Tooru Hiyama

Last Updated :2023/02/02

Affiliations, Positions
Health Service Center, Professor
E-mail
tohiyamahiroshima-u.ac.jp
Other Contact Details
HEALTH SERVICE CENTER, HIROSHIMA UNIVERSITY, 1-7-1, KAGAMIYAMA, HIGASHIHIROSHIMA 739-8521, JAPAN, Japan
TEL : (+81)82-424-6191 FAX : (+81)82-422-7156
Self-introduction
I am conducting research and social activities related to gastrointestinal cancer screening and medical risk management.

Basic Information

Major Professional Backgrounds

  • 2002/10/01, 2007/03/31, Hiroshima University, Health Service Center, Research Assistant
  • 1991/06/01, 1993/03/30, Hiroshima University, Medical Hospital, Resident
  • 1999/04/01, 2002/09/30, National Sanatorium Kamo Hospital, Department of Internal Medicine, Medical Doctor
  • 1993/04/01, 1996/03, Miyoshi Medical Association Hospital, Department of Internal Medicine, Medical Doctor
  • 2007/04/01, 2012/05/30, Hiroshima University, Health Service Center, Research associate
  • 2012/06/01, 2021/03/31, Hiroshima University, Health Service Center, Associate Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1996/04, 1999/03
  • Hiroshima University, Faculty of Medicine, Japan, 1985/04, 1991/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Gastroenterology

Research Keywords

  • medical risk management
  • health Service of university
  • gastrointestinal endoscopy

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, Intensive, Introduction to Overseas Dispatch and Study Abroad
  2. 2022, Liberal Arts Education Program1, Intensive, Introduction to Overseas Dispatch and Study Abroad
  3. 2022, Liberal Arts Education Program1, 3Term, Introduction to Student Wellness
  4. 2022, Undergraduate Education, 4Term, Family Nursing
  5. 2022, Undergraduate Education, Year, Clinical diagnosis and treatment I

