MEGUMI SASATANI

Last Updated :2025/04/07

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Professor
Web Site
https://bunshi12.hiroshima-u.ac.jp/
E-mail
mtoyoshhiroshima-u.ac.jp
Other Contact Details
1-2-3，Kasumi，Minami-ku，Hiroshima, Japan
TEL : (+81)82-257-5893 FAX : (+81)82-257-5843
Self-introduction
Our current research projects can be summarized as follows 1. To elucidate radiation-induced cancer risk at low doses/ low dose rates 2. To reveal the role of stem cells in radiation carcinogenesis; 3. To develop an animal model susceptible to radiation-induced diseases

Basic Information

Major Professional Backgrounds

  • 2003/04/01, 2005/03/31, JSPS, Research Fellow, Japan Society for the Promotion of Science
  • 2005/04/01, 2006/03/31, Kyoto University, Radiation Biology Center, Part-time Researcher
  • 2006/04/01, 2007/03/31, Kyoto University, Graduate School of Medicine, Research Associate
  • 2007/04/01, 2018/01/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor
  • 2018/02/01, Hiroshima University, Research Institute for Radiation Biology and Medicine, Associate Professor

Educational Backgrounds

  • Okayama University, Faculty of Pharmaceutical Science, 1995/04, 1999/03
  • Okayama University, Graduate School of Natural Science and Technology, Divisions of Pharmaceutical Science and Clinical Pharmaceutical Science, 1999/04, 2001/03
  • Kyoto University, Graduate School of Medicine, Phisiology, 2001/04, 2005/03

Academic Degrees

  • Master of Pharmaceutical Science, Okayama University
  • Ph.D., Kyoto University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
  • Medicine,dentistry, and pharmacy;Basic medicine;General physiology
  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy

Research Keywords

  • Radiation biology

Affiliated Academic Societies

  • The Japan Radiation Research Society, 2001/04
  • Japanese Cancer Association
  • The Japanese Environmental Mutagen Society (JEMS)
  • The Molecular Biology Society of Japan

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Radiation Biology & Radiation Health Risk Sciences
  2. 2025, Undergraduate Education, Intensive, Practice for medical research
  3. 2025, Undergraduate Education, 1Term, Nuclear Pharmacy
  4. 2025, Undergraduate Education, 2Term, Outline of Immunology
  5. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Experimental Oncology
  6. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Experimental Oncology
  7. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Experimental Oncology
  8. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Experimental Oncology
  9. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  10. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  11. 2025, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology
  12. 2025, Graduate Education (Doctoral Program) , Second Semester, History of Hiroshima Restoration

