JIE KOU

Last Updated :2025/07/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor
E-mail
jiaekohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Science, Osaka University
  • Master of Science, Osaka University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Ophthalmology

Research Activities

Academic Papers

  1. HIF-1a-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells, Dis Model Mech, 17(4), dmm050640-dmm050640, 20240501
    Link to Paper Search Results by DOI
  2. Effects of Ripasudil, a Rho-Kinase Inhibitor, on Scar Formation in a Mouse Model of Filtration Surgery., Current eye research, 48(9), 826-835, 20230529
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  3. Functional Analysis of Semaphorin 3A in Retinal Ganglion Cells under Hypoxia In Vitro., Biology Bulletin, 50(2), 194-202, 20230221
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  4. Synergistic effect of TONS504-mediated photodynamic antimicrobial chemotherapy and additives widely contained in ophthalmic solutions: benzalkonium chloride and ethylenediaminetetraacetic acid., Photochem Photobiol Sci (2022), 20220720
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  5. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue., J Photochem Photobiol B, 221, 20210608
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  6. Functional analysis of mesencephalic astrocyte-derived neurotrophic factor in retinal ganglion cells under oxidative stress., Cell Biochem Funct, 39(1), 98-106, 20210101
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  7. Efficacy of Photodynamic Anti-Microbial Chemotherapy for Acanthamoeba Keratitis In Vivo., Lasers in Surgery and Medicine, 28, 166-171, 20201208
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  8. AntimicrobialPhotodynamicTherapywiththephotosensitizerTONS504 eradicatesAcanthamoeba, Photodiagnosis and Photodynamic Therapy, 28, 166-171, 201912
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  9. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi, LASERS IN MEDICAL SCIENCE, 34(4), 743-747, 201906
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  10. An in vitro study of scarring formation mediated by human Tenon fibroblasts: Effect of Y-27632, a Rho kinase inhibitor, CELL BIOCHEMISTRY AND FUNCTION, 37(2), 113-124, 201903
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  11. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, Lasers Med Sci, 1455-1460, 201809
  12. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, LASERS IN MEDICAL SCIENCE, 33(7), 1455-1460, 201809
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  13. Role of macrophage migration inhibitory factor (MIF) in the effects of oxidative stress on human retinal pigment epithelial cells, CELL BIOCHEMISTRY AND FUNCTION, 35(7), 426-432, 201710
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  14. Down-regulation of semaphorin 3F in rat retinal ganglion cells in response to optic nerve crush, CELL BIOCHEMISTRY AND FUNCTION, 34(5), 378-384, 201606
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  15. Effects of topical adrenergic agents on prostaglandin E2-induced aqueous flare and intraocular pressure elevation in pigmented rabbits, JAPANESE JOURNAL OF OPHTHALMOLOGY, 60(2), 95-102, 201603
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  16. Up-regulation of semaphorin 4A expression in human retinal pigment epithelial cells by PACAP released from cocultured neural cells, CELL BIOCHEMISTRY AND FUNCTION, 33(1), 29-36, 2015
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  17. Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro, LASERS IN MEDICAL SCIENCE, 30(1), 383-387, 2015
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  18. Oxidative stress regulates expression of claudin-1 in human RPE cells, CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 9(5), 461-468, 2014
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  19. ★, Neuropeptides Released From Trigeminal Neurons Promote the Stratification of Human Corneal Epithelial Cells, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(1), 125-133, 2014
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  20. Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats, CELL BIOCHEMISTRY AND FUNCTION, 31(6), 482-488, 2013
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  21. Up-regulation of matrix metalloproteinase-1 and interleukin-6 expression in cocultures of corneal fibroblasts and neural cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 419(3), 537-542, 2012
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  22. Differential expression of semaphorin 3A and its receptors during mouse retinal development, CELL BIOCHEMISTRY AND FUNCTION, 30(7), 563-568, 2012
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Invited Lecture, Oral Presentation, Poster Presentation

