ATSUO YOSHINO

Last Updated :2026/06/03

Affiliations, Positions
Health Service Center, Associate Professor
E-mail
yoshinohiroshima-u.ac.jp
Self-introduction
I have been studying pain from the view of psychiatry and neuroimaging. I have been also treating chronic pain by psychosocial approach such as cognitive behavioral therapy.

Basic Information

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medicine, Japan, 2006/04, 2010/03
  • Hiroshima University, Faculty of Medicine, Japan, 1996/04, 2002/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science

Research Keywords

  • Neuroimaging
  • Chronic pain
  • Cognitive behavioral therapy

Affiliated Academic Societies

  • Sigma Xi
  • Society for Neuroscience
  • World Federation of Societies of Biological Psychiatry
  • International Association for the Study of Pain

Research Activities

Academic Papers

  1. Multifaceted analysis of presenteeism: contributions of pain, psychological factors and daily functioning - a cross-sectional study in Japan, BMJ OPEN, 15(8), 20250812
    Link to Paper Search Results by DOI
  2. Individualized cognitive behavioral therapy for chronic pain in Japan: study protocol for a multicenter randomized controlled trial, TRIALS, 26(1), 20251111
    Link to Paper Search Results by DOI
  3. Magnetoencephalographic detection of the epileptic activity localized in the hippocampus using stereotactic electroencephalography and magnetoencephalography simultaneously, EPILEPSIA, 66(9), 3453-3464, 202509
    Link to Paper Search Results by DOI
  4. Factors Associated With the Severity of Chronic Constipation Among Japanese University Students, JGH OPEN, 9(7), 20250722
    Link to Paper Search Results by DOI
  5. Comparison of depressive symptoms and eating behaviors among Japanese university students with subthreshold depression before and during the COVID-19 pandemic, FRONTIERS IN PSYCHIATRY, 16, 20250616
    Link to Paper Search Results by DOI
  6. Effects of the COVID-19 pandemic on the mental health of Japanese university students without depressive symptoms at university entrance, BIOPSYCHOSOCIAL MEDICINE, 19(1), 20250704
    Link to Paper Search Results by DOI
  7. Changed resting-state connectivity of anterior insular cortex affects subjective pain reduction after knee arthroplasty: A longitudinal study, BRAIN RESEARCH BULLETIN, 217, 20241015
    Link to Paper Search Results by DOI
  8. Vaccination Status, Vaccine Awareness and Attitudes, and Infection Control Behaviors of Japanese College Students: A Comparison of 2021 and 2023, VACCINES, 12(9), 202409
    Link to Paper Search Results by DOI
  9. Unraveling pain experience and catastrophizing after cognitive behavioral therapy, SCIENTIFIC REPORTS, 14(1), 20240726
    Link to Paper Search Results by DOI
  10. Changes in Resting-State Brain Activity After Cognitive Behavioral Therapy for Chronic Pain: A Magnetoencephalography Study, JOURNAL OF PAIN, 25(8), 202408
    Link to Paper Search Results by DOI
  11. Magnetoencephalographic detection of synchronized epileptic activity between the hippocampus and insular cortex, EPILEPSY & BEHAVIOR REPORTS, 26, 2024
    Link to Paper Search Results by DOI
  12. Clinical effects of online cognitive behavioral group therapy for chronic pain patients and developing a therapeutic alliance: A pre-post pilot trial, HEALTH SCIENCE REPORTS, 7(5), 202405
    Link to Paper Search Results by DOI
  13. Clinical effects of online cognitive behavioral group therapy for chronic pain patients and developing a therapeutic alliance: A pre–post pilot trial, HEALTH SCIENCE REPORTS, 7, e2141, 20240501
  14. Changes in Resting-State Brain Activity After Cognitive Behavioral Therapy for Chronic Pain: A Magnetoencephalography Study, JOURNAL OF PAIN, 20240404
  15. Neuroimaging-based evidence for sympathetic correlation between brain activity and peripheral vasomotion during pain anticipation, SCIENTIFIC REPORTS, 14(1), 20240209
    Link to Paper Search Results by DOI
  16. Prevalence and associated factors of chronic constipation among Japanese university students, FRONTIERS IN PUBLIC HEALTH, 12, 20240116
    Link to Paper Search Results by DOI
  17. A Case of a Father and Son With Complex Regional Pain Syndrome Type 1 Exhibiting Different Resting-State Functional Connectivity on Functional MRI, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(1), 20240119
    Link to Paper Search Results by DOI
  18. Is a booster dose of COVID-19 vaccines effective on newly dominant omicron subvariants among university students? Comparison between BA.1 and BA.2 dominancy, AMERICAN JOURNAL OF INFECTION CONTROL, 51(8), 907-911, 202308
    Link to Paper Search Results by DOI
  19. Verification of the brain network marker of major depressive disorder: Test-retest reliability and anterograde generalization performance for newly acquired data, JOURNAL OF AFFECTIVE DISORDERS, 326, 262-266, 20230401
    Link to Paper Search Results by DOI
