014
  52. Oxidative stress and endothelial dysfunction: clinical evidence and therapeutic implications., Trends in Cardiovascular Medicine, 24(4), 165-169, 2014
  53. Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women., BMJ open, 3(11), e003659, 2013
  54. Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study., Heart, 99(24), 1837-1842, 2013
  55. A novel noninvasive and simple method for assessment of endothelial function: enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement., Atherosclerosis, 229(2), 324-330, 2013
  56. Autologous bone-marrow mesenchymal stem cell implantation and endothelial function in a rabbit ischemic limb model., PLoS One, 8(7), e67739, 2013
  57. Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation., Arteriosclerosis, Thrombosis, and Vascular Biology, 33(6), 1401-1408, 2013
  58. Flow-mediated vasodilation and anatomical variation of the brachial artery (double brachial artery) in healthy subjects and patients with cardiovascular disease., Circulation Journal, 77(4), 1073-1080, 2013
  59. Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors., Arteriosclerosis, Thrombosis, and Vascular Biology, 32(9), 2295-2303, 2012
  60. Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome., Circulation, 126(5), 598-603, 2012
  61. Deep echo attenuation without calcification increases the risk of periprocedural myonecrosis after elective percutaneous coronary intervention in patients with coronary artery disease., Internal Medicine, 51(7), 691-698, 2012
  62. Geranylgeranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans., Arteriosclerosis, Thrombosis, and Vascular Biology, 32(1), 153-160, 2012
  63. Flow-mediated vasodilation is augmented in a corkscrew collateral artery compared with that in a native artery in patients with thromboangiitis obliterans (Buerger disease)., Journal of Vascular Surgery, 54(6), 1689-1697, 2011
  64. Rho-associated kinase activity, endothelial function, and cardiovascular risk factors., Arteriosclerosis, Thrombosis, and Vascular Biology, 31(10), 2353-2359, 2011
  65. Color doppler flows of corkscrew collaterals in Thromboangiitis obliterans (Buerger's disease) using color duplex ultrasonography., Journal of the American College of Cardiology, 57(25), 2539, 2011
  66. Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia: a comparison of atherosclerotic peripheral arterial disease and Buerger disease., Circulation: Cardiovascular Interventions, 4(1), 15-25, 2011
  67. Vascular function and circulating progenitor cells in thromboangitis obliterans (Buerger's disease) and atherosclerosis obliterans., Hypertension, 57(1), 70-78, 2011
  68. Calcium channel blocker and Rho-associated kinase activity in patients with hypertension., Journal of Hypertension, 29(2), 373-379, 2011
  69. Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil., Atherosclerosis, 214(1), 117-121, 2011
  70. Effect of prodromal angina pectoris on the infarct progression in patients with first ST-elevation acute myocardial infarction., Circulation Journal, 74(8), 1651-1657, 2010
  71. Coronary angioscopic findings eight months after sirolimus-eluting stent implantation: a comparison between ST-elevation myocardial infarction and stable angina pectoris., EuroIntervention, 6(2), 251-256, 2010
  72. Accidental connection between the atrial and ventricular stylets during a stimulation threshold test for pacemaker implantation., Journal of Cardiovascular Medicine, 11(3), 190-192, 2010
  73. Therapeutic hypothermia in combination with percutaneous coronary intervention in out-of-hospital cardiac arrest due to left main coronary artery disease., Heart and Vessels, 24(5), 376-379, 2009
