Kennosuke Ichikawa

Last Updated :2026/04/14

Affiliations, Positions
Hiroshima University, Assistant Professor
E-mail
kennosuke-ichikawahiroshima-u.ac.jp
Self-introduction

The ultimate objective of our research is to realize sustainable food production by implementing genetic modifications in poultry. My past research results and other related work are also made available on this personal website.

Basic Information

Major Professional Backgrounds

  • 2026/04, Hiroshima University, Genome Editing Innovation Center, Assistant Professor
  • 2025/04, 2026/03, University of Edinburgh, The Roslin Institute, Postdoctoral Research Associate
  • 2023/04, 2025/03, University of Edinburgh, The Roslin Institute, JSPS Overseas Research Fellow
  • 2022/04, 2023/03, Hiroshima University, Genome Editing Innovation Center, Researcher
  • 2019/04, 2022/03, Japan Society for the Promotion of Science, Research Fellowships for Young Scientists (DC1)

Educational Backgrounds

  • Hiroshima University, Graduate School of Integrated Sciences for Life, 2019/04, 2022/03
  • Hiroshima University, Graduate School of Biosphere Science, 2017/04, 2019/03
  • Hiroshima University, Faculty of Applied Biological Science, 2013/04, 2017/03

Academic Degrees

  • Ph. D., Hiroshima University

Research Keywords

  • Chickens
  • Genome Editing
  • Primordial Germ Cells
  • Sex-determination
  • Host Immune Response
  • Avian Influenza Virus

Research Activities

Academic Papers

  1. Transcriptome profiles for defining avian primordial germ cell development, Protein Expression and Purification, 202601
  2. Long-Term Rock Dove ( Columba livia ) Primordial Germ Cell Culture: A Tool for Avian Conservation, 20250920
  3. Propagation of goose primordial germ cells in vitro relies on FGF and BMP signalling pathways, Communications Biology, 20250225
  4. A cell-matrix interaction regulates the undifferentiated state and self-renewal capacity of avian primordial germ cells, bioRxiv, 20250129
  5. Innovations in poultry reproduction using cryopreserved avian germ cells, Reproduction in Domestic Animals, 59(5), 20240527
  6. Wnt signaling blockade is essential for maintaining the pluripotency of chicken embryonic stem cells, Poultry Science, 103361-103361, 202312
  7. Evaluation of expression systems for recombinant protein production in chicken egg bioreactors, Biotechnology Journal, 20231027
  8. Lipofection with Lipofectamine™ 2000 in a heparin‐free growth medium results in high transfection efficiency in chicken primordial germ cells, Biotechnology Journal, 20230816
  9. Transcription activator-like effector nuclease-mediated deletion safely eliminates the major egg allergen ovomucoid in chickens, Food and Chemical Toxicology, 175, 113703-113703, 202305
  10. Lentilactobacillus hilgardiiH-50 strongly inhibits lipopolysaccharide-induced inflammatory responses in mouse splenocytes via its specific surface layer proteins, Journal of Applied Microbiology, 134(3), 20230301
  11. Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms, Genes, 14, 612, 20230228
  12. Genome editing in chickens, Gene and Genome Editing, 3-4, 100015, 202212
  13. Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis, Scientific Reports, 12(1), 13528, 20220817
  14. Screening of the optimal CpG-oligodeoxynucleotide for anti-inflammatory responses in avian macrophage cell line HD11, The Journal of Poultry Science, 60(1), 2023002, 20220406
  15. Knock-in of the duck retinoic acid-inducible gene I (RIG-I) into the Mx gene in DF-1 cells enables both stable and immune response-dependent RIG-I expression, Biochemistry and Biophysics Reports, 27, 101084-101084, 202109
  16. Targeted Knock-in of a Fluorescent Protein Gene into the Chicken Vasa Homologue Locus of Chicken Primordial Germ Cells using CRIS-PITCh Method, The Journal of Poultry Science, 59, 182-190, 2021
  17. Comparison of sex determination mechanism of germ cells between birds and fish: Cloning and expression analyses of chicken forkhead box L3‐like gene, Developmental Dynamics, 248(9), 826-836, 20190617