Research Activities

Academic Papers

  1. Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 100(4), 584-594, 20240402
    Link to Paper Search Results by DOI
  2. Morphology dynamics in intestinal crypt during postnatal development affect age-dependent susceptibility to radiation-induced intestinal tumorigenesis in Apc Min/+ mice: possible mechanisms of radiation tumorigenesis, CARCINOGENESIS, 44(1), 105-118, 20230515
    Link to Paper Search Results by DOI
  3. Newly discovered genomic mutation patterns in radiation-induced small intestinal tumors of ApcMin/+ mice, PLOS ONE, 18(10), 20231012
    Link to Paper Search Results by DOI
  4. Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract, JOURNAL OF RADIATION RESEARCH, 64(2), 210-227, 20230323
    Link to Paper Search Results by DOI
  5. Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver, JOURNAL OF RADIATION RESEARCH, 64(2), 228-249, 20230323
    Link to Paper Search Results by DOI
  6. Effects of oxygen on the response of mitochondria to X-irradiation and reactive oxygen species-mediated fibroblast activation, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 99(5), 769-778, 20230504
    Link to Paper Search Results by DOI
  7. Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila, GENES AND ENVIRONMENT, 45(1), 20230323
    Link to Paper Search Results by DOI
  8. Melatonin and MitoEbselen-2 Are Radioprotective Agents to Mitochondria, GENES, 14(1), 202212
    Link to Paper Search Results by DOI
  9. ACTIVATION OF HUMAN FIBROBLASTS BY CHRONIC RADIATION RATHER THAN ACUTE RADIATION, RADIATION PROTECTION DOSIMETRY, 198(13-15), 1098-1103, 20220909
    Link to Paper Search Results by DOI
  10. Radiation affects glutathione redox reaction by reduced glutathione peroxidase activity in human fibroblasts, Journal of Radiation Research, 63(2), 183-191, 20220317
  11. Kinetics of DNA Repair Under Chronic Irradiation at Low and Medium Dose Rates in Repair Proficient and Repair Compromised Normal Fibroblasts, Radiation Research, 197(4), 332-349, 20220401
  12. Formation of DNA Damage Foci in Human and Mouse Primary Fibroblasts Chronically Exposed to Gamma Radiation at 0.1 mGy/min., Radiation Research, 196(1), 40-54, 20210701
    Link to Paper Search Results by DOI
  13. Suppression of replication fork progression in low dose specific p53 dependent S-phase DNA damage checkpoint., Oncogene, 25, 5291-5932, 2006
  14. Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system, Int. J. Mol. Med., 19(4), 649-652, 2007
  15. Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus, Int. J. Mol. Med., 19(5), 733-739, 2007
  16. Chromosome aberrations do not persist in the lymphocytes or bone marrow cells of mice irradiated in utero or soon after birth., Radiat. Res, 167(6), 693-702, 2007
  17. p21 provides stage specific DNA damage control to preimplantation embryos., Oncogene, 226(42), 6141-6149, 2007
  18. Roles of neuropeptides in O,O,S-trimethylphosphorothioate (OOS-TMP)-induced anorexia in mice., Biochem Biophys Res Commun., 362(1), 177-182, 2007
  19. The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha., Int. J. Mol. Med., 21(4), 439-445, 2008
  20. Analysis of p53 dependent damage response in sperm-irradiated mouse embryos, Journal of Radiation Research, 50(1), 11-17, 2009
  21. Cleft palate caused by perfluorooctane sulfonate is caused mainly by extrinsic factors., Toxicology, 256(1-2), 42-47, 2009
  22. Levels of N-acylethanolamines in O,O,S-trimethylphosphorothioate (OOS-TMP)-treated C57BL/6J mice and potential anti-obesity, anti-diabetic effects of OOS-TMP in hyperphagia and hyperglycemia mouse models., Pharmacol. Biochem. Behav., 92(1), 1-5, 2009
  23. Paternal monoenergetic neutron exposure results in abnormal sperm, and embryonal lethality and transgenerational tumorigenesis in mouse F1 offspring, Oncology Report, 23(5), 1351-1360, 2010
  24. Estimation of biological effect of Tritium, Journal of Plasma and Fusion Research, 20110901
  25. Radiation induction of delayed recombination in Schizosaccharomyces pombe, DNA REPAIR, 7(8), 1250-1261, 20080802
    Link to Paper Search Results by DOI
  26. DEVELOPMENT OF A SENSITIVE ASSAY SYSTEM FOR TRITIUM RISK ASSESSMENT USING REV1 TRANSGENIC MOUSE, FUSION SCIENCE AND TECHNOLOGY, 60(3), 1204-1207, 201110
    Link to Paper Search Results by DOI
  27. Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells, CELL CYCLE, 13(8), 1248-1255, 20140415
    Link to Paper Search Results by DOI
  28. A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic gamma-Irradiation, PLOS ONE, 9(8), 20140805
    Link to Paper Search Results by DOI
  29. RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure, PLOS ONE, 10(2), 2015
    Link to Paper Search Results by DOI
  30. Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low-dose irradiated human fibroblasts, ONCOTARGET, 7(3), 3559-3570, 2016
  31. Hydrogen Peroxide Enhances TGF beta-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells, ANTICANCER RESEARCH, 37(3), 987-995, 201703
    Link to Paper Search Results by DOI
  32. A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells, CELL CYCLE, 16(6), 565-573, 2017
    Link to Paper Search Results by DOI
  33. Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells, SCIENTIFIC REPORTS, 7, 20170510
    Link to Paper Search Results by DOI
  34. Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level, CARCINOGENESIS, 38(5), 570-578, 201705
    Link to Paper Search Results by DOI
  35. Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP), AMERICAN JOURNAL OF HYPERTENSION, 31(1), 43-47, 201801
    Link to Paper Search Results by DOI
  36. ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts, CELL CYCLE, 16(24), 2345-2354, 2017
    Link to Paper Search Results by DOI
  37. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist, MOLECULAR CANCER THERAPEUTICS, 17(2), 432-442, 201802
    Link to Paper Search Results by DOI
  38. Tritium biology in Japan: A search for a new approach, FUSION ENGINEERING AND DESIGN, 128, 28-32, 201803
    Link to Paper Search Results by DOI
  39. Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGF beta Signaling, MOLECULAR CANCER RESEARCH, 16(11), 1676-1686, 201811
    Link to Paper Search Results by DOI
  40. The in vivo role of Rev1 in mutagenesis and carcinogenesis, GENES AND ENVIRONMENT, 42(1), 20200228
    Link to Paper Search Results by DOI
  41. Mechanism of turnover or persistence of radiation-induced myofibroblast in vitro, CELL CYCLE, 19(23), 3375-3385, 20201201
    Link to Paper Search Results by DOI
  42. Somatic Cell Mutation Induced by Sunlight in Drosophila, Journal of Epidemiology, 1999
  43. The novel surveillance mechanism of the Trp53-depenent S-phase checkpoint ensures chromosome damage repair and preimplantation-stage development of mouse embryos fertilized with X-irradiated sperm, Radiat. Res, 158(6), 735-742, 2002
  44. The involvement of cell cycle checkpoint-hila by a longer wavelength light band of solar UV, Photochem. Photobiol. Sci., 1(3), 178-183, 2002
  45. Alternative methods to evaluate the protective ability of sunscreen against photo-genotoxicity, Journal of photochemistry and photobiology B: Biology, 73(1-2), 59-66, 2004
  46. Generation of multipotent stem cells from postnatal mouse testis, Cell, 119(7), 1001-1012, 2004
  47. Transcription independent suppression of DNA synthesis by p53 in sperm irradiated mouse zygotes, Oncogene, 24(20), 3229-3235, 2005
  48. Dimorphic gene expression patterns of anorexigenic and orexigenic peptides in hypothalamus account male and female hyperphagia in Akita type 1 diabetic mice, Biochem Biophys Res Commun., 352(3), 703-708, 2006
  49. Delayed and stage specific phosphorylation of H2AX during preimplantation development of gamma-irradiated mouse embryos, Reproduction, 133(2), 415-422, 2007

Invited Lecture, Oral Presentation, Poster Presentation

  1. Dose rate-dependent cellular senescence in response to chronic g-irradiation via the ATM/TP53/p21 pathway, 2015/03/04, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2016
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  2. KAKENHI, The role of translesion DNA synthesis on radiation and chemical induced carcinogenesis, 2010, 2012
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  3. KAKENHI, Role of Rev1, repair enzyme in translesion DNA synthesis, in tumorigenesis, 2008, 2009
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  4. KAKENHI, 2006, 2007
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  5. 2013, 2016
  6. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  7. KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2020, 2022