Research Activities

Academic Papers

  1. Attitudes and Behavior toward COVID-19 Vaccination in Japanese University Students: A Cross-Sectional Study, VACCINES, 10(6), 202206
  2. Screening and surveillance for gastric cancer: Does family history play an important role in shaping our strategy?, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 18(4), 353-362, 202208
  3. Diagnostic Accuracy of H. pylori Status by Conventional Endoscopy: Time-Trend Change After Eradication and Impact of Endoscopic Image Quality, FRONTIERS IN MEDICINE, 8, 20220128
  4. Clinical validity of endoscopic submucosal dissection for submucosal invasive gastric cancer: a single-center study, Gastric Cancer, 15(1), 97-105, 2012
  5. Clinical features of pharyngeal intraepithelial neoplasias and outcomes of treatment by endoscopic submucosal dissection, Gastrointest Endosc, 76(6), 1095-1103, 2012
  6. Relationship between Endoscopic and Histologic Gastric Atrophy and Intestinal Metaplasia, HELICOBACTER, 18(2), 151-157, 2013
  7. Outcome of endoscopic submucosal dissection for gastric neoplasm in relationship to endoscopic classification of submucosal fibrosis, Gastric Cancer, 16(3), 404-410, 2013
  8. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions, Japanese Journal of Cancer Research, 89(11), 1187-1194, 19980401
  9. Overexpression of human telomerase RNA is an early event in oesophageal carcinogenesis., Virchows arch, 434, 483-7, 19990401
  10. B-cell monoclonality inHelicobacter pylori-associated chronic atrophic gastritis., Virchows arch, 438, 232-7, 20010401
  11. Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability., Int J Oncol, 18, 1207-12, 20010401
  12. Cell proliferation in polypoid type and superficial type serrated adenomas of the colorectum., In Recent Advances in Gastroenterological Carcinogenesis= Monduzzi Editore= Bologna, I, 773-778, 19960401
  13. Alteration of p73 preferentialy occur in gastric adenocarcinomas with foveolar epithelial phenotype., Int J Cancer, 83, 192-196, 19990401
  14. Eradication therapy of Helicobacter pylori for low-grade mucosa-associated lymphoid tisue lymphomas of the stomach., Exp.Oncol., 22, 78-81, 20000401
  15. c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma., Oncol.Rep., 8, 289-292, 20010401
  16. Microsatellite instability at D18S61 is associated with no regression of gastric mucosa-associated lymphoid tissue lymphoma after Helicobacter pylori eradication, Oncol.Rep., 8, 293-297, 20010401
  17. Human telomerase reverse transcriptase, p53 and Ki-67 expression and apoptosis in colorectal serrated adenoma., Scand. J. Gastroenterol., 37, 1194-1200, 20020401
  18. Nodular gastritis in adults is caused by Heliccobacter pylori infection., Dig Dis Sci, 48, 968-975, 20030401
  19. Frequnet loss of heterozygosity onchromosome 10p15, a putative telomerase repressor・senescence gene locus, in gastric cancer., Oncol.Rep., 10, 1297-1299, 20030401
  20. Clinicopathological features of gastric mucosa-associated lymphoid tissue lymphoma: A comparison with diffuse large B-cell lymphoma without a mucosa-associated lymphoid tissue lymphoma component, J Gastroen Hepatol, 16, 734-739, 20010401
  21. K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer., Int J Cancer, 97, 562-566, 20020401
  22. p53 codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis., Int J Cancer, 100, 304-308, 20020401
  23. Minute depressed colon cancer with submucosal invasion., Gastrointest Endosc, 57, 564-565, 20030401
  24. Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach., Oncol.Rep., 10, 797-802, 20030401
  25. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer., Int. J. Mol. Med., 12, 169-174, 20030401
  26. Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma, J.Clin.Gastroenterol., 37(5), 381-386, 20030401
  27. p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas, J Gastroeterol Hepatol, 18(9), 1047-1053, 20030401
  28. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer, Int. J. Mol. Med., 12(2), 169-174, 20030401
  29. Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma., Int J Oncol, 23, 901-911, 20030401
  30. Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types., Int. J. Mol. Med., 12, 437-442, 20030401
  31. Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan., J Gastroenterol Hepatol., 18, 1202-1207, 20030401
  32. Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer, Oncol.Rep., 10, 1837-1841, 20030401
  33. Necessity of multiple gastric biopsies from different sites for detection of clarithromycin-resistant Helicobacter pylori strains., Scand. J. Gastroenterol., 38, 942-946, 20030401
  34. Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions., Oncol.Rep., 11, 51-55, 20040401
  35. A combination of the Helicobacter pylori stool antigen test and urea breath test is useful for clinical evaluation of eradication therapy: a multicenter study, J Gastroenterol Hepatol, 20, 1241-1245, 20050801
  36. Characteristics and trends of clarithromycin-resistant Helicobacter pylori isolates in Japan over a decade, Pathobiology, 71, 159-163, 20040901
  37. Chromosomal and microsatellite instability in sporadic gastric cancer, J Gastroenterol Hepatol, 19, 756-760, 20040501
  38. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma, Int J Oncol, 24, 539-547, 20040201
