SHIGERU TANAKA

Last Updated :2025/02/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
E-mail
tanakamdhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General pharmacology
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Research Keywords

  • stroke
  • GPCR
  • neuronal protection
  • autophagy

Affiliated Academic Societies

  • Society for Neuroscience
  • The Japan Academy of Neurosonology
  • The Molecular Biology Society of Japan

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Biological Responses

Research Activities

Academic Papers

  1. Protein kinase C (PKC) inhibitor Calphostin C activates PKC in a light-dependent manner at high concentrations via the production of singlet oxygen, EUROPEAN JOURNAL OF PHARMACOLOGY, 984, 20241205
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  2. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 662, 58-65, 20230625
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  3. Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells, FRONTIERS IN PHARMACOLOGY, 14, 20231107
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  4. Identification of protein kinase C domains involved in its translocation induced by propofol, EUROPEAN JOURNAL OF PHARMACOLOGY, 955, 20230915
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  5. P2Y2 receptor mediates dying cell removal via inflammatory activated microglia, JOURNAL OF PHARMACOLOGICAL SCIENCES, 153(1), 55-67, 202309
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  6. GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice, NEUROBIOLOGY OF DISEASE, 172, 20221001
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  7. ★, Potential role of inducible GPR3 expression under stimulated T cell conditions, JOURNAL OF PHARMACOLOGICAL SCIENCES, 148(3), 307-314, 202203
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  8. ★, GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons, MOLECULAR AND CELLULAR NEUROSCIENCE, 118, 20220101
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  9. ★, Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system, BRAIN RESEARCH, 1750, 20210101
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  10. Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats, PHARMACEUTICALS, 14(4), 202104
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  11. ★, Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli, NEUROBIOLOGY OF DISEASE, 68, 215-227, 2014
  12. ★, The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells during Postnatal Development, PLOS ONE, 4(6), 2009
  13. Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant, JOURNAL OF PHARMACOLOGICAL SCIENCES, 148(1), 187-195, 202201
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  14. Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 534, 583-589, 20210101
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  15. Syntaxin 3 interacts with serotonin transporter and regulates its function, JOURNAL OF PHARMACOLOGICAL SCIENCES, 145(4), 297-307, 202104
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  16. Component of nicotine-induced intracellular calcium elevation mediated through alpha 3-and alpha 5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells, PLOS ONE, 15(11), 20201130
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  17. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884, 20201005
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  18. Histone deacetylase 10 knockout activates chaperone-mediated autophagy and accelerates the decomposition of its substrate, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 523(1), 246-252, 20200226
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  19. SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism, JOURNAL OF PHARMACOLOGICAL SCIENCES, 139(1), 29-36, 2019
  20. Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene, MOLECULAR AND CELLULAR NEUROSCIENCE, 98, 46-53, 2019
  21. The Role of Cysteine String Protein alpha Phosphorylation at Serine 10 and 34 by Protein Kinase C gamma for Presynaptic Maintenance, JOURNAL OF NEUROSCIENCE, 38(2), 278-290, 2018
  22. Propofol induced diverse and subtype-specific translocation of PKC families, JOURNAL OF PHARMACOLOGICAL SCIENCES, 137(1), 20-29, 2018
  23. Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4-and 3-repeat tau, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37(7), 2441-2457, 2017
  24. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling, NEUROCHEMISTRY INTERNATIONAL, 93, 82-94, 2016
  25. Discovery and characterization of GPR6 inverse agonists, FASEB JOURNAL, 28(1), 2014
  26. A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(41), 29934-29942, 2013