  1. The Neuroprotective Role of IGFBP-5 in Retinal Ganglion Cells Under Oxidative Stress: Mechanisms and Therapeutic Implications, Ko JA, Minamoto A, Komatsu K, Hirooka K, Sakaguchi H, ARVO 2025, 2025/05/08, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Salt Lake City, Utah
  2. Analysis of inflammatory changes induced by mechanical stress on RPE in an animal model, Minamoto A, Ko JA, Ashimori A, Higashijima F, Kimura K, Kiuchi Y, Sakaguchi H, ARVO2025, 2025/05/08, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Salt Lake City, Utah
  3. IGFBP-5 as a Critical Factor in Retinal Ganglion Cell Survival: Exploring Its Role in Oxidative Stress and Therapeutic Implications, Mizukami M, Ko JA, Minamoto A, Hirooka K, Kiuchi Y, Cell Bio 2024, 2024/12/17, Without Invitation, English, AN INTERNATIONAL FORUM FOR CELL BIOLOG, San Diego, California
  4. The Role of Nerve Growth Factor Secreted by Glial Cells in Protecting Retinal Ganglion Cells from Oxidative Stress: Analysis Using a 3D Co-Culture System, Ko JA, Minamoto A, Komatsu K, Hirooka K, Kiuchi Y, Cell Bio 2024, 2024/12/16, Without Invitation, English, AN INTERNATIONAL FORUM FOR CELL BIOLOG, San Diego, California
  5. Mechanical stress on Retinal Pigment Epithelium induces angiogenesis and histological changes in a neovascular age-related macular degeneration model, Minamoto A, Ko JA, Ashimori A, Kimura K, Kiuchi Y, Cell Bio 2024, 2024/12/16, Without Invitation, English, AN INTERNATIONAL FORUM FOR CELL BIOLOG, San Diego, California
  6. NGF Inhibition in Glial Cells Confirms Neuroprotective Role in RGC Co-Culture, Ko JA, Minamoto A, Hirooka K, Kiuchi Y, EGS2024, 2024/06/02, Without Invitation, English, European Glaucoma Society, Dublin,Ireland
  7. Response to anti-VEGF antibodies in RPE to mechanical stress using animal models, Minamoto A, Ko JA, Ashimori A, Higashijima F, Kimura K, Kiuchi Y, ARVO 2024, 2024/05/08, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Seattle, Wash
  8. Functional analysis of glia cells in retinal ganglion cells using coculture system, Ko JA, Minamoto A, Okumichi H, Hirooka K, Kiuchi Y, Cell Bio 2023, 2023/12/03, Without Invitation, English, The American Society for Cell Biology, Boston, MA
  9. Functional Analysis of Glia Cells in RGC using Coculture System, Ko JA, Minamoto A, Okumichi H, Hirooka K, Kiuchi Y, ARVO)2023, 2023/04/24, Without Invitation, English, The Association for Research in Vision and Ophthalmology, New Orleans, America
  10. Functional analysis of the angiogenesis-related factors induced by mechanical stressed RPE using animal model, Minamoto A, Ko JA, Ashimori A, Higashijima F, Wakuta M, Kimura K, Kiuchi Y, ISER2023, 2023/02/19, Without Invitation, English, International Society for Eye Research, Gold Coast, Queensland, Australia
  11. Functional Analysis of Glia Cells in RGC using coculuture system, Komatsu K, Ko JA, Minamoto A, Okumichi H, Hirooka K, Kiuchi Y, ISER2023, 2023/02/19, Without Invitation, English, International Society for Eye Research, Gold Coast, Queensland, Australia
  12. Functional Analysis of Glia Cells in RGC using coculture system., Ko JA, Minamoto A, Komatsu K, Okumichi H, Kiuchi Y, 15th EGS Congress, 2022/06/06, Without Invitation, English, European Glaucoma Society, Athens Greece
