tomoaki shintani

Last Updated :2025/06/11

Affiliations, Positions
Hiroshima University Hospital(Center for Oral Clinical Examination), Associate Professor or Lecturer
E-mail
tshintanhiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi minami-ku, Hiroshima, Japan, 734-8551, Japan
TEL : (+81)82-257-5727 FAX : (+81)82-257-5727

Basic Information

Major Professional Backgrounds

  • 2005/03/01, 2007/03/31, Hiroshima University, Hospital, Research Associate
  • 2007/04/01, 2020/07/31, Hiroshima University, Hospital, Assistant Professor
  • 2001/04/01, 2002/10/04, Hiroshima University, Hospital, Clinical Fellow
  • 2020/08/01, Hiroshima University, Hospital, Lecturer

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Dental Research, Japan, 1997/04, 2001/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University
  • Doctor of Dental Surgery, Hiroshima University

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry

Research Keywords

  • cancer
  • Metastasis
  • vitaminD
  • Angiogenesis
  • HBp17

Affiliated Academic Societies

  • American Association of Cancer Research
  • Japanese Society for Evidence and the Dental Professional
  • The Japanese Stomatological Society

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Early Clinical Exposure I
  2. 2025, Undergraduate Education, 3Term, Examination and Diagnosis
  3. 2025, Undergraduate Education, Second Semester, Early Clinical Exposure II
  4. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  5. 2025, Undergraduate Education, Second Semester, Early Clinical Exposure III
  6. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  7. 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
  8. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  9. 2025, Undergraduate Education, Year, Clinical Practice (Oral Clinical Examination)
  10. 2025, Undergraduate Education, 4Term, Practicum of Oral Health
  11. 2025, Undergraduate Education, 1Term, Oral Health Management A