  74. History of diabetes mellitus as a neurologic predictor in comatose survivors of cardiac arrest of cardiac origin treated with mild hypothermia., Resuscitation, 80(8), 881-887, 2009
  75. The decrease in QRS amplitude after aortic valve replacement in patients with aortic valve stenosis., Journal of Electrocardiology, 42(5), 410-413, 2009
  76. Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy., Coronary Artery Disease, 20(3), 214-218, 2009
  77. Incidence and treatment of left ventricular apical thrombosis in Tako-tsubo cardiomyopathy., Internal Journal of Cardiology, 146(3), e58-e60, 2011
  78. Electrocardiographic prediction of short-term prognosis in patients with acute myocardial infarction associated with the left main coronary artery., Journal of Electrocardiology, 42(2), 106-110, 2009
  79. Trends in gender difference in mortality after acute myocardial infarction., Journal of Cardiology, 52(3), 232-238, 2008
  80. Clinical profile of patients with symptomatic glycyrrhizin-induced hypokalemia., Journal of the American Geriatrics Society, 56(8), 1579-1581, 2008
  81. Torsade de pointes associated with bradycardia and takotsubo cardiomyopathy., Canadian Journal of Cardiology, 24(8), 640-642, 2008
  82. Therapeutic hypothermia after out-of-hospital cardiac arrest due to Brugada syndrome., Resuscitation, 79(2), 332-335, 2008
  83. Role of telemetry monitoring to detect the onset of tako-tsubo cardiomyopathy in consciousness disturbance., Journal of the American Geriatrics Society, 56(6), 1159-1160, 2008
  84. Assessment of medications in patients with tako-tsubo cardiomyopathy., Internal Journal of Cardiology, 134(3), e120-e123, 2009
  85. Impact of admission hyperglycemia and diabetes mellitus on short- and long-term mortality after acute myocardial infarction in the coronary intervention era., American Journal of Cardiology, 99(12), 1674-1679, 2007
  86. Effects of Cerebral Blood Flow and Vessel Conditions on Speech Recognition in Patients With Postlingual Adult Cochlear Implant: Predictable Factors for the Efficacy of Cochlear Implant, EAR AND HEARING, 39(3), 540-547, 2018
  87. Physiological Diagnostic Criteria for Vascular Failure, HYPERTENSION, 72(5), 1060-1071, 201811
  88. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism, HYPERTENSION RESEARCH, 41(11), 932-938, 201811
  89. Hyperuricemia and endothelial function: From molecular background to clinical perspectives, ATHEROSCLEROSIS, 278, 226-231, 201811
  90. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(14), 20180717
  91. Effect of short-term colchicine treatment on endothelial function in patients with coronary artery disease, INTERNATIONAL JOURNAL OF CARDIOLOGY, 281, 35-39, 20190415
  92. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, EUROPEAN JOURNAL OF NUTRITION, 58(3), 989-996, 201904
  93. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A, CIRCULATION JOURNAL, 83(5), 1064-+, 201905
  94. Review of the Long-term Effects of Autologous Bone-Marrow Mononuclear Cell Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia, SCIENTIFIC REPORTS, 9, 20190522
  95. Systematic review of the clinical outcomes of mineralocorticoid receptor antagonist treatment versus adrenalectomy in patients with primary aldosteronism, HYPERTENSION RESEARCH, 42(6), 817-824, 201906
  96. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, JOURNAL OF HYPERTENSION, 37(5), 1083-1095, 201905
  97. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, SCIENTIFIC REPORTS, 9, 20190715
  98. Bilirubin and Endothelial Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 26(8), 688-696, 2019
  99. Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment, HYPERTENSION RESEARCH, 42(8), 1175-1185, 201908