  39. Clinicopathologic and endoscopic features of colorectal serrated adenoma:differences between polypoid and superficial types, Gastrointest Endosc, 59(2), 213-219, 20040201
  40. Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients, Oncol Rep, 16(1), 11-15, 20060501
  41. Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma, J Clin Gastroenterol, 37(5), 381-386, 20040501
  42. Defensive medicine practices among gastroenterologists in Japan, World J Gastroenterol, 12(47), 7671-7675, 20061201
  43. Frequent loss of heterozygosity on chromosome 10p14-p15 in esophageal dysplasia and squamous cell carcinoma, Oncol Rep, 12, 333-337, 20040401
  44. Genetic progression and divergence in superficial esophageal squamous cell carcinoma by loss of heterozygosity analysis, Oncol Rep, 16, 685-691, 20061201
  45. Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer, World J Gastroenterol, 13(28), 3829-3835, 20070101
  46. Involvement of Kr?ppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma, World J Gastroenterol, 13(29), 3932-3938, 20070801
  47. Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma, Pathobiology, 72, 220-224, 20050901
  48. Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer, Dis Colon Rectum, 50(1), 13-21, 20060101
  49. Medical malpractice litigation related to gastrointestinal endoscopy in Japan: A two-decade review of civil court cases, World J Gastroenterol, 12(42), 6857-6860, 20061201
  50. Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer, Dis Colon Rectum, 50(1), 13-21, 20070601
  51. Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study, Scand J Gastroenterol, 42, 760-764, 20070601
  52. Genetic polymorphisms and esophageal cancer risk, Int J Cancer, 121, 1643-1658, 20070801
  53. Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia, J Gastroenterol Hepatol, 22, 304-310, 20070301
  54. Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials, J Gastroenterol Hepatol, 22, 1566-1570, 20071001
  55. Rapid progression of Epstein -Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report, Clin J Gastroenterol, 1, 105-109, 20081218
  56. Strategy for treatment of nonerosive reflux disease in Asia, World J Gastroenterol, 14(20), 3123-3128, 20080724
  57. Genetic polymorphisms and head and neck cancer risk (Review), Int J Oncol, 32, 945-973, 20080430
  58. Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma, Cancer Sci, 100(6), 1075-1081, 20091001
  59. Cheilitis granulomatosa as an early manifestation of Crohn's disease, Clin J Gastroenterol, 2, 190-193, 20091001
  60. ★, Trend in Japanese malpractice litigation involving gastrointestinal endoscopy, Am J Gastroenterol, 104(1), 251-252, 20090101
  61. Characteristics of esophageal squamous cell carcinomas and lugol-voiding lesions in patients with head and neck squamous cell carcinoma, J Clin Gastroenterol, 44(2), e27-33, 2010
  62. Synchronous and subsequent lesions of serrated adenomas and tubular adenomas of the colorectum, Pathobiology, 77(5), 273-277, 2010
  63. Diagnostic yield of capsule endoscopy vs. double-balloon endoscopy for patients who have undergone total enteroscopy with obscure gastrointestinal bleeding, Hepatogastroenterology, 59(116), 955-959, 2011
  64. ★, Change in malpractice claims in Japanese gastroenterological practice, Am J Gastroenterol, 107(1), 143-144, 2012
  65. Compliance with standard precautions among gastrointestinal endoscopists and andendoscopy nurses in Japan, Am J Infect Control, 40(1), 80, 2012
  66. Removal of a sewing needle penetrating the wall of the third portion of the duodenum by double- balloon endoscopy, Clin J Gastroenterol, 5(1), 79-81, 2012
  67. Microsatellite instability is a genetic marker for the development of multiple gastric cancers., Int J Cancer., 95(6), 350-353, 20011101
  68. High incidence of B-cell monoclonality in follicular gastritis: a possible association between follicular gastritis and MALT lymphoma., Virchows Arch., 440(4), 376-380, 20020401
  69. Somatic mutations of mitochondrial DNA in digestive tract cancers., J Gastroenterol Hepatol., 20(11), 1679-1684, 20051101
  70. Nuclear and mitochondrial DNA microsatellite instability in gastrointestinal stromal tumors., Pathobiology., 73(2), 93-97, 20060901
  71. Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer., World J Gastroenterol., 13(28), 3829-3835, 20070701
  72. Clinicopathologic features of Japanese hyperplastic/serrated polyposis syndrome, J Gastroenterol Hepatol, 28(11), 1693-1698, 2013
  73. Clinical outcomes of endoscopic submucosal dissection for superficial Barrett's adenocarcinoma, Gastrointest Endosc, 80(2), 239-245, 2014
  74. Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma, WORLD JOURNAL OF GASTROENTEROLOGY, 13(29), 3932-3938, 20070807
  75. Metachronous multiple esophageal squamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection, ENDOSCOPY, 41(4), 304-309, 200904
  76. Meta-analysis used to identify factors associated with the effectiveness of proton pump inhibitors against non-erosive reflux disease, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24(8), 1326-1332, 200908
  77. Natural Course of Lugol-Voiding Lesions in Patients with Superficial Esophageal Squamous Cell Carcinoma, Digestion, 82(1), 60-65, 2010