Research Activities

Academic Papers

  1. ★, Effect of Stimulated Salivary Volume on Dysbiosis of the Salivary Microbiome in Children and Young Adults, INTERNATIONAL DENTAL JOURNAL, 75(3), 1759-1770, 202506
  2. Consideration of the work environment in a case of an industrial homeworker with allergic contact dermatitis by UV-curing acrylic resin, ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, 79(9-10), 315-320, 20241125
  3. Potential role of circulating tumor cells and cell-free DNA as biomarkers in oral squamous cell carcinoma: A prospective single-center study, PLOS ONE, 19(12), 20241227
  4. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model, ORAL DISEASES, 30(8), 5294-5304, 202411
  5. ★, Potential treatment of squamous cell carcinoma by targeting heparin-binding protein 17/fibroblast growth factor-binding protein 1 with vitamin D3 or eldecalcitol, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 60(6), 583-589, 202406
  6. Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 139(1), 92-100, 202501
  7. Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan, SCIENTIFIC REPORTS, 14(1), 20240515
  8. A case of treatment-related myelodysplastic syndrome in the early stage after radiotherapy in a patient with cancer of the oral floor, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 36(6), 860-865, 202411
  9. YAP/TAZ interacts with RBM39 to confer resistance against indisulam, ONCOGENESIS, 13(1), 20240715
  10. Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(8), 20240416
  11. Analysis of Oral and Gut Microbiome Composition and Its Impact in Patients with Oral Squamous Cell Carcinoma, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(11), 202406
  12. Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells, STEM CELL REVIEWS AND REPORTS, 20(1), 347-361, 202401
  13. Effect of Periodontal Treatment on Reducing Chronic Inflammation in Systemically Healthy Patients With Periodontal Disease, AMERICAN JOURNAL OF MEDICINE, 137(3), 202403
  14. Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long-term follow-up: A case report, MOLECULAR MEDICINE REPORTS, 29(3), 202403
  15. Clinical significance of integrin alphaV and beta superfamily members and focal adhesion kinase activity in oral squamous cell carcinoma: a retrospective observational study, PATHOLOGY & ONCOLOGY RESEARCH, 30, 20240118
  16. Interaction of Integrin ホアvホイ8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation, ANTICANCER RESEARCH, 43(11), 4833-4841, 202311
  17. Skin Symptoms That Appeared after Fixation with a Titanium Plate in a Jaw Deformity Patient Suffering from Palmoplantar Pustulosis: A Case Report, DENTISTRY JOURNAL, 11(11), 202311
  18. Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study, JOURNAL OF PERSONALIZED MEDICINE, 13(11), 202311
  19. Distinctive Biological Properties between Mesenchymal Stem Cell Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems, APPLIED SCIENCES-BASEL, 13(23), 202312
  20. Relationship between CD4+T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study, JOURNAL OF CLINICAL PERIODONTOLOGY, 50(11), 1520-1529, 202311
  21. A case report of allergic reaction with acute facial swelling: a rare complication of dental acrylic resin, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 51(7), 202307
  22. AXL activates YAP through the EGFR-LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma, ONCOGENE, 42(39), 2869-2877, 20230922
  23. Taste-taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic, SUPPORTIVE CARE IN CANCER, 31(9), 202309
  24. Resting saliva volume as a risk factor for hypogeusia: A retrospective study, PHYSIOLOGY & BEHAVIOR, 267, 20230801
  25. A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification, STEM CELL REVIEWS AND REPORTS, 19(6), 1812-1827, 202308
  26. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation, SCIENTIFIC REPORTS, 13(1), 20230608
  27. A case of multiple myeloma diagnosed by extramedullary disease in the submandibular region, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 35(3), 247-250, 202305
  28. Tumor-Infiltrating CD45RO(+) Memory Cells Are Associated with Favorable Prognosis in Oral Squamous Cell Carcinoma Patients, CANCERS, 15(8), 202304
  29. Retrospective study on the therapeutic efficacy of zinc acetate hydrate administration to patients with hypozincemia-induced dysgeusia, BMC ORAL HEALTH, 23(1), 20230318
  30. Impact of oral hygiene on febrile neutropenia during breast cancer chemotherapy, BREAST CANCER, 30(1), 151-155, 202301
  31. Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine, JOURNAL OF PERSONALIZED MEDICINE, 12(10), 202210
  32. VEGF-A promotes the motility of human melanoma cells through the VEGFR1-PI3K/Akt signaling pathway, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 58(8), 758-770, 202209
  33. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
  34. Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(3), 202203
  35. ★, Impact of Maximum Tongue Pressure in Patients with Jaw Deformities Who Underwent Orthognathic Surgery, DIAGNOSTICS, 12(2), 202202
  36. Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis., Oncology Reports, 17(3), 591-596, 20070301
  37. Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1(HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis, Oncology Report, 17(3), 591-596, 20070301