  100. Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men, JOURNAL OF CLINICAL LIPIDOLOGY, 13(4), 664-672, 201908
  101. Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus, AMERICAN JOURNAL OF HYPERTENSION, 32(7), 695-702, 201907
  102. Relationships Between Calcium Channel Blockers and Vascular Function Tests, AMERICAN JOURNAL OF HYPERTENSION, 32(7), 640-648, 201907
  103. Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency, INTERNAL MEDICINE, 58(21), 3107-3111, 2019
  104. Brachial-Ankle Pulse Wave Velocity Versus Its Stiffness Index beta-Transformed Value as Risk Marker for Cardiovascular Disease, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 8(24), 20191217
  105. Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(2), 20200121
  106. Long-Term Clinical Outcomes of Autologous Bone Marrow Mononuclear Cell Implantation in Patients With Severe Thromboangiitis Obliterans, CIRCULATION JOURNAL, 84(4), 650-655, 202004
  107. Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13(3), 421-427, 202006
  108. Giant multiple xanthomas in familial hypercholesterolaemia, EUROPEAN HEART JOURNAL, 40(33), 2831-2831, 20190901
  109. Non-Invasive Central Venous Pressure Measurement Using Enclosed-Zone Central Venous Pressure (ezCVP (TM)), CIRCULATION JOURNAL, 84(7), 1112-1117, 202007
  110. Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A, HYPERTENSION RESEARCH, 43(8), 781-790, 202008
  111. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, SCIENTIFIC REPORTS, 10(1), 20200710
  112. Perspectives on the management of hypertension in Japan, EXPERT OPINION ON PHARMACOTHERAPY, 21(10), 1179-1187, 20200702
  113. Vascular function is further impaired in subjects aged 80 years or older, HYPERTENSION RESEARCH, 43(9), 914-921, 202009
  114. Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study, BMJ OPEN, 10(7), 2020
  115. Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study, BMJ OPEN DIABETES RESEARCH & CARE, 8(1), 2020
  116. Ionizing Irradiation Induces Vascular Damage in the Aorta of Wild-Type Mice, CANCERS, 12(10), 202010
  117. Daily Low-intensity Pulsed Ultrasound Ameliorates Renal Fibrosis and Inflammation in Experimental Hypertensive and Diabetic Nephropathy, HYPERTENSION, 76(6), 1906-1914, 202012
  118. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 105(11), 202011
  119. Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia, SCIENTIFIC REPORTS, 10(1), 20201116
  120. Antithrombotic therapy for stroke prevention in patients with atrial fibrillation in Japan, EXPERT OPINION ON PHARMACOTHERAPY, 21(17), 2115-2124, 20201121
  121. Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study, PLOS ONE, 15(12), 20201203
  122. Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy, JOURNAL OF CLINICAL MEDICINE, 9(12), 202012
  123. Association of Body Mass Index with Endothelial Function in Asian Men, INTERNATIONAL JOURNAL OF CARDIOLOGY, 324, 186-192, 20210201
  124. Bach1 plays an important role in angiogenesis through regulation of oxidative stress, MICROVASCULAR RESEARCH, 134, 202103
  125. Smoking status and endothelial function in Japanese men, SCIENTIFIC REPORTS, 11(1), 20210108
  126. Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle-Brachial Index, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(23), 20201201
  127. Pathophysiological Association of Endothelial Dysfunction with Fatal Outcome in COVID-19, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(10), 202105
  128. Lower triglyceride levels are associated with better endothelial function, JOURNAL OF CLINICAL LIPIDOLOGY, 15(3), 500-511, 2021
