MAKOTO SUZUKI

Last Updated :2024/06/04

Affiliations, Positions
Amphibian Research Center, Assistant Professor
Web Site
E-mail
makotoshiroshima-u.ac.jp
Other Contact Details
1-3-1 Kagami-yama, Higashi-hiroshima, Hiroshima 739-8526, Japan
TEL : (+81)82-424-5284 FAX : (+81)82-424-5284
Self-introduction
Makoto Suzuki studies molecular and cellular mechanisms controlling epithelial organ development such as neural tube closure, and human birth defects using amphibians as model organisms.

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Amphibian Research Center / Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2016/09/23, 2017/08/28, Princeton University, Department of Molecular Biology, Visitng Fellow
  • 2009/04/01, 2019/03/31, The Graduate University for Advanced Studies, School of Life Science, Assistant Professor
  • 2008/10/01, 2019/03/31, National Institute for Basic Biology, Division of Morphogenesis, Assistant Professor
  • 2007/04/01, 2008/09/30, National Institute for Basic Biology, Division of Morphogenesis, JSPS Research Fellow (PD)

Educational Backgrounds

  • TOHOKU UNIVERSITY, Graduate School of Life Sciences, Doctoral program, Japan, 2004/04, 2007/03
  • TOHOKU UNIVERSITY, Graduate School of Life Sciences, Master's program, Japan, 2002/04, 2004/03
  • TOHOKU UNIVERSITY, Faculty of Science, Japan, 1998/04, 2002/03

Academic Degrees

  • Master's degree of Life Sciences, TOHOKU UNIVERSITY
  • Ph.D., TOHOKU UNIVERSITY

Educational Activity

  • [Bachelor Degree Program] School of Science : Biological Sciences : Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biology;Biological Science;Developmental biology
  • Biology;Biological Science;Cell biology

Affiliated Academic Societies

  • International Society of Developmental Biologists
  • Molecular Biology Society of Japan
  • The Zoological Society of Japan
  • Japanese Society of Developmental Biologists
  • Xenopus Community in Japan