  20. Interoceptive accuracy is related to the psychological mechanisms of the burning mouth syndrome: a cross-sectional study, BMC ORAL HEALTH, 22(1), 20220719
    Link to Paper Search Results by DOI
  21. Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 76(8), 367-376, 202208
    Link to Paper Search Results by DOI
  22. Age-related white matter changes revealed by a whole-brain fiber-tracking method in bipolar disorder compared to major depressive disorder and healthy controls, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 75(2), 46-56, 202102
    Link to Paper Search Results by DOI
  23. Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation, JOURNAL OF AFFECTIVE DISORDERS, 279, 20-30, 20210115
    Link to Paper Search Results by DOI
  24. Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study, SCIENTIFIC REPORTS, 11(1), 20210224
    Link to Paper Search Results by DOI
  25. Cardiorespiratory synchronisation and systolic blood pressure correlation of peripheral arterial stiffness during endoscopic thoracic sympathectomy, Scientific Reports, 11, 5966, 2021
  26. Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study, Scientific Reports, 11, 4425, 2021
  27. Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation, Journal of Affective Disorders, 279, 20-30, 2021
  28. Pain-related beliefs, cognitive processes, and electroencephalography band power as predictors and mediators of the effects of psychological chronic pain interventions, Pain, 162, 2036-2050, 2021
  29. Brain changes associated with impaired attention function in chronic pain, Brain and Cognition, in press, 2021
  30. Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training, NEUROIMAGE, 245, 20211215
    Link to Paper Search Results by DOI
  31. Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation., Journal of affective disorders, 279, 2021
  32. Age-related white matter changes revealed by a whole-brain fiber-tracking method in bipolar disorder compared to major depressive disorder and healthy controls., Psychiatry and clinical neurosciences, 75(2), 2021
  33. Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students, VACCINES, 10(8), 202208
    Link to Paper Search Results by DOI
  34. Attitudes and Behavior toward COVID-19 Vaccination in Japanese University Students: A Cross-Sectional Study, VACCINES, 10(6), 202206
    Link to Paper Search Results by DOI
  35. Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report, JOURNAL OF AFFECTIVE DISORDERS, 271, 224-227, 2020
  36. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 2020
  37. Neuroimaging studies about the relationship between negative emotions and pain, PAIN RESEARCH, 35(1), 17-23, 2020
    Link to Paper Search Results by DOI
  38. Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10(1), 20201008
    Link to Paper Search Results by DOI
  39. Altered Resting-State Connectivity with Pain-Related Expectation Regions in Female Patients with Severe Knee Osteoarthritis, JOURNAL OF PAIN RESEARCH, 13, 3227-3234, 2020
    Link to Paper Search Results by DOI
  40. White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder, BRAIN AND BEHAVIOR, 10(12), 202012
    Link to Paper Search Results by DOI
  41. White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder, Brain and Behavior, 10, e1868, 2020
  42. Altered Resting-State Connectivity with Pain-Related Expectation Regions in Female Patients with Severe Knee Osteoarthritis, Journal of Pain Research, 13, 3227-3234, 2020
  43. White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder., Brain and behavior, 10(12), 2020
  44. Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report., Journal of affective disorders, 271, 2020
  45. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study., Frontiers in human neuroscience, 14, 2020
  46. Altered Resting-State Connectivity with Pain-Related Expectation Regions in Female Patients with Severe Knee Osteoarthritis., Journal of pain research, 13, 2020
  47. Role of coping with negative emotions in cognitive behavioral therapy for persistent somatoform pain disorder: Is it more important than pain catastrophizing?, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 73(9), 560-565, 2019
  48. Predicting Ventral Striatal Activation During Reward Anticipation From Functional Connectivity at Rest, FRONTIERS IN HUMAN NEUROSCIENCE, 13, 2019
  49. Role of coping with negative emotions in cognitive behavioral therapy for persistent somatoform pain disorder: Is it more important than pain catastrophizing?, Psychiatry and clinical neurosciences, 73(9), 2019
  50. Predicting Ventral Striatal Activation During Reward Anticipation From Functional Connectivity at Rest., Frontiers in human neuroscience, 13, 2019
  51. Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model, SCIENTIFIC REPORTS, 8, 20180215
    Link to Paper Search Results by DOI
  52. Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain, PSYCHOLOGICAL MEDICINE, 48(7), 1148-1156, 201805
    Link to Paper Search Results by DOI