  129. Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study, PLOS ONE, 16(8), 2021
  130. Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction, ANTIOXIDANTS, 10(8), 202108
  131. An overview of pharmacotherapy for cerebral vasospasm and delayed cerebral ischemia after subarachnoid hemorrhage, EXPERT OPINION ON PHARMACOTHERAPY, 22(12), 1601-1614, 20210813
  132. Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 28(9), 963-973, 2021
  133. A body shape index is associated with endothelial dysfunction in both men and women, SCIENTIFIC REPORTS, 11(1), 20210909
  134. Regenerative medicine for radiation emergencies, JOURNAL OF RADIATION RESEARCH, 62, I21-I29, 202104
  135. Stair climbing activity and vascular function in patients with hypertension, HYPERTENSION RESEARCH, 44(10), 1274-1282, 202110
  136. Upstroke time as a marker of atherosclerosis in patients with diabetes mellitus who have a normal ankle-brachial index, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 35(11), 202111
  137. Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction, CANCERS, 13(21), 202111
  138. Falsely normalized ankle-brachial index despite the presence of lower-extremity peripheral artery disease: two case reports, JOURNAL OF MEDICAL CASE REPORTS, 15(1), 20211217
  139. Vascular Dysfunction Predicts Future Deterioration of Left Ventricular Ejection Fraction in Patients with Heart Failure with Mildly Reduced Ejection Fraction, JOURNAL OF CLINICAL MEDICINE, 10(24), 202112
  140. Short stature is associated with low flow-mediated vasodilation in Japanese men, HYPERTENSION RESEARCH, 45(2), 308-314, 202202

Publications such as books

  1. 2017, Therapeuic Angiogenesis, Exercise, Springer, 2017, Scholarly Book, Joint work, Maruhashi T, Kihara Y, Higashi Y, 229-246
  2. 2017, Diabetes and Aging-related Complications, Diabetes and Endothelial Dysfunction, Springer, 2017, Scholarly Book, Joint work, Maruhashi T, Kihara Y, Higashi Y, 45-59
  3. 2016, Current Therapy in Cardiovascular Diseases 2016-2017, Raynaud phenomenon, 2016, Scholarly Book, Joint work, Maruhashi T, Kihara Y, 626, 499-501
  4. 2015, Angiotensin-converting enzyme~Advice from 50 experts, Which dose control the action of coronary artery, angiotensin or nitric oxide?, 南江堂, 2015, 2015, Scholarly Book, Joint work, Maruhashi T, Higashi Y, 38-41
  5. 2009, Heart View, 2009, Scholarly Book, Joint work, Maruhashi T, Ishihara M, 95-98
  6. 2018, Hyperuricemia and Gout, Uric acid and endothelial dysfunction, 2018, 3月, Scholarly Book, Joint work, 日本語, Tatsuya Maruhashi,Yasuki Kihara, Yukihito Higashi, 91

Invited Lecture, Oral Presentation, Poster Presentation

  1. Hematocrit and Hemoglobin are Associated with Vascular Function and Vascular Structure in Men, Kishimoto S, Higashi Y, Harada T, Tamaji T, Takaeko Y, Yusoff FM, Hashimoto H, Kajikawa M, Maruhashi T, Kihara Y, The 84th Annual Scientific Meeting of the Japanese Circulation Society, 2020/07/27, Without Invitation, English, Japanese Circulation Society, Yokohama
  2. High-normal Triglycerides are Associated with Increased Cardiovascular Events in Patients with Coronary Artery Disease, Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Haruki Hashimoto, Yuji Takaeko, Yakayuki Yamaji, Takahiro Harada, Yu Hashimoto, Farina Mohamad Yusoff, Yasuki Kihara, Kensuke Noma, Ayumu Nakashima, Yukihito Higashi, FMD-J Investigators, The 84th Annual Scientific Meeting of the Japanese Circulation Society, 2020/07/27, Without Invitation, English, Japanese Circulation Society, Yokohama