  78. Advantages of endoscopic submucosal dissection versus endoscopic oblique aspiration mucosectomy for superficial esophageal tumors, J Gastroenterol Hepatol, 26(2), 275-280, 2011
  79. Genetic pathways of multiple esophageal squamous cell carcinomas, Oncol Rep, 25(2), 453-459, 2011
  80. Prevalence and impact of musculoskeletal pain in Japanese gastrointestinal endoscopists: A controlled study, World J Gastroetnerol, 17(11), 1488-1493, 2011
  81. Value of a new stick-type rapid urine test for the diagnosis of Helicobacter pylori infection in the Vietnamese population, World J Gastroenterol, 20(17), 5087-5091, 2014
  82. Differences in K-ras and mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients, BMC Gastroenterol, 14, 203, 2014
  83. Rate of unintended Helicobacter pylori eradication in the Vietnamese, Helicobacter, 20, 156-157, 2015
  84. The number of criminal prosecutions of physicians for medical negligence related to gastroenterology is on the rise in Japan, Scand J Gastroenterol, 50(5), 619-620, 2015
  85. Causes of delayed diagnoses of cancers in Japan from the viewpoint of malpractice litigations, Dig Liver Dis, 48, 687-691, 2016
  86. Interobserver and intraobserver agreement for gastric mucosa atrophy, BMC Gastroenterol, 15, 95, 2015
  87. The performance of a modified Glasgow Blatchford Score in predicting clinical interventions in patients with acute nonvariceal upper gastrointestinal bleeding: a Vietnamese prospective multi center cohort study, Gut Liver, 10(3), 375-381, 2016
  88. Long-term prognosis after endoscopic submucosal dissection for early gastric cancer in super-elderly patients, Surg Endosc Other Interevent Tech, 30(10), 4321-4329, 2016
  89. Risk factors for esophageal stenosis after entire circumferential endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma, Surg Endosc Other Inetervent Tec, 30(9), 4049-4056, 2016
  90. Early diagnosis of Helicobacter pylori infection in Vietnamese patients with acute peptic ulcer bleeding: a prospective study, Gastroenterol Res Pract, 2017, 3845067, 2017
  91. Clinical usefulness of the VS classification system using magnifying endoscopy with blue laser imaging for early gastric cancer, Gastroenterol Res Pract, 2017, 3649705, 2017
  92. Asia-Pacific Colorectal Screening score: A useful tool to stratify risk for colorectal advanced neoplasms in Vietnamese patients with irritable bowel syndrome, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33(1), 150-155, 201801
  93. Abnormal Gastroesophageal Flap Valve Is Associated With High Gastresophageal Reflux Disease Questionnaire Score and the Severity of Gastroesophageal Reflux Disease in Vietnamese Patients With Upper Gastrointestinal Symptoms, JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, 24(2), 226-232, 201804
  94. Evaluation of the visibility of early gastric cancer using linked color imaging and blue laser imaging, BMC GASTROENTEROLOGY, 17, 20171208
  95. Curative Criteria After Endoscopic Resection for Superficial Esophageal Squamous Cell Carcinomas, DIGESTIVE DISEASES AND SCIENCES, 63(6), 1605-1612, 201806
  96. The Distribution of Incomplete Gastric Intestinal Metaplasia (GIM) Subtype among Biopsy Sites according to the Updated Sydney System and Its Association with GIM Extension, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2018
  97. Diagnosis of superficial esophageal squamous cell carcinoma invasion depth before endoscopic submucosal dissection, DISEASES OF THE ESOPHAGUS, 31(7), 201807
  98. Magnifying Endoscopy with Narrow Band Imaging in Estimating the Invasion Depth of Superficial Esophageal Squamous Cell Carcinomas, DIGESTION, 98(4), 249-256, 2018
  99. The endoscopic and clfinicopathologic characteristics of early-onset gastric cancer in Vietnamese patients, Asian Pacific Journal of Cancer Prevention, 19(7), 1883-1886, 2018
  100. Medical malpractice litigation pertaining to intestinal obstruction in Japan: 20-year review of civil court cases, Cogent Medicine, 5, 1529847, 2018
  101. Identifying high-risk individuals for gastric cancer surveillance rom western and eastern perspectives: lessons to learn and possibility to develop an integrated approach for daily practice, World Journal of Gastroenterology, 25(27), 3546-3562, 2019
  102. Otorhinolaryngology litigations in Japan, European Archives of Otorhinolaryngology, in printing, 2019
  103. Use of endoscopic assessment of gastric atrophy for gastric cancer risk stratification to reduce the need for gastric mapping, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 55(4), 402-407, 20200402
  104. Age Cutoff and Yield of Prompt Esophagogastroduodenoscopy to Detect Malignancy in Vietnamese with Upper Gastrointestinal Symptoms: An Endoscopic Database Review of 472,744 Patients from 2014 to 2019, CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2021, 20211211

Social Activities

History as Peer Reviews of Academic Papers

  1. 2016, Gastric Cancer, Editor
  2. 2015, Journal of Gastroenterology, Editor
  3. 2014, Journal of Gastroenterology, Editor
  4. 2013, Journal of Gastroenterology, Editor
  5. 2012, Journal of Gastroenterology, Editor
  6. 2011, Journal of Gastroenterology, Editor
  7. 2010, Journal of Gastroenterology, Editor