  53. Effects of behavioural activation on the neural circuit related to intrinsic motivation, BJPSYCH OPEN, 4(5), 317-323, 201809
    Link to Paper Search Results by DOI
  54. Effects of behavioral activation program without psychotropic medication treatment for depression in late adolescence: case report, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 14, 2159-2164, 2018
    Link to Paper Search Results by DOI
  55. Effects of behavioural activation on the neural circuit related to intrinsic motivation, BJPSYCH OPEN, 4(5), 317-323, 2018
  56. Effects of behavioral activation program without psychotropic medication treatment for depression in late adolescence: case report., Neuropsychiatric disease and treatment, 14, 2018
  57. Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices, JOURNAL OF AFFECTIVE DISORDERS, 208, 610-614, 20170115
    Link to Paper Search Results by DOI
  58. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain, SCIENTIFIC REPORTS, 7, 20170617
    Link to Paper Search Results by DOI
  59. Functional alterations of Postcentral gyrus Modulated by angry Facial expressions during intraoral Tactile stimuli in Patients with Burning Mouth syndrome: a Functional Magnetic resonance imaging study, FRONTIERS IN PSYCHIATRY, 8, 20171106
    Link to Paper Search Results by DOI
  60. Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices, JOURNAL OF AFFECTIVE DISORDERS, 208, 610-614, 2017
  61. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain, SCIENTIFIC REPORTS, 7(1), 2017
  62. Functional alterations of Postcentral gyrus Modulated by angry Facial expressions during intraoral Tactile stimuli in Patients with Burning Mouth syndrome: a Functional Magnetic resonance imaging study, FRONTIERS IN PSYCHIATRY, 8, 2017
  63. fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support, PLOS ONE, 10(5), 20150522
    Link to Paper Search Results by DOI
  64. Do Individuals with Alcohol Dependence Show Higher Unfairness Sensitivity? The Relationship Between Impulsivity and Unfairness Sensitivity in Alcohol-Dependent Adults, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 39(10), 2016-2021, 201510
    Link to Paper Search Results by DOI
  65. Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 69(12), 763-772, 201512
    Link to Paper Search Results by DOI
  66. Neural Basis of Anticipatory Anxiety Reappraisals, PLOS ONE, 9(7), 2014
  67. ★, Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: A preliminary resting-state fMRI study, PSYCHIATRY RESEARCH-NEUROIMAGING, 221(3), 246-248, 20140330
    Link to Paper Search Results by DOI
  68. Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder: A preliminary fMRI study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 68(3), 188-196, 201403
    Link to Paper Search Results by DOI
  69. Visual imagery while reading concrete and abstract Japanese kanji words: An fMRI study, NEUROSCIENCE RESEARCH, 79, 61-66, 201402
    Link to Paper Search Results by DOI
  70. Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 9(4), 487-493, 201404
    Link to Paper Search Results by DOI
  71. The dorsolateral prefrontal network is involved in pain perception in knee osteoarthritis patients, NEUROSCIENCE LETTERS, 581, 109-114, 2014
  72. ★, Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study, NEUROIMAGE-CLINICAL, 2, 782-789, 2013
    Link to Paper Search Results by DOI
  73. ★, Sadness Enhances the Experience of Pain and Affects Pain-Evoked Cortical Activities: An MEG Study, JOURNAL OF PAIN, 13(7), 628-635, 201207
    Link to Paper Search Results by DOI
  74. F-MRI analysis using self-referential negative emotion task on the effect of cognitive behavioral therapy for depressive patients, NEUROSCIENCE RESEARCH, 71, E210-E210, 2011
  75. Psychosocial functioning in patients with treatment-resistant depression after group cognitive behavioral therapy, BMC PSYCHIATRY, 10, 20100316
    Link to Paper Search Results by DOI
  76. ★, Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala: An fMRI study, NEUROIMAGE, 50(3), 1194-1201, 2010
  77. The efficacy of combined treatment by cognitive behavior therapy and pharmacotherapy, 41(8), 1009-1015, 201208
  78. Enhancement of subjective pain experience and changes of brain function on sadness, 27(1), 7-15, 20120310
  79. Functional brain imaging analysis of emotional formation and control mechanism to primitive sensation, 232(1), 28-32, 20100102
  80. Neuroimaging studies of treatment-resistant depression, 18(1), 45-53, 20070325
  81. Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis., Scientific reports, 10(1), 2020
  82. Pain-related beliefs, cognitive processes, and electroencephalography band power as predictors and mediators of the effects of psychological chronic pain interventions., Pain, 162(7), 2021
  83. Brain changes associated with impaired attention function in chronic pain., Brain and cognition, 154, 2021
  84. Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training., NeuroImage, 245, 2021