  3. Association Between Endothelial Function Measured by Enclosed Zone Flow-mediated Vasodilation and Cardiovascular Risk Factors, Masato Kajikawa, Haruka Morimoto, Haruki Hashimoto, Shogo Matsui, Tatsuya Maruhashi, Shinji Kishimoto, Yuji Takaeko, Takayuki Yamaji, Takahiro Harada, Farina Mohamad Yusoff, Yasuki Kihara, Toshio Tsuji, Yukihito Higashi, 92th Scientific Session, American Heart Association, 2019/11/18, Without Invitation, English, American Heart Association, Philadelphia
  4. Eplerenone Improves Vascular Function, Arterial Stiffness and Rho-associated Kinase Activity in Patients with Idiopathic Hyperaldosteronism, Shinji Kishimoto, Masato Kajikawa, Haruki Hashimoto, Shogo Matsui, Tatsuya Maruhashi, Yuji Takaeko, Takayuki Yamaji, Takahiro Harada, Farina Mohamad Yusoff, Yasuki Kihara, Kensuke Noma, Yukihito Higashi, 92th Scientific Sessions, American Heart Association, 2019/11/16, Without Invitation, English
  5. Association of Extremely High Levels of High-density Lipoprotein Cholesterol with Endothelial Dysfunction in Men., Yuji Takaeko, Masato Kajikawa, Haruki Hashimoto, Shogo Matsui, Tatsuya Maruhashi, Shinji Kishimoto, Yukihito Higashi, 92th Scientific Sessions, American Heart Association, 2019/11/16, Without Invitation, English
  6. Patients with Diastolic Ventricular Hypertrophy and Ventricular Dysfunction may occur Heart Failure with Preserved Ejection Fraction through Endothelial Dysfunction, Shinji Kishimoto, Masato Kajikawa, Tatsuya Maruhashi, Yuji Takaeko, Takayuki Yamaji, Takahiro Harada, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Yukihito Higashi, 2019/10/04, Without Invitation, Japanese
  7. Usefulness of vascular function tests for cardiovascular risk prediction in patients with coronary artery disease: FMD-J Study A, Tatsuya Maruhashi, Shogo Matsui, Masato Kajikawa, Yuji Takaeko, Haruki Hashimoto, Shinji Kishimoto, Takayuki Hidaka, Ayumu Nakashima, Farina Mohamad Yusoff, Kensuke Noma, Yasuki Kihara, Yukihito Higashi, Hirofumi Tomiyama, Akira Yamashina, Bonpei Takase, Toru Suzuki, 91th Scientific Session, American Heart Association, 2018/11/10, Without Invitation, English
  8. Lower urinary tract sympsoms in men is an early phenotype of endothelial dysfunction, Shogo Matsui, Masato Kajikawa, Yuji Takaeko, Haruki Hashimoto, Shinji Kishimoto, Tatsuya Maruhashi, Takayuki Hidaka, Ayumu Nakashima, Farina Mohamad Yusoff, Kensuke Noma, Yasuki Kihara, Yukihito Higashi, 91th Scientific Session, American Heart Association, 2018/11/10, Without Invitation, English
  9. Association of poor tooth brushing behavior with cardiovascular outcome: two-year follow-up prospective observational study., Shogo Matsui, Masato Kajikawa, Yuji Takaeko, Haruki Hashimoto, Shinji Kishimoto, Tatsuya Maruhashi, Takayuki Hidaka, Ayumu Nakashima, Farina Mohamad Yusoff, Kensuke Noma, Yasuki Kihara, Yukihito Higashi, 91th Scientific Session, American Heart Association, 2018/11/10, Without Invitation, English
  10. Assessment of endothelium-depenent and -independent vasodilation: from mehodology to clinial perspctives., Joint Hypertension 2018 Scietiic Sessions AHA Council on Hypertensin AHA Council on Kidney in Cardiovaslar Disease American Society of Hypetension, 2018/09/08, With Invitation, English, Chicago
  11. Depth extraction system for earlobe crease to support diagnosis of arteriosclerosis, Harutoyo Hirano, Daichi Uematsu, Masato Futagawa, Toshio Tsuji, Haruki Hashimoto, Shinji Kishimoto, Nozomu Oda, Masato Kajikawa, Tatsuya Maruhashi, Yukihito Higashi, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2018/07/17, Without Invitation, English
  12. Lower Urinary Tract Symptoms in men as an ealry phenotype of endothelial function, Shogo Matsui, Masato Kajikawa, Yuji Takaeko, Haruki Hashimoto, Shinji Kishimoto, Tatsuya Maruhashi, Takayuki Hidaka, Ayumu Nakashima, Farina Mohamad Yusoff, Kensuke Noma, Yasuki Kihara, Yukihito Higashi, Pulse of Asia, 2018/05/19, Without Invitation, English
