tomoaki shintani
Last Updated :2025/06/11
- Affiliations, Positions
- Hiroshima University Hospital(Center for Oral Clinical Examination), Associate Professor or Lecturer
- E-mail
- tshintan
hiroshima-u.ac.jp
- Other Contact Details
- 1-2-3 Kasumi minami-ku, Hiroshima, Japan, 734-8551, Japan
TEL : (+81)82-257-5727 FAX : (+81)82-257-5727
Basic Information
Major Professional Backgrounds
- 2005/03/01, 2007/03/31, Hiroshima University, Hospital, Research Associate
- 2007/04/01, 2020/07/31, Hiroshima University, Hospital, Assistant Professor
- 2001/04/01, 2002/10/04, Hiroshima University, Hospital, Clinical Fellow
- 2020/08/01, Hiroshima University, Hospital, Lecturer
Educational Backgrounds
- Hiroshima University, Graduate School, Division of Dental Research, Japan, 1997/04, 2001/03
Academic Degrees
- Doctor of Philosophy in Medical Science, Hiroshima University
- Doctor of Dental Surgery, Hiroshima University
In Charge of Primary Major Programs
Research Fields
- Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry
Research Keywords
- cancer
- Metastasis
- vitaminD
- Angiogenesis
- HBp17
Affiliated Academic Societies
- American Association of Cancer Research
- Japanese Society for Evidence and the Dental Professional
- The Japanese Stomatological Society
Educational Activity
Course in Charge
- 2025, Undergraduate Education, First Semester, Early Clinical Exposure I
- 2025, Undergraduate Education, 3Term, Examination and Diagnosis
- 2025, Undergraduate Education, Second Semester, Early Clinical Exposure II
- 2025, Undergraduate Education, First Semester, Dental Research Practices I
- 2025, Undergraduate Education, Second Semester, Early Clinical Exposure III
- 2025, Undergraduate Education, Second Semester, Dental Research Practices II
- 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
- 2025, Undergraduate Education, First Semester, Dental Research Practices III
- 2025, Undergraduate Education, Year, Clinical Practice (Oral Clinical Examination)
- 2025, Undergraduate Education, 4Term, Practicum of Oral Health
- 2025, Undergraduate Education, 1Term, Oral Health Management A
Research Activities
Academic Papers
- ★, Effect of Stimulated Salivary Volume on Dysbiosis of the Salivary Microbiome in Children and Young Adults, INTERNATIONAL DENTAL JOURNAL, 75(3), 1759-1770, 202506
- Consideration of the work environment in a case of an industrial homeworker with allergic contact dermatitis by UV-curing acrylic resin, ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, 79(9-10), 315-320, 20241125
- Potential role of circulating tumor cells and cell-free DNA as biomarkers in oral squamous cell carcinoma: A prospective single-center study, PLOS ONE, 19(12), 20241227
- Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model, ORAL DISEASES, 30(8), 5294-5304, 202411
- ★, Potential treatment of squamous cell carcinoma by targeting heparin-binding protein 17/fibroblast growth factor-binding protein 1 with vitamin D3 or eldecalcitol, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 60(6), 583-589, 202406
- Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 139(1), 92-100, 202501
- Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan, SCIENTIFIC REPORTS, 14(1), 20240515
- A case of treatment-related myelodysplastic syndrome in the early stage after radiotherapy in a patient with cancer of the oral floor, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 36(6), 860-865, 202411
- YAP/TAZ interacts with RBM39 to confer resistance against indisulam, ONCOGENESIS, 13(1), 20240715
- Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(8), 20240416
- Analysis of Oral and Gut Microbiome Composition and Its Impact in Patients with Oral Squamous Cell Carcinoma, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(11), 202406
- Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells, STEM CELL REVIEWS AND REPORTS, 20(1), 347-361, 202401
- Effect of Periodontal Treatment on Reducing Chronic Inflammation in Systemically Healthy Patients With Periodontal Disease, AMERICAN JOURNAL OF MEDICINE, 137(3), 202403
- Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long-term follow-up: A case report, MOLECULAR MEDICINE REPORTS, 29(3), 202403
- Clinical significance of integrin alphaV and beta superfamily members and focal adhesion kinase activity in oral squamous cell carcinoma: a retrospective observational study, PATHOLOGY & ONCOLOGY RESEARCH, 30, 20240118