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 3Term, The life science of amphibians
  2. 2024, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  3. 2024, Undergraduate Education, 3Term, Regulation of Animal Morphology
  4. 2024, Undergraduate Education, First Semester, Special Study for Graduation
  5. 2024, Undergraduate Education, Second Semester, Special Study for Graduation
  6. 2024, Undergraduate Education, Second Semester, Seminar for Amphibian Biology
  7. 2024, Undergraduate Education, First Semester, Practice for Fundamental Biology I
  8. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
  9. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  10. 2024, Undergraduate Education, 3Term, Laboratory Work in Biology A
  11. 2024, Graduate Education (Master's Program) , 3Term, Research Methods in Life Science
  12. 2024, Graduate Education (Master's Program) , 1Term, Seminar for Advanced Research in Basic Biology A
  13. 2024, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology B
  14. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  15. 2024, Graduate Education (Master's Program) , 1Term, Seminar for Advanced Research in Basic Biology C
  16. 2024, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology D
  17. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Basic Biology A
  18. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Basic Biology B
  19. 2024, Graduate Education (Doctoral Program) , 2Term, Seminar for Advanced Research in Basic Biology E
  20. 2024, Graduate Education (Doctoral Program) , 3Term, Seminar for Advanced Research in Basic Biology F
  21. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  22. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  23. 2024, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  24. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  25. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  26. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  27. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  28. 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  29. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  30. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Optimization of CRISPR/Cas9-mediated gene disruption in Xenopus laevis using a phenotypic image analysis technique, DEVELOPMENT GROWTH & DIFFERENTIATION, 64(4), 219-225, 202205
  2. Cryo-injury procedure-induced cardiac regeneration shows unique gene expression profiles in the newt Pleurodeles waltl, DEVELOPMENTAL DYNAMICS, 251(5), 864-876, 202205
  3. Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, 20220329
  4. Invention sharing is the mother of developmental biology (Part 3), Development, Growth & Differentiation, 64, 4-4, 202201
  5. Invention sharing is the mother of developmental biology (Part 2), Development, Growth & Differentiation, 63, 458-458, 202112
  6. Invention sharing is the mother of developmental biology, Development, Growth & Differentiation, 63, 395-396, 202110
  7. Spontaneous neoplasia in the western clawed frog Xenopus tropicalis, microPublication Biology, 20200831
  8. Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis, CELL REPORTS, 30(11), 3875-+, 20200317
  9. Skin regeneration of amphibians: A novel model for skin regeneration as adults, Development, Growth & Differentiation, 60, 316-325, 2018
  10. Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter, PLoS Biology, 16, e2004426, 2018
  11. ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling, Proceedings of the National Academy of Sciences of the United States of America, 115, 5474-5479, 2018
  12. ★, Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure, Development, 144, 1307-1316, 2017
  13. Mechanical roles of apical constriction, cell elongation, and cell migration during neural tube formation in Xenopus, Biomechanics and Modeling in Mechanobiology, 15, 1733-1746, 2016
  14. Differences in the mechanical properties of the developing cerebral cortical proliferative zone between mice and ferrets at both the tissue and single-cell levels, Frontiers in Cell and Developmental Biology, 4, 139, 2016
  15. Mechanical regulation of three-dimensional epithelial fold pattern formation in the mouse oviduct, Biophysical Journal, 111, 650-665, 2016
  16. In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration, Genes to Cells, 21, 358-369, 2016
  17. ★, Cell movement and polarity required for animal development, Leading Author's, 4, e006, 2015
  18. Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates, BMC Biology, 12, 40, 2014
  19. Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulation, Developmental Biology, 382, 482-495, 2013
  20. Transgenic Xenopus laevis for live imaging in cell and developmental biology, Development, Growth & Differentiation, 55, 422-433, 2013
  21. ★, Molecular mechanisms of cell shape changes that contribute to vertebrate neural tube closure, Development, Growth & Differentiation, 54, 266-276, 2012
  22. Translation of incenp during oocyte maturation is required for embryonic development in Xenopus laevis, Biology of Reproduction, 86, 161, 2012
  23. ★, MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization, Development, 137, 2329-2339, 2010
  24. Analysis of hoxa11 and hoxa13 expression during patternless limb regeneration in Xenopus, Developmental Biology, 338, 148-157, 2010
  25. Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity, Proceedings of the National Academy of Sciences of the United States of America, 106, 14426-14431, 2009
  26. Effects of activation of Hedgehog signaling on patterning, growth and differentiation in Xenopus froglet limb regeneration, Developmental Dynamics, 238, 1887-1896, 2009
  27. Mitf contributes to melanosome distribution and melanophore dendricity, Pigment Cell & Melanoma Research, 21, 56-62, 2008
  28. Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians, Developmental Biology, 312, 171-182, 2007
  29. ★, Transgenic Xenopus with prx1 limb enhancer reveals crucial contribution of MEK/ERK and PI3K/AKT pathways in blastema formation during limb regeneration, Developmental Biology, 304, 675-686, 2007
  30. ★, Limb regeneration in Xenopus laevis froglet, TheScientificWorldJOURNAL, 6, 26-37, 2006
  31. Analysis of scleraxis and dermo-1 genes in a regenerating limb of Xenopus laevis, Developmental Dynamics, 235, 1065-1073, 2006
  32. ★, Nerve-dependent and -independent events in blastema formation during Xenopus froglet limb regeneration, Developmental Biology, 286, 361-375, 2005
  33. Joint development in Xenopus laevis and induction of segmentations in regenerating froglet limb (spike), Developmental Dynamics, 233, 1444-1453, 2005

Publications such as books

  1. 2021/05, Comparative Endocrinology, 2021, Scholarly Book, Joint work, Japanese
  2. 2014, Xenopus Development, Chapter 9: Neural tube closure in Xenopus, John Wiley & Sons, 2014

Invited Lecture, Oral Presentation, Poster Presentation

  1. NBRP Clawed frogs / Newt – Genetic and genomic resources of amphibian model organisms and their applications, Makoto Suzuki, Takeshi Igawa, Nanoka Suzuki, Ichiro Tazawa, Keisuke Nakajima, Nobuaki Furuno, Ken-ichi T. Suzuki, Haruki Ochi, Takashi Kato, Toshinori Hayashi, Hajime Ogino, The 13th International Meeting of the Asian Network of Research Resource Centers (ANRRC 2022), 2022/11/08, Without Invitation, English
  2. Mislocalization of ACTB in epithelial cells underlies the etiology of facial cleft in Baraitser-Winter syndrome, Takayuki Tsujimoto, Hiroshi Kurosaka, Yuka Murata, Makoto Suzuki, Yushi Ou, Toshihiro Inubushi, Chisato Morita, Hajime Ogino, Takashi Yamashiro, 14th International cleft congress, 2022/07/11, Without Invitation, English
  3. Morphological and behavioral characteristics of Xenopus tropicalis inbred strains in NBRP, Igawa, T., Suzuki, M., Suzuki, N., Kashiwagi, A., Kashiwagi, K., Ochi, H. and Ogino, H., 18th International Xenopus Conference, 2021/08/19, With Invitation, English
  4. Differential cellular stiffness as a mechanism for tissue elongation on growing embryo, Koyama H., Suzuki M., Yasue N., Sasaki H., Ueno N. and Fujimori T., 53rd Annual meeting of the Japanese society of developmental biologists, 2020/05/21, Without Invitation, English, Online
  5. Convergent evolution of duplicated genes in different evolutionary lineages, Tanouchi M., Igawa T., Suzuki M., Suzuki N. and Ogino H., 53rd JSDB/APDBN Meeting, 2020/05/20, Without Invitation, English
  6. Generation of Xenopus tropicalis inbred strains and their genome polymorphism data by NBRP in Japan, Igawa T., Suzuki M., Suzuki N., Kashiwagi A., Kashiwagi K., Ochi H., Ogino H., Xenopus Resources and Emerging Technology Meeting, 2019/10/13, With Invitation, English, Woods Hole, USA
  7. The 4th National BioResource Project of Xenopus tropicalis, Igawa, T., Kashiwagi, A., Kashiwagi, K., Suzuki, N., Suzuki, M., Tazawa, I., Furuno, N., Ochi, H., Kato, T., Mori, T., Ogino, H., 52nd annual meeting of the JSDB, 2019/05/16, Without Invitation, English, Osaka, Japan
  8. Distinct intracellular calcium ion dynamics regulate apical constriction and differentially contribute to neural tube closure, Suzuki, M., Ueno, N., Joint meeting of the 22nd International Congress of Zoology & the 87th Meeting of the ZSJ, 2016/11/15, With Invitation, English
  9. Regulation of microtubule organization by xMID is essential for maintaining tissue integrity in Xenopus neural tube closure, Suzuki, M., Hara, Y., Yamamoto, T.S., Takagi, C., Ueno, N., 16th international society of developmental biologists congress, 2009/09/08, With Invitation, English, Edinburgh, UK