  13. Novel measuement of Endothelial Function assessed by Short Time Flow-mediated Vasodilation: Comparison with Conventional Flow-mediated Vasodilation, Shogo Matsui, Masato Kajikawa, Yuji Takaeko, Haruki Hashimoto, Shinji Kishimoto, Tatsuya Maruhashi, Takayuki Hidaka, Ayumu Nakashima, Farina Mohamad Yusoff, Kensuke Noma, Yasuki Kihara, Yukihito Higashi, Pulse of Asia, 2018/05/19, Without Invitation, English
  14. A Comparison of Brachial Artery Diameter with Flow-mediaed vasodilaion as vascular marker for cardiovascular risk assessment: FMD-J Study, Tatsuya Maruhashi, Shogo Matsui, Masato Kajikawa, Haruki Hashimoto, Shinji Kishimoto, Hirofumi Tomiyama, Akira Yamashina, Kensuke Noma, Yasuki Kihara, Yukihito Higashi, Pulse of Asia, 2018/05/19, Without Invitation, English
  15. Vascular Function tests and CardiovascularRisk Prediction in Patients with CoronaryArtery Disease: FMD-J (Flow-MediatedDilation Japan) Study A, Maruhashi T, Tomiyama H, YamashinaA, Takase B, Suzuki T, Kihara Y,Higashi Y, 第82回日本循環器学会学術集会, 2018/03/25, Without Invitation, English, Osaka
  16. Enclosed zone flow-mediated vasodilationmeasured by the mean pressure method isuseful for assessment of endothelialfunction, Kajikawa M, Morimoto H, Matsui S,Oda N, Maruhashi T, Kinoshimoto S,Hashimoto H, Hidaka T, FarinaMohanmad Yusoff, Kihara Y, Noma K,Nakashima A, Hirano H, Ukawa T,Tsuji T, Higashi Y, 第82回日本循環器学会学術集会, 2018/03/24, Without Invitation, English, Osaka
  17. Patients with Diastolic VentricularDysfunction and Ventricular Hypertrophy mayoccur Heart Failure with Preserved EjectionFraction through Endothelial Dysfunction, Kishimoto S, Higashi Y, MaruhashiT, Kajikawa M,Matsui S, HashimotoH, Hidaka T, Noma K, Kihara Y, 第82回日本循環器学会学術集会, 2018/03/24, Without Invitation, English, Osaka
  18. 強皮症に伴う手指壊疽に対して低周波超音波を用いた1例, Kajikawa M, Matsui S, Maruhashi T, Kishimoto S, Iwamoto Y, Noma K, Nakashima A, Kihara Y, Higashi Y, 第17回日本再生医療学会総会, 2018/03/23, Without Invitation, Japanese, Kanagawa
  19. Impairment of Endothelial Function inPatients Receiving Antihypertensive DrugTreatment Regardless of Blood PressureLevel: FMD-J Study, Maruhashi T, Higashi Y, Iwamoto Y,Kajikawa M, Kishimoto S, Matsui S,Hashimoto H, Hidaka T, Noma K,Tomiyama H, Takase B, Yamashina A,Kihara Y, 第82回日本循環器学会学術集会, 2018/03/23, Without Invitation, English, Osaka
  20. コレステロールが血管機能に与える影響およびLDLコレステロールの至適目標値:スタチン治療患者とスタチン未治療患者での検討, Matsui S, Higashi Y, Kajikawa M, Marhashi T, Hashimoto H, Kishimoto S, Hidaka T, Noma K, Kihara Y, 第117回日本内科学会中国地方会, 2017/11/18, Without Invitation, Japanese, Shimane
  21. Vascular function is impaired in subjectswith decreased circulating level of pigmentepithelium-derived factor, Kajikawa M, Higashi Y, Maruhashi T,Iwamoto Y, Oda N, Kishimoto S,Matsui S, Hidaka T, Noma K,Nakashima A, Matsui T, Yamagishi S,Kihara Y, AHA Scientific Sessions 2017, 2017/11/12, Without Invitation, English, Anaheim
  22. Endothelial function measured by enclosedzone flow-mediated vasodilation predictscardiovascular events, Kajikawa M, Morimoto H, Oda N, IdeiN, Hirano H, Maruhashi T, KishimotoS, Matsui S, Hidaka T, Farina BMY,Kihara Y, Noma K, Nakashima A,Ukawa T, Tsuji T, Higashi Y, AHA Scientific Sessions 2017, 2017/11/12, Without Invitation, English
  23. Effect of Coffee with a High Content ofChlorogenic Acids and Low Content ofHydroxyhydroquinone on PostprandialEndothelial Dysfunction, Kajikawa M, Maruhashi T, Hidaka T,Nakano Y, Kurisu S, Matsumoto T,Iwamoto Y, Kishimoto S, Matsui S,Hashimoto H, Farina BMY, Kihara Y,Noma K, Nakashima A, Watanabe T,Tone H, Hibi M, Osaki N, KatsuragiY, Higashi Y, AHA Scientific Sessions 2017, 2017/11/12, Without Invitation, English, Anaheim