  38. Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer., Int J Radiat Oncol Biol Phys., 69(5), 1534-1543, 20071201
  39. Spongolactams, farnesyl transferase inhibitors from a marine sponge: isolation through an LC/MS-guided assay, structures, and semisyntheses., J Org Chem., 72(19), 7190-7198, 20070914
  40. Zooxanthellamide D, a polyhydroxy polyene amide from a marine dinoflagellate, and chemotaxonomic perspective of the Symbiodinium polyols., J Nat Prod., 70(3), 407-411, 20070301
  41. Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in mice., Int J Radiat Oncol Biol Phys., 67(3), 870-878, 20070301
  42. Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion., Oncol Rep., 17(2), 417-423, 20070201
  43. Novel relationship between the antifungal activity and cytotoxicity of marine-derived metabolite xestoquinone and its family., Biosci Biotechnol Biochem, 69(9), 1749-1752, 20050901
  44. Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer., Clin Cancer Res., 10(24), 8613-8619, 20041215
  45. Primary intraosseous carcinoma of mandible associated with elevation of serum carcinoembryonic antigen level, Oral Oncology Extra, 41(10), 267-271, 20051101
  46. Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade., Mol Cancer Ther., 6(2), 471-483, 20070201
  47. The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples., 20090301
  48. A case of angioleiomyoma in the cheek with remarkable lipidization., 54, 621-625, 20081201
  49. Spongolactams, farnesyl transferase inhibitors from a marine sponge: Isolation through an LC/MS-Guided assay, structures, and semisyntheses, JOURNAL OF ORGANIC CHEMISTRY, 72(19), 7190-7198, 20070914
  50. Induction of alpha 2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion, ONCOLOGY REPORTS, 17(2), 417-423, 200702
  51. Zooxanthellamide D, a polyhydroxy polyene amide from a marine dinoflagellate, and chemotaxonomic perspective of the Symbiodinium polyols, JOURNAL OF NATURAL PRODUCTS, 70(3), 407-411, 200703
  52. 1 alpha,25(OH)2D3 down-regulates HBp17/FGFBP-1 expression via NF-kappa B pathway, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 136, 98-101, 201307
  53. ★, 1 alpha,25(OH)(2)D-3 inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 50(9), 802-806, 201410
  54. The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan, ORAL DISEASES, 21(5), 626-633, 201507
  55. Comparison of the prognosis of bisphosphonate-related osteonecrosis of the jaw caused by oral and intravenous bisphosphonates, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(7), 840-844, 201507
  56. Evaluation of novel orthotopic nude mouse models for human small-cell lung cancer., J Thorac Oncol., 201302
  57. Bisphosphonate-related osteonecrosis of the jaw successfully treated with surgical resection and its histopathological features: A long-term follow-up report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 27(2), 283-286, 201503
  58. ★, Eldecalcitol (ED-71), an analog of 1 alpha,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 164, 79-84, 201611
  59. ★, Eldecalcitol (ED-71), an analog of 1 alpha,25(OH)(2)D-3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 53(9), 810-817, 201720
  60. ★, Prevalence of Torus Mandibularis in Young Healthy Dentate Adults, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75(12), 2593-2598, 201712
  61. ★, Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease, JOURNAL OF GASTROENTEROLOGY, 53(2), 269-280, 201802
  62. Current status of dental metal allergy in Japan, JOURNAL OF PROSTHODONTIC RESEARCH, 63(3), 309-312, 201907
  63. Evaluation of Porphyromonas gingivalis infection using serum antibody titer, Journal of Japanese Society for Evidence and the Dental Professional, 10(1), 39-43, 201803
  64. ★, Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1), IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 56(3), 222-233, 202003
  65. Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 200(3), 302-309, 202006
  66. ★, Oral environment and taste function of Japanese HIV-infected patients treated with antiretroviral therapy, AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 32(7), 829-834, 20200702
  67. Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients, PLOS ONE, 15(8), 20200806
  68. Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients, PLOS ONE, 15(10), 20201008
  69. Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome, PLOS ONE, 15(10), 20201028
  70. Clinical Outcomes of Post-exposure Prophylaxis following Occupational Exposure to Human Immunodeficiency Virus at Dental Departments of Hiroshima University Hospital, CURRENT HIV RESEARCH, 18(6), 475-479, 20200801
  71. Enhanced KRT13 gene expression bestows radiation resistance in squamous cell carcinoma cells, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 57(3), 300-314, 20210302
  72. Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 32(5), 1240-1250, 20210510
  73. ★, Heparin-Binding Protein 17/Fibroblast Growth Factor-Binding Protein-1 Knockout Inhibits Proliferation and Induces Differentiation of Squamous Cell Carcinoma Cells, CANCERS, 13(11), 20210607
  74. Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates, HEART AND VESSELS, 36(11), 1721-1729, 202111