Publications such as books

  1. 2017, Neuroimaging of Pain, Neuroimaging studies of somatoform pain disorder: How far have we come?, Springer, 2017, Scholarly Book, Joint work, English, Atsuo Yoshino, Yasumasa Okamoto, Shigeto Yamawaki

Invited Lecture, Oral Presentation, Poster Presentation

  1. Changes in resting-state functional connectivity after cognitive behavioral therapy for chronic pain, Yoshino A, Okamoto Y, Okada G, Yokoyama S, Jinnin R, Takamura M, Ichikawa N and Yamawaki S, Neuroscience 2018, 2018/11/05, Without Invitation, English
  2. Similarities and differences of spontaneous neural activity in patients with chronic pain and depression: A resting state fMRI study, Atsuo Yoshino, Yasumasa Okamoto, Naofumi Otsuru, Go Okada, Shigeto Yamawaki, 16th World Congress on Pain, 2016, Without Invitation, English
  3. Distinctive spontaneous neural activity in patients with somatoform pain disorder: A resting state fMRI study, Yoshino Atuo, Yamawaki Shigeto, The International College of Neuropsychopharmacology, 2014/06/22, Without Invitation, English
  4. Neural responses to low-pain stimuli during sadness in patients with somatoform pain disorder: An fMRI study, World Congress of Biological Psychiatry, 2013, Without Invitation
  5. Sadness enhances the experience of pain and affects brain regions associated with pain, The International College of Neuropsychopharmacology, 2012, Without Invitation
  6. Emotional regulation of cortical activations evoked by pain perception – an MEG study–, Society for Neuroscience, 2008, Without Invitation
  7. Usefulness of spatial filter on the pain perception: an MEG study., International Society for the Advancement of Clinical Magnetoencephalography, 2006, Without Invitation

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2018, 2021
  2. KAKENHI, 2015, 2017
    Permalink
  3. KAKENHI, 2015, 2018
  4. KAKENHI, 2012, 2014
    Permalink

Social Activities

History as Peer Reviews of Academic Papers

  1. 2020, Journal of Pain Research
  2. 2020, Journal of Affective Disorders
  3. 2020, Frontiers in Human Neuroscience
  4. 2019, Frontiers in Psychology
  5. 2019, Frontiers in Neuroscience
  6. 2019, Brain and Behavior
  7. 2019, Biopsychosocial Medicine
  8. 2018, Scientific Reports
  9. 2018, Brain Imaging and Behavior
  10. 2017, Neuropsychiatry
  11. 2017, Journal of Neuroimaging
  12. 2016, Scientific Reports
  13. 2016, PlosOne
  14. 2016, Journal of International Medical Research
  15. 2016, Brain and Behavior, Others
  16. 2015, Psychology & Psychotherapy, 1
  17. 2015, Psychiatry and Clinical Neuroscience, 1
  18. 2015, The Tohoku Journal of Experimental Medicine, 1
  19. 2014, Clinical Neurophysiology, 1