- Interaction of Integrin ホアvホイ8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation, ANTICANCER RESEARCH, 43(11), 4833-4841, 202311
- Skin Symptoms That Appeared after Fixation with a Titanium Plate in a Jaw Deformity Patient Suffering from Palmoplantar Pustulosis: A Case Report, DENTISTRY JOURNAL, 11(11), 202311
- Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study, JOURNAL OF PERSONALIZED MEDICINE, 13(11), 202311
- Distinctive Biological Properties between Mesenchymal Stem Cell Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems, APPLIED SCIENCES-BASEL, 13(23), 202312
- Relationship between CD4+T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study, JOURNAL OF CLINICAL PERIODONTOLOGY, 50(11), 1520-1529, 202311
- A case report of allergic reaction with acute facial swelling: a rare complication of dental acrylic resin, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 51(7), 202307
- AXL activates YAP through the EGFR-LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma, ONCOGENE, 42(39), 2869-2877, 20230922
- Taste-taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic, SUPPORTIVE CARE IN CANCER, 31(9), 202309
- Resting saliva volume as a risk factor for hypogeusia: A retrospective study, PHYSIOLOGY & BEHAVIOR, 267, 20230801
- A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification, STEM CELL REVIEWS AND REPORTS, 19(6), 1812-1827, 202308
- Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation, SCIENTIFIC REPORTS, 13(1), 20230608
- A case of multiple myeloma diagnosed by extramedullary disease in the submandibular region, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 35(3), 247-250, 202305
- Tumor-Infiltrating CD45RO(+) Memory Cells Are Associated with Favorable Prognosis in Oral Squamous Cell Carcinoma Patients, CANCERS, 15(8), 202304
- Retrospective study on the therapeutic efficacy of zinc acetate hydrate administration to patients with hypozincemia-induced dysgeusia, BMC ORAL HEALTH, 23(1), 20230318
- Impact of oral hygiene on febrile neutropenia during breast cancer chemotherapy, BREAST CANCER, 30(1), 151-155, 202301
- Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine, JOURNAL OF PERSONALIZED MEDICINE, 12(10), 202210
- VEGF-A promotes the motility of human melanoma cells through the VEGFR1-PI3K/Akt signaling pathway, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 58(8), 758-770, 202209
- Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
- Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(3), 202203
- ★, Impact of Maximum Tongue Pressure in Patients with Jaw Deformities Who Underwent Orthognathic Surgery, DIAGNOSTICS, 12(2), 202202
- Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis., Oncology Reports, 17(3), 591-596, 20070301
- Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1(HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis, Oncology Report, 17(3), 591-596, 20070301
- Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer., Int J Radiat Oncol Biol Phys., 69(5), 1534-1543, 20071201
- Spongolactams, farnesyl transferase inhibitors from a marine sponge: isolation through an LC/MS-guided assay, structures, and semisyntheses., J Org Chem., 72(19), 7190-7198, 20070914
- Zooxanthellamide D, a polyhydroxy polyene amide from a marine dinoflagellate, and chemotaxonomic perspective of the Symbiodinium polyols., J Nat Prod., 70(3), 407-411, 20070301
- Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in mice., Int J Radiat Oncol Biol Phys., 67(3), 870-878, 20070301
- Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion., Oncol Rep., 17(2), 417-423, 20070201
- Novel relationship between the antifungal activity and cytotoxicity of marine-derived metabolite xestoquinone and its family., Biosci Biotechnol Biochem, 69(9), 1749-1752, 20050901
- Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer., Clin Cancer Res., 10(24), 8613-8619, 20041215
- Primary intraosseous carcinoma of mandible associated with elevation of serum carcinoembryonic antigen level, Oral Oncology Extra, 41(10), 267-271, 20051101
- Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade., Mol Cancer Ther., 6(2), 471-483, 20070201
- The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples., 20090301
- A case of angioleiomyoma in the cheek with remarkable lipidization., 54, 621-625, 20081201