  13. Efficacy and safety of photodynamic antimicrobial chemotherapy for Acanthamoeba keratitis., Chikama T, Pertiwia YD, Sueoka K, Shinji K, Ko JA, Kiuchi Y, Sakaguchi T, ACS2020, 2021/04/28, Without Invitation, English, Asia Cornea Sciety, Osaka, Japan (Web)
  14. An in vitro study of the effect of Ripasudil, a Rho kinase inhibitor, on scarring formation., Minamoto A, Ko JA, Komatsu K, Okumichi H, Kiuchi Y, 14th EGS Congress, 2020/12/12, Without Invitation, English, EGS, Brussles, Belgium
  15. Functional analysis of Sema3A in retinal ganglion cells under hypoxia., Komatsu K, Ko JA, Okumichi H, Kiuchi Y, 14th EGS Congress, 2020/12/12, Without Invitation, English, EGS, Brussles, Belgium
  16. Functional Analysis of Glia Cells in Retinal Ganglion Cells using coculture system., Ko JA, Komatsu K, Okumichi H, Kiuchi Y, 14th EGS Congress, 2020/12/12, Without Invitation, English, EGS, Brussles, Belgium
  17. Effects of retina with midbrain coculture system on the neuroprotection of retinal ganglion cells, Ko JA, Kiuchi Y, Society for Neuroscience 2019, 2019/10/20, Without Invitation, English, Society for Neuroscience, Chicago, IL, USA
  18. TONS504 mediated photodynamic antimicrobial chemotherapy inactivation for Acanthamoeba keratitis in rabbits in vivo, Yunialthy D.P, Chikama T, Sueoka K, Ko JA, Kiuchi Y, ARVO 2019 Annual Meeting, 2019/05/01, Without Invitation, English, ARVO, VANCOUVER
  19. Functional Analysis of MANF in Retinal Ganglion Cells by Oxidative Stress, Ko JA, Ibrahim DG, Okumichi H, Kiuchi Y, ISER 2018(Biennial Meeting of the International Society for Eye Research), 2018/09/09, Without Invitation, English, ISER, Berfast
  20. Functional Analysis of MANF in Retinal Ganglion Cells by Oxidative Stress, Ko JA, Ibrahim DG, Okumichi H, Kiuchi Y, European Glaucoma Society Congress, 2018/05/19, Without Invitation, English, Florence
  21. In Vitro Effectiveness of Photodynamic Antimicrobial Chemotherapy with TONS504 for Eradication of Acanthamoeba., Pertiwi YD, Chikama T, Sueoka K, Ko JA, Kiuchi Y, ARVO2018, 2018/05/01, Without Invitation, English, ARVO, honolulu
  22. Effcacy of Photodynamic Antimicrobial Therapy with TONS504PDT-Acanthamoeba, Pertiwi Yunialthy D, Chikama T,Sueoka K,Ko JA,Kiuchi Y,Sakaguchi T, Japan Cornea Conference 2018 (42nd Japan Cornea Society / 34th Annual Meeting of Keratoplasty Society of Japan), 2018/02/17, Without Invitation, English, hiroshima
  23. Effects of rho-associated protein kinase inhibitor Y-27632 on scarring formation after glaucoma filtration surgery, Ko JA, Ibrahim DG, Kiuchi Y, ASCB (American Society for Cell Biology), 2017/12/05, Without Invitation, English, The American Society for Cell Biology, Philadelphia
  24. Functional Analysis of MIF in Human retinal pigment epithelium by Oxidative stress, Ko JA, Sotani Y, Kiuchi Y, ARVO2017 Annual Meeting, 2017/05/07, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Baltimore
  25. Antimicrobial efficacy ofphotodynamic therapy with TONS504 againstpathogenic filamentous fungi, Chikama T, Sueoka K, Ko JA, Kiuchi Y, Sakaguchi T, Obana A, ARVO2017 Annual Meeting, 2017/05/07, Without Invitation, English, The Association for Research in Vision and Ophthalmology, Baltimore