Publications such as books

  1. Internal Medicine for Dental Treatments Patients with Medical Diseases, Dementia/Alzheimer's disease, Springer Singapore, 2024, 2, Textbook, Joint work, Nishimura M., Shintani T., Okamoto T., Muramatsu K., Kawai T., Yamahara K., Maeda T., Terayama Y., Okada S., and Kamatani T, 978-981-99-3296-2

Invited Lecture, Oral Presentation, Poster Presentation

  1. Local Recurrence in Cases of Backward Extension of Oral Cancer, Ito N., Koizumi K., Shintani T., Asada K., Fukutani T., Obayashi F., Higaki M., Hamada A., Yamasaki S., Yoshioka Y., Yanamoto S., 9th International Academy of Oral Oncology, 2023/11/01, Without Invitation, English, other
  2. Eldecalcitol(ED-71),an analog of 1alpha,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas., Shintani T, Rosli SNZ, Takatsu F, Toratani S, Choon YF , Usui E, and Okamoto T, The 18th Vitamin D Workshop, 2015/05, Without Invitation, English, Delft, Netherlands, experimental
  3. The influence of anti-HIV drug on oral environment and taste function, Shintani T., Yamasaki N., Iwata T., Saitou S., Okada M., Mastui K., Unei H., Fujita K., Hamamoto K., Kinoshita K., Ikeda Y., Fujii T., Shiba H., 2018/11, Without Invitation, Japanese, published
  4. The oral environment and taste function in HIV-positive patients, Shintani T., Yamasaki N., Iwata T., Saitou S., Kitagawa M., Ogawa I., Okada M., Mastui K., Unei H., Fujita K., Hamamoto K., Kinoshita K., Ikeda Y., Fujii T., Kurihara H., Shiba H, The 11th Annual Meeting of Japanese Society for Evidence and the Dental Professional, 2018/08, Without Invitation, Japanese, other
  5. Serum antibody titer of periodontal bacteria against Porphyromonas gingivalis infection focusing on genotype of fimbria, Shintani T., Ouhara K., Kitagawa M., Ogawa I., Kurihara H, The 11th Annual Meeting of Japanese Society for Evidence and the Dental Professional, 2018/08, Without Invitation, Japanese, published
  6. Dental hygienist's activities and the effects in dental clinical support for HIV-infected patients, Okada M, Matsui K, Iwata T, Shintani T, Kinoshita K, Miyahara A, Ikeda Y, Saitou S, Maruyama E, Hamamoto K, Yamasaki N, Fujii T, Shiba H, The 19th Japanese HIV dental medical workshop, 2018/01, With Invitation, Japanese, preprint
  7. Activity report on the support that dental hygienists provide in the dental clinical practice for people infected with HIV, Okada M, Nakaoka M, Iwata T, Shintani T, Shiba H., The13 Annual Meeting of the Japan Dental Hygienists Association, 2018/09, Without Invitation, Japanese, preprint
  8. An index and the periodontal pathogens which are related to an outcome for three months of patients with stroke patient, Nishi H, Ohta K, Shigeishi H, Shintani T, Obayashi T, Kurihara H, Kawaguchi H., The 15th Annual Meeting of the Japanese Society of Oral Care, 2018/05, Without Invitation, Japanese, preprint
  9. The serum IgG antibody titers for Fusobacterium is associated with an outcome for three months of patients with stroke, Nishi H, Ohta K, Shigeishi H, Shintani T, Obayashi T, Kurihara H, Kawaguchi H., The 28th Annual Meeting of The Japanese Society of Oral Medicine, The 31st Annual Meeting of The Japanese Society of Oral Diagnosis / Oral Medicine, 2018/09, Without Invitation, Japanese, preprint
  10. Oral bacteria is associated with complications in the chemotherapy, Nishi H, Obayashi T, Shintani T, Kitagawa M, Ogawa I, Kurihara H, Kawaguchi H., The 102nd Hiroshima Conference on Education and Science in Dentistry, 2018/10, Without Invitation, Japanese, preprint
  11. Association between oral bacteria and chemotherapy complications, Nishi H, Shintani T, Kitagawa M, Ohta K, Obayashi T, Ogawa I, Kurihara H, Kawaguchi H., The 27th Annual Meeting of the Japanese Society for Oral Infectious Disease, 2018/10, Without Invitation, Japanese, preprint

Awards

  1. 2000/09, Scholar Awards, Annual Meeting of Japanese Tissue Culture Association, 2000, Japanese Tissue Culture Association, FGF-BP/HBp17を標的とした扁平上皮癌の分子標的治療に関する研究
  2. 2005/05, Best Posters, Annual Meeting of Japanese Stomatological Society, 2006, Japanese Stomatological Society, Clinical Tumor Dormancy: Biology and Regulation of Dormant Lung Metastases in a Murine Melanoma Model
  3. 2018/11/17, The 66th Japanese Association for Dental Research / Joseph Lister Award 2018 First prize, Japanese Association for Dental Research President

Social Activities

History as Peer Reviews of Academic Papers

  1. 2024, Biochimica et Biophysica Acta, Others, 1
  2. 2024, The Journal of Nutritional Biochemistry, Others, 1
  3. 2024, Cancers, Others, 1
  4. 2024, Translational Cancer Research, Others, 2
  5. 2024, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Others, 3
  6. 2024, Scientific report, Others, 1
  7. 2024, In Vitro Cellular & Developmental Biology - Animal, Others, 13
  8. 2023, BMC Oral Health, Others, 1
  9. 2023, Frontiers, Others, 1
  10. 2023, In Vitro Cellular & Developmental Biology - Animal, Others, 6
  11. 2022, In Vitro Cellular & Developmental Biology - Animal, Others, 4
  12. 2021, Biomedicines, Others, 1
  13. 2021, International journal of molecular science, Others, 1