- Spongolactams, farnesyl transferase inhibitors from a marine sponge: Isolation through an LC/MS-Guided assay, structures, and semisyntheses, JOURNAL OF ORGANIC CHEMISTRY, 72(19), 7190-7198, 20070914
- Induction of alpha 2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion, ONCOLOGY REPORTS, 17(2), 417-423, 200702
- Zooxanthellamide D, a polyhydroxy polyene amide from a marine dinoflagellate, and chemotaxonomic perspective of the Symbiodinium polyols, JOURNAL OF NATURAL PRODUCTS, 70(3), 407-411, 200703
- 1 alpha,25(OH)2D3 down-regulates HBp17/FGFBP-1 expression via NF-kappa B pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 136, 98-101, 201307
- ★, 1 alpha,25(OH)(2)D-3 inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 50(9), 802-806, 201410
- The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan, ORAL DISEASES, 21(5), 626-633, 201507
- Comparison of the prognosis of bisphosphonate-related osteonecrosis of the jaw caused by oral and intravenous bisphosphonates, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(7), 840-844, 201507
- Evaluation of novel orthotopic nude mouse models for human small-cell lung cancer., J Thorac Oncol., 201302
- Bisphosphonate-related osteonecrosis of the jaw successfully treated with surgical resection and its histopathological features: A long-term follow-up report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 27(2), 283-286, 201503
- ★, Eldecalcitol (ED-71), an analog of 1 alpha,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 164, 79-84, 201611
- ★, Eldecalcitol (ED-71), an analog of 1 alpha,25(OH)(2)D-3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 53(9), 810-817, 201720
- ★, Prevalence of Torus Mandibularis in Young Healthy Dentate Adults, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75(12), 2593-2598, 201712
- ★, Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease, JOURNAL OF GASTROENTEROLOGY, 53(2), 269-280, 201802
- Current status of dental metal allergy in Japan, JOURNAL OF PROSTHODONTIC RESEARCH, 63(3), 309-312, 201907
- Evaluation of Porphyromonas gingivalis infection using serum antibody titer, Journal of Japanese Society for Evidence and the Dental Professional, 10(1), 39-43, 201803
- ★, Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1), IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 56(3), 222-233, 202003
- Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 200(3), 302-309, 202006
- ★, Oral environment and taste function of Japanese HIV-infected patients treated with antiretroviral therapy, AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 32(7), 829-834, 20200702
- Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients, PLOS ONE, 15(8), 20200806
- Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients, PLOS ONE, 15(10), 20201008
- Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome, PLOS ONE, 15(10), 20201028
- Clinical Outcomes of Post-exposure Prophylaxis following Occupational Exposure to Human Immunodeficiency Virus at Dental Departments of Hiroshima University Hospital, CURRENT HIV RESEARCH, 18(6), 475-479, 20200801
- Enhanced KRT13 gene expression bestows radiation resistance in squamous cell carcinoma cells, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 57(3), 300-314, 20210302
- Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 32(5), 1240-1250, 20210510
- ★, Heparin-Binding Protein 17/Fibroblast Growth Factor-Binding Protein-1 Knockout Inhibits Proliferation and Induces Differentiation of Squamous Cell Carcinoma Cells, CANCERS, 13(11), 20210607
- Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates, HEART AND VESSELS, 36(11), 1721-1729, 202111
Publications such as books
- Internal Medicine for Dental Treatments Patients with Medical Diseases, Dementia/Alzheimer's disease, Springer Singapore, 2024, 2, Textbook, Joint work, Nishimura M., Shintani T., Okamoto T., Muramatsu K., Kawai T., Yamahara K., Maeda T., Terayama Y., Okada S., and Kamatani T, 978-981-99-3296-2
Invited Lecture, Oral Presentation, Poster Presentation
- Local Recurrence in Cases of Backward Extension of Oral Cancer, Ito N., Koizumi K., Shintani T., Asada K., Fukutani T., Obayashi F., Higaki M., Hamada A., Yamasaki S., Yoshioka Y., Yanamoto S., 9th International Academy of Oral Oncology, 2023/11/01, Without Invitation, English, other