Invited Lecture, Oral Presentation, Poster Presentation

  1. Analyses of chicken innate immune responses to viral pathogens, Shihyuan Cheng; Kennosuke Ichikawa; Satoko Kobayashi; Tenkai Watanabe; Takumi Terada; Ryo Ezaki; Mei Matsuzaki; Yuko Uchida; Hiroyuki Horiuchi, 2026 ASBMB Annual Meeting, 2026/03/07, American Society for Biochemistry and Molecular Biology, Washington, D.C.
  2. Analyses of chicken innate immune responses to viral pathogens, Shihyuan Cheng; Satoko Kobayashi; Kennosuke Ichikawa; Tenkai Watanabe; Takumi Terada; Ryo Ezaki; Mei Matsuzaki; Yuko Uchida; Hiroyuki Horiuchi, The 48th annual meeting of the molecular biology society of Japan, 2025/12/04, The molecular biology society of Japan, Yokohama
  3. Improved Cryopreservation of Chicken Gonadal Germ Cells via Vitrification, B Bernal Juarez; Dominique Meunier; Kennosuke Ichikawa; Marcel H Blank; Guillermo Tellez; Bence Lazar; Barbara Vegi; Eszter Varkony; Elen Gocza; Krisztina Liptoi; SJ Hiemstra; H Woelders; Mike McGrew, 61st meeting Society for Low Temperature Biology, Olsztyn
  4. 鳥類始原生殖細胞の未分化性維持機構に関する研究, ○市川健之助; 元榮柚花; 江崎 僚; 松崎芽衣; 堀内浩幸; Mike J. McGrew, 日本家禽学会2024年度秋季大会, 2024/09/19
  5. Somatic Differentiation of Chicken Primordial Germ Cells Exhibits Partial Epithelial-to-Mesenchymal Transition (EMT)-like Features, ○Kennosuke Ichikawa; Yuzuha Motoe; Mei Matsuzaki; Ryo Ezaki; Hiroyuki Horiuchi; Mike J. McGrew, JAACT2023, 2023/12/01
  6. Genome editing of poultry species for investigating disease resistance., Kennosuke Ichikawa; Lorna Taylor; Tuan Jun; Alewo Idoko-Akoh; Sudeepta Panda; ○Mike J. McGrew, JAACT2023, 2023/11/28
  7. Transcription Activator-Like Effector Nuclease-Mediated Deletion Safely Eliminates the Major Egg Allergen Ovomucoid in Chickens, ○Ryo Ezaki; Tetsushi Sakuma; Daisuke Kodama; Ryou Sasahara; Taichi Shiraogawa; Kennosuke Ichikawa; Mei Matsuzaki; Akihiro Handa; Takashi Yamamoto; Hiroyuki Horiuchi, JAACT2023, 2023/11/28
  8. Identification of feminization-related potential factors and processes in chicken primordial germ cells, ○Kennosuke Ichikawa; Yoshiaki Nakamura; Hidemasa Bono; Ryo Ezaki; Mei Matsuzaki; Mike J. McGrew; Hiroyuki Horiuchi, Avian Model Systems 11, 2023/09/13
  9. ニワトリマクロファージ様細胞HD11において強力な抗炎症応答を示す CpGオリゴDNAの選抜, ○市川健之助; 松崎芽衣; 江崎 僚; 堀内浩幸; 山本祥也, 第46回鳥類内分泌研究会, 2022/12/10
  10. ニワトリエピブラスト培養細胞は多能性幹細胞になりえるのか, ○梶原 亮太; 市川 健之助; 江崎 僚; 松崎 芽衣; 堀内 浩幸, 第45回日本分子生物学会年会, 2022/12/01
  11. 分化したニワトリ始原生殖細胞の性状解析 －鳥類始原生殖細胞の新規培養系の確立に向けて－, ○市川健之助; 元榮柚花; 江崎 僚; 松崎芽衣; 堀内浩幸, 第45回日本分子生物学会年会, 2022/12/01
  12. Genetic Engineering in Chicken Primordial Germ Cells, ○Tenkai Watanabe; Kennosuke Ichikawa; Ryo Ezaki; Mei Matsuzaki; Hiroyuki Horiuchi, International Seminar 2022: Front-line of genome editing technology, 2022/11/12

External Funds

Acceptance Results of Competitive Funds

  1. JSPS Overseas Research Fellowship, Establishment of a novel culture system for avian primordial germ cells focusing on epithelial-mesenchymal transition, 2023/04, 2025/03
  2. Early Career Researcher ISP Grant, Enhancing the self-renewal capacity of cultured avian primordial germ cells by activating FAK signalling, 2023/07, 2024/03
  3. ニワトリ始原生殖細胞の体細胞分化機構の解明 -上皮間葉転換に着目して-, 2022/04, 2023/03
  4. 2019/04, 2022/03
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