Last Updated :2024/07/18

Affiliations, Positions
Hiroshima University, Professor

Basic Information

Major Professional Backgrounds

  • 2024/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Professor
  • 2019/04, 2024/03, Nagahama Institute of Bio-Science and Technology, Faculty of Bio-Science, Professor
  • 2013/01, 2019/03, Osaka University, Institute for Protein Research, Associate Professor
  • 2009, 2012/07, Osaka Bioscience Institute
  • 2004, 2007, Harvard University
  • 2003, The University of Tokyo
  • 1998, 2001, The University of Tokyo, The Institute of Medical Science
  • 1990, 1996, Kyoto University, Faculty of Engineering

Educational Backgrounds

  • Kyoto University, Japan, 1990/04, 1994/03

Academic Degrees

  • PhD, The University of Tokyo

Research Keywords

  • genome evolution
  • whole genome duplication
  • cilia
  • GWAS
  • retina
  • genome research
  • goldfish

Affiliated Academic Societies


Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 2Term, Advanced Biology
  2. 2024, Undergraduate Education, 4Term, Biochemistry A
  3. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  4. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  5. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  6. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  7. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Single-cell transcriptomics of the goldfish retina reveals genetic divergence in the asymmetrically evolved subgenomes after allotetraploidization, Communications Biology, 5(1), 20221226
  2. Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina., Investigative ophthalmology & visual science, 63(5), 14-14, 20220502
  3. Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour, Scientific Reports, 11(1), 202108
  4. Whole-genome resequencing of large yellow croaker (Larimichthys crocea) reveals the population structure and signatures of environmental adaptation., Scientific reports, 11(1), 11235-11235, 20210527
  5. Functional analysis of Samd11, a retinal photoreceptor PRC1 component, in establishing rod photoreceptor identity., Scientific reports, 11(1), 4180-4180, 20210218
  6. The potential role of Arhgef33 RhoGEF in foveal development in the zebra finch retina., Scientific reports, 10(1), 21450-21450, 20201208
  7. Sex chromosome and sex locus characterization in goldfish, Carassius auratus (Linnaeus, 1758)., BMC genomics, 21(1), 552-552, 20200811
  8. Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the IFT machinery is required for intraciliary retrograde protein trafficking., The Journal of biological chemistry, 295(38), 13363-13376, 20200729
  9. The Genetic Basis of Morphological Diversity in Domesticated Goldfish., Current biology : CB, 30(12), 2260-2274, 20200508
  10. Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells., Cellular and molecular life sciences : CMLS, 77(7), 1251-1266, 202004
  11. Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development., Cell reports, 30(3), 658-671, 20200121
  12. De novo assembly of the goldfish (Carassius auratus) genome and the evolution of genes after whole-genome duplication., Science advances, 5(6), eaav0547, 201906
  13. miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation., Scientific reports, 9(1), 3445-3445, 20190305
  14. Compound heterozygous splice site variants in the SCLT1 gene highlight an additional candidate locus for Senior-Løken syndrome., Scientific reports, 8(1), 16733-16733, 201811
  15. Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors., Cell reports, 25(1), 130-145, 20181002
  16. Goldfish: An old and new model system to study vertebrate development, evolution, and human disease., Journal of biochemistry, 165(3), 209-218, 201809
  17. Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity., Cell reports, 22(13), 3548-3561, 20180327
  18. Intraflagellar transport proteins are involved in thrombocyte filopodia formation and secretion., Platelets, 1-10, 201711
  19. Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(39), E8264-E8273, 201709
  20. Ick Ciliary Kinase Is Essential for Planar Cell Polarity Formation in Inner Ear Hair Cells and Hearing Function, JOURNAL OF NEUROSCIENCE, 37(8), 2073-2085, 201702
  21. Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(47), 24465-24474, 201611
  22. Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice, PLOS ONE, 10(7), 201507
  23. Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control, PLOS ONE, 10(6), 201506
  24. Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells, GENES TO CELLS, 20(5), 408-426, 201505
  25. Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements, HUMAN MOLECULAR GENETICS, 23(11), 2953-2967, 201406
  26. ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport, EMBO JOURNAL, 33(11), 1227-1242, 201406
  27. Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model, PLOS GENETICS, 9(12), 201312
  28. Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model, PLoS Genetics, 9(12), e1003983, 2013
  29. OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis, DEVELOPMENT GROWTH & DIFFERENTIATION, 54(4), 474-480, 201205
  30. Presynaptic Dystroglycan-Pikachurin Complex Regulates the Proper Synaptic Connection between Retinal Photoreceptor and Bipolar Cells, JOURNAL OF NEUROSCIENCE, 32(18), 6126-6137, 201205
  31. Kinesin-2 family in vertebrate ciliogenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(7), 2388-2393, 201202
  32. Analysis of Transcriptional Regulatory Pathways of Photoreceptor Genes by Expression Profiling of the Otx2-Deficient Retina, PLOS ONE, 6(5), e19685, 201105
  33. Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(52), 22671-22676, 201012
  34. Post-translational Maturation of Dystroglycan Is Necessary for Pikachurin Binding and Ribbon Synaptic Localization, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(41), 31208-31216, 201010
  35. Blimp1 Suppresses Chx10 Expression in Differentiating Retinal Photoreceptor Precursors to Ensure Proper Photoreceptor Development, JOURNAL OF NEUROSCIENCE, 30(19), 6515-6526, 201005
  36. Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes, FEBS LETTERS, 584(4), 753-758, 201002
  37. Drosophila asterless and Vertebrate Cep152 Are Orthologs Essential for Centriole Duplication, GENETICS, 180(4), 2081-2094, 200812
  38. Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation, NATURE NEUROSCIENCE, 11(8), 923-931, 200808
  39. elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8, NATURE CELL BIOLOGY, 10(4), 437-U140, 200804
  40. Mechanism of positioning the cell nucleus in vertebrate photoreceptors, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(37), 14819-14824, 200709
  41. Reverse genetic analysis of neurogenesis in the zebrafish retina, DEVELOPMENTAL BIOLOGY, 293(2), 330-347, 200605
  42. oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo, CURRENT BIOLOGY, 16(10), 945-957, 200605
  43. Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling, CANCER RESEARCH, 64(23), 8496-8501, 200412
  44. OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 293(1), 470-477, 200204
  45. CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression, NUCLEIC ACIDS RESEARCH, 29(10), 2154-2162, 200105
  46. Comparative PCR: A simple and sensitive method for quantifying low-abundance mRNA species, GENOMICS, 67(2), 140-145, 200007
  47. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin, JOURNAL OF HUMAN GENETICS, 43(3), 169-177, 1998
  48. Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia, JOURNAL OF HUMAN GENETICS, 43(2), 115-122, 1998
  49. Cloning and characterization of a novel member of the human mad gene family (MADH6), GENOMICS, 42(3), 446-451, 199706
  50. Isolation of a novel human cDNA (rhoHP1) homologous to Rho genes, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1351(1-2), 13-16, 199703
  51. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1, CYTOGENETICS AND CELL GENETICS, 78(3-4), 285-288, 1997
  52. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1, Cytogenetic and Genome Research, 78(3-4), 285-288, 19970101