  24. Impaired endothelial function in patientsreceiving antihypertensive drug treatmentregardless of achieved blood pressurelevel: FMD-J Study, Maruhashi T, Higashi Y, Kajikawa M,Iwamoto Y,, Kishimoto S, Matsui S,Hashimoto H, Hidaka T, Noma K,Nakashima A, Kihara Y, AHA Scientific Sessions 2017, 2017/11/12, Without Invitation, English, Anaheim
  25. 酸化成分低減クロロゲン酸含有コーヒーは食後の血管内皮障害を抑制する, Kajikawa M, Maruhashi T, Kishimoto S, Matsui S, Noma K, Hidaka T, Kurisu S, Nakano Y, Kihara Y, Watanabe T, Touji H, Hibi S, Osaki N, Katuragi H, Hgashi Y, 第40回日本高血圧学会総会, 2017/10/20, Without Invitation, Japanese, Ehime
  26. 新規血管内皮機能測定装置改良型enclosed zoneflow-mediated vasodilation (ezFMD)の有用性, Kajikawa M, Morimoto H, Matsui S, Oda N, Hirno H, Maruhashi T, Kishimoto S, Iwamoto Y, Hidaka T, Nakashima A, Noma K, Kihara Y, Ukawa S, Tuji T, Higashi Y, 2017/10/20, Without Invitation, Japanese, Ehime
  27. Optimal Cut-off Level of Low-Density LipoproteinCholesterol for Normal Vascular Function in a GeneralPopulation, Matsui S, Higashi Y, Kajikawa M, MaruhashiT, Kishimoto S, Oda N, Hidaka T, NakashimaA, Noma K, Kihara Y, ESC Congress 2017, 2017/08/27, Without Invitation, English, Barcelona
  28. Short Term Colchicine Treatment ImprovesEndothelial Function in Patients withCardiovascular Disease, Kajikawa M, Kurisu S, Maruhashi T,Hidaka T, Iwamoto Y, Kishimoto S,Matsui S, Hashimoto H, Farina BMY,Kihara Y, Noma K, Nakashima A,Matsushita A, Tomiyama H, Ueda S,Higashi Y, AHA Scientific Sessions 2017, Without Invitation, English, Anaheim

Awards

  1. 2017/04/16, The 2nd Annual Scientific Meeting of Japanese Society for Vascular Failure Best Presentation Award, 日本血管不全学会, Relationship between nitroglycerine-induced vasodilation in coronary artery and brachial artery.
  2. 2014, The 32th Koujinkai Award
  3. 2013/04/20, The pulse of Asia 2013 Seoul Best Poster Award, Intima-media thickness of Brachial Artery is a Useful Marker of Atherosclerosis
  4. 2013, Hiroshima University Hospital Article Award (High Impact Award)
  5. 2012/12/22, The 7th Meeting of Hypertension and Coronary Artery Disease Best Presentation Award, Relationship between hyperbilirubinemia, oxidativestress, and endothelial function in patients with Girbert syndrome
  6. 2012, Hiroshima Univerity Scholarship for Oversea Presentation in 2012
  7. 2018/05/19, Pulse of Asia 2018 Travel Grant, Pulse of Asia

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI (Grant-in-Aid for Young Scientists (B)), Usefulness and mechanism of intermittent compression of lower limb for angiogenesis, 2016, 2017
  2. Research grant of Mitsubishi Tanabe Pharma, Role of resistin-like molecular beta (RELM beta) on the regulation of endothlial NO synthase (eNOS), 2017, 2017
  3. The 10th Research Award on Molecular and Cellular Cardiology, The role of Bach1 on angiogenesis, 2014, 2014
  4. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2019, 2020

Social Activities

History as Peer Reviews of Academic Papers

  1. 2020, Computed Methods and Programs in Biomedicine Update, Others, 1
  2. 2020, BMC Geriatrics, Others, 1
  3. 2020, Journal of American Heart Association, Editor, 1
  4. 2020, Journal of Cardiology, Others, 2
  5. 2020, Journal of Clinical Medicine, Others, 1
  6. 2020, Internal Medicine, Others, 1
  7. 2020, Hypertension Research, Others, 3
  8. 2020, Scientific Report, Others, 2
  9. 2020, Journal of Atherosclerosis and Thrombosis, Others, 1
  10. 2018, Circulation Journal, Others, reviewer, 1
  11. 2018, Journal of Atherosclerosis and Thrombosis, Others, reviewer, 1
  12. 2018, vascular failure, Others, reviewer, 1