- Eldecalcitol(ED-71),an analog of 1alpha,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas., Shintani T, Rosli SNZ, Takatsu F, Toratani S, Choon YF , Usui E, and Okamoto T, The 18th Vitamin D Workshop, 2015/05, Without Invitation, English, Delft, Netherlands, experimental
- The influence of anti-HIV drug on oral environment and taste function, Shintani T., Yamasaki N., Iwata T., Saitou S., Okada M., Mastui K., Unei H., Fujita K., Hamamoto K., Kinoshita K., Ikeda Y., Fujii T., Shiba H., 2018/11, Without Invitation, Japanese, published
- The oral environment and taste function in HIV-positive patients, Shintani T., Yamasaki N., Iwata T., Saitou S., Kitagawa M., Ogawa I., Okada M., Mastui K., Unei H., Fujita K., Hamamoto K., Kinoshita K., Ikeda Y., Fujii T., Kurihara H., Shiba H, The 11th Annual Meeting of Japanese Society for Evidence and the Dental Professional, 2018/08, Without Invitation, Japanese, other
- Serum antibody titer of periodontal bacteria against Porphyromonas gingivalis infection focusing on genotype of fimbria, Shintani T., Ouhara K., Kitagawa M., Ogawa I., Kurihara H, The 11th Annual Meeting of Japanese Society for Evidence and the Dental Professional, 2018/08, Without Invitation, Japanese, published
- Dental hygienist's activities and the effects in dental clinical support for HIV-infected patients, Okada M, Matsui K, Iwata T, Shintani T, Kinoshita K, Miyahara A, Ikeda Y, Saitou S, Maruyama E, Hamamoto K, Yamasaki N, Fujii T, Shiba H, The 19th Japanese HIV dental medical workshop, 2018/01, With Invitation, Japanese, preprint
- Activity report on the support that dental hygienists provide in the dental clinical practice for people infected with HIV, Okada M, Nakaoka M, Iwata T, Shintani T, Shiba H., The13 Annual Meeting of the Japan Dental Hygienists Association, 2018/09, Without Invitation, Japanese, preprint
- An index and the periodontal pathogens which are related to an outcome for three months of patients with stroke patient, Nishi H, Ohta K, Shigeishi H, Shintani T, Obayashi T, Kurihara H, Kawaguchi H., The 15th Annual Meeting of the Japanese Society of Oral Care, 2018/05, Without Invitation, Japanese, preprint
- The serum IgG antibody titers for Fusobacterium is associated with an outcome for three months of patients with stroke, Nishi H, Ohta K, Shigeishi H, Shintani T, Obayashi T, Kurihara H, Kawaguchi H., The 28th Annual Meeting of The Japanese Society of Oral Medicine, The 31st Annual Meeting of The Japanese Society of Oral Diagnosis / Oral Medicine, 2018/09, Without Invitation, Japanese, preprint
- Oral bacteria is associated with complications in the chemotherapy, Nishi H, Obayashi T, Shintani T, Kitagawa M, Ogawa I, Kurihara H, Kawaguchi H., The 102nd Hiroshima Conference on Education and Science in Dentistry, 2018/10, Without Invitation, Japanese, preprint
- Association between oral bacteria and chemotherapy complications, Nishi H, Shintani T, Kitagawa M, Ohta K, Obayashi T, Ogawa I, Kurihara H, Kawaguchi H., The 27th Annual Meeting of the Japanese Society for Oral Infectious Disease, 2018/10, Without Invitation, Japanese, preprint
Awards
- 2000/09, Scholar Awards, Annual Meeting of Japanese Tissue Culture Association, 2000, Japanese Tissue Culture Association, FGF-BP/HBp17を標的とした扁平上皮癌の分子標的治療に関する研究
- 2005/05, Best Posters, Annual Meeting of Japanese Stomatological Society, 2006, Japanese Stomatological Society, Clinical Tumor Dormancy: Biology and Regulation of Dormant Lung Metastases in a Murine Melanoma Model
- 2018/11/17, The 66th Japanese Association for Dental Research / Joseph Lister Award 2018 First prize, Japanese Association for Dental Research President
Social Activities
History as Peer Reviews of Academic Papers
- 2024, Biochimica et Biophysica Acta, Others, 1
- 2024, The Journal of Nutritional Biochemistry, Others, 1
- 2024, Cancers, Others, 1
- 2024, Translational Cancer Research, Others, 2
- 2024, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Others, 3
- 2024, Scientific report, Others, 1
- 2024, In Vitro Cellular & Developmental Biology - Animal, Others, 13
- 2023, BMC Oral Health, Others, 1
- 2023, Frontiers, Others, 1
- 2023, In Vitro Cellular & Developmental Biology - Animal, Others, 6
- 2022, In Vitro Cellular & Developmental Biology - Animal, Others, 4
- 2021, Biomedicines, Others, 1
- 2021, International journal of molecular science, Others, 1