Invited Lecture, Oral Presentation, Poster Presentation

  1. 古くて新しいポリコーム:そのエピジェネティック制御機構をマウスと一緒に考える SAMドメイン蛋白質Samd7は網膜桿体視細胞の最終分化をエピジェネティックに制御する組織特異的なポリコーム複合体1の構成要素である, 大森 義裕; 久保 竣; 今 鉄男; 古橋 真佑; 成田 宏隆; 上野 明希子; 堤 崚太郎; 茶屋 太郎; 上野 真治; 古関 明彦; 中川 敦史; 古川 貴久, 生命科学系学会合同年次大会, 2017/12, 生命科学系学会合同年次大会運営事務局
  2. Senior Loken症候群における新規遺伝子座(SCLT1遺伝子変異)の同定, 片桐聡; 林孝彰; 村井法之; 大森義裕; 岩田岳; 松井善一; 吉武和敏; 久保寛之; 久保寛之; 古川貴久; 常岡寛, 日本眼科学会雑誌, 2016/03/02
  3. 繊毛キナーゼによる繊毛内輸送システムの制御と繊毛関連疾患の発症メカニズム, OMORI YOSHIHIRO; CHAYA TARO; FURUKAWA TAKAHISA, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 2014
  4. Otx2欠損マウス網膜の遺伝子発現プロファイル解析と錐体双極細胞に発現する膜貫通蛋白質Tmem215の同定, YOSHIDA REIYO; IRIE SHOICHI; OKAMOTO SHIO; KITAMURA TAMIKI; RYU CHIHARU; OMORI YOSHIHIRO; FURUKAWA TAKAHISA, 日本分子生物学会年会プログラム・要旨集(Web), 2014
  5. 繊毛キナーゼICKは発生過程における繊毛形成と繊毛の先端におけるタンパク質輸送の制御に必須である, 茶屋太郎; 大森義裕; 古川貴久, 日本分子生物学会年会プログラム・要旨集(Web), 2013
  6. Cfmは軟骨性細胞の分化制御に必須の分子である, 水橋孝治; 金本隆司; 森石武史; 村西由紀; 宮崎敏博; 寺田晃士; 大森義裕; 伊東昌子; 小守壽文; 古川貴久, 日本分子生物学会年会プログラム・要旨集(Web), 2013
  7. Intestinal cell kinase(ICK)は神経前駆細胞における繊毛の形成とヘッジホッグシグナル伝達経路の構成因子の繊毛への局在を制御する, 茶屋太郎; 大森義裕; 古川貴久, 日本生化学会大会(Web), 2012
  8. ジストログリカンの新規リガンド分子ピカチュリンの結合解析と病態への関与, 金川基; 大森義裕; 久我敦; 遠藤玉夫; 古川貴久; 戸田達史, 日本糖質学会年会要旨集, 2011/06/27
  9. Identification of Evolutionally Conserved Genes Involved in DNA Repair Process., SAITO AKIHIKO; SHIMADA YOSHIKAZU; NISHINO NAOKI; SUZUKI MIKIO; OMORI YOSHIHIRO; HIRANO HISANOBU; FUJIWARA TSUTOMU; TAKAHASHI EIICHI; HORIE MASATO, 日本分子生物学会年会プログラム・講演要旨集, 1997/12
  10. Analysis of peroxisome film protein in yeast Candida tropicalis., OMORI YOSHIHIRO; KAMATA YASUSHI; UEDA MITSUYOSHI; TANAKA ATSUO, 日本農芸化学会関西支部講演会講演要旨集, 1996/02