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024
  2. Practical Research Project for Rare / Intractable Diseases, 2021/04/01, 2022/03/31
  3. Practical Research Project for Rare / Intractable Diseases, 2021/01/18, 2022/03/31
  4. 2019/09, 2021/03
  5. JSPS Grants-in-Aid for Challenging Research (Exploratory), 2018/06, 2021/03
  6. NIBB Research Grant for Young Scientists (1st), 2017
  7. JSPS Grants-in-Aid for Scientific Research (C), Exploring of the principle of epithelial tubulogenesis by intra- and extracellular small molecules, 2015/07, 2018/03
  8. MEXT Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), 2015/06, 2020/03
  9. JSPS Grant-in-Aid for Scientific Research (C), 2015/04, 2019/03
  10. JSPS Grant-in-Aid for Scientific Research (B), Cellular dynamics during collective cell migration, 2015/04, 2018/03
  11. MEXT Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Cross-talk between moving cells and microenvironment as a basis of emerging order in multicellular systems, 2013/04, 2015/03
  12. JSPS Grant-in-Aid for Scientific Research (B), Identification of the biological significance of small chemicals for morphogenesis, 2012/04, 2015/03
  13. MEXT Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), 2011/04, 2013/03
  14. JSPS Grant-in-Aid for Young Scientists (B), Second messenger systems required for epithelial morphogenesis in vivo, 2011/04, 2014/03
  15. SOKENDAI Research Grant for Young Scientists, 2010
  16. JSS Support for Travel Expenses for Sasakawa Grant recipients, 2009
  17. JSPS Grant-in-Aid for Research Activity start-up, Function and regulatory mechanism of the microtubule cytoskeleton required for epithelial morphogenesis in vivo, 2009/08, 2011/03
  18. JSPS Grant-in-Aid for JSPS Fellows, 2007/04, 2009/03
  19. JSS Sasakawa Scientific Research Grant, 2006/04, 2007/03

Social Activities

History as Committee Members

  1. Guest Editor, 2020/08, 2023/09, Development, Growth & Differentiation, the official journal of the Japanese Society of Developmental Biologists
  2. Review Editor, 2020/07, 2024/03, Frontiers in Cell and Developmental Biology - Morphogenesis and Patterning

History as Peer Reviews of Academic Papers

  1. 2022, Developmental Dynamics, Reviewer, 1
  2. 2022, Development, Growth & Differentiation, Reviewer, 2
  3. 2021, Developmental Dynamics, Reviewer, 1
  4. 2021, Journal of Visualized Experiments, Reviewer, 1
  5. 2021, Development, Growth & Differentiation, Reviewer, 1
  6. 2020, Frontiers in Cell and Developmental Biology, Reviewer, 1
  7. 2019, Developmental Dynamics, Reviewer, 1
  8. 2018, Zoological Science, Reviewer, 1
  9. 2017, Development, Growth & Differentiation, Reviewer, 1
  10. 2017, Developmental Dynamics, Reviewer, 1
  11. 2015, Developmental Dynamics, Reviewer, 1
  12. 2014, Development, Growth & Differentiation, Reviewer, 1
  13. 2013, Development, Reviewer, 1
  14. 2012, Development, Growth & Differentiation